Article
Endocrinology & Metabolism
Jackie Elliott, Gordon Sloan, Lynda Stevens, Dinesh Selvarajah, Giorgio Cruccu, Rajiv A. Gandhi, Peter Kempler, John H. Fuller, Nishi Chaturvedi, Solomon Tesfaye
Summary: This study analyzed the EURODIAB Prospective Complications Study data to investigate the incidence and risk factors of painful DPN. It found that female sex was a risk factor for painful DPN and there was less evidence of diabetic nephropathy in painful DPN cases.
Article
Clinical Neurology
Julian Theuriet, Florent Cluse, Alice Gravier-Dumonceau, Geraldine Picard, Sterenn Closs, Veronique Rogemond, Noemie Timestit, Francoise Bouhour, Philippe Petiot, Vincent Davy, Eve Chanson, Joaquin Arzalluz-Luque, Romain Marignier, Jerome Honnorat, Antoine Pegat
Summary: This study aimed to investigate peripheral nervous system (PNS) symptoms in patients with cerebrospinal fluid (CSF) GFAP-Abs. It was found that 24% of the GFAP-Abs patients presented with PNS involvement, including cranial nerve injury and lower limb radiculopathy.
JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Styliani Ntavidi, Panagiota Katsanou, George Marakomichelakis, Maria-Iosifina Kasdagli, Eleni Antiochou, Ioulia Mpali, Anda-Monica Kakou, Konstantinos Tsioufis, George Dimitriadis, Vaia Lambadiari
Summary: The aim of this study was to assess the association between the stages of diabetic peripheral neuropathy (DPN) and hypertension (HTN) in a Greek population with diabetes. The multivariate analysis showed that non-dippers had a significantly higher risk of developing medium-to-severe DPN compared to dippers, while females had a significantly lower risk of developing moderate/severe DPN compared to males.
Article
Endocrinology & Metabolism
Chao Yu, Lei Zhuang, Feng Xu, Li-hua Zhao, Xiao-hua Wang, Chun-hua Wang, Li-yan Ning, Xiu-lin Zhang, Dong-mei Zhang, Xue-qin Wang, Jian-bin Su
Summary: Increased serum ADA levels may be a potential risk factor for diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lei Zhuang, Chao Yu, Feng Xu, Li-hua Zhao, Xiao-hua Wang, Chun-hua Wang, Li-yan Ning, Xiu-lin Zhang, Dong-mei Zhang, Xue-qin Wang, Jian-bin Su
Summary: This study found that increased plasma D-dimer levels may be associated with diabetic peripheral neuropathy in patients with type 2 diabetes. Elevated plasma D-dimer levels may be a promising indicator for DPN.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jia-Lin Yuan, Le Sun, Bao-Lin Su, Chuang-Xiong Hong
Summary: This case presents a specific adverse drug reaction of corticosteroids that causes diabetes mellitus and subsequently leads to peripheral neuropathy in an acute onset. Mecobalamin and Acupuncture were employed and steroids were discontinued, 8 months later he recovered part of his strength and sensation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Chenxi Li, Weimin Wang, Qiuhe Ji, Xingwu Ran, Hongyu Kuang, Xuefeng Yu, Hui Fang, Jing Yang, Jing Liu, Yaoming Xue, Bo Feng, Minxiang Lei, Dalong Zhu
Summary: This study aimed to investigate the prevalence and risk factors of painful diabetic peripheral neuropathy (PDPN) in mainland China among patients with type 2 diabetes mellitus (T2DM) and diabetic peripheral neuropathy (DPN). A nationwide cross-sectional study was conducted, involving T2DM patients with DPN from 25 provinces in China. The study found that over half of the patients with DPN in mainland China had PDPN. Various factors such as age, education level, duration of diabetes, cholesterol levels, and comorbidities were independently associated with PDPN.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Jonathan Enders, Daniel Elliott, Douglas E. Wright
Summary: Diabetic peripheral neuropathy (DPN) is a complication of metabolic syndrome and diabetes, causing sensory changes such as slow nerve conduction, nerve degeneration, loss of sensation, pain, and gait abnormalities. Nonpharmacologic approaches, including dietary interventions and exercise, show promise in treating DPN. These lifestyle interventions have the potential to provide meaningful relief for patients and identify new therapeutic targets.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Endocrinology & Metabolism
Jiayi Liu, Xiaoyong Yuan, Jin Liu, Geheng Yuan, Yalan Sun, Donghui Zhang, Xin Qi, Huijuan Li, Junqing Zhang, Bing Wen, Xiaohui Guo
Summary: This study investigated the prevalence and risk factors of DPN, PAD, and foot deformity among diabetes patients in Beijing, China. The study found a higher prevalence of foot deformities compared to DPN and PAD, and identified various factors associated with these conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Petra Baum, Klaus V. Toyka, Matthias Blueher, Joanna Kosacka, Marcin Nowicki
Summary: The pathogenesis of diabetic neuropathy is complex, with low-grade intraneural inflammation being a common feature. In addition to iron deficiency, obesity and dyslipidemia may also contribute to neuropathy. Anti-inflammatory compounds with different modes of action could potentially be used for treatment or prevention of diabetic neuropathy if further substantiated by human tissue data and intervention studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Rodica Pop-Busui, Barbara H. Braffett, Hunter Wessells, William H. Herman, Catherine L. Martin, Alan M. Jacobson, Aruna Sarma
Summary: This study examined the associations between diabetic peripheral neuropathy (DPN) and urological complications in patients with type 1 diabetes. The results showed that DPN is associated with erectile dysfunction and lower urinary tract symptoms in men.
Article
Endocrinology & Metabolism
Lam-Chung Cesar Ernesto, Martinez Zavala Nestor, Ibarra-Salce Raul, Pozos Varela Francisco Javier, Mena Ureta S. Tania, Berumen Hermosillo Francisco, Campos Munoz Alejandro, Janka Zires Marcela, Paloma Almeda-Valdes
Summary: The Ipswich touch test (IpTT) demonstrated the best diagnostic performance and agreement in detecting sensory neuropathy among Hispanic patients with type 1 diabetes (T1D). It is considered a useful and simple screening tool for diabetic neuropathy and should be included in future guidelines for diabetic foot examination.
ENDOCRINE PRACTICE
(2021)
Review
Neurosciences
Yifan Cheng, Yinuo Chen, Kezheng Li, Shuwei Liu, Chunyang Pang, Lingfei Gao, Jiali Xie, L. V. Wenjing, Huan Yu, Binbin Deng
Summary: This review aims to summarize the current knowledge on the pathogenesis of DPN, with a focus on the mechanism and application of inflammatory response.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Jamie Burgess, Bernhard Frank, Andrew Marshall, Rashaad S. Khalil, Georgios Ponirakis, Ioannis N. Petropoulos, Daniel J. Cuthbertson, Rayaz A. Malik, Uazman Alam
Summary: Diabetic peripheral neuropathy is a common complication of diabetes that significantly impacts quality of life and healthcare burden. Current screening methods for early detection of DPN have limitations, highlighting the need for further research and clinical practices to improve accuracy and early detection.
Article
Neurosciences
Tingting Fan, Ying Yu, Yong-long Chen, Pan Gu, Stanley Wong, Zheng-yuan Xia, Jessica Aijia Liu, Chi-wai Cheung
Summary: Diabetes patients with painful diabetic neuropathy (PDN) exhibit spinal atrophy and degeneration of astrocytes, leading to pain hypersensitivity. The impaired acetylation of STAT3 in astrocytes and aberrant activation of HDAC5 promote astrocyte deficiency, contributing to the development of PDN in a rat model of type 1 diabetes (T1D). Restoring STAT3 signaling or inhibiting HDAC5 rescues astrocyte deficiency and attenuates PDN, highlighting the therapeutic potential for targeting the HDAC5-STAT3 axis in diabetic spinal cord pathogenesis.
Letter
Gastroenterology & Hepatology
Asuman Celikbilek, Mehmet Celikbilek
LIVER INTERNATIONAL
(2020)
Article
Clinical Neurology
Hikmet Sacmaci, Seda Sabah Ozcan
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Letter
Clinical Neurology
Asuman Celikbilek
JOURNAL OF PAIN RESEARCH
(2020)
Article
Clinical Neurology
Hikmet Sacmaci, Nermin Tanik, Seda Sabah Ozcan, Yavuz Selim Intepe, Tulin Akturk, Bulent Ciftci, Levent Ertugrul Inan
ACTA NEUROLOGICA BELGICA
(2020)
Letter
Anesthesiology
Asuman Celikbilek
Article
Toxicology
S. S. Ozcan, G. Gurel, M. Cakir
Summary: This study evaluated mRNA expression levels of TRP channels in PBMCs of psoriasis patients, finding that compared to controls, some TRP channel genes showed decreased expression levels in the patient group, while others showed increased levels. Different expression patterns of TRP channels may play a role in the pathogenesis of psoriasis.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Letter
Virology
Asuman Celikbilek
JOURNAL OF MEDICAL VIROLOGY
(2021)
Meeting Abstract
Oncology
I. Vardaki, S. Sabah Ozcan, P. Fonseca, A. Ullen, J. Yachnin, T. Panaretakis
ANNALS OF ONCOLOGY
(2021)
Article
Clinical Neurology
BE. Sahin, A. Celikbilek, Y. Kocak, L. Hizmali
Summary: This study investigated the characteristics of COVID-19-related headache and their relationship with clinical severity. The results showed that bilateral, prolonged, moderate to severe headaches that were resistant to analgesics were more frequent in COVID-19 infected patients. Older age, high body mass index, and low education level were associated with greater severity of the disease. Female sex and being a healthcare worker were more common in milder cases.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Clinical Neurology
B. E. Sahin, A. Celikbilek, Y. Kocak, G. T. Saltoglu, N. M. Konar, L. Hizmali
Summary: This study examined the plasma levels of biomarkers GFAP and S100B in relation to persistent neurological symptoms in COVID-19 patients. The results showed that elevated GFAP levels were associated with disease severity but not with neurological symptoms, while high serum S100B levels were associated with multiple neurological symptoms.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Virology
Burc E. Sahin, Asuman Celikbilek, Yusuf Kocak, Bilal Ilanbey, Gamze T. Saltoglu, Naime M. Konar, Lokman Hizmali
Summary: This study examined the levels of neuron-specific enolase (NSE) and neurofilament light chain (NFL) in the plasma of patients with COVID-19 and neurological symptoms. The results showed that high serum levels of NSE were associated with disease severity, while serum NFL levels may play a role in the subacute phase of COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Clinical Neurology
Burc Esra Sahin, Asuman Celikbilek, Yusuf Kocak, Aydan Koysuren, Lokman Hizmali
Summary: This study found a significant relationship between neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) with neurological symptoms (NS) in COVID-19 patients. Advanced age, higher body mass index, and comorbidities were more common in severe cases. However, in the multivariate model, NLR and PLR were not independently associated with disease severity.
JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE
(2023)
Article
Clinical Neurology
Celikbilek Asuman, Koysuren Aydan, Konar Naime Meric
Summary: This study investigated the association between serum vitamin D levels, pre-stroke sleep quality, and the occurrence of poststroke depression and anxiety in acute ischemic stroke patients. The results showed that decreased serum vitamin D levels at admission were associated with a higher risk for poststroke depression and anxiety in patients with poor pre-stroke sleep quality during the early stages of acute ischemic stroke.
SLEEP AND BREATHING
(2023)
Meeting Abstract
Immunology
Havva Ozgen Kilgoz, Seda Sabah Ozcan, Hale Gokcan, Neziha Yilmaz, Hilmi Ataseven, Meral Akdogan, Ertugrul Kayacetin, Ihsan Gursel
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Ozlem Balbaloglu, Seda Sabah Ozcan
ARCHIVES OF MEDICAL SCIENCE
(2020)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
