Journal
NEUROSCIENCE LETTERS
Volume 462, Issue 3, Pages 203-206Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.07.029
Keywords
FGF2; Cell excitability; K+ current; Dentate gyrus; Rat
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Fibroblast growth factor 2 (FGF2) is involved in hippocampus-dependent learning. In this study, the effects of FGF2 on the excitability were investigated in granule cells of rat dentate gyrus. Hippocampal slices were used to perform patch clamp recordings in granule cells. Extracellularly applied FGF2 early quenched the depolarization-induced repetitive firing, suggesting a decreased excitability under these conditions. Consistently, transient and sustained voltage-gated K+ currents decreased in a dose-dependent manner, repolarization phase of action potential was slowed down, after hyperpolarization was reduced, and membrane resistance was decreased. These effects were not mediated by tyrosine kinase FGF2 receptors. Moreover, an involvement of G protein signaling was ruled out, as well as an intracellular action of FGF2. Considering the relationship between FGF2 and hippocampal functions, the modulation of neuron excitability by activity-driven FGF2 release may be regarded as a part of a homeostatic mechanism of self-regulation of hippocampal activity. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
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