Article
Dentistry, Oral Surgery & Medicine
Aree Wanasuntronwong, Supassanan Kaewsrisung, Nattapon Rotpenpian, Tawepong Arayapisit, Prasit Pavasant, Weera Supronsinchai
Summary: The study aimed to investigate the efficacy and mechanisms of cannabidiol on orofacial nociception induced by CFA in male Mus musculus mice. Cannabidiol was found to inhibit pain-like behaviors and trigeminal nociceptive pathway induced by CFA injection, with a 50% inhibitory concentration of 3 mg/kg. Cannabidiol's antinociceptive effects were mediated by vanilloid receptor 1 but not by CGRP, suggesting its potential use in pain treatment.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-ting Wang, Kai Lu, Dan-dan Yao, Shu-xia Zhang, Gang Chen
Summary: In this study, Forsythoside B (FB) from Forsythia suspensa was found to be effective in relieving chronic inflammatory pain and exhibited anti-anxiety effects. The mechanisms involved the reduction of proinflammatory cytokines and modulation of microglia and astrocytes activation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Weibo Zhang, Jie Lyu, Juxiang Xu, Piao Zhang, Shuxia Zhang, Yeru Chen, Yongjie Wang, Gang Chen
Summary: This study revealed that chronic inflammation pain induced by CFA injection resulted in abnormal expression of 27 metabolites and enrichment of seven metabolic pathways, potentially implicating neurotransmitter release and pain conductivity.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Claire Demiot
Summary: The study evaluated the effect of the ACE inhibitor ramipril in a mouse model of oxaliplatin-induced acute pain syndrome, showing that ramipril can prevent cold sensitivity and improve tactile sensitivity in treated mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Yuanyuan Wu, Yuerong Chen, Yunyun Xu, Wenqin Ni, Chalian Lin, Xiaomei Shao, Zui Shen, Xiaofen He, Chao Wang, Jianqiao Fang
Summary: Pain sufferers often dislike the environment associated with pain, known as pain aversion. The amygdala, a limbic structure in the brain, plays a critical role in emotion and pain. However, research on aversion caused by inflammatory pain is limited, and the underlying mechanisms are not well understood. This study used proteomics analysis to identify potential proteins involved in pain aversion in rats. Glutamate transporter-1 (GLT-1) was found to have correlation with pain aversion and may modulate the excitability of glutamatergic neurons. This study highlights the extensive biological changes in the amygdala induced by inflammatory pain.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Reem S. S. Alazragi, Hanadi M. M. Baeissa
Summary: This study aimed to examine the anti-arthritic properties of grapefruit juice and found that it can reduce inflammation levels, slow down cartilage degradation, and improve joint function.
Article
Biochemistry & Molecular Biology
Quan Ma, Xi Chen, Jinli Sun, Li Wang, Weichao Jiang, Xi Zhang, Sifang Chen
Summary: The study found that complete Freund's adjuvant can induce mirror-image pain (MIP) and identified potential molecular mechanisms through quantitative proteomics in the spinal cord. Additionally, neuronal activity of spinal cord neurons is upregulated during MIP after CFA treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wen Yin, Li Liu, Yuxi Zhou, Yunchun Zhang, Dexu Kong, Saihong Xu, Dan Tang, Dan Huang, Daxiang Wen, Yingfu Jiao, Yinghui Fan, Po Gao, Weifeng Yu
Summary: The study showed that CFA treatment suppressed behaviors and calcium responses associated with TRPV1-mediated histamine-dependent itch and TRPA1-mediated histamine-independent itch. Furthermore, CFA treatment increased nociceptive DRG neurons but decreased most known pruriceptors, which may explain itch suppression. This study suggested a unified adaptive change of increased pain and decreased itch under CFA-induced inflammatory conditions.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biotechnology & Applied Microbiology
Prince Allawadhi, Amit Khurana, Nilofer Sayed, Chandraiah Godugu, Divya Vohora
Summary: This study assessed the mechanistic effects of cerium oxide nanoparticles (CONPs) on rheumatoid arthritis and found that CONPs exhibited anti-rheumatoid arthritis activity both in vitro and in vivo.
Article
Chemistry, Analytical
Noy Turgeman Dahan, Jean-Jacques Vatine, Irit Weissman-Fogel, Hana Karpin, Sharon Shmuely, Tami Bar-Shalita
Summary: This study developed a reliable and valid protocol called Quantitative Dynamic Allodynography (QDA) for measuring Dynamic Mechanical Allodynia (DMA) in a clinical setting. The QDA showed high test-retest and inter-rater reliability, and correlated with other measures of pain and quality of life.
Article
Pharmacology & Pharmacy
Muhammad Asif Faheem, Tasleem Akhtar, Nadia Naseem, Usman Aftab, Muhammad Shoaib Zafar, Safdar Hussain, Muhammad Shahzad, Glenda Carolyn Gobe
Summary: The study evaluated the anti-arthritic activity of chrysin and compared it with the non-steroidal anti-inflammatory agent, piroxicam. Results showed that chrysin significantly reduced arthritis score, inflammatory cells, erythrocyte sedimentation rate, and rheumatoid factor. Chrysin also regulated the mRNA levels of tumor necrosis factor, nuclear factor kappa-B, and toll-like recepter-2, and increased anti-inflammatory cytokines interleukin-4 and -10, thereby reducing the severity of arthritis.
Article
Cell Biology
Yi-Fan Deng, Ping Xiang, Jing-Yi Du, Jian-Fen Liang, Xiang Li
Summary: This study aimed to investigate the contribution of ferroptosis in the spinal cord and dorsal root ganglion to painful behaviors induced by complete Freund's adjuvant in rats. The results revealed that ferroptosis-related changes in iron overload, lipid peroxidation, and mitochondrial morphology were associated with the inflammatory pain model. Intrathecal administration of a ferroptosis inhibitor alleviated the pain behaviors in the rats.
NEURAL REGENERATION RESEARCH
(2023)
Article
Plant Sciences
Oluwakemi O. Ariyo, Abayomi M. Ajayi, Benneth Ben-Azu, Adegbuyi O. Aderibigbe
Summary: The ethylacetate fraction of Morus mesozygia leaf extract showed anti-arthritic activity, reducing inflammation and pain, and improving associated behavioral deficits. It demonstrated these effects by inhibiting oxidative stress and inflammation response in arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Philip V. Reducha, Jesper P. Boemers, Lars Edvinsson, Kristian A. Haanes
Summary: This study aimed to investigate the behavioral changes similar to migraine caused by CFA application on the skull in rats, and the potential mitigating effects of the CGRP specific antibody fremanezumab after CFA application. The results showed that surgical application of CFA to the dura caused periorbital allodynia and increased CGRP positive fibers in the trigeminal ganglion. However, fremanezumab did not alleviate periorbital allodynia, although it reduced the amount of CGRP positive fibers.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Rana Dawood Naseer, Faqir Muhammad, Bilal Aslam, Muhammad Naeem Faisal
Summary: This study aimed to encapsulate geranium essential oil in chitosan nanoparticles and investigate its anti-arthritic and anti-inflammatory potential in a rat model of arthritis. The results showed that the geranium essential oil nanoparticles significantly reduced joint swelling and improved blood parameters and inflammatory markers.
INFLAMMOPHARMACOLOGY
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)