Article
Neurosciences
Jia-Ying Li, Yang-Jung Yu, Chun-Lin Su, Yu-Qi Shen, Chih-Hua Chang, Po-Wu Gean
Summary: Drug-associated conditioned cues promote drug-seeking behavior by recalling drug reward memory. Inhibition of the BLA-NAc neural projection can disrupt the consolidated methamphetamine-associated memory during reconsolidation. This study provides evidence that the BLA-NAc pathway is involved in the post-retrieval processing of drug-associated memory.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Johannes Petzold, Karen K. Szumlinski, Edythe D. London
Summary: Research suggests that modulation of the mGlu(5) receptor with allosteric modulators may offer a promising approach for ameliorating the devastating consequences of methamphetamine abuse. Further clinical research is needed to understand the mechanisms underlying these effects and develop tailored medications for Methamphetamine Use Disorder.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Lidia E. W. Spelta, Yuli Y. S. Torres, Sarah C. W. S. E. F. de Oliveira, Mauricio Yonamine, Alexis Bailey, Rosana Camarini, Raphael C. T. Garcia, Tania Marcourakis
Summary: This study demonstrates that cocaine use induces plastic changes in the hippocampal cholinergic muscarinic system, while withdrawal leads to a resetting of the system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Neurosciences
Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wang
Summary: METH leads to compulsive drug-seeking and drug-taking behavior, resulting in addiction and neurotoxicity; L-THP has inhibitory effects on the occurrence, maintenance, and relapse of METH addiction; L-THP can enhance nerve cell plasticity and improve nerve cell function through brain-derived neurotrophic factor pathways.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Ching Mei Wu, Ted Weita Lai
Summary: The study found that depleting microglia from mouse brain did not have a significant impact on cocaine-induced behavioral sensitization, suggesting that microglia may not have a net effect on cocaine-induced long-lasting behavioral changes.
Article
Psychiatry
Aram Parsegian, M. Julia Garcia-Fuster, Elaine Hebda-Bauer, Stanley. J. J. Watson, Shelly. B. B. Flagel, Huda Akil
Summary: Adolescent drug use affects addiction liability in adulthood, with variations depending on genetic background and cocaine exposure. This study explores the role of genetic rat models and epigenetic chromatin modifications in behavioral profiles and cocaine sensitization.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Zhi-yuan Wang, Liang-kun Guo, Xiao Han, Rui Song, Guo-ming Dong, Chun-ming Ma, Ning Wu, Jin Li
Summary: The study investigated the effects of naltrexone on the properties of incentive salience and reward-related memory in methamphetamine addiction using mouse models. Naltrexone was found to reduce methamphetamine-induced hyper locomotion and suppress the development of locomotor sensitization, suggesting its therapeutic potential in treating methamphetamine addiction. These findings demonstrate that naltrexone could intervene in the incentive salience and reward-related memory properties, contributing to its therapeutic effects on methamphetamine addicts in clinical studies.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Biochemistry & Molecular Biology
Elissa K. Fultz, Sema G. Quadir, Douglas Martin, Daniel M. Flaherty, Paul F. Worley, Tod E. Kippin, Karen K. Szumlinski
Summary: Methamphetamine (MA) is a highly addictive drug with increasing global use. There is no approved pharmacotherapy for MA use disorder, and little is known about the neurobiological determinants of vulnerability to the disease. Studies suggest that ERK activation in the medial prefrontal cortex may play a role in the affective valence of MA and its reinforcing properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Marsida Kallupi, Jenni Kononoff, Philippe A. Melas, Johanna S. Qvist, Giordano de Guglielmo, Eric R. Kandel, Olivier George
Summary: The study found that DBS of the NAcc shell did not decrease cocaine intake, but had therapeutic effects on reducing negative emotional states during withdrawal.
Article
Biochemistry & Molecular Biology
Li Zhu, Feifei Wu, Zhilan Yan, Lijun He, Shufei Wang, Haohao Hu, Eyleen L. K. Goh, Yingjie Zhu, Fanglin Guan, Teng Chen
Summary: The decreased expression of a novel microRNA, novel-m009C, is found to be implicated in the hyperlocomotion induced by METH. The study identifies dopamine receptors D1 and D2 as regulators of novel-m009C expression in the nucleus accumbens, and increasing the levels of novel-m009C attenuates the rewarding effects of METH. These findings provide insights into the molecular mechanism underlying METH addiction and suggest a potential treatment strategy targeting small non-coding RNAs.
MOLECULAR PSYCHIATRY
(2022)
Article
Cell Biology
Ying-Jian Gu, Lei Chen, Lin Cheng, Ming-Yuan Zhou, Yun Wang
Summary: Chronic exposure to methamphetamine can lead to neurotoxicity in both rodents and humans, resulting in disorders like use disorder, abuse, addiction, and behavioral sensitization. Changes in non-coding RNA expression in specific brain regions are linked to methamphetamine's behavioral effects, highlighting the importance of studying their relationship for potential therapeutic targets.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Ewa Niedzielska-Andres, Lucyna Pomierny-Chamiolo, Michal Andres, Maria Walczak, Lori A. Knackstedt, Malgorzata Filip, Edmund Przegalinski
Summary: This review highlights the significance of glutamate transmission in the development of substance use disorders, particularly in relation to relapse. It discusses the changes in glutamate levels in different brain regions during cocaine exposure, withdrawal, and reinstatement of seeking behavior, as well as the role of glutamate transporters and metabotropic glutamate receptors. The analysis suggests that targeting these glutamatergic adaptations could be crucial for developing effective medications for cocaine use disorder.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
Travis M. Moschak, T. Joseph Sloand, Regina M. Carelli
Summary: Distress tolerance (DT) is the ability to persist in challenging goal-directed behavior in the face of stress. Preclinical study in rats reveals that low DT is associated with heightened drug-seeking behavior. The study also demonstrates that the prelimbic cortex (PrL) plays an important role in DT and drug-seeking behavior, particularly in male rats with a history of cocaine.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Ana Filosevic Vujnovic, Lara Saftic Martinovic, Marta Medija, Rozi Andretic Waldowski
Summary: Due to its similarities in genetics, cellular response, and behavior, Drosophila is a commonly used model organism in addiction research. This study used LC-MS/MS to examine the concentration changes of neurotransmitters, metabolites, and drugs in the whole head homogenates of male flies after the administration of volatilized cocaine and methamphetamine. The results showed that the effects of these substances on neurotransmitter systems varied over time.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)