Journal
NEUROSCIENCE LETTERS
Volume 468, Issue 3, Pages 344-347Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.11.029
Keywords
Circadian rhythm; Suprachiasmatic nucleus; Bicuculline; Field potential; SCN firing rhythm; GABA
Categories
Funding
- MEXT [15790127]
- Grants-in-Aid for Scientific Research [15790127] Funding Source: KAKEN
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Gamma-aminobutyric acid (GABA), and its biosynthetic enzyme, glutamic decarboxylase, are widely distributed in the suprachiasmatic nucleus (SCN). In the present study, we examined the role of the GABA(A) receptor on in vitro SCN responses to photic-like signals. We found that 100 mu M GABA(A) receptor antagonist bicuculline partially blocked field potentials evoked by optic nerve stimulation. NMDA- and SP-induced phase shifts of SCN neuronal activity rhythms, were blocked with 10 mu M bicuculline. Application of 100 mu M bicuculline alone induced phase advance of SCN neuronal activity rhythm. These results show that NMDA- and SP-induced phase shifts are blocked by bicuculline and suggest GABA has an important role as neurotransmitter in the neuronal network regulating phase shifts of the circadian clock. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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