Article
Clinical Neurology
Britt A. Fedor, Anna C. J. Kalisvaart, Shivani Ralhan, Tiffany F. C. Kung, Maxwell MacLaren, Frederick Colbourne
Summary: This study found that striatal intracerebral hemorrhage generally does not respond to rehabilitation under certain conditions. This highlights the difficulty in replicating and extending previous research.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Review
Rehabilitation
Mariah Balinski, Sangeetha Madhavan
Summary: The purpose of this systematic review was to determine the number of treadmill training sessions needed to make a meaningful change in gait speed for chronic stroke survivors. The study found that at least 30 treadmill sessions (preferably within 10 weeks, with each session lasting at least 40 minutes) are necessary to achieve a meaningful change in gait speed.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Behavioral Sciences
Ling-Yi Liao, Pei-Dong Xu, Xiang-Qin Fang, Qing-Hua Wang, Yong Tao, Huan Cheng, Chang-Yue Gao
Summary: This study analyzed 304 patients with intracerebral hemorrhage and found that lower NIHSS scores, younger age, and drinking increased the risk of post-stroke spasticity, while smoking and hemorrhage in the thalamus reduced the risk.
BRAIN AND BEHAVIOR
(2023)
Article
Biology
Rathi Ratha Krishnan, Edgar Quan Yi Yeo, Chien Joo Lim, Karen Sui Geok Chua
Summary: This study compared inpatient rehabilitation outcomes between different subtypes of stroke and identified predictors of discharge outcomes. Despite the initial severity of stroke being worse in intracerebral hemorrhage patients, they achieved similar functional gains, independence levels, and return-home rates compared to cerebral infarction patients after inpatient rehabilitation.
Review
Clinical Neurology
Turner S. Baker, John Durbin, Zachary Troiani, Luis Ascanio-Cortez, Rebecca Baron, Anthony Costa, Fred Rincon, Frederick Colbourne, Patrick Lyden, Stephan A. Mayer, Christopher P. Kellner
Summary: Therapeutic hypothermia has shown significant benefits in improving long-term outcomes in intracerebral hemorrhage in preclinical studies, but clinical studies have not yet confirmed these findings. More randomized controlled studies are needed to determine the true effectiveness of therapeutic hypothermia in this condition.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Medicine, Research & Experimental
Guoyuan Pan, Huimei Zhang, Anqi Zhu, Yao Lin, Lili Zhang, Bingyun Ye, Jingyan Cheng, Weimin Shen, Lingqin Jin, Chan Liu, Qingfeng Xie, Xiang Chen
Summary: Treadmill training increased caveolin-1 expression, improved neuroprotection, reduced neuronal loss and apoptosis, and protected mitochondrial integrity in rats with cerebral ischaemic injury.
Article
Clinical Neurology
Edith H. Svensson, Martin Soderholm
Summary: Higher baseline FGF23 levels were significantly associated with incident intracerebral hemorrhage (ICH), particularly in lobar and non-lobar ICH. FGF23 was also significantly associated with fatal ICH, ICH with large volume, and ICH with poor functional outcome. Further studies are needed to determine if this association is causal.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Xiaorong Cheng, Shunqin Mao, Yibao Zhang, Xiaoyun Peng, Rui Ma, Yingcun Bao, Qun Li, Mei Liu, Dengjuan Sun, Bo Wan, Lulu Wang, Fang Zhang
Summary: This systematic review aims to investigate the beneficial effects of early physical rehabilitation for ICH patients compared with standard rehabilitation care. The methods include searching for randomized control trials, performing meta-analysis, evaluating rehabilitation effectiveness, and assessing risk of bias. The study aims to provide insight for clinicians to improve rehabilitation outcomes for ICH patients.
Article
Cardiac & Cardiovascular Systems
Elizabeth W. Regan, Reed Handlery, Jill C. Stewart, Joseph L. Pearson, Sara Wilcox, Stacy Fritz
Summary: This study integrated survivors of stroke into a standard exercise-based CR program and evaluated the impact through physical function measures and qualitative assessment. Results showed that exercise-based CR could significantly improve cardiovascular endurance, health status, and quality of life for survivors of stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Physiology
Liam P. Kelly, Fabien Andre Basset, Jason McCarthy, Michelle Ploughman
Summary: The study evaluated the safety and feasibility of treadmill aerobic exercise in moderate normobaric hypoxia among chronic hemiparetic stroke survivors. Results showed that moderate normobaric hypoxia exposure appeared to be a safe and feasible method to increase cardiovascular strain during submaximal exercise in chronic hemiparetic stroke survivors.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jawed Nawabi, Frieder Schlunk, Andrea Dell Orco, Sarah Elsayed, Federico Mazzacane, Dmitriy Desser, Ly Vu, Estelle Vogt, Haoyin Cao, Maik F. H. Boehmer, Burak Han Akkurt, Peter B. Sporns, Marco Pasi, Ulf Jensen-Kondering, Gabriel Broocks, Tobias Penzkofer, Jens Fiehler, Alessandro Padovani, Uta Hanning, Andrea Morotti
Summary: Non-contrast computed tomography (NCCT) markers are reliable predictors for predicting parenchymal hematoma expansion in intracerebral hemorrhage (ICH). This study investigates whether NCCT features can also identify patients at risk of intraventricular hemorrhage (IVH) growth.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Morotti, Giorgio Busto, Gregoire Boulouis, Elisa Scola, Alessandro Padovani, Ilaria Casetta, Enrico Fainardi
Summary: The combined analysis of non-contrast CT and CT perfusion markers improves the prediction of hematoma expansion and outcome in intracerebral hemorrhage.
EUROPEAN RADIOLOGY
(2023)
Review
Clinical Neurology
Sarah N. N. Ohashi, Jonathan H. H. DeLong, Mariel G. G. Kozberg, David J. J. Mazur-Hart, Susanne J. J. van Veluw, Nabil J. J. Alkayed, Lauren H. H. Sansing
Summary: Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral hemorrhage and subarachnoid hemorrhage. Inflammatory immune responses play a crucial role in the pathophysiology of these types of stroke, both affecting tissue recovery and injury. Understanding these processes can lead to the development of effective therapeutic strategies.
Review
Rehabilitation
Jorge Motta Anjos, Mansueto Gomes Neto, Franciele Silva dos Santos, Katna de Oliveira Almeida, Edimar Alcides Bocchi, Yasmin de Souza Lima Bitar, Andre Rodrigues Duraes
Summary: High-intensity interval training has positive effects on the functioning and health-related quality of life of post-stroke patients. It improves cardiorespiratory fitness, balance, and gait speed, leading to better physical function in these patients.
CLINICAL REHABILITATION
(2022)
Article
Clinical Neurology
Magnus Thoren, Irene Escudero-Martinez, Tomas Andersson, Shih-Yin Chen, Nicole Tsao, Dheeraj Khurana, Simone Beretta, Andre Peeters, Georgios Tsivgoulis, Christine Roffe, Niaz Ahmed
Summary: This study investigated the association between reperfusion and the development of early cerebral edema after stroke thrombectomy. The results showed that successful reperfusion was associated with a lower risk of early cerebral edema. Severe early neurological deficits may weaken the association between reperfusion and lower risk of cerebral edema.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Engineering, Biomedical
Ki Yeun Nam, Hyun Jung Kim, Bum Sun Kwon, Jin-Woo Park, Ho Jun Lee, Aeri Yoo
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2017)
Article
Dentistry, Oral Surgery & Medicine
H. Kim, J. -W. Park, K. Nam
JOURNAL OF ORAL REHABILITATION
(2017)
Article
Gastroenterology & Hepatology
J. -W. Park, G. -J. Sim, H. -J. Kim, J. -S. Yeo, H. -J. Hong, B. S. Kwon
NEUROGASTROENTEROLOGY AND MOTILITY
(2017)
Article
Clinical Neurology
Seungyeon Kim, Joonghyun Park, Bum Sun Kwon, Jin-Woo Park, Ho Jun Lee, Jin-Ho Choi, Kiyeun Nam
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2017)
Article
Rehabilitation
Yeon-Gyo Nam, Jin Won Lee, Jin Woo Park, Ho Jun Lee, Ki Yeun Nam, Jun Hyung Park, Chang Seon Yu, Myong Ryol Choi, Bum Sun Kwon
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2019)
Article
Gastroenterology & Hepatology
Jin-Woo Park, Hyojun Kim, Taejune Park, Jeong-Seok Yeo, Ho-Jin Hong, Jin-Young Oh
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Otorhinolaryngology
Yong-Jin Cho, Wi-Sun Ryu, Hojun Lee, Dong-Eog Kim, Jin-Woo Park
Article
Neurosciences
Yongjin Cho, Jin-Woo Park, Kiyeun Nam
Article
Medicine, General & Internal
Jin-Woo Park, Chi-Hoon Oh, Bo-Un Choi, Ho-Jin Hong, Joong-Hee Park, Tae-Yeon Kim, Yong-Jin Cho
Summary: This study compared the effects of two different tongue-strengthening exercises on the swallowing function in older adults, finding that regardless of the method used, tongue-strengthening exercises significantly improved lingual strength and swallowing function in the elderly.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
SeokJoon Hwang, Minsu Seo, Dongin Lim, Min Suk Choi, Jin-Woo Park, Kiyeun Nam
Summary: This literature review investigated the characteristics and management of bisphosphonate-associated bilateral atypical femoral fractures (AFFs). A comprehensive analysis of 43 patients with bilateral AFFs revealed that 67% had prodromal symptoms, 49% occurred simultaneously, and 51% occurred sequentially. X-ray was used for initial diagnosis, with 53% having complete fractures. Surgical treatment was performed for all patients, except for those with incomplete fractures who received either surgical or medical treatments. Teriparatide was the most commonly used medication after bisphosphonate discontinuation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Taejune Park, Hyojun Kim, Jin-Woo Park, Kiyeun Nam
MEDICINA DELLO SPORT
(2019)
Article
Rehabilitation
Heejae Kim, Bum Sun Kwon, Jin-Woo Park, Hojun Lee, Kiyeun Nam, Taejune Park, Yongjin Cho, Taeyeon Kim
ANNALS OF REHABILITATION MEDICINE-ARM
(2018)
Article
Rehabilitation
Hyojun Kim, Bum Sun Kwon, Jin-Woo Park, Ho Jun Lee, Jung Whan Lee, Eun Kyoung Lee, Tae June Park, Hee Jae Kim, Yongjin Cho, Taeyeon Kim, Kiyeun Nam
ANNALS OF REHABILITATION MEDICINE-ARM
(2018)
Article
Rehabilitation
Kyoung Hwan Lee, Jin Woo Park, Ho Jun Lee, Ki Yeun Nam, Tae June Park, Hee Jae Kim, Bum Sun Kwon
ANNALS OF REHABILITATION MEDICINE-ARM
(2017)
Article
Clinical Neurology
Hyojun Kim, Ho Jun Lee, Jin-Woo Park
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2018)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)