Article
Health Care Sciences & Services
Takashi Uehara, Masayoshi Kurachi, Takashi Kondo, Hitoshi Abe, Hiroko Itoh, Tomiki Sumiyoshi, Michio Suzuki
Summary: Oxidative stress is implicated as a potential mechanism of schizophrenia. Researchers synthesized novel compounds and found that they exhibited antipsychotic properties, indicating their potential to alleviate symptoms of schizophrenia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Giridhari Pal, Khalid Anwer, Abdullah Alshetaili, Jyotirmoyee Jena, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Aditi Sharma, Ashraf Al-Brakati, Simona Bungau, Tapan Behl
Summary: The study evaluated the effects of NO modulators and antioxidant treatments on endocrine, cellular, and oxidative stress markers in repetitively stressed rats. The results showed that these treatments have different impacts on cellular markers, and the complex interaction between NO and cellular markers plays a crucial modulatory role in this phenomenon.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Nan Su, Weiqi Zhang, Nicole Eter, Peter Heiduschka, Mingyue Zhang
Summary: Schizophrenia is associated with abnormalities in visual processes, and abnormal Nrg1 expression has been observed in clinical studies. This study investigated the effects of Nrg1 overexpression on visual function in transgenic mice. The results showed that Nrg1 overexpression changed visual function, suggesting its potential as a biomarker for psychiatric disorders and a tool for diagnosis in psychiatry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tianjie Yuan, Danyun Fu, Rui Xu, Jiahui Ding, Jinhong Wu, Yuan Han, Wenxian Li
Summary: Stress-induced hyperalgesia is a health-threatening condition that lacks effective therapeutic intervention, impairing the quality of life. The co-chaperone protein FK506-binding protein 5 (FKBP5) was reported to modulate steroid sensitivity and inhibition of FKBP51 possessed anxiolytic and anti-hyperalgesic in the stressed-mice model. However, whether corticosterone and FKBP5 play a role in chronic stress-induced corneal hyperalgesia remains unknown.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Genetics & Heredity
Atefeh Moradkhani, Abduladheem Turki Jalil, Marwan Mahmood Saleh, Elmira Vanaki, Hossein Daghagh, Behrouz Daghighazar, Zahra Akbarpour, Hossein Ghahramani Almanghadim
Summary: This study investigated the allelic and genotypic correlation of the mononucleotide rs35753505 polymorphism of Neuregulin 1 (NRG1) gene with psychopathology and intelligence. The results showed a significant correlation between this polymorphism and Positive and Negative Syndrome Scale (PANSS) test results, and a significant decrease in overall intelligence in patients with schizophrenia compared to the control group.
Article
Biochemistry & Molecular Biology
Jihye Lee, Huiyoung Kwon, Eunbi Cho, Jieun Jeon, In-Kyu Lee, Wan-Seob Cho, Se Jin Park, Seungheon Lee, Dong Hyun Kim, Ji Wook Jung
Summary: Stress and stress hormones can lead to various neurological disorders, including anxiety disorders. This study found that Hydrangea macrophylla and its active ingredient, thunberginol C, have potential in preventing and treating stress-induced neurological disorders by regulating signaling pathways and reducing inflammation and oxidative stress.
Article
Agriculture, Multidisciplinary
Zhi Wang, Suwei Jin, Tianji Xia, Yongguang Liu, Yunfeng Zhou, Xinmin Liu, Ruile Pan, Yonghong Liao, Mingzhu Yan, Qi Chang
Summary: Nelumbo nucifera Gaertn. is an important aquatic vegetable, and its dried stamen (Nelumbinis stamen, NS) is a valuable nutraceutical usually used as a herbal tea. NS significantly mitigated CRS-induced skeletal muscle dysfunction and fatigue in mice possibly by lowering serum corticosterone levels and restoring Sestrin2 expression in the gastrocnemius to regulate metabolism, preserve mitochondrial homeostasis, and promote antioxidant capacity. These results demonstrate that NS can be used as a nutraceutical or supplement for controlling stress-induced muscle dysfunction and fatigue.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Neurosciences
Bhedita J. Seewoo, Eng Guan Chua, Yasmin Arena-Foster, Lauren A. Hennessy, Anastazja M. Gorecki, Ryan Anderton, Jennifer Rodger
Summary: The composition of gut microbiome is closely related to mood-related behaviors, including depression. This study found that chronic restraint stress (CRS) led to changes in gut microbiome composition, while low-intensity repetitive transcranial magnetic stimulation (LI-rTMS) treatment was associated with the restoration of the gut microbiome and improvement in depressive symptoms and inflammatory processes.
NEUROBIOLOGY OF STRESS
(2022)
Review
Cell Biology
Bruno Vincent, Subhamita Maitra
Summary: Alzheimer's disease and schizophrenia have common fronto-temporal anomalies that may result in coexisting symptoms. β-amyloid precursor protein and neuregulin 1, two neuronal proteins, have been considered in explaining the relationship between these two disorders. However, the mechanisms behind the development of co-morbid symptoms are still unclear.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Paulina Misztak, Magdalena Sowa-Kucma, Patrycja Panczyszyn-Trzewik, Bernadeta Szewczyk, Gabriel Nowak
Summary: Chronic stress is a key factor in the development of depressive symptoms. The combination of fluoxetine and zinc induces a more pronounced antidepressant effect in the chronic restraint stress model. Zinc supplementation enhances the effectiveness of fluoxetine and plays a role in epigenetic regulation.
Article
Veterinary Sciences
Sen Yang, Qiang Zheng, Guoan Yin
Summary: Adverse stress, such as long-term food restriction and activity limitation, can lead to depression-like mental state in sows. This study aimed to establish a pig depression model using acute stress and evaluate the model's feasibility. Results showed that after acute stress, pigs exhibited decreased feed intake, sucrose preference, and hippocampal 5-HT levels, as well as increased serum COR levels and fear. The overall score for the model was 0.57, suggesting that modeling was feasible. This novel model provides insight into the biological mechanisms underlying mood disorders in pigs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Franziska Kessler, Angelika Gruempel-Schlueter, Christian Looft, Stefanie Petow
Summary: This study compared the effect of different housing conditions (single cages and floor pens) on the morphology of the adrenal gland in laying hens. The results showed that hens in floor pens had higher body weight, a slightly higher adrenal-interrenal ratio, indicating a potential chronic stress condition.
Article
Agriculture, Dairy & Animal Science
T. Bartels, J. Berk, K. Cramer, E. Kanitz, W. Otten
Summary: The study analyzed the effects of corticosterone supplementation on feather corticosterone concentrations (fCORT) in layer pullets, finding that increased corticosterone levels led to decreased body weight, shorter and lighter feathers, and a delayed molt. The results suggest that fCORT measurement can be a useful tool for evaluating long-term stress in chickens and may have implications for animal welfare research.
Article
Behavioral Sciences
Stefan Guerra, Rose Chesworth, Cynthia Shannon Weickert, Tim Karl
Summary: Handling methods significantly affect various behavioral domains, thus the impact of routine handling procedures should be considered when testing behavioral phenotypes. Handling did not alter the main schizophrenia-relevant characteristics of Nrg1 III tg mice but did affect the acoustic startle response in a genotype- and sex-specific manner. Future research should assess the effect of handling on other genetic models.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Sanjeev K. Bhardwaj, Qiming Cui, Luc Moquin, Alain Gratton, Bruno Giros, Lalit K. Srivastava
Summary: Reduced expression of schizophrenia-associated gene DTNBP1 and its protein product dysbindin-1 in the brains of schizophrenia patients has been reported. Mouse models with DTNBP1 knockout show altered dopaminergic, glutamatergic, and GABAergic neurotransmission in cortico-limbic regions. Dysbindin-1 deficiency in dopamine neurons leads to impaired mesolimbic dopamine transmission, affecting locomotor behavior and prepulse inhibition.
Letter
Pharmacology & Pharmacy
Lyndsey L. Anderson, Jonathon C. Arnold, Iain S. McGregor, Tamara R. Nation
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Rheumatology
Zubeyir Salis, Blanca Gallego, Tuan V. Nguyen, Amanda Sainsbury
Summary: This study aimed to define the association between change in body mass index (BMI) and the incidence and progression of the structural defects of knee osteoarthritis as assessed by radiography. The results showed that change in BMI was positively associated with both the incidence and progression of knee osteoarthritis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Medicine, Research & Experimental
Jonathon C. Arnold, Danielle McCartney, Anastasia Suraev, Iain S. McGregor
Summary: Global interest in CBD is increasing, with clinical trial evidence supporting high doses for treating childhood epilepsies. However, the therapeutic benefits of low-dose CBD products are still being debated. This review evaluated the efficacy and safety of low oral doses of CBD and found that doses of 300 mg or higher showed evidence of reducing anxiety and anti-addiction effects, but the effects on insomnia, neurological disorders, and chronic pain were limited and inconsistent.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Rheumatology
Zubeyir Salis, Amanda Sainsbury
Summary: This study aimed to define the association between change in body mass index (BMI) and the risk of knee and hip replacement. The results showed that an increase in BMI was positively associated with the risk of knee replacement, but not hip replacement. The findings suggest that weight loss interventions could reduce the burden of knee replacement surgery.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Endocrinology & Metabolism
Felipe Q. da Luz, Amanda Sainsbury, Zubeyir Salis, Phillipa Hay, Taki Cordas, Charles M. Morin, Leo Paulos-Guarnieri, Luisa Pascoareli, Renatha El Rafihi-Ferreira
Summary: Sleep problems compound the negative effects of other health issues, such as eating disorders, particularly binge eating. This systematic review with meta-analyses found that individuals with binge eating had poorer overall sleep quality, greater hypersomnia/daytime sleepiness, insomnia, and difficulty falling asleep compared to those without binge eating. Healthcare professionals are advised to routinely screen for poor overall sleep quality and address sleep difficulties in individuals with binge eating.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Public, Environmental & Occupational Health
Matthew N. Ahmadi, Elif Inan-Eroglu, Gita D. Mishra, Amanda Salis, Emmanuel Stamatakis
Summary: This study examined the association between changes in physical activity and diet with obesity development and changes in body fat percentage, body mass index, and waist circumference. The results showed that increasing physical activity combined with improving diet was most effective in reducing the risk of obesity. Improvements in physical activity or diet mutually attenuated the deleterious associations of the other behavior's deterioration.
PREVENTIVE MEDICINE
(2023)
Article
Rheumatology
Zubeyir Salis, Amanda Sainsbury
Summary: This study aimed to investigate the association between changes in body mass index (BMI) and the incidence and progression of hip osteoarthritis. The results showed that changes in BMI were not associated with the occurrence or progression of hip osteoarthritis.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Endocrinology & Metabolism
Claudia Harper, Judith Maher, Michelle Hsu, Anne Grunseit, Radhika Seimon, Amanda Sainsbury
Summary: This study aimed to explore the behaviors and experiences of postmenopausal women who had followed a 4-month VLED, followed by a food-based, moderately energy-restricted diet for an additional 8 months. The study found that the rapid and significant weight loss, in conjunction with ease of use, was motivational and helped instill confidence in the participants. Additionally, participants reported that ongoing occasional use of meal replacement products provided a useful and easy new strategy for countering weight regain and supporting their weight maintenance regimen.
OBESITY SCIENCE & PRACTICE
(2023)
Article
Health Care Sciences & Services
Zubeyir Salis, Blanca Gallego, Amanda Sainsbury
Summary: This study shows that categorizing continuous predictor variables can alter the results of analysis and potentially lead to different conclusions. Therefore, researchers in rheumatology should avoid this practice.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Geriatrics & Gerontology
Zubeyir Salis, Li-Yung Lui, Nancy E. Lane, Kristine Ensrud, Amanda Sainsbury
Summary: This study aimed to determine whether weight loss has any clear benefit for radiographic hip osteoarthritis in older adults. The results showed no associated benefit of weight loss for the development or progression of hip osteoarthritis.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Neurosciences
Rose Chesworth, Gabriela Visini, Tim Karl
Summary: The study investigates if genetic risk for schizophrenia affects drug reward and reinforcement for cocaine. The results suggest that Nrg1 mutation impairs response inhibition for cocaine and limits control over its use.
PSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Georgia Watt, Tim Karl, Rose Chesworth
Summary: Circadian rhythm has significant impacts on the physiological domains and behavior expression in mice, such as body temperature, hormone levels, and immune function. However, the effects on cognitive behavior are not well-established, and there is limited research on the impact of circadian rhythm on operant responding in mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hiba Jebeile, Natalie B. Lister, Sol Libesman, Kylie E. Hunter, Caitlin M. McMaster, Brittany J. Johnson, Louise A. Baur, Susan J. Paxton, Sarah P. Garnett, Amy L. Ahern, Denise E. Wilfley, Sarah Maguire, Amanda Sainsbury, Katharine Steinbeck, Lisa Askie, Caroline Braet, Andrew J. Hill, Dasha Nicholls, Rebecca Jones, Genevieve Dammery, Alicia M. Grunseit, Kelly Cooper, Theodore K. Kyle, Faith A. Heeren, Fiona Quigley, Rachel D. Barnes, Melanie K. Bean, Kristine Beaulieu, Maxine Bonham, Kerri N. Boutelle, Braulio Henrique Magnani Branco, Simona Calugi, Michelle Cardel, Kelly Carpenter, Hoi Lun Cheng, Riccardo Dalle Grave, Yngvild S. Danielsen, Marcelo Demarzo, Aimee Dordevic, Dawn M. Eichen, Andrea B. Goldschmidt, Anja Hilbert, Katrijn Houben, Mara Lofrano do Prado, Corby K. Martin, Anne McTiernan, Janell L. Mensinger, Carly Pacanowski, Wagner Luiz do Prado, Sofia M. Ramalho, Hollie A. Raynor, Elizabeth Rieger, Eric Robinson, Vera Salvo, Nancy E. Sherwood, Sharon Simpson, Hanna Skjakodegard, Evelyn Smith, Stephanie Partridge, Marian A. Tanofsky-Kraff, Rachael P. Taylor, Annelies Van Eyck, Krista Varady, Alaina L. Vidmar, Victoria Whitelock, Jack Yanovski, Anna Seidler
Summary: The EDIT Collaboration aims to identify risk factors and intervention strategies for eating disorders in weight management interventions. They conducted a systematic review and meta-analysis using individual participant data (IPD) from randomized controlled trials. The analysis will examine the factors associated with changes in eating disorder risk during and after interventions, as well as predictors of intervention effectiveness in reducing eating disorder risk. The findings will inform screening and monitoring protocols for early intervention.
Review
Psychiatry
Isabella Lobo, Felipe Q. da Luz, Phillipa Hay, Tamiris L. Gaeta, Paula Costa Teixeira, Taki Athanassios Cordas, Amanda Sainsbury, Zubeyir Salis
Summary: This systematic review compared the weight change in people with or without binge eating who underwent various weight loss treatments. The results showed no significant difference in weight loss between the two groups.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2023)
Article
Pharmacology & Pharmacy
Dilara Bahceci, Lyndsey L. L. Anderson, Richard C. C. Kevin, Peter T. T. Doohan, Jonathon C. C. Arnold
Summary: This study investigated the changes of endocannabinoids and related lipid signaling molecules during seizure activity. The results showed that a hyperthermia-induced seizure increased the concentration of certain monoacylglycerols in the hippocampus of Dravet syndrome mouse model, providing new clues for the development of future therapeutic approaches.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)