Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda da Valerio, Samira Luisa Apostolos Pereira, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Jr, Adriana Bastos Conforto, Leandro Tavares Lucato, Marcelo Delboni Lemos, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study examined the relationships between symptoms and somatosensory profiles in patients with central neuropathic pain (CNP) caused by different types of lesions to the central nervous system. The results suggest that CNP of different etiologies may have different pain descriptors and somatosensory profiles, likely due to differences in lesion locations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Andrew D. Gaudet, Laura K. Fonken, Monica T. Ayala, Steven F. Maier, Linda R. Watkins
Summary: Aging increases susceptibility to pain and death after SCI in mice, while deletion of miR-155 reduces pain symptoms and mortality. Aging mice exhibit heightened heat sensitivity and evoked pain symptoms, highlighting the importance of studying geriatric models of SCI.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Giuseppe Forte, Valentina Giuffrida, Angelica Scuderi, Mariella Pazzaglia
Summary: Neuropathic pain is a common chronic condition that severely affects patients with spinal cord injuries. Current treatment options are limited, but nanomedicine shows potential for improving therapeutic efficacy. However, its application in treating neuropathic pain following spinal cord injuries still needs further improvement.
Article
Multidisciplinary Sciences
Tyler S. Nelson, Ghanshyam P. Sinha, Diogo F. S. Santos, Peter Jukkola, Pranav Prasoon, Michelle K. Winter, Ken E. McCarson, Bret N. Smith, Bradley K. Taylor
Summary: Peripheral nerve injury enhances the excitability of Y1-INs in the spinal cord dorsal horn, leading to the development of allodynia and affective pain. Inhibition of Y1-INs or administration of Y1 agonists can alleviate allodynic symptoms. Conditional deletion of Npy1r in dorsal horn neurons prevents the anti-hyperalgesic effects of intrathecal Y1 agonists. These findings suggest that Y1-INs in the spinal cord are a promising target for the treatment of neuropathic pain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Eva Widerstrom-Noga, Kimberly D. Anderson, Linda E. Robayo, Salome Perez, Alberto Martinez-Arizala, Lindsey Calle-Coule, Nicholas P. Cherup, Gabriel E. Fernandez
Summary: Many people with spinal cord injury (SCI) suffer from chronic pain, including neuropathic pain, which is often difficult to treat due to its complex nature. A multimodal approach, involving pharmacological treatments, physical rehabilitation, cognitive training, and pain education, may be the most effective strategy for managing pain in this population. This study developed an educational resource called SeePain, which was evaluated and modified based on stakeholder input, including SCI patients, their loved ones, and healthcare providers. The final resource is a comprehensive guide intended to improve health literacy and enhance communication between SCI patients and their healthcare providers. Future research will validate the effectiveness of SeePain using a large sample of SCI patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Neurosciences
Zhihao Zhang, Zhijie Zhu, Xiaoshuang Zuo, Xuankang Wang, Cheng Ju, Zhuowen Liang, Kun Li, Jiawei Zhang, Liang Luo, Yangguang Ma, Zhiwen Song, Xin Li, Penghui Li, Huilin Quan, Peipei Huang, Zhou Yao, Ning Yang, Jie Zhou, Zhenzhen Kou, Beiyu Chen, Tan Ding, Zhe Wang, Xueyu Hu
Summary: This study investigated the mechanisms of photobiomodulation (PBM) in relieving neuropathic pain (NP) after spinal cord injury (SCI). It was found that PBM therapy inhibited the activation of microglia and astrocytes, decreased the expression of CXCL10 in glial cells, and mediated the NF-κB signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Valerie Dietz, Katelyn Knox, Sherilynne Moore, Nolan Roberts, Karla Kassandra Corona, Jennifer N. Dulin
Summary: Spinal cord injury often leads to immediate and sustained neurological dysfunction, including neuropathic pain. This study found that the severity of the injury negatively correlated with the manifestation of mechanical hypersensitivity and suggests that the protection of dorsal horn neurons may be required for the development of neuropathic pain.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Neurosciences
Chang Sun, Junhao Deng, Yifei Ma, Fanqi Meng, Xiang Cui, Ming Li, Jiantao Li, Jia Li, Pengbin Yin, Lingjie Kong, Licheng Zhang, Peifu Tang
Summary: This article presents a comprehensive overview of recent advances in understanding the role of microglia in the development of neuropathic pain following spinal cord injury (SCI). It delves into the detrimental and protective effects of microglia on neuropathic pain following SCI, as well as the mechanisms underlying their interconversion. The article also provides a thorough overview of potential avenues for future research in this area.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Medicine, General & Internal
Dominika Mech, Katarzyna Korgol, Antonina Kurowska, Bartlomiej Adamski, Malgorzata Miazga, Grazyna Biala, Marta Kruk-Slomka
Summary: Spinal cord injury is a neurological condition that causes significant motor dysfunction, and current treatments only provide moderate efficacy, leaving patients with long-term disabilities. A scientific review is needed to summarize recent developments in therapeutic methods for SCI. This review focuses on pharmacological treatments and the challenges faced by patients depending on the location of the injury, addressing issues such as spasticity, neuropathic pain, neuroprotection, neurotransmission, and oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jay Karri, Shengai Li, Yen-Ting Chen, Argyrios Stampas, Sheng Li
Summary: Central neuromodulation targeting the Pain Neuromatrix-Central Autonomic Network interface produced parasympathetic changes and pain relief in SCI + NP persons, while increasing pain threshold in AB persons without affecting autonomic function. This suggests different responses to neuromodulation between individuals with spinal cord injury and chronic neuropathic pain and able-bodied controls.
Article
Pharmacology & Pharmacy
Yoki Nakamura, Ayako Fukuta, Keita Miyashita, Fang Fang Zhang, Dengli Wang, Keyue Liu, Hidenori Wake, Kazue Hisaoka-Nakashima, Masahiro Nishibori, Norimitsu Morioka
Summary: The study demonstrates that increased HMGB1 around the injured sciatic nerve may induce nociceptive hypersensitivity through the activation of spinal microglia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Immunology
Jing Zhu, Fei Huang, Yonglin Hu, Wei Qiao, Yingchao Guan, Zhi-Jun Zhang, Su Liu, Ying Liu
Summary: Secondary chronic neuropathic pain (NP) after spinal cord injury (SCI) significantly reduces quality of life. The mechanisms of NP in SCI have been studied, and reducing neuroinflammation has shown potential for improving NP-related behaviors. Non-coding RNAs have been found to play important roles in SCI, regulating gene expression, inhibiting inflammation, and influencing the prognosis of NP.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Neurosciences
Eric Brown, Ayma F. Malik, Elizabeth R. Moese, Abigail F. McElroy, Angelo C. Lepore
Summary: Neuropathic pain (NP) is a common and debilitating comorbidity of spinal cord injury (SCI). This study investigates the neural activity changes in the pain circuitry following cervical spinal cord injury. The findings reveal complex changes in neuronal activation, with increased activation in some neurons and decreased activation in inhibitory neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Rehabilitation
Xiaoyi Zhou, Shaofeng Chen, Yajun Cheng, Kai Chen, Ming Li, Yushu Bai, Xianzhao Wei
Summary: The study aimed to adapt the SCIPI into a simplified Chinese version and examine its reliability and validity in screening for neuropathic pain in SCI patients. The results showed that the SC-SCIPI demonstrated good internal consistency, reliability, and construct validity, indicating its applicability in clinical practice for neuropathic pain screening.
DISABILITY AND REHABILITATION
(2023)
Article
Biochemistry & Molecular Biology
Da-Jeong Chang, Hwi-Young Cho, Seyoung Hwang, Nayeon Lee, Chunggab Choi, Hyunseung Lee, Kwan Soo Hong, Seung-Hun Oh, Hyun Sook Kim, Dong Ah Shin, Young Wook Yoon, Jihwan Song
Summary: The study demonstrated that transplantation of genetically modified human neural stem cells overexpressing BDNF (F3.BDNF) in a rat spinal cord injury model can promote functional recovery, reduce inflammatory cell and astrocyte numbers, and improve hyperalgesia following SCI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Afraiz Tariq Satti, Jiyoun Kim, Eunsurk Yi, Hwi-young Cho, Sungbo Cho
Summary: This study investigated a driver drowsiness detection system based on electromyography signals, proposing an algorithm that detects weak muscle activity as a sign of driver drowsiness. Results showed an increase in driver drowsiness level and decrease in muscle activity during driving tasks, with frequency components shifting over time. The proposed algorithm demonstrated good real-time performance and the microneedle electrode showed comparable results with traditional electrodes, highlighting its potential for use in monitoring driver drowsiness.
Article
Clinical Neurology
Hye Rim Suh, Hwi-young Cho, Hee Chul Han
Summary: By injecting MIA into the intervertebral discs of rats, a reliable model for IVD degeneration was created. The study revealed that MIA injection led to spinal deformities, changes in the intervertebral discs and cartilage, which are crucial for understanding the mechanisms of low back pain in patients with IVD degeneration.
Article
Clinical Neurology
Tae-Sung In, Jin-Hwa Jung, Kyoung-Sim Jung, Hwi-Young Cho
Summary: The study demonstrates that a multidimensional treatment model combined with core stability exercise can significantly improve pain, disability, and sitting posture in patients with low back pain.
PAIN RESEARCH & MANAGEMENT
(2021)
Article
Environmental Sciences
Sung-Hyeon Kim, Ho-Jin Shin, Hwi-Young Cho
Summary: Recent studies have shown that breathing type may affect balance ability. This study investigated the differences in balance ability according to the type of breathing in healthy young adults. The findings indicated that voluntary thoracic and abdominal breathing can impact sway velocity, variability, and complexity in balance ability measurements.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ji-Eun Baek, Jin-Hwa Jung, Ho-Jin Shin, Sung-Hyeon Kim, Si-Yoon Sung, Su-Jin Park, Suk-Chan Hahm, Hwi-Young Cho, Min-Goo Lee
Summary: This study aimed to investigate the impact of a forest healing anti-aging program on the psychological, physiological, and physical health of older individuals with mild cognitive impairment (MCI). The findings showed that participating in the program led to significant improvements in psychological, physiological, and physical indicators for the participants.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ho-Jin Shin, Sung-Hyeon Kim, Hwi-Young Cho, Jae-Hon Lee
Summary: This study aimed to investigate the effect of meditation accompanied with stabilization exercise in the marine region on pain, tactile sense, muscle characteristics, muscle strength, balance, quality of life, and depression in female caregivers of people with severe physical disabilities. The results showed that this intervention significantly improved pain, muscle strength, and depression in female caregivers. Performing these activities in the marine region also led to greater benefits on tactile sense, balance, and quality of life.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Correction
Biotechnology & Applied Microbiology
Tae-Sung In, Jin-Hwa Jung, Kyoung-Sim Jung, Hwi-Young Cho
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Environmental Sciences
Ju-Yeon Jung, Hwi-Young Cho, Chang-Ki Kang
Summary: The forward head posture of visual display terminal (VDT) users leads to various physical and cognitive symptoms. This study investigated the effects of different workstations on posture, muscle properties, blood velocity, preference, and working memory, and found that maintaining a neutral alignment significantly improved working memory performance, muscle properties, and blood velocity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ju-Hyung Park, Seung-Jea Lee, Ho-Jin Shin, Hwi-Young Cho
Summary: This study investigated the effect of load and bar position on muscle activity during squat exercise. The results showed that muscle activity increased with higher loads, and significant differences in muscle activity were observed between high bar back squats and low bar back squats. High bar back squats required more lower extremity force and were beneficial for quadriceps strengthening, while low bar back squats required more trunk muscle activity and were more effective for carrying heavy loads.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biotechnology & Applied Microbiology
Kyoung-Sim Jung, Jin-Hwa Jung, Tae-Sung In, Hwi-Young Cho
Summary: This study demonstrates that pelvic tilt taping has a significant effect on muscle strength, pelvic inclination, and gait function in patients with stroke. The additional application of lateral pelvic tilt taping further strengthens these effects.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Environmental Sciences
Eui-Young Jung, Jin-Hwa Jung, Hwi-Young Cho, Sung-Hyeon Kim
Summary: Stretching can have a positive effect on balance ability by causing biomechanical and physiological changes in the postural muscles. The study found that stretching the plantar flexor muscles can improve balance ability, as evidenced by a reduction in sway area in the closed-eye condition and an increase in reach distance for dynamic balance ability. These findings suggest that plantar flexor stretching should be considered as a rehabilitation method to enhance balance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Neurosciences
Youngkyung Kim, Kyu-won Park, Eunji Lee, Young Wook Yoon
Summary: Traumatic spinal cord injury causes secondary damage due to oxygen and energy deprivation. PPAR gamma, known for its role in cell survival mechanisms, has the potential for neuroprotection. However, the role of endogenous spinal PPAR gamma in SCI is not well established.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Sport Sciences
Ho-Jin Shin, Sung-Hyeon Kim, Hwi-Young Cho
Summary: This study found that visual feedback has a positive effect on the acquisition and retention of squats, while the effect of tactile feedback on retention is not significant. Therefore, it is recommended to use visual feedback for the acquisition and retention of squats in exercise novices.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Health Care Sciences & Services
Yong-Hee Kim, Hwi-Young Cho, Sung-Hyeon Kim
Summary: This study evaluated the short-term effects of centralization of the glenohumeral joint (CGH) and dynamic humeral centering (DHC) on pain, disability, and grip strength in patients with secondary subacromial impingement syndrome (SIS). The results showed that both CGH and DHC led to improvements in pain and disability, while only CGH improved shoulder strength and grip strength.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
