Article
Geriatrics & Gerontology
Kuniyasu Kamiya, Takahiro Tachiki, Yuho Sato, Katsuyasu Kouda, Etsuko Kajita, Junko Tamaki, Sadanobu Kagamimori, Masayuki Iki
Summary: This study found that CAF110 was associated with the presence and incidence of low muscle mass, but not low muscle strength.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Cell Biology
Jakob Proemer, Cinzia Barresi, Ruth Herbst
Summary: Muscle-specific kinase (MuSK) is the key regulator of neuromuscular junction development and its activation and signaling are tightly regulated. Recent studies using omics techniques have contributed to a better understanding of MuSK signaling. Impaired MuSK signaling causes muscle weakness, but the underlying pathophysiology is often unclear. This review focuses on recent advances in deciphering MuSK activation and downstream signaling, as well as the role of MuSK in non-muscle tissue.
CELLULAR SIGNALLING
(2023)
Article
Developmental Biology
Lauren J. Walker, Rebecca A. Roque, Maria F. Navarro, Michael Granato
Summary: Using a zebrafish pectoral fin model, the study shows similarities in the development of neuromuscular synapses between axial and appendicular muscles, but differences in the MuSK, Agrin, and Lrp4 signaling pathways. This highlights distinct differences between axial and appendicular synapse development.
Article
Developmental Biology
Jun Yu, Marilyn Janice Oentaryo, Chi Wai Lee
Summary: The study demonstrates the essential role of local protein synthesis in presynaptic differentiation at developing neuromuscular junctions. Newly synthesized proteins play a crucial role at agrin bead-neurite contacts. Axonal MT1-MMP translation is shown to be vital in mediating agrin-induced presynaptic differentiation, in addition to the recognized long-range transport of MT1-MMP proteins.
Article
Neurosciences
Taro Inoue, Bisei Ohkawara, Samira Bushra, Shunsuke Kanbara, Hiroaki Nakashima, Hiroyuki Koshimizu, Hiroyuki Tomita, Mikako Ito, Akio Masuda, Naoki Ishiguro, Shiro Imagama, Kinji Ohno
Summary: Zonisamide enhances agrin-dependent AChR clustering by upregulating the Nrg1/ErbB signaling pathways at the NMJ.
Article
Engineering, Biomedical
Ji Hyun Kim, In Kap Ko, Myung Jae Jeon, Ickhee Kim, Margaret Maria Vanschaayk, Anthony Atala, James J. Yoo
Summary: Efficient innervation is crucial for successful grafting and functional recovery of bioengineered skeletal muscle constructs. In this study, a 3D bioprinted human skeletal muscle construct with pre-formed AChR clusters is developed and shown to accelerate innervation in vivo, leading to functional muscle reconstruction in a rat model of pelvic floor muscle injury.
ACTA BIOMATERIALIA
(2021)
Article
Zoology
Wen-Yo Tu, Wentao Xu, Jianmin Zhang, Shuyuan Qi, Lei Bai, Chengyong Shen, Kejing Zhang
Summary: Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron disease characterized by the loss of control of skeletal muscles. Degeneration of neuromuscular junctions (NMJs) is an early event in ALS. Poly-GA, the most abundant form of DPR in C9-ALS, is released from cells and impairs NMJs through inhibiting Agrin-MuSK signaling.
ZOOLOGICAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Jedd Pratt, Giuseppe De Vito, Marco Narici, Ricardo Segurado, Ludmilla Pessanha, Jackie Dolan, Judith Conroy, Colin Boreham
Summary: This study confirms the relevance of plasma CAF as a biomarker for sarcopenia, showing significant associations with muscle mass and elevated levels in sarcopenic individuals. Gender differences were observed, with males showing elevated CAF levels in low grip strength or low ALM, while only low ALM in females had significantly raised CAF concentrations compared to healthy controls.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Neurosciences
Anselmo Canciani, Cristina Capitanio, Serena Stanga, Silvia Faravelli, Luigi Scietti, Lisa Mapelli, Teresa Soda, Egidio D'Angelo, Pascal Kienlen-Campard, Federico Forneris
Summary: Neurotrypsin is a specific nervous system serine protease with important roles in synaptic plasticity and neuromuscular junction degeneration. This study provides insights into the regulatory effects of NT on agrin signaling, as well as the molecular mechanisms and biological significance of NT-agrin interactions. The results have important implications for understanding the pathology of neurological disorders.
MOLECULAR NEUROBIOLOGY
(2022)
Editorial Material
Health Care Sciences & Services
Cyrus Motamed
Summary: Sugammadex is used in various emergency situations, including emergency surgery and rapid sequence intubation. The trend of using sugammadex after rocuronium instead of succinylcholine is increasing. In other emergency situations, such as anaphylactic shock caused by rocuronium or when intubation or ventilation is not possible, priority should be given to maintaining ventilation and hemodynamic stability, according to the traditional guidelines. Prompt reversal of neuromuscular blockade should be done if necessary for resuming ventilation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Geriatrics & Gerontology
Jedd Pratt, Laura Whitton, Anthony Ryan, Thorhildur Juliusdottir, Jackie Dolan, Judith Conroy, Marco Narici, Giuseppe De Vito, Colin Boreham
Summary: The genes AGRN and PRSS12 are associated with muscle mass and strength, indicating their importance in maintaining muscle health during aging. This study provides novel evidence supporting the role of the neuromuscular junction (NMJ) in sarcopenia phenotypes.
Article
Cell Biology
Roberta Sartori, Adam Hagg, Sandra Zampieri, Andrea Armani, Catherine E. Winbanks, Lais R. Viana, Mouna Haidar, Kevin Watt, Hongwei Qian, Camilla Pezzini, Pardis Zanganeh, Bradley J. Turner, Anna Larsson, Gianpietro Zanchettin, Elisa S. Pierobon, Lucia Moletta, Michele Valmasoni, Alberto Ponzoni, Shady Attar, Gianfranco Da Dalt, Cosimo Sperti, Monika Kustermann, Rachel E. Thomson, Lars Larsson, Kate L. Loveland, Paola Costelli, Aram Megighian, Stefano Merigliano, Fabio Penna, Paul Gregorevic, Marco Sandri
Summary: The study showed that diminished BMP signaling is associated with cancer-induced muscle wasting, and increasing BMP signaling could prevent muscle wasting. This presents an attractive strategy to counteract the loss of functional musculature in cancer patients.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Qiao Ding, Kaamini Kesavan, Kah Meng Lee, Elyse Wimberger, Thomas Robertson, Melinder Gill, Dominique Power, Jeryn Chang, Atefeh T. Fard, Jessica C. Mar, Robert D. Henderson, Susan Heggie, Pamela A. McCombe, Rosalind L. Jeffree, Michael J. Colditz, Massimo A. Hilliard, Dominic C. H. Ng, Frederik J. Steyn, William D. Phillips, Ernst J. Wolvetang, Shyuan T. Ngo, Peter G. Noakes
Summary: A defect in the n-agrin-LRP4-MuSK signaling pathway has been identified in muscle from MND patients for the first time. This signaling pathway plays a crucial role in maintaining the stability of the neuromuscular junction. These findings provide a potential therapeutic target for prolonging muscle function in MND patients.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Clinical Neurology
Zheng Yu, Meiying Zhang, Hongyang Jing, Peng Chen, Rangjuan Cao, Jinxiu Pan, Bin Luo, Yue Yu, Brandy M. Quarles, Wencheng Xiong, Michael H. Rivner, Lin Mei
Summary: The study aimed to investigate the pathogenic role of human anti-LRP4/agrin antibodies in mice and found that the antibodies led to MG symptoms in the mice. The antibodies impaired neuromuscular junction function and disrupted agrin-dependent LRP4-MuSK interaction, providing insights into the pathogenic mechanisms of these antibodies.
Article
Clinical Neurology
Zheng Yu, Meiying Zhang, Hongyang Jing, Peng Chen, Rangjuan Cao, Jinxiu Pan, Bin Luo, Yue Yu, Brandy M. Quarles, Wencheng Xiong, Michael H. Rivner, Lin Mei
Summary: The study found that antibodies against LRP4/agrin from a patient with MG can induce MG symptoms in mice, including weight loss and muscle weakness. These antibodies impair the neuromuscular junction by interfering with agrin-dependent LRP4-MuSK interaction, leading to compromised neuromuscular transmission and fragmentation of the neuromuscular junction.
Article
Physiology
A. Bernareggi, E. Luin, B. Pavan, G. Parato, M. Sciancalepore, R. Urbani, P. Lorenzon
Article
Engineering, Biomedical
Paola D'Andrea, Denis Scaini, Luisa Ulloa Severino, Violetta Borelli, Sabina Passamonti, Paola Lorenzon, Antonella Bandiera
Article
Cell Biology
M. Sciancalepore, T. Coslovich, P. Lorenzon, G. Ziraldo, G. Taccola
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2015)
Article
Biophysics
Paola D'Andrea, Deborah Civita, Michela Cok, Luisa Ulloa Severino, Francesca Vita, Denis Scaini, Loredana Casalis, Paola Lorenzon, Ivan Donati, Antonella Bandiera
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
(2017)
Review
Biochemistry & Molecular Biology
Katarina Mis, Zoran Grubic, Paola Lorenzon, Marina Sciancalepore, Tomaz Mars, Sergej Pirkmajer
Article
Neurosciences
Annalisa Bernareggi, Elisa Ren, Arthur Giniatullin, Elisa Luin, Marina Sciancalepore, Rashid Giniatullin, Paola Lorenzon
Article
Food Science & Technology
Paola Sist, Federica Tramer, Paola Lorenzon, Ranieri Urbani, Urska Vrhovsek, Annalisa Bernareggi, Marina Sciancalepore
JOURNAL OF FUNCTIONAL FOODS
(2018)
Article
Biochemistry & Molecular Biology
Katarina Gros, Giulia Parato, Sergej Pirkmajer, Katarina Mis, Matej Podbregar, Zoran Grubic, Paola Lorenzon, Tomaz Mars
JOURNAL OF MOLECULAR NEUROSCIENCE
(2014)
Article
Toxicology
Giorgia Del Favero, Silvio Sosa, Mark Poli, Aurelia Tubaro, Orfeo Sbaizero, Paola Lorenzon
TOXICOLOGY LETTERS
(2014)
Article
Biochemistry & Molecular Biology
Paola D'Andrea, Marina Sciancalepore, Katerina Veltruska, Paola Lorenzon, Antonella Bandiera
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2019)
Review
Neurosciences
Annalisa Bernareggi, Marina Sciancalepore, Paola Lorenzon
Article
Oncology
Alessandra Bosutti, Annalisa Bernareggi, Gabriele Massaria, Paola D'Andrea, Giuliano Taccola, Paola Lorenzon, Marina Sciancalepore
EXPERIMENTAL CELL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Paola Lorenzon, Sandra Furlan, Barbara Ravara, Alessandra Bosutti, Gabriele Massaria, Annalisa Bernareggi, Marina Sciancalepore, Gabor Trautmann, Katharina Block, Dieter Blottner, Paul F. Worley, Sandra Zampieri, Michele Salanova, Pompeo Volpe
Summary: The study demonstrates that Homer 2 plays a crucial role in skeletal muscle adaptation and plasticity, with specific effects on muscle fiber cross-sectional area and gene expression. Further investigation is needed to determine the impact of Homer 2 deficiency on neuromuscular junction remodeling.
Review
Biochemistry & Molecular Biology
Annalisa Bernareggi, Alessandra Bosutti, Gabriele Massaria, Rashid Giniatullin, Tarja Malm, Marina Sciancalepore, Paola Lorenzon
Summary: Piezo1 channels play a crucial role in the physiology of skeletal muscle, particularly in controlling myogenic precursor activity and the regeneration and vascularization of skeletal muscle. Pharmacological activation of Piezo1 channels with Yoda1 has shown potential in promoting skeletal muscle regeneration and may be a promising therapeutic strategy for skeletal muscle disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katarina Gros, Urska Matkovic, Giulia Parato, Katarina Mis, Elisa Luin, Annalisa Bernareggi, Marina Sciancalepore, Tomaz Mars, Paola Lorenzon, Sergej Pirkmajer
Summary: Neuronal agrin has an age-dependent role in promoting the proliferation of human myoblasts by binding to Lrp4 and activating MuSK.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
