Article
Pharmacology & Pharmacy
Mingli Duan, Yurui Jia, Lifang Huo, Yiting Gao, Jia Wang, Wei Zhang, Zhanfeng Jia
Summary: The study found that vincristine-induced mechanical allodynia and hyperalgesia in rats are related to the PIEZO2 channel. By gene knockdown and pharmacological inhibition of the PIEZO2 channel, mechanical hypersensitivity caused by vincristine can be alleviated. Further experiments showed that vincristine enhances the mechanical activation of PIEZO2 currents by increasing the static plasma membrane tension of cells. Therefore, inhibiting the PIEZO2 channel may be an effective method to attenuate vincristine-induced mechanical hypersensitivity.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Jeffrey R. McArthur, Nehan R. Munasinghe, Rocio K. Finol-Urdaneta, David J. Adams, Macdonald J. Christie
Summary: Research has shown that Pn3a produces analgesic effects by inhibiting HVA Ca(v), with enhanced inhibition observed when co-administered with opioid agonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Li-Ping Xia, Hao Luo, Qiang Ma, Ya-Kai Xie, Wei Li, Hailan Hu, Zhen-Zhong Xu
Summary: GPR151 in nociceptive dorsal root ganglion neurons plays a crucial role in the pathogenesis of neuropathic pain by controlling neuronal hyperexcitability and promoting spinal microglial activation, indicating its potential as a therapeutic target for neuropathic pain treatment.
Article
Pharmacology & Pharmacy
Mohammad-Reza Ghovanloo, Mark Estacion, Grant P. Higerd-Rusli, Peng Zhao, Sulayman Dib-Hajj, Stephen G. Waxman
Summary: CBG selectively inhibits Na(v)1.7 channels in DRG neurons, contributing to its analgesic properties. At lower concentrations, CBG blocks sodium G(max) and slows recovery from inactivation, while higher concentrations also induce a hyperpolarizing shift in the half-voltage of inactivation. Experimental results suggest that CBG attenuates DRG excitability.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Donghang Zhang, Wenling Zhao, Jin Liu, Mengchan Ou, Peng Liang, Jia Li, Yali Chen, Daqing Liao, Siqi Bai, Jiefei Shen, Xiangdong Chen, Han Huang, Cheng Zhou
Summary: NALCN plays a significant role in chronic neuropathic pain, and knockdown of NALCN can significantly alleviate pain-related symptoms.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yiru Wang, Xinyi Wang, Renfei Qi, Ying Lu, Yu Tao, Dongsheng Jiang, Yufang Sun, Xinghong Jiang, Chunfeng Liu, Yuan Zhang, Jin Tao
Summary: The study reveals a novel mechanism by which IL-33/ST2 suppresses A-type K+ currents in sensory neurons, leading to increased neuronal excitability and pain sensitivity. This mechanism involves the suppression of the tumorigenicity 2 (ST2) receptor and the activation of a Syk-dependent p38 beta signaling pathway. Targeting IL-33/ST2-mediated p38 beta signaling may represent a therapeutic approach to ameliorate pain behaviors.
Article
Anesthesiology
Dongman Chao, Christina M. Mecca, Guoliang Yu, Ian Segel, Michael S. Gold, Quinn H. Hogan, Bin Pan
Summary: Dorsal root ganglion field stimulation can relieve neuropathic pain by blocking spontaneous activity in injured neurons, leading to reduced pain behavior and ongoing pain. The effects are more significant in injured neurons, affecting both pain behavior and ongoing pain.
Article
Biochemistry & Molecular Biology
Huijing Xie, Ju Li, Nan Lian, Min Xie, Minming Wu, Kuo Tang, Yi Kang, Peilin Lu, Tao Li
Summary: Impaired branched-chain amino acid catabolism in dorsal root ganglion neurons sensitizes mice to mechanical pain by increasing lactate production and expression of the mechanotransduction channel Piezo2.
Article
Biology
Yucheng Xiao, Jonathan W. Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore R. Cummins
Summary: In this study, the authors demonstrate that I-NaR can be reconstituted in a heterologous system by coexpression of sodium channel alpha-subunits and A-type fibroblast growth factor homologous factors (FHFs). They also identify the N-terminus of FHF as the critical molecule responsible for A-type FHFs-mediated I-NaR. Moreover, knockdown of FHF4A significantly reduces I-NaR amplitude and suppresses excitability in nociceptive sensory neurons.
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Physiology
Kate Poole
Summary: Many aspects of mammalian physiology are regulated by mechanical processes, and mechanically activated ion channels play a vital role in this mechanotransduction. These ion channels act as force sensors and are directly activated by mechanical inputs, leading to changes in ionic flux across the plasma membrane. Recent research has revealed the widespread expression of these channels in mammalian cells, not only in touch sensation and hearing, but also in various other processes such as the development of mechanoresponsive structures and mechanically driven homeostatic maintenance. The diverse functions of mechanically activated ion channels highlight their significance in mammalian physiology.
ANNUAL REVIEW OF PHYSIOLOGY
(2022)
Article
Neurosciences
Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim, Riki Kawaguchi, Lubin Chen, Mahmoud El-Rifai, Daniel H. Geschwind, Sulayman D. Dib-Hajj, Stephen G. Waxman, Clifford J. Woolf
Summary: Mutations in the Scn9a gene can lead to various pain and neuropathy disorders. Previous studies have shown that the Nav1.7 gene mutation affects sodium conductance and neuronal excitability, but does not affect mechanical and thermal sensitivity in young mice. However, this new research demonstrates that as mice with this mutation age, they develop insensitivity to pain and cold, as well as skin lesions. Electrophysiology and RNA sequencing reveal a loss of sodium conductance and decreased expression of cLTMR genes in aged mice with the mutation.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yingqiao Wang, Raghav Garg, Jane E. Hartung, Adam Goad, Dipna A. Patel, Flavia Vitale, Michael S. Gold, Yury Gogotsi, Tzahi Cohen-Karni
Summary: Utilizing nanomaterial-assisted photothermal stimulation, Ti3C2Tx (MXene) demonstrates excellent potential as a candidate for remote, non-genetic, optical modulation of neuronal electrical activity with high spatiotemporal resolution. The material's photothermal response, low cytotoxicity, and ease of large-scale synthesis make it a promising tool for modulating electrophysiology at various scales.
Article
Multidisciplinary Sciences
Haohao Wu, Charles Petitpre, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab, Francois Lallemend
Summary: The study identified three main types of proprioceptive neurons (Ia, Ib and II PNs) and found that they segregate into eight distinct subgroups. Importantly, Ia-PN subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)