Journal
NEUROSCIENCE LETTERS
Volume 517, Issue 1, Pages 60-63Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.04.026
Keywords
Cancer induced bone pain; MCP-1; CCR2; Chemokine; Rat
Categories
Funding
- National Natural Science Fund of China (NSFC) [81000479, 81171057]
- NSFC for Distinguished Young Scholars [30872442]
- Natural Science Fund of Jiangsu Province [BK2011305]
- Department of Health Fund of Jiangsu Province [H200917]
- Science and Technology Fund of Suzhou City [ZS0901]
Ask authors/readers for more resources
In this study, we examined the involvement of chemokine monocyte chemoattractant protein-1 (MCP-1) in the spinal cord of a rat model of cancer-induced bone pain (CIBP). In this model. CIBP was established by an intramedullary injection of Walker 256 cells into the tibia of rats. We observed a significant increase in expression levels of MCP-1 and its receptor CCR2 in the spinal cord of CIBP rats. Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody attenuated the mechanical allodynia established in CIBP rats. Likewise, an intrathecal injection of exogenous recombinant MCP-1 induced a striking mechanical allodynia in naive rats. These results suggest that increases in spinal MCP-1 and CCR2 expression are involved in the development of mechanical allodynia associated with bone cancer rats. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available