Biographical-Item
Psychology, Clinical
Mary V. Seeman
Summary: Philip Seeman's discovery of the dopamine D2 receptor's isolation is an example of how a small step can lead to a major shift in our understanding of the etiology of schizophrenia.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Behavioral Sciences
Francesco Matrisciano
Summary: Schizophrenia is a severe psychiatric disorder caused by gene x environment interaction and characterized by cognitive deficits, emotional and behavioral abnormalities. Genetic and epigenetic abnormalities in GABAergic interneurons lead to changes in neurotransmission, synaptic plasticity, and neuronal development. Epigenetic alterations during pregnancy or early life stages are associated with schizophrenia vulnerability and inflammatory processes. An animal model of schizophrenia showed changes in DNA methylation activity of genes related to schizophrenia, as well as altered expression and function of mGlu2/3 receptors in the frontal cortex. Despite antipsychotic medications being the main treatment for schizophrenia, a significant percentage of patients show poor response and treatment-resistance. This study explores the potential role of epigenetic abnormalities linked to changes in metabotropic glutamate 2/3 receptors in the variability of response to antipsychotics.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe De Simone, Benedetta Mazza, Licia Vellucci, Annarita Barone, Mariateresa Ciccarelli, Andrea de Bartolomeis
Summary: Schizophrenia is a global mental illness characterized by dysconnectivity within and between brain networks due to alterations in dopaminergic and glutamatergic synapses. Impairments in inflammatory processes, mitochondrial functions, energy expenditure, and oxidative stress are closely associated with the pathophysiology of schizophrenia. Antipsychotics, the main treatment for schizophrenia, may affect antioxidant pathways, mitochondrial protein levels, and gene expression. This systematic review examines the mechanisms of antioxidants in antipsychotic action and the impact of first- and second-generation compounds on mitochondrial functions and oxidative stress. Clinical trials also suggest that antioxidants may improve cognitive and psychotic symptoms in schizophrenia patients.
Review
Biochemistry & Molecular Biology
Andrea de Bartolomeis, Mariateresa Ciccarelli, Giuseppe De Simone, Benedetta Mazza, Annarita Barone, Licia Vellucci
Summary: Schizophrenia is a severe psychiatric illness affecting millions of people worldwide, and it is characterized by synaptic plasticity and brain connectivity. Antipsychotics, the primary pharmacological treatment, act on dopamine D2 receptors while also involving non-canonical mechanisms such as the involvement of dopamine transporter and chaperone effects. These mechanisms expand the understanding of dopamine's role in schizophrenia therapy and may have implications for the treatment of treatment-resistant schizophrenia (TRS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Bethany H. Dennis, Stuart A. Neale, Fiona E. N. LeBeau, Thomas E. Salt
Summary: Aberrant cortical oscillations in the beta and gamma range are associated with symptoms of schizophrenia and other psychiatric conditions. Activation of Group II mGlu receptors, and mGlu2 specifically, with orthosteric agonists reduced the power of both beta and gamma oscillations in ACC without a significant effect on oscillation peak frequencies.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Immunology
Md Abdul Alim, Mirjana Grujic, Paul W. Ackerman, Per Kristiansson, Pernilla Eliasson, Magnus Peterson, Gunnar Pejler
Summary: Mast cells play a role in communication between peripheral nerves and immune cells, expressing glutamate receptors and being sensitive to glutamate signaling. Glutamate induces upregulation of various glutamate receptors and gene expression in mast cells, including pro-inflammatory components and transcription factors. The presence of a functional glutamate-glutamate receptor axis in mast cells is supported by in vitro and in vivo evidence, revealing a novel principle of communication between immune cells and nerve cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Andrea de Bartolomeis, Giuseppe De Simone, Mariateresa Ciccarelli, Alessia Castiello, Benedetta Mazza, Licia Vellucci, Annarita Barone
Summary: Schizophrenia is a severe mental illness characterized by alterations in synaptic plasticity and functional connectivity. Antipsychotics, the cornerstone of pharmacological treatment for schizophrenia, have been found to affect synaptic architecture and reshape neuronal functional units. Different antipsychotics may lead to different patterns of co-activation in brain regions.
Article
Biochemistry & Molecular Biology
Banny Silva Barbosa Correia, Joao Victor Nani, Raniery Waladares Ricardo, Danijela Stanisic, Tassia Brena Barroso Carneiro Costa, Mirian A. F. Hayashi, Ljubica Tasic
Summary: This study evaluated the effects of antipsychotic drugs on blood serum lipids in an SCZ animal model and normal control rats, revealing similar lipid alterations to those seen in SCZ patients. The use of psychostimulants in normal rats resulted in decreased ω-3 fatty acids, similar to the first episode of psychosis in SCZ. CLZ was found to reverse lipid metabolism changes in SHR.
Article
Biochemistry & Molecular Biology
Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Piotr Stepnicki, Andrea G. Silva, Oliwia Koszla, Ewa Kedzierska, Angelika Grudzinska, Marta Kruk-Slomka, Grazyna Biala, Marian Castro
Summary: The study investigates a potential antipsychotic drug D2AAK3, which shows affinity to multiple receptors and demonstrates effects of reducing hyperactivity and improving memory consolidation in animal experiments.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Magda Kondej, Tomasz M. Wrobel, Katarzyna M. Targowska-Duda, Anton Leandro Martinez, Alba Paz, Olga Wronikowska-Denysiuk, Maria Loza, Marian Castro, Agnieszka A. Kaczor, Oliwia Koszta, Piotr Stepnicki, Agata Zieba
Summary: This study discovered a class of compounds with multitarget characteristics, showing strong affinity for dopamine and serotonin receptors involved in schizophrenia pharmacotherapy. The compounds displayed low affinity for off-target receptors and demonstrated favorable pharmacological properties.
Article
Clinical Neurology
Matthew Harlin, Craig Chepke, Frank Larsen, Karimah S. Bell Lynum, Sanjeda R. Chumki, Heather Fitzgerald, Pedro Such, Jessica Madera-McDonough, Murat Yildirim, Moeen Panni, Stephen R. Saklad
Summary: Aripiprazole 2-month ready-to-use 960 mg and Aripiprazole lauroxil 1064 mg are both long-acting injectable formulations used for the treatment of schizophrenia. Comparing the drug concentrations, both formulations maintain therapeutic levels over the 2-month dosing interval.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Review
Chemistry, Medicinal
Danish Mahmood, Sattam K. Alenezi, Md. Jamir Anwar, Faizul Azam, Kamal A. Qureshi, Mariusz Jaremko
Summary: Psychedelics, when used in medically supervised low doses, have shown good tolerance and efficacy in treating various neuropsychiatric disorders. They primarily work by modulating serotonin receptors to impact brain connectivity and may share some common pathways with certain antipsychotic drugs through complex neurotransmitter interactions.
Article
Behavioral Sciences
Gary Remington, Margaret K. Hahn, Sri Mahavir Agarwal, Araba Chintoh, Ofer Agid
Summary: The introduction of chlorpromazine led to schizophrenia being repositioned as a biological illness. The evolution of antipsychotics, from 'typical' to 'atypical', and drug development that aligns with the illness' heterogeneity and complexity are explored. It may be time to reconsider the notion of developing drugs that specifically treat 'schizophrenia'.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell & Tissue Engineering
Pallavi Asthana, Gajendra Kumar, Lukasz M. Milanowski, Ngan Pan Bennett Au, Siu Chung Chan, Jianpan Huang, Hemin Feng, Kin Ming Kwan, Jufang He, Kannie Wai Yan Chan, Zbigniew K. Wszolek, Chi Him Eddie Ma
Summary: This study reveals the impact of disrupted cerebellar circuitry on motor recovery after peripheral nerve injury (PNI). Restoring cerebellar circuitry through deep cerebellar nuclei (DCN) stimulation and balancing neurotransmitter levels led to full motor recovery in ataxia mice. The study also highlights the role of glutamatergic system in motor deficits and cerebellar disorders.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Psychiatry
Yuta Kawakita, Masahiro Takeshima, Tomonari Komatsu, Aya Imanishi, Dai Fujiwara, Yu Itoh, Kazuo Mishima
Summary: This study retrospectively compared the incidence of appendicitis in patients with schizophrenia with and without a history of clozapine exposure, finding a relationship between clozapine exposure and appendicitis onset.
Article
Psychology, Clinical
Chiara Fabbri, Julian Mutz, Cathryn M. Lewis, Alessandro Serretti
Summary: This study was the first to comprehensively evaluate the predictors of wellbeing in relation to the history of MDD. The identified variables are important to identify individuals at risk and promote wellbeing.
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Neurosciences
Dekel Taliaz, Alessandro Serretti
Summary: The validity of clinical trials in psychiatry has been under discussion in the past two decades. The commonly used method of randomized controlled trials (RCTs) faces challenges when applied in the psychiatric field due to strict participant criteria and inconsistency in endpoint parameters. This has led to problematic clinical practice in psychiatry.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Pharmacology & Pharmacy
Vincenzo Oliva, Giuseppe Fanelli, Manuel Zamparini, Cristina Zarbo, Matteo Rocchetti, Letizia Casiraghi, Fabrizio Starace, Alessandra Martinelli, Alessandro Serretti, Giovanni de Girolamo, DiAPASon Consortium
Summary: Antipsychotic polypharmacy (APP) is commonly used in patients with schizophrenia spectrum disorders (SSDs) despite recommendations against it. This study found high rates of APP and lower levels of physical activity in both residential and outpatient patients. However, patients on APP showed trends of reduced sedentariness and higher levels of light physical activity compared to those on monopharmacy.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Kristina Mozuraityte, Agne Stanyte, Naomi A. Fineberg, Alessandro Serretti, Julija Gecaite-Stonciene, Julius Burkauskas
Summary: This study conducted a scoping review of published literature to examine the relationship between mental fatigue and various psychiatric disorders. The findings suggest that mental fatigue is studied in mood disorders, anxiety disorders, obsessive-compulsive disorder, and obsessive-compulsive personality disorder. Cognitive factors such as unhelpful beliefs about sleep and symptom-focussed rumination, as well as personality risk factors, were found to be relevant in predicting mental fatigue symptoms. Further investigation is needed to explore mental fatigue in adult psychiatric samples.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Psychiatry
Fabio Panariello, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Alessandro Serretti, Chiara Fabbri
Summary: This study aimed to identify factors associated with side effects of psychotropic drugs in a real-world setting enriched with treatment-resistant depression (TRD) patients. Results showed that the severity of depressive symptoms was associated with total, psychic, and neurological side effects, while autonomic side effects were higher in patients with somatic comorbidities and lower in patients receiving trazodone. Multivariate analyses revealed that depressive symptom severity was associated with psychic and total side effects, generalized anxiety disorder (GAD) with neurological side effects, and somatic comorbidities remained associated with autonomic side effects. Trazodone was associated with lower side effects and with augmentation treatments. Augmentation therapies showed opposite effects depending on response status, i.e. increased or decreased the risk of side effects in responders and non-responders/resistant patients, respectively.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Vincenzo Oliva, Giuseppe Fanelli, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Chiara Fabbri, Alessandro Serretti
Summary: This study found that different clinical subtypes of major depressive disorder (MDD), particularly melancholic features and typical neurovegetative symptoms, may be associated with distinct underlying genetics. These findings contribute to a better understanding of the genetic heterogeneity of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Genetics & Heredity
Raffaella Zanardi, Matteo Carminati, Francesco Attanasio, Chiara Fabbri, Alessandro Serretti
Summary: Nonpharmacological treatments for depression show effectiveness and tolerability in certain patients with diverse response. Genetic variables associated with treatment efficacy need to be examined to assist treatment selection. Most studies using candidate gene approach yielded poorly replicated findings due to small sample sizes, while a few methylome-wide and genome-wide association studies (GWASs) provided interesting results with the use of polygenic risk scores in small samples of electroconvulsive therapy (ECT) and cognitive-behavioral therapy. Further GWAS with larger sample sizes, such as the gen-ECT-ic consortium, can enhance our understanding of the genetic factors underlying treatment response in nonpharmacological therapies for depression.
PSYCHIATRIC GENETICS
(2023)
Editorial Material
Pharmacology & Pharmacy
Paolo Olgiati, Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Sang-Hun Lee, Jin-Man Jung, Moon-Ho Park
Summary: This study aimed to explain the relationship between body mass index (BMI) and functional prognosis according to stroke subtype. The findings suggest that overweight and obese patients may have better stroke outcomes in certain stroke subtypes, contradicting the traditional belief that obesity is a risk factor for stroke.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Neurosciences
Seung-Hoon Lee, Cheolmin Shin, Young-Hoon Ko, Moon -Soo Lee, Moon Ho Park, Chi-Un Pae, Ho-Kyoung Yoon, Changsu Han
Summary: This study examined the blood adipokine levels in geriatric depression, taking into account the effects of metabolic syndrome. The results showed that metabolic syndrome significantly affected the blood adipokine levels and only PAI-1 was associated with the diagnosis of depression.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychiatry
Youngsoo Jang, Hye-mi Cho, Young-Eun Mok, Su-hyuk Chi, Changsu Han, Hyun-suk Yi, Moon -Soo Lee
Summary: This study investigated the impact of prolonged COVID-19 on school mental health. It found that prolonged COVID-19 had a significant impact on the mental health of adolescents, especially those aged 13-18, who spent a lot of time at school.
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Neurosciences
Suhyuk Chi, Young Eun Mok, June Kang, Jeong-An Gim, Changsu Han, Moon-Soo Lee
Summary: This study aimed to identify the cytokines involved in the pathogenesis of tic disorders. The results showed that tic disorder patients and healthy controls exhibit different cytokine profiles, and significant correlations were found only in patients with mild symptoms.
Review
Neurosciences
Alessandro Serretti
Summary: Anhedonia is a core symptom of depression and other psychiatric disorders, referring to a lack of pleasure or reward. It is not only a psychological distress but also encompasses a range of reward processing deficits. Anhedonia is a relevant risk factor for suicidal behaviors and may operate independently of the severity of depressive episodes. It has also been associated with inflammation, which can have a reciprocal detrimental effect on depression. The neurophysiological bases of anhedonia mainly involve changes in striatal and prefrontal areas, with dopamine playing a key role as the neurotransmitter involved. Anhedonia is believed to have a significant genetic component and polygenic risk scores may be a tool for predicting an individual's risk for developing anhedonia. Traditional antidepressants have shown limited benefit in treating anhedonia, also considering their potential to worsen anhedonia in some individuals. Other treatments such as agomelatine, vortioxetine, ketamine, and transcranial magnetic stimulation may be more effective. Psychotherapy, particularly cognitive-behavioral therapy and behavioral activation, is widely supported as beneficial for anhedonia. In conclusion, evidence suggests that anhedonia is partially independent from depression and requires careful evaluation and targeted treatment.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychiatry
Alexander Kautzky, Lucie Bartova, Gernot Fugger, Markus Dold, Daniel Souery, Stuart Montgomery, Joseph Zohar, Julien Mendlewicz, Chiara Fabbri, Alessandro Serretti, Dan Rujescu, Siegfried Kasper
Summary: This study investigates the differences in presentation and treatment outcomes of treatment-resistant depression (TRD) among different age groups. It finds that age has an impact on depressive symptoms and treatment outcomes. In TRD patients, symptom load and hospitalization time increase with age, while treatment responders do not show this trend. Older patients are more likely to have symptoms such as inner tension, reduced appetite, concentration difficulties, and lassitude.
EUROPEAN PSYCHIATRY
(2023)
Article
Clinical Neurology
Suhyuk Chi, Young Eun Mok, Jong-ha Lee, Sang-il Suh, Changsu Han, Moon-Soo Lee
Summary: This study analyzed the differences in functional connectivity and brain network parameters between suicidal and non-suicidal major depressive disorder (MDD) patients using a data-driven whole-brain approach. The results showed that suicidal patients had different functional connectivity profiles compared to non-suicidal patients, and they may overthink future risks and have a more pronounced egocentric bias. These features can disrupt cognitive recovery and resilience, leading to more suicidal behaviors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
