Journal
NEUROSCIENCE LETTERS
Volume 553, Issue -, Pages 211-215Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.08.029
Keywords
Brain derived neurotrophic factor; BDNF; 5-HT6 receptors; Neurogenesis; Serotonin; Antidepressant drugs
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Funding
- De Montfort University
- BBSRC
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In support of the neurotrophic hypothesis of depression chronic antidepressant drug treatment increases brain-derived neurotrophic factor (bdnf) gene expression and neurogenesis. Regarding 5-HT active drugs, the 5-HT receptor behind these effects remains unidentified. Here we report the effect of repeated 5-HT6-receptor stimulation on bdnf expression and cell survival. The previously reported acute stimulatory action of the selective 5-HT6 agonist LY-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. The effect on 5-HT6-mediated cell survival was also dependent on a similar length of treatment. Hence, our study found no support for a primary effect of 5-HT6 receptors in the mediation of chronic antidepressant drug-induced up-regulation of bdnf expression or neurogenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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