Journal
NEUROSCIENCE LETTERS
Volume 531, Issue 2, Pages 166-169Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.10.044
Keywords
Coffee volatiles; Elevated plus-maze; Mouse; Pentobarbital-induced sleep; Psychological stress
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Funding
- Notre Dame Seishin University
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To clarify the relationship between the volatile compounds present in roasted coffee beans and psychological stress, we investigated the stress-reducing potential of coffee volatiles in mice using a variety of behavioral pharmacology methods. In the elevated plus-maze test, exposure to coffee volatiles increased the time spent in and the number of entries into the open arms without increasing spontaneous locomotor activity. Pentobarbital-induced sleep time was prolonged by volatile exposure. No significant effects were detected in the open-field or forced-swim tests. These results suggest that coffee volatiles lower the arousal level and exert anti-anxiety-like, stress-reducing effects in mice. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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