Journal
NEUROSCIENCE LETTERS
Volume 545, Issue -, Pages 132-137Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.04.035
Keywords
Early life stress; Adolescence; Prefrontal cortex; Glutamate; Magnetic resonance spectroscopy; Rat
Categories
Funding
- Major Program of National Natural Science Foundation of China [20930027]
- National Natural Science Foundation of China [60971075]
- NIDA [T32-DA022975]
- Clinical Neurosciences Division of the National Center for Posttraumatic Stress Disorder
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The present study investigated the effect of early life stress in adolescent rats on brain metabolites, serum corticosterone, and depressive-like behavior. A group of rats was subject to early life stress from postnatal day (PND) 1 to 14. A matched control group was studied. Behavioral tests, serum corticosterone and high-resolution proton magnetic resonance spectroscopy were conducted between PND 30 and 40. In this study, adolescent rats exposed to early life stress demonstrated depressive-like behavior and increased serum corticosterone during adolescence. They also showed reduced glutamate, glutamine, and N-acetylaspartate (NAA) levels in the prefrontal cortex. A reduced myo-inositol level, consistent with astroglial deficits, was observed but was not statistically significant. Together, these findings characterize the effect of early life stress on adolescent animals and underscore the long-lasting and detrimental effects of childhood adversities. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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