Journal
NEUROSCIENCE LETTERS
Volume 450, Issue 2, Pages 191-195Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.11.017
Keywords
Stroke; Axon sprouting; Spinal cord; Photothrombosis
Categories
Funding
- American Heart Association [0615509Z]
- National Institutes of Health [P01 NS032636, R01 NS36265, P30 NS057105, K25 NS4339, R21 EB007924]
Ask authors/readers for more resources
Functional reorganization of brain cortical areas occurs following stroke in humans, and many instances of this plasticity are associated with recovery of function. Rodent studies have shown that following a cortical stroke, neurons in uninjured areas of the brain are capable of sprouting new axons into areas previously innervated by injured cortex. The pattern and extent of structural plasticity depend on the species, experimental model, and lesion localization. In this study, we examined the pattern of axon sprouting in spinal cord after a localized lesion which selectively targeted the primary motor cortex in adult mice. We subjected mice to a stereotaxic-guided photothrombotic stroke of the left motor cortex, followed 2 weeks later by an injection of the neuronal tracer biotinylated dextran amine (BDA) into the uninjured right motor cortex. BDA-positive axons originating from the uninjured motor cortex were increased in the gray matter of the right cervical spinal cord in stroke mice, compared to sham control mice. These results show that axon sprouting can occur in the spinal cord of adult wild-type mice after a localized stroke in motor cortex. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available