Article
Biochemistry & Molecular Biology
Tae-Kyeong Lee, Jae-Chul Lee, Dae Won Kim, Bora Kim, Hyejin Sim, Jong Dai Kim, Ji Hyeon Ahn, Joon Ha Park, Choong-Hyun Lee, Moo-Ho Won, Soo Young Choi
Summary: The study demonstrates that ischemic brain damage or death induced under hyperthermic conditions is more severe and widespread than under normothermic conditions, with differing effects of HO-1 expression in neurons and astrocytes based on brain subregions and temperature conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Shuang Wu, Yan-Feng Zhang, Yue Gui, Tian Jiang, Cheng-Mei Zhou, Jing-Yi Li, Jia-Le Suo, Yong-Nan Li, Rui-Lin Jin, Shu-Lei Li, Jia-Yue Cui, Bai-Hong Tan, Yan-Chao Li
Summary: In this study, a new method for detecting neuronal death using two membrane-bound dyes, rhodamine R6 and DiOC6(3), was reported. The staining pattern produced by this method is similar to Fluoro-Jade B in kainic acid-damaged brains in mice. The increased staining of rhodamine R6 and DiOC6(3) is associated with increased levels of phospholipids and free cholesterol in the perinuclear cytoplasm of damaged neurons.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Junya Onodera, Hidetaka Nagata, Ai Nakashima, Yuji Ikegaya, Ryuta Koyama
Summary: Our study demonstrated that neuronal BDNF prevents microglia from engulfing mossy fiber synapses in the hippocampus, while microglial BDNF affects the structural and functional properties of neurons.
Article
Biochemistry & Molecular Biology
Ilia Komoltsev, Daria Shalneva, Olga Kostyunina, Aleksandra Volkova, Stepan Frankevich, Natalia Shirobokova, Anastasia Belikova, Sofia Balan, Olesya Chizhova, Olga Salyp, Daria Bashkatova, Pavel Kostrukov, Aleksandra Soloveva, Margarita Novikova, Natalia Gulyaeva
Summary: Acute and chronic corticosterone (CS) elevations after traumatic brain injury (TBI) may cause hippocampal damage and late posttraumatic behavioral pathology. This study found that CS-dependent changes were present 3 months post TBI, with objective memory impairments and delayed spatial memory deficits. Moderate CS elevation predicted delayed mortality and masked the extent of morphological and behavioral deficits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Reza Rahimian, Louis-Charles Beland, Sachiko Sato, Jasna Kriz
Summary: Galectins, soluble beta-galactoside-binding proteins found in multicellular organisms, play a crucial role in neurodegenerative diseases, acting as key modulators of brain innate immune responses with dual effects in neuroinflammatory environments.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Hyun Joo Shin, Kyung Eun Kim, Eun Ae Jeong, Hyeong Seok An, So Jeong Lee, Jaewoong Lee, Gu Seob Roh
Summary: Type 2 diabetes is associated with an increased risk of Alzheimer's disease. Glial cell activation plays a crucial role in the development of neuroinflammation in both diabetes and AD. In a study with diabetic mice fed a high-fat diet, it was found that amyloid-beta oligomer treatment led to the retraction of microglial process and increased levels of galectin-3 and lipocalin-2 in the hippocampus, suggesting their involvement in amyloid toxicity mechanisms and glial activation under diabetic conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Cho
Summary: Research found that microglia activation is associated with neuronal lesions in diabetes, with STAT3 activation playing a crucial role in neuronal apoptosis in the diabetic hippocampus.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Yeo Sung Yoon, In Koo Hwang, Soo Young Choi, Dae Won Kim
Summary: Purpurin has significant therapeutic effects on oxidative stress in HT22 cells and ischemic damage in gerbil hippocampus by improving cell survival, reducing DNA fragmentation and reactive oxygen species, inhibiting apoptosis-related protein levels, and decreasing inflammatory responses.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joana R. Guedes, Pedro A. Ferreira, Jessica M. Costa, Ana L. Cardoso, Joao Peca
Summary: Microglia are tissue-resident macrophages that play roles in surveillance, neuronal support, and immune defense in the brain. They participate in engulfing neuronal precursors, modulating synaptic signaling, and shaping synaptic plasticity. Microglia in different brain regions exhibit distinct characteristics that may potentially contribute to the maturation and function of specific neuronal circuits.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Neurosciences
Natasa R. Mijailovic, Katarina Vesic, Dragana Arsenijevic, Maja Milojevic-Rakic, Milica M. Borovcanin
Summary: Cognitive impairment may result from normal aging or various neurodegenerative and psychiatric diseases. Gal-3, a member of the galectin family, has received attention for its role in neuroinflammation and neurodegeneration, but its relationship with cognitive impairment is still unclear. Gal-3 acts as a fine-tuner of microglia morphology and phenotype in modulating inflammatory response. It also has the potential to serve as a biomarker and be targeted therapeutically in neuropsychiatric diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Sergi Borrego-Ecija, Agnes Perez-Millan, Anna Antonell, Laura Fort-Aznar, Elif Kaya-Tilki, Alberto Leon-Halcon, Albert Llado, Laura Molina-Porcel, Mircea Balasa, Jordi Junca-Parella, Javier Vitorica, Jose Luis Venero, Tomas Deierborg, Antonio Boza-Serrano, Raquel Sanchez-Valle
Summary: Neuroinflammation plays a significant role in the progression of frontotemporal dementia (FTD), and Gal-3 levels were found to be significantly increased in FTD patients, particularly in brain tissue and cerebrospinal fluid (CSF). Gal-3 shows potential as a diagnostic marker for FTD, especially in cases with MAPT mutations, and its levels correlate with markers of neuronal injury.
ALZHEIMERS & DEMENTIA
(2023)
Article
Peripheral Vascular Disease
Ferdinand Althammer, Ranjan K. Roy, Matthew K. Kirchner, Elba Campos-Lira, Kathryn E. Whitley, Steven Davis, Juliana Montanez, Hildebrando Candido Ferreira-Neto, Jessica Danh, Rafaela Feresin, Vinicia Campana Biancardi, Usama Zafar, Marise B. Parent, Javier E. Stern
Summary: Heart failure is associated with depression and cognitive decline. This study found that neuroinflammation, hypoperfusion, and neuronal deficits occur in the hippocampus of heart failure rats. Inhibiting AT1aRs can reverse neuroinflammation and improve cognitive performance.
Article
Biology
Felix Christopher Nebeling, Stefanie Poll, Lena Christine Justus, Julia Steffen, Kevin Keppler, Manuel Mittag, Martin Fuhrmann, Laura L. Colgin
Summary: Microglia play a crucial role in sensing neuronal activity and actively participate in the stability and rewiring of hippocampal synapses. This study reveals the mechanisms underlying microglial motility and their interaction with dendritic spines, highlighting their significance for hippocampal learning and memory processes.
Article
Neurosciences
Senthilkumar Deivasigamani, Mariya T. Miteva, Silvia Natale, Daniel Gutierrez-Barragan, Bernadette Basilico, Silvia Di Angelantonio, Laetitia Weinhard, Dmitry Molotkov, Sukrita Deb, Constantin Pape, Giulia Bolasco, Alberto Galbusera, Hiroki Asari, Alessandro Gozzi, Davide Ragozzino, Cornelius T. Gross
Summary: This study found that mice lacking Complement receptor 3 showed a deficit in the perinatal elimination of neurons in the developing cortex, resulting in increased cortical thickness and enhanced functional connectivity in these regions in adulthood. These findings demonstrate the importance of complement in promoting neuronal elimination in the developing cortex.
Article
Multidisciplinary Sciences
Kyu Ri Hahn, Hyun Jung Kwon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: In this study, the researchers synthesized the Tat-CHIP fusion protein and successfully delivered it into brain cells. The results showed that Tat-CHIP has antioxidant and neuroprotective effects, making it a potential therapeutic agent against ischemic damage.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)