Article
Gastroenterology & Hepatology
Yanrong Wang, Mingbiao Qiao, Xue Yao, Zhonghui Feng, Ruiqi Hu, Jianguo Chen, Lei Liu, Jinbo Liu, Yueshan Sun, Yuanbiao Guo
Summary: Intestinal barrier dysfunction is a prevalent pathogenic factor underlying various disorders, and lidocaine may ameliorate it in IBS by potentially modulating the expression of CRHR2 on intestinal epithelial cells. CRHR2 expression was downregulated in rats under water avoidance stress, leading to decreased tight junction proteins and increased intestinal permeability. Lidocaine improved the severity of IBS rats by modulating intestinal epithelial TJs and protecting intestinal epithelial barrier function.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Integrative & Complementary Medicine
Mengzhu Sun, Yujie Zhang, Yafang Song, Jing Guo, Tingting Zhao, Yuhang Wang, Lixia Pei, Jianhua Sun
Summary: This study aimed to investigate the effects of electroacupuncture (EA) at bilateral Tianshu (ST25) and Zusanli (ST36) acupoints on stress-induced irritable bowel syndrome (IBS). The results demonstrated that EA alleviated visceral hypersensitivity, modulated gut microbiota dysbiosis, and suppressed the overexpression of corticotropin-releasing factor (CRF) in colon tissues, suggesting its potential as a treatment for IBS.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Yi Feng Liang, Xiao Qi Chen, Meng Ting Zhang, He Yong Tang, Guo Ming Shen
Summary: Irritable bowel syndrome (IBS) is a stress-related disorder characterized by psychological and gastrointestinal dysfunction. In addition to intestinal symptoms, IBS patients also experience mood disorders such as anxiety and depression. Corticotropin-releasing hormone has been found to play a key role in IBS with comorbid mood disorders.
Article
Endocrinology & Metabolism
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura
Summary: Growing evidence suggests that visceral hypersensitivity and impaired gut barrier function play a crucial role in the development of irritable bowel syndrome (IBS). The APJ system, which modulates the CRF-TLR4-proinflammatory cytokine signaling, is involved in the regulation of visceral sensation and gut permeability. Inhibition of apelinergic signaling may offer a promising therapeutic option for IBS by attenuating the GI changes mediated via AMPK, NO, and opioid signaling.
Article
Medicine, Research & Experimental
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura
Summary: Phlorizin was found to improve visceral hypersensitivity and colonic hyperpermeability in IBS models by inhibiting SGLT2, and these effects were mediated via the AMPK, NO, and opioid pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura
Summary: In this study, it was found that Imeglimin can improve visceral hypersensitivity and colonic hyperpermeability in the IBS rat model by acting on AMPK and opioid receptors, suggesting its potential effectiveness in the treatment of IBS.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jing Liu, Rui Peng, Qian Tan, Bocun Li, Jianyi Chen, Guangya Liu, Yawen Wang, Chao Li, Jia Li, Hua Wang
Summary: In this study, label-free LC-MS-based proteomics analysis was used to investigate the molecular mechanisms of IBS-D and the effects of acupuncture on colonic mucosa protein abundance in rats. The results showed that IBS-D is closely related to energy metabolism and muscular excitation/contraction. Both traditional acupuncture and syndrome differentiation acupuncture can reverse the impairments of normal energy metabolism. Additionally, the syndrome differentiation acupuncture can regulate proteins related to inflammation, wound repair and cell protection against oxidative stress, which may contribute to its analgesic effect.
Review
Neurosciences
Yuanzhen Yang, Jiaqi Wang, Chaoyang Zhang, Yi Guo, Meidan Zhao, Man Zhang, Zhongzheng Li, Feifei Gao, Yu Luo, Yiru Wang, Junyi Cao, Mingfang Du, Yuzhe Wang, Xiaowei Lin, Zhifang Xu
Summary: This review explores the central and peripheral analgesic mechanisms of acupuncture in the treatment of Irritable Bowel Syndrome (IBS). Acupuncture can alleviate inflammation and pain, regulate emotional components, and improve pain caused by IBS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biology
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce
Summary: CRH plays a role in regulating multiple biological systems, and is also associated with reproduction, neuropsychiatric, gastrointestinal, immune disorders, and tumor development. Further research on the physiological functions of CRH will help determine its role in human diseases and may serve as novel therapeutic targets.
Article
Medicine, Research & Experimental
Wen-Ying Chang, Yi-Ting Yang, Meng-Ping She, Chia-Hung Tu, Tsung-Chun Lee, Ming-Shiang Wu, Chin-Hung Sun, Ling-Wei Hsin, Linda Chia-Hui Yu
Summary: Irritable bowel syndrome (IBS) is associated with abnormal serotonin metabolism and mucosal neurite outgrowth, and 5-HT7 receptor plays a role in the process. Increased mucosal density of 5-HT7-expressing nerve fibers and elevated levels of neurotrophins contribute to visceral hypersensitivity in IBS. A novel 5-HT7 antagonist may be used as an oral analgesic for IBS-related pain.
LABORATORY INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Yuanxia Lv, Jing Wen, Yingying Fang, Haoyuan Zhang, Jianwu Zhang
Summary: CRF is a 41-amino acid polypeptide that coordinates various systems in the body, mediating visceral hypersensitivity like in irritable bowel syndrome. However, the lack of sufficient understanding of the multiple variants of CRF-R1 and CRF-R1 antagonists hinders the successful translation of preclinical studies into clinical trials. Investigating the sites of action of central and peripheral CRF is crucial for accelerating this translation process.
Article
Oncology
He-Yong Tang, Xi-Qiuyu Chen, Hao Wang, Hao-Ran Chu, Cai-Feng Zhu, Shun Huang, Meng-Ting Zhang, Guo-Ming Shen
Summary: This study found that acupuncture treatment can effectively alleviate diarrhea symptoms in IBS-D rats. It achieves this by regulating the expression of certain genes and proteins, reducing the release of inflammatory factors, chemokines, and neurotransmitters, thus lowering visceral hypersensitivity.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Neurosciences
Angelica Roque, Kinberli Marcela Valles Mendez, Roberto Ruiz, Edel Pineda, Naima Lajud
Summary: Maternal separation during early life has both short-term and long-term effects on neuropeptide expression and HPA axis activity in the hippocampus and hypothalamus of rats, resulting in cognitive impairments and behavioral abnormalities in adulthood.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Gastroenterology & Hepatology
Michael Camilleri, Alexandra Zhernakova, Sotto Bozzarelli, Mauro D'Amato
Summary: Genetic predisposition plays a significant role in the pathophysiology of irritable bowel syndrome (IBS). This review provides a comprehensive overview of genetic research in IBS and discusses new concepts in IBS genetics. While genetic research in IBS has been limited and inconclusive, the availability of large international cohorts and population-based biobanks presents unprecedented opportunities for well-powered studies. This review focuses on recent advances in identifying genes involved in digestion, ion channel function, neurotransmitters, neuronal pathways, and gut motility control.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)