Article
Psychiatry
Dawei Miao, Xiaoguang Zhou, Xiaoyuan Wu, Chengdong Chen, Le Tian
Summary: This study investigated the differences in functional connectivity density (FCD) between AD and MCI, and found significant differences in global FCD values between AD, MCI, and healthy controls. These findings provide new insights into the progressive brain changes from MCI to AD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Yuping Cao, Huan Yang, Zhenhe Zhou, Zaohuo Cheng, Xingfu Zhao
Summary: The study demonstrates abnormal DMN network homogeneity in MCI patients, with significant differences in specific brain regions. These results emphasize the importance of the DMN in the pathophysiology of cognitive problems in MCI.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Qi Feng, Luoyu Wang, Xue Tang, Hanjun Hu, Xiuhong Ge, Zhengluan Liao, Zhongxiang Ding
Summary: By studying the dynamic and static changes of brain networks using the triple network model, sFC and dFC may serve as potential biomarkers for AD and aMCI.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Zhenrong Fu, Mingyan Zhao, Yirong He, Xuetong Wang, Jiadong Lu, Shaoxian Li, Xin Li, Guixia Kang, Ying Han, Shuyu Li
Summary: The study revealed that structural covariance and connectivity strength are decreased in individuals with subjective cognitive decline (SCD) compared to normal controls (NC), and structural covariance patterns in specific large-scale brain networks show divergent changes at the early Alzheimer's disease (aMCI) stage and dementia (AD) stage.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Giulia Quattrini, Moira Marizzoni, Francesca B. Pizzini, Ilaria Boscolo Galazzo, Marco Aiello, Mira Didic, Andrea Soricelli, Diego Albani, Melissa Romano, Olivier Blin, Gianluigi Forloni, Xavier Golay, Jorge Jovicich, Pradeep J. Nathan, Jill C. Richardson, Marco Salvatore, Giovanni B. Frisoni, Michela Pievani
Summary: The study investigated the validity of DMN and LIN perfusion as Alzheimer's disease markers in patients with aMCI. The results showed a significant correlation between decreased perfusion in DMN and LIN with amyloidosis, APOE epsilon 4 status, and memory impairment, supporting their potential as markers for AD in aMCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Hyun Kook Lim
Summary: Mild cognitive impairment (MCI) is an intermediate stage between normal aging and dementia. Depression is prevalent in MCI patients and influences the disease progression. This study investigated the functional connectivity differences in the default mode network (DMN) of MCI patients with and without depression. The results showed increased functional connectivity in the anterior DMN of MCI patients with depression.
Article
Neurosciences
Weina Yao, Haifeng Chen, Xiaoning Sheng, Hui Zhao, Yun Xu, Feng Bai
Summary: The study found that abnormal interaction patterns of DMN subsystems in the early stages of AD appeared as core-centered connection abnormalities, which may serve as potential neuroimaging features for monitoring the development of AD. The impaired cognition was found to be related to disturbances in the interactions between DMN subsystems, particularly in the core subsystem. Additionally, the abnormal regulatory processes of the core subsystem were significantly associated with the levels of cerebrospinal fluid A beta and tau in AD-spectrum patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Zachary D. Green, Eric D. Vidoni, Russell H. Swerdlow, Jeffrey M. Burns, Jill K. Morris, Robyn A. Honea
Summary: This study aimed to investigate the impact of family history on cognitively healthy individuals, and the results showed that individuals with a family history had increased connectivity, possibly serving as compensation.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Huan Yang, Xiaoyu Zhao, Tenglong Wang, Zhenhe Zhou, Zaohuo Cheng, Xingfu Zhao, Yuping Cao
Summary: This study investigates the functional connectivity changes within and between the cingulo-opercular network (CON) and default mode network (DMN) in patients with mild cognitive impairment (MCI). The results show significantly lower functional connectivity within CON in the MCI group compared to healthy controls. However, there were no distinct differences in functional connectivity within DMN and between CON and DMN. These findings contribute to our understanding of network dysfunction in MCI and could inform targeted treatment.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Neurosciences
Verity Smith, John Duncan, Daniel J. Mitchell
Summary: The study revealed that the default mode network (DMN) in the brain becomes more active during decision-making based on naturalistic contexts compared to symbolic cues. While anterior DMN regions are sensitive to the need for contextual control, posterior DMN regions are responsible for processing contextual content and showing stronger representation of the significance of the modulated sound.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Marilena M. M. DeMayo, Jinglei Lv, Shantel L. L. Duffy, Arkiev D'Souza, Loren Mowszowski, Sharon L. L. Naismith, Fernando Calamante
Summary: This study found an association between decreased N-acetylaspartate (NAA) in the hippocampus and changes in functional connectivity within the default mode network (DMN) in older people with mild cognitive impairment (MCI). Understanding these correlations may provide insight into the processes underlying cognitive decline.
BRAIN CONNECTIVITY
(2023)
Article
Clinical Neurology
Mingxi Dang, Caishui Yang, Kewei Chen, Peng Lu, He Li, Zhanjun Zhang
Summary: This study reveals the changes in grey matter covariance during the development and reversion of mild cognitive impairment (MCI) and emphasizes the importance of considering grey matter covariance along with hippocampal degeneration in the early detection of MCI and Alzheimer's disease.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Psychology, Multidisciplinary
Ramana V. Vishnubhotla, Rupa Radhakrishnan, Kestas Kveraga, Rachael Deardorff, Chithra Ram, Dhanashri Pawale, Yu-Chien Wu, Janelle Renschler, Balachundhar Subramaniam, Senthilkumar Sadhasivam
Summary: The intensive Samyama meditation program positively increased brain functional connectivity, particularly between the salience network and default mode network. Meditators showed improved mindfulness scores correlated with increased connectivity within the salience network, indicating the beneficial effects of the program on brain networks and mindfulness.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Matej C. Perovnik, Chris Tang, Mauro Namias, David Eidelberg
Summary: The progression of Alzheimer's disease is associated with two metabolic networks, the AD-related pattern (ADRP) and the default mode network (DMN). The expression levels of ADRP and DMN were measured in individuals with mild cognitive impairment, and it was found that cognitive decline correlated with increases in ADRP and declines in DMN. Baseline ADRP levels were able to predict conversion to dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)