Article
Neurosciences
Casey M. Imperio, Elizabeth F. Chua
Summary: This study investigates the effects of High Definition transcranial Direct Current Stimulation (HD-tDCS) on memory and metamemory, and finds that HD-tDCS has positive effects on cued recall tasks and subjective once-knew-it ratings, but has no significant improvement on other memory tasks and aspects of metamemory.
Article
Neurosciences
Casey M. Imperio, Elizabeth F. Chua
Summary: This study aimed to investigate the effects of remotely supervised tDCS on semantic memory and metamemory tasks. The results showed no significant effects of rs-tDCS on metamemory monitoring accuracy or memory performance, but there were effects depending on the order of completing the tasks.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Remi Moirand, Laetitia Imbert, Frederic Haesebaert, Gabrielle Chesnoy, Benoit Bediou, Emmanuel Poulet, Jerome Brunelin
Summary: This study investigated the clinical interest of a 10 session tDCS regimen in patients with mild to severe treatment-resistant depression. The results showed that bifrontal add-on tDCS, combined with antidepressant medication, can be a safe and suitable approach to achieve remission in these patients. However, further studies are needed to confirm these findings in a larger sample size.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychology, Experimental
Kelly A. Vaughn, Emily M. Watlington, Paulina Linares Abrego, Benjamin J. Tamber-Rosenau, Arturo E. Hernandez
Summary: The left DLPFC plays an important role in language control for bilinguals, but stimulating this area does not benefit nonlinguistic control.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2021)
Article
Neurosciences
Stefan Schulreich, Lars Schwabe
Summary: The right dlPFC plays a crucial role in continuously updating prior knowledge in uncertain environments, with transcranial direct current stimulation enhancing belief updating processes. Additionally, cortisol increases are associated with enhanced positive value updating, but not with negative value updating.
Article
Neurosciences
Shuang Liu, Siyu Zhai, Dongyue Guo, Sitong Chen, Yuchen He, Yufeng Ke, Dong Ming
Summary: Research in the cognitive neuroscience field suggests that attention bias towards negative information is associated with a higher risk of depression. Transcranial direct current stimulation (tDCS) treatment has been found to improve depression symptoms, but the neural mechanism underlying this improvement is still unknown. This study investigated the effects of tDCS on affect-biased attention and found that tDCS had a positive impact on emotion regulation and emotion-related attention biases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Gemma Massetti, Carlotta Lega, Zaira Cattaneo, Alberto Gallace, Giuseppe Vallar
Summary: Humans are the only species capable of experiencing pleasure from aesthetic stimuli, and the left dorsolateral prefrontal cortex (DLPFC) plays a critical role in aesthetic judgments. Experiment results showed that musicians were slower than non-musicians in judging music, indicating a more analytical judgment due to musical expertise. However, no significant effects of stimulating the left DLPFC were found in the aesthetic appreciation of music.
Article
Biochemistry & Molecular Biology
Laetitia Imbert, Remi Moirand, Benoit Bediou, Olivier Koenig, Gabrielle Chesnoy, Eric Fakra, Jerome Brunelin
Summary: Research suggests that applying transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) may improve emotional processing accuracy in patients with major depressive disorder (MDD). This finding provides a new possibility for alleviating depressive symptoms.
Article
Neurosciences
Furong Huang, Yan Song, Yan Jiang, Qingbai Zhao, Jing Luo
Summary: This study investigates the role of the right temporoparietal junction (TPJ) and the left dorsolateral prefrontal cortex (DLPFC) in generating creative ideas through transcranial direct current stimulation. The results show that the TPJ is responsible for considering both novelty and appropriateness attributes, while the DLPFC mainly regulates the novelty attribute. These findings suggest complementary mechanisms in generating original and valuable ideas.
Article
Multidisciplinary Sciences
Annalisa Palmisano, Francesco Bossi, Cecilia Barlaba, Francesco Febbraio, Riccardo Loconte, Antonella Lupo, Michael A. Nitsche, Davide Rivolta
Summary: The study investigated the role of the left Dorsolateral Prefrontal Cortex (L-DLPFC) in facial emotion recognition and implicit attitudes toward other races through neuromodulation techniques. The results indicated that the L-DLPFC plays a critical role in humans' rating of facial expressions and variability in other-race emotional judgments, shedding light on the neural bases of the human emotional system and its gender-related differences.
Article
Behavioral Sciences
Michael J. Imburgio, Hannah K. Ballard, Astin C. Cornwall, Darrell A. Worthy, Jessica A. Bernard, Joseph M. Orr
Summary: This study investigated the effects of bifrontal tDCS on behavioral and physiological correlates of subcortical dopamine activity. The results showed that stimulation did not significantly affect the measures, but effect sizes were often moderately large. Exploratory analyses suggested that the stimulation's impact on eye blink rate might be dependent on pre-stimulation dopamine levels.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychology, Social
Shuoqi Xiang, Senqing Qi, Yangping Li, Luchun Wang, David Yun Dai, Weiping Hu
Summary: The study demonstrated that L+R- stimulation benefits divergent thinking, especially in LTA individuals, with no significant effects on convergent thinking. Differences in bilateral dorsolateral prefrontal cortex activation between low-trait-anxious and high-trait-anxious groups may explain this sensitivity. Future research on tDCS effects on creativity should consider trait anxiety levels.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Article
Psychiatry
Jerome Brunelin, Shirley Fecteau
Summary: Stimulating the DLPFC using bifrontal tDCS may prevent stress-induced acute effects on both biological and behavioral outcomes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Yong Liu, Qingjin Liu, Jia Zhao, Xuechen Leng, Jinfeng Han, Feng Xia, Yazhi Pang, Hong Chen
Summary: Chronic stress negatively impacts cognition and mental health, but tDCS of the DLPFC may improve attentional control and relieve stress. In a study of 40 chronically stressed individuals, anodal tDCS led to significant reductions in perceived stress, anxiety, and depressive symptoms, as well as improved performance in attentional control tasks.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Substance Abuse
Sensen Song, Anna Zilverstand, Wenjun Gui, Xuefei Pan, Xiaolin Zhou
Summary: Excitatory neuromodulation targeting the dorsolateral prefrontal cortex can lead to immediate reduction in craving and consumption, as well as sustained effects during short-, mid- and long-term abstinence periods, across different populations and stimulation techniques.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)