Journal
NEUROSCIENCE LETTERS
Volume 498, Issue 3, Pages 218-221Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.05.012
Keywords
Depression; Gene; Bipolar disorder; Early onset; COMT
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Funding
- Lundbeck A/S
- Belgian National Fund for Scientific Research (FNRS) [3.4.530.07 F]
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Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG + AG genotypes were more represented in the subgroup of early onset MD patients (p = 0.04). Additionally, we observed an association between rs737865 alleles and early onset MD (p = 0.04). Rs4680 genotype was associated with early onset BD as well (p = 0.01). In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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