Article
Cell Biology
Chang-Ning Fu, Hui Wei, Wen-Shuang Gao, Sha-Sha Song, Shou-Wei Yue, Yu-Juan Qu
Summary: This study reveals that the AMPK-ERK-NOX4 pathway plays a crucial role in mediating obesity-induced increases in neuropathic pain. Activation of AMPK can inhibit the ERK-NOX4 pathway, oxidative stress, and inflammation caused by high-fat diets, ultimately reducing neuropathic pain in obese individuals.
Article
Neurosciences
Kyeongmin Kim, Guanghai Nan, Leejeong Kim, Minjee Kwon, Kyung Hee Lee, Myeounghoon Cha, Bae Hwan Lee
Summary: This study aimed to investigate the effects of insular cortex stimulation (ICS) on neuropathic pain and determine how ICS modulates pain. The results showed that the most effective pain relief was achieved with ICS at 50 Hz-120 μA in a single trial, and its effects lasted for 4 days after repetitive ICS termination. The expression levels of phosphorylated extracellular signal-regulated kinase (pERK), astrocytes, and microglia were increased in neuropathic rats, but they were decreased after ICS, particularly in layers 2-3 of the insular cortex where pERK and neurons colocalize.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Multidisciplinary Sciences
Christian Litke, Anna M. Hagenston, Ann-Kristin Kenkel, Eszter Paldy, Jianning Lu, Rohini Kuner, Daniela Mauceri
Summary: This study reveals the role of histone deacetylase 4 (HDAC4) in sensitization of spinal cord neurons and its regulation of the organic anion transporter OAT1. Noxious stimuli cause HDAC4 to be exported from the nucleus and inactivated, while a mutant form of HDAC4 remains in the nucleus. The regulation of OAT1 by HDAC4 is shown to be involved in the development of inflammatory hypersensitivity. This research highlights HDAC4 as an important epigenetic regulator and suggests OAT1 as a potential target for pain-relieving therapies.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Liren Li, Liying Bai, Kangli Yang, Jian Zhang, Yan Gao, Mingjun Jiang, Yin Yang, Xuan Zhang, Li Wang, Xueli Wang, Yiming Qiao, Ji-Tian Xu
Summary: The study reveals that the upregulation of KDM6B induced by neuropathic pain demethylates H3K27me3, facilitating the binding of STAT3 with the IL-6 promoter, consequently leading to an increase in IL-6 expression in the DRG and dorsal horn which contributes to the development and maintenance of neuropathic pain. Targeting KDM6B may be a promising therapeutic strategy for the treatment of chronic pain.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Meng-Hua Zhou, Shao-Rui Chen, Li Wang, Yuying Huang, Meichun Deng, Jixiang Zhang, Jiyuan Zhang, Hong Chen, Jiusheng Yan, Hui-Lin Pan
Summary: The study identified the roles of PKC and alpha 2 delta-1 in controlling NMDAR activity, showing that co-expression of alpha 2 delta-1 significantly increased NMDAR activity, while PKC activation only increased receptor activity in cells co-expressing alpha 2 delta-1. Furthermore, phosphoproteomics analysis identified the phosphorylation sites responsible for NMDAR potentiation by PKC and alpha 2 delta-1.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Baowen Liu, Ningbo Li, Zhigang He, Xianwei Zhang, Guangyou Duan
Summary: Studies have shown that SGK1 plays a crucial role in the development of pathological pain, and blocking SGK1 significantly alleviates pain-like responses and the development of pathological pain. Therefore, targeting SGK1 may be a novel therapeutic strategy for pain management.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Hung-Chen Wang, Kuang- Cheng, Kuang-Yi Tseng, Aij-Lie Kwan, Lin-Li Chang
Summary: In this study, the effects and roles of AAV-GlyR alpha 1/3 on cell cytotoxicity and inflammatory response were investigated. The results showed that AAV-GlyR alpha 3 significantly reduced CFA-induced inflammatory pain and suppressed CFA-induced ERK phosphorylation, without causing obvious histopathological injury.
MOLECULAR MEDICINE
(2023)
Article
Neurosciences
Meiling Han, Fan Zhang, Ying Wang, Yangyuxin Huang, Yanni He, Jinxuan Ren, Yu-Tao Deng, Yibo Gao, Xue Li, Lina Yu, Longfei Ma, Bao-Chun Jiang, Min Yan
Summary: Deregulated spinal cord proteins induced by nerve injury are crucial for neuropathic pain. Transcriptome and translatome analyses reveal that chromobox 2 (CBX2), an upregulated protein with unchanged mRNA level, plays a role in neuronal and astrocyte hyperactivities and pain hypersensitivities. The ERK pathway, CXCL13 upregulation in neurons, and further induction of astrocyte activation may be downstream signaling mechanisms of CBX2 in pain processing. Targeting CBX2 upregulation could be therapeutically beneficial.
NEUROSCIENCE LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Vincent Yaccarino, Max Y. Jin, Alaa Abd-Elsayed, Jacob M. Kraemer, Nalini Sehgal
Summary: This article briefly introduces the evolution, mechanisms, applications, and complications of peripheral nerve stimulation. The latest technology provides new treatment options for chronic neuropathic pain of the upper extremity.
Article
Immunology
Wei Li, Jie Liang, Shaohua Li, Luoyang Wang, Shuo Xu, Suli Jiang, Meiying Song, Haining Meng, Dongchang Zhai, Lei Tang, Yanyan Yang, Li Zhang, Bei Zhang
Summary: This article summarizes the mechanisms of nerve damage and pain caused by excessive activation of the NLRP3 inflammasome.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chih-Cheng Wu, Cheng-Yi Chang, Chung-Yuh Tzeng, Jen-Hsuan Huang, Chih-Jen Hung, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Chun-Jung Chen
Summary: In this study, the preventive effects of intrathecal bupivacaine administration against neuropathic pain were investigated. Bupivacaine attenuated pain behaviors and inflammatory alternations by suppressing microglia M1 polarization and pro-inflammatory cytokine expression. The Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1 (HMGB1)/Toll-Like Receptor 4 (TLR4)/NF-kappa B inflammatory axes were identified as key players in microglia polarization and cytokine expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Psychology, Developmental
Craig A. Erickson, Charles R. Tessier, Christina Gross, Ernest Pedapati, Logan K. Wink, Kelli C. Dominick, Rebecca C. Shaffer, Hilary Rosselot, Michael P. Hong, Andrew P. Bantel, Elizabeth Berry-Kravis, Paul S. Horn, Ryan Adams, John A. Sweeney
Summary: This study investigated the activity of ERK1/2 in autism spectrum disorder (ASD). The results showed that lymphocytic ERK1/2 activation was faster in individuals with ASD, and this was correlated with greater social impairment. The differences in ERK1/2 activation were more pronounced in younger individuals.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Shu-Ling Chiu, Graham Hugh Diering, Bing Ye, Kogo Takamiya, Chih-Ming Chen, Yuwu Jiang, Tejasvi Niranjan, Charles E. Schwartz, Tao Wang, Richard L. Huganir
Article
Hematology
Charles Fouillade, Celine Baron-Menguy, Valerie Domenga-Denier, Christelle Thibault, Kogo Takamiya, Richard Huganir, Anne Joutel
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Behavioral Sciences
Abby Adamczyk, Rebeca Mejias, Kogo Takamiya, Jennifer Yocum, Irina N. Krasnova, Juan Calderon, Jean Lud Cadet, Richard L. Huganir, Mikhail V. Pletnikov, Tao Wang
BEHAVIOURAL BRAIN RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Munal Babu Kandel, Saki Yamamoto, Ryosuke Midorikawa, Jyoji Morise, Yoshihiko Wakazono, Shogo Oka, Kogo Takamiya
JOURNAL OF NEUROCHEMISTRY
(2018)
Article
Neurosciences
Yi-Mei Yang, Jamila Aitoubah, Amanda M. Lauer, Mutsuo Nuriya, Kogo Takamiya, Zhengping Jia, Bradford J. May, Richard L. Huganir, Lu-Yang Wang
JOURNAL OF PHYSIOLOGY-LONDON
(2011)
Article
Neurosciences
Wei Wang, Ronald S. Petralia, Kogo Takamiya, Jun Xia, Yun-Qing Li, Richard L. Huganir, Yuan-Xiang Tao, Myron Yaster
Article
Neurosciences
Martijn Schonewille, Zhenyu Gao, Henk-Jan Boele, Maria F. Vinueza Veloz, Wardell E. Amerika, Antonia A. M. Simek, Marcel T. De Jeu, Jordan P. Steinberg, Kogo Takamiya, Freek E. Hoebeek, David J. Linden, Richard L. Huganir, Chris I. De Zeeuw
Article
Neurosciences
Lauren Makuch, Lenora Volk, Victor Anggono, Richard C. Johnson, Yilin Yu, Kerstin Duning, Joachim Kremerskothen, Jun Xia, Kogo Takamiya, Richard L. Huganir
Article
Multidisciplinary Sciences
Anubhuti Goel, Linda W. Xu, Kevin P. Snyder, Lihua Song, Yamila Goenaga-Vazquez, Andrea Megill, Kogo Takamiya, Richard L. Huganir, Hey-Kyoung Lee
Article
Multidisciplinary Sciences
Makiko Miyamoto, Yoshiyuki Tsuboi, Kuniya Honda, Masayuki Kobayashi, Kogo Takamiya, Richard L. Huganir, Masahiro Kondo, Masamichi Shinoda, Barry J. Sessle, Ayano Katagiri, Daiju Kita, Ikuko Suzuki, Yoshiyuki Oi, Koichi Iwata
Article
Multidisciplinary Sciences
Lisa A. Humphries, Meredith H. Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O. Humbert, Oscar Silva, June L. Round, Kogo Takamiya, Richard L. Huganir, Janis K. Burkhardt, Sarah M. Russell, M. Carrie Miceli
Article
Multidisciplinary Sciences
Rajani Maiya, Seonok Lee, Karen H. Berger, Eric C. Kong, Justin B. Slawson, Leslie C. Griffith, Kogo Takamiya, Richard L. Huganir, Ben Margolis, Ulrike Heberlein
Article
Multidisciplinary Sciences
Jyoji Tsutajima, Takato Kunitake, Yoshihiko Wakazono, Kogo Takamiya
Article
Biochemistry & Molecular Biology
Jyoji Morise, Saki Yamamoto, Ryosuke Midorikawa, Kogo Takamiya, Motohiro Nonaka, Hiromu Takematsu, Shogo Oka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)