Article
Clinical Neurology
Bianca Raffaelli, Elisabeth Storch, Lucas Hendrik Overeem, Maria Terhart, Mira Pauline Fitzek, Kristin Sophie Lange, Uwe Reuter
Summary: This study found that sex hormones may modulate CGRP release in the trigeminovascular system. In female participants with episodic migraine, plasma and tear fluid CGRP concentrations were higher during menstruation. However, female participants with combined oral contraception and those in the postmenopause had similar CGRP levels to the control group.
Article
Biochemistry & Molecular Biology
Benjamin M. Zemel, Lianteng Zhi, Eric V. Brown, Stephen R. Tymanskyj, Qiansheng Liang, Manuel Covarrubias
Summary: The study suggests that a physical interaction between Kv3.4 channel and functional PKC epsilon primarily determines its stability and localization in DRG neurons, without significantly affecting its gating.
Article
Chemistry, Multidisciplinary
Jie Mi, Jian-Kun Xu, Zhi Yao, Hao Yao, Ye Li, Xuan He, Bing-Yang Dai, Li Zou, Wen-Xue Tong, Xiao-Tian Zhang, Pei-Jie Hu, Ye Chun Ruan, Ning Tang, Xia Guo, Jie Zhao, Ju-Fang He, Ling Qin
Summary: The study demonstrates that electrical stimulation can enhance fracture healing by increasing CGRP expression, promoting angiogenesis and osteogenesis, offering an innovative strategy for enhancing bone regeneration using bioelectronic devices.
Article
Multidisciplinary Sciences
Sara Caxaria, Sabah Bharde, Alice M. Fuller, Romy Evans, Bethan Thomas, Petek Celik, Francesco Dell'Accio, Simon Yona, Derek Gilroy, Mathieu-Benoit Voisin, John N. Wood, Shafaq Sikandar
Summary: We demonstrated the role of neutrophils in fibromyalgia by using a back-translational approach in mice. Adoptive transfer of neutrophils from mice with chronic widespread pain or patients with fibromyalgia can induce mechanical pain in recipient mice, sensitize spinal cord neurons, and cause changes in the expression of neutrophil proteins that lead to neutrophil infiltration into dorsal root ganglia. These findings suggest an immunological basis for chronic widespread pain in fibromyalgia mediated by neutrophils.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Cristina Fraquelli, Jasmine Hauzinger, Christian Humpel, Maria Nolano, Vincenzo Provitera, Vinay Kumar Sharma, Peng Loh, Zenon Pidsudko, Georgios Blatsios, Josef Troger
Summary: This study investigated the presence and source of serpinins in the skin, and found that serpinin was present in the dorsal root ganglia and sensory nerves of rats, with colocalization with substance P. Although predominantly found in its free form in the skin, the serpinins may have functional significance in the sensory innervation of the skin.
Article
Biochemistry & Molecular Biology
Ruirui Lu, Katharina Metzner, Fangyuan Zhou, Cathrin Flauaus, Annika Balzulat, Patrick Engel, Jonas Petersen, Rebekka Ehinger, Anne Bausch, Peter Ruth, Robert Lukowski, Achim Schmidtko
Summary: The sodium-activated potassium channel Slack plays a role in sensory neurons and is involved in mediating sodium-activated potassium current (I-KNa) and modulating neuronal activity. Studies found that Slack activity is reduced in sensory neurons after peripheral nerve injury, contributing to neuropathic pain hypersensitivity, and that it is associated with ATP-sensitive P2X3 receptors. Experiments showed that Slack-mediated I-KNa can be bidirectionally modulated in response to P2X3 activation, suggesting a potential novel strategy for treating neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Julien Pujo, Giada De Palma, Jun Lu, Heather J. J. Galipeau, Michael G. G. Surette, Stephen M. M. Collins, Premysl Bercik
Summary: Abdominal pain is common in gastrointestinal disorders, and gut microbiota and sex both play a role in determining visceral sensitivity. Germ-free mice displayed greater pain responses to colorectal distension, and the production of CGRP was higher in germ-free mice, especially in females.
Article
Medicine, Research & Experimental
Ying Zhao, Qiang Wang, Chen Xie, Yuling Cai, Xue Chen, Yuhui Hou, Liu He, Jianping Li, Min Yao, Shuangxi Chen, Wutian Wu, Xiaojia Chen, An Hong
Summary: This study developed a novel low-molecular-weight peptide agonist CH02 targeting FGFR, which effectively promoted nerve regeneration, enhanced axon growth of sensory neurons, and robustly improved nerve regeneration and sensory-motor behavioral recovery in a rat spinal dorsal root injury model.
Article
Anesthesiology
Xiao-Long Zhang, Jin-Jun Zhang, Zi-Hang Chen, Kai-Bin Yang, Xi Zhang, Yi-Bin Xiao, Yi Lei, Xian-Ying Cao, Man-Xiu Xie
Summary: Research has shown that the SIRT1 protein plays a role in the different pain vulnerability of adults and minors. The interaction between SIRT1 and the ClC-3 channel contributes to the pain vulnerability difference between adults and minors. Additionally, there is a negative correlation between serum SIRT1 levels and pain scores in chronic pain patients.
Article
Engineering, Biomedical
Uyen N. Nguyen, Fei San Lee, Sydney M. Caparaso, Jack T. Leoni, Adan L. Redwine, Rebecca A. Wachs
Summary: This study evaluated the effects of type I collagen concentration on adult rat DRG neurite growth. It was found that increasing collagen concentration significantly reduced neurite length while increasing gel stiffness. These findings are important for studying sensory neuron growth and designing biomaterials for nerve regeneration applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Neurosciences
Xiao-Xing Song, Lin-Yu Jin, Qiang Li, Xin-Feng Li, Yan Luo
Summary: This study investigated the antinociceptive effects of selective ER beta agonists on discogenic low back pain (DLBP) related behavior by regulating substance P in the spinal cord and dorsal root ganglia. The results showed that activation of ER beta could improve both axial and radiating behavioral disorders of DLBP and decrease substance P content. This study provides a therapeutic target for managing DLBP in the clinic.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Chemistry, Analytical
Rahul Atmaramani, Srivennela Veeramachaneni, Liz Valeria Mogas, Pratik Koppikar, Bryan J. Black, Audrey Hammack, Joseph J. Pancrazio, Rafael Granja-Vazquez
Summary: It has been found that the plasticity of axons of sensory neurons plays a critical role in pathological pain states, actively participating in pain signaling through the local expression of ion channels and signal transduction molecules. Using microfluidic systems to isolate axon-like structures of the dorsal root ganglion (DRG) lays the foundation for constructing complex in vitro models for studying pain signaling and for targeted pharmacological and genetic research.
Article
Neurosciences
Jichao Ma, Duyen Nguyen, Jazune Madas, Ariege Bizanti, Anas Mistareehi, Andrew M. Kwiat, Jin Chen, Mabelle Lin, Richard Christie, Peter Hunter, Maci Heal, Shane Baldwin, Susan Tappan, John B. Furness, Terry L. Powley, Zixi (Jack) Cheng
Summary: By using immunohistochemistry labeling and imaging techniques, the distribution and morphology of CGRP-IR axon innervation in the whole mouse stomach muscular layers were characterized. CGRP-IR axons were found to densely interact with blood vessels and run parallel with the longitudinal and circular muscles, forming contacts with myenteric ganglion neurons. This study provides important information for understanding the role of CGRP-IR axons in gastric function regulation.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Biochemical Research Methods
Aseer Intisar, Seung Joon Lee, Yu-Gyeong Kim, Woon-Hae Kim, Hyun Young Shin, Min Young Kim, Jong Man Kim, Jungmin Lee, Yun Jeoung Mo, Yu Seon Kim, Seung-Hoon Kim, Yun-Il Lee, Minseok S. Kim
Summary: This study introduces a rapid method for enriching neurons from the mouse embryonic dorsal root ganglion using fully-automated continuous centrifugal microfluidics, achieving effective isolation within 13 minutes. The purified neurons showed improved viability and purity compared to conventional chemical purification methods, highlighting the potential of this automated system to advance neurological research.
Article
Cell Biology
Fangyuan Zhou, Katharina Metzner, Patrick Engel, Annika Balzulat, Marco Sisignano, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui Lu
Summary: The study reveals that Slack serves as a modulator of TRPA1-mediated activation of sensory neurons, but not TRPV1-mediated activation.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)