Lack of an association between Paraoxonase 1 gene polymorphisms (Q192R, L55M) and Alzheimer's disease: A meta-analysis

The association between Paraoxonase 1 (PON1) gene polymorphisms (Q192R, L55M) and Alzheimer's disease (AD) risk has been reported inconsistent results. To assess the association between PON1 polymorphisms and AD risk, a meta-analysis was performed. Based on comprehensive searches of the PubMed, Embase, Web of Science, Weipu, and CBM databases, a total of 10 studies including 3081 AD cases and 3054 controls were identified. The pooled odds ratio (OR) with 95% confidence interval (95% Cl) were performed. There was no significant association between PON1 Q192R polymorphism and AD risk in all comparison models (R vs. Q OR = 0.89, 95% CI = 0.82-0.96; RR vs. QQ OR = 0.83, 95% CI = 0.68-1.01; RR + RQ vs. QQ OR = 0.86, 95% CI = 0.75-0.97; and RR vs. QR + QQ OR = 0.94, 95% CI = 0.81-1.11). For the PON1 L55M polymorphism, lack of an association was also found (L vs. M, OR = 0.95.95% CI = 0.86-1.05; LL vs. MM, OR = 0.67, 95% CI = 0.51-0.88; LL vs. ML + MM, OR = 0.82, 95% CI = 0.69-0.98; and LL + ML vs. MM, OR = 0.75, 95% CI = 0.58-0.96). On subgroup analysis by ethnicity, similar results were found. Conclusively, the present meta-analysis revealed that PON1 gene polymorphisms (Q192R, L55M) were unlikely to contribute to AD susceptibility. (C) 2012 Elsevier Ireland Ltd. All rights reserved.