Review
Neurosciences
Harun Najib Noristani
Summary: This article describes the different response of ascending dorsal column axons and descending corticospinal tract (CST) axons after spinal cord injury (SCI), as well as the efficacy of molecules targeting intrinsic axon regeneration in promoting their regrowth. Accumulating evidence suggests important differences in regenerative response between dorsal column and CST axons when targeting intrinsic pro-regenerative molecules.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Juntan Li, Yo Shinoda, Shuhei Ogawa, Shunsuke Ikegaya, Shuo Li, Yukihiro Matsuyama, Kohji Sato, Satoru Yamagishi
Summary: FLRT2 protein and leucine-rich transmembrane (FLRT) proteins play crucial roles in various developmental processes and pathological conditions. The expression pattern of FLRT2 in CNS development was analyzed using Flrt2-LacZ knock-in mice, revealing dynamic changes in expression in different brain regions during development and after spinal cord injury.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Cell Biology
David Parker
Summary: This study compares the properties of synapses made by regenerated axons with unlesioned axons in a lamprey model. Regenerated synapses below the lesion site show similar properties to unlesioned synapses, but differ in the number of synaptic vesicles and postsynaptic quantal amplitude. Axons above the lesion site have similar synaptic inputs to unlesioned animals, but with reduced release probability and facilitated inputs over spike trains.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Chengjun Li, Tian Qin, Jinyun Zhao, Rundong He, Haicheng Wen, Chunyue Duan, Hongbin Lu, Yong Cao, Jianzhong Hu
Summary: The study reveals that bone marrow mesenchymal stem cell-derived exosome-educated macrophages have great potential as therapeutic candidates for spinal cord injury, promoting neurovascular regeneration and functional recovery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Caixia Fan, Wen Yang, Lulu Zhang, Hui Cai, Yan Zhuang, Yanyan Chen, Yannan Zhao, Jianwu Dai
Summary: Spinal cord injury is a severe damage to the central nervous system, often leading to the loss of spinal cord structure and function. Researchers have developed a new hydrogel material with mechanical and electrical properties similar to the spinal cord, which can be used for spinal cord regeneration. By introducing glutathione and MMP-responsive proteins into the hydrogel, biomolecules can be released in response to the microenvironment of spinal cord injury, promoting axon regeneration and angiogenesis, and improving motor function recovery.
Article
Cell Biology
Agnes E. Haggerty, Ines Maldonado-Lasuncion, Yohshiro Nitobe, Kentaro Yamane, Megan M. Marlow, Hua You, Chi Zhang, Brian Cho, Xiaowei Li, Sashank Reddy, Hai-Quan Mao, Martin Oudega
Summary: The study found that combining MSC and NHC for treating spinal cord injuries can reduce the number of inflammatory cells, promote a shift from pro-inflammatory to anti-inflammatory environment at the injury site, decrease injury size, increase the presence of astrocytes and axons, but has no significant impact on MSC transplant survival and hind limb function.
Review
Cell Biology
Vasiliki Tsata, Daniel Wehner
Summary: The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, like fish and salamanders. The cellular and molecular basis of this difference is starting to emerge, including the identification of target cells reacting to injury and cues directing pro-regenerative responses. Zebrafish is one of the most understood models in terms of successful spinal cord regeneration, with neuron-intrinsic and extrinsic factors playing pivotal roles in axon regeneration and function recovery.
Review
Emergency Medicine
Yu Zhang, Shuhai Yang, Chang Liu, Xiaoxiao Han, Xiaosong Gu, Songlin Zhou
Summary: Spinal cord injury often results in permanent disability due to the loss of functional recovery. The formation of a glial scar around the damaged tissue can interrupt the healing process, and therapeutic treatments targeting scar components are important for improving functional recovery.
Article
Engineering, Biomedical
Jingjia Ye, Shuang Jin, Wanxiong Cai, Xiangfeng Chen, Hanyu Zheng, Tianfang Zhang, Wujie Lu, Xiaojian Li, Chengzhen Liang, Qixin Chen, Yaxian Wang, Xiaosong Gu, Bin Yu, Zuobing Chen, Xuhua Wang
Summary: A self-assembling hydrogel depot that releases anti-inflammatory drugs and growth factors locally has been proposed as a solution to repair severe spinal cord injuries and promote nerve regrowth.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Neurosciences
Chun Cui, Lin-Fang Wang, Shu-Bing Huang, Peng Zhao, Yong-Quan Chen, Yi-Bo Wu, Chen-Meng Qiao, Wei-Jiang Zhao, Yan-Qin Shen
Summary: The study found that the expression of NPY decreased in adult zebrafish spinal cord after injury, and inhibiting NPY expression impeded descend axon regeneration and locomotor recovery. This suggests that NPY in motoneurons may promote recovery by regulating motoneuron proliferation through activation of NPY1R.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Jin Young Hong, Junseon Lee, Hyun Kim, Changhwan Yeo, Wan-Jin Jeon, Yoon Jae Lee, In- Hyuk Ha
Summary: Spinal cord injury often leads to the formation of glial scar tissue, hindering neural regeneration. This study demonstrates that Shinbaro2 (Sh2) can ameliorate glial scars and promote axon growth after spinal cord injury. Sh2 reduces inflammation, inhibits scar formation, and enhances motor function recovery.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Masayasu Okada, Yosuke Kawagoe, Toshiyuki Takasugi, Motohiro Nozumi, Yasuyuki Ito, Hayato Fukusumi, Yonehiro Kanemura, Yukihiko Fujii, Michihiro Igarashi
Summary: Mammalian axon growth and axon regeneration share mechanistic similarities, with GAP-43 being a classical molecular marker involved in both processes. In this study, we characterized the S142 phosphorylation site of GAP-43 using a specific antibody and confirmed its role in axonal growth and regeneration. Our findings suggest that the pS142 antibody can serve as a candidate molecular marker for axonal growth in both rodents and humans.
NEUROCHEMICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Qiong Zhang, Mingfu Liu, Haibin Nong, Yanan Zhang, Yiguang Bai, Pan Liu, Shaohui Zong, Gaofeng Zeng
Summary: TFHL has shown to improve motor function recovery and promote spinal cord tissue repair in rats with spinal cord injury (SCI). It reduces apoptosis and improves the functional status of neurons. TFHL also improves cell morphology, microstructure, and axonal regeneration of damaged spinal motor neurons, and promotes the secretion of neurotrophic factors. Furthermore, TFHL promotes autophagy and related protein expression both in vivo and in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Ajay Pal, HongGeun Park, Aditya Ramamurthy, Ahmet S. Asan, Thelma Bethea, Meenu Johnkutty, Jason B. Carmel
Summary: In this study, the researchers developed a plasticity protocol in rats that aims to activate both sensory and motor connections in the spinal cord. They found that repeated application of this protocol in rats with spinal cord injury improved their forelimb dexterity and reduced hyperreflexia. This study shows the importance of targeting the sensory and motor systems in the spinal cord for promoting recovery after spinal cord injury.
Article
Biochemistry & Molecular Biology
Weihong Du, Yongbing Deng, Rong Jiang, Luyao Tong, Ruixue Li, Xue Jiang
Summary: Recent evidence suggests that demyelination and axonal degeneration occur in spinal cord injury during the secondary injury phase. Treatment with clemastine, an FDA-approved drug, was shown to preserve myelin integrity, decrease axonal loss, and improve functional recovery in a rat SCI model. This indicates that myelination-enhancing strategies could potentially be a therapeutic approach for functional recovery in SCI.
NEUROCHEMICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Therese B. Deramaudt, Malika Ali, Stephane Vinit, Marcel Bonay
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Neurosciences
Mei-Tsen Lin, Stephane Vinit, Kun-Ze Lee
Summary: The intermittent hypoxia associated with intermittent hypercapnia or sustained hypercapnia induced a greater ventilatory response than sustained hypercapnia during stimulus exposure. In subchronically injured animals, intermittent hypoxia associated with sustained hypercapnia or intermittent hypercapnic-hypoxia significantly enhanced tidal volume to a similar magnitude, but only intermittent hypercapnic-hypoxia and intermittent hypoxia were able to evoke long-term facilitation of tidal volume at the chronic injured stage. Mild intermittent hypercapnia did not further enhance the therapeutic effectiveness of intermittent hypoxia-induced respiratory recovery, but sustained hypercapnia associated with intermittent hypoxia may blunt ventilatory responses at the chronic injured stage.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Physiology
Pauline Michel-Flutot, Arnaud Mansart, Therese B. Deramaudt, Isley Jesus, Kun-Ze Lee, Marcel Bonay, Stephane Vinit
Summary: The study reveals that there was no significant spontaneous recovery of diaphragmatic activity observed up to 30 days post-injury in a C57BL/6 mouse model of high spinal cord injuries, but a partial restoration of the injured diaphragm was observed at 7 days post-injury during a respiratory challenge. Additionally, there was an increase in phrenic motoneuronal excitability between 1-7 days post-injury on the injured side, reflecting plasticity in the mouse respiratory system following a C2 cervical hemisection.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Physiology
Abdallah Fayssoil, Pauline Michel-Flutot, Frederic Lofaso, Robert Carlier, Mostafa El Hajjam, Stephane Vinit, Arnaud Mansart
Summary: Ultrasound imaging is an accurate and reproducible technique for assessing and monitoring diaphragm and rectus abdominis structure and function in rats. Measuring respiratory parameters provides normal eupneic values. Histological studies and plethysmography were used to validate the technique and assess the physiological implications.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Critical Care Medicine
Kun-Ze Lee, Li-Min Liou, Stephane Vinit
Summary: Cervical magnetic stimulation can be used to assess post-injury excitability of phrenic motor outputs, with shorter latency and increased amplitude observed in response to acute injury. Placing the stimulation more laterally at the left spinal cord in subchronic and chronic injury stages generally leads to larger motor-evoked potentials of the diaphragm.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Neurosciences
Margo Randelman, Lyandysha V. Zholudeva, Stephane Vinit, Michael A. Lane
Summary: This article reviews the anatomical incompleteness and neuroplasticity resulting from spinal cord injuries, as well as how non-invasive respiratory treatments can enhance recovery. It focuses on current clinically used respiratory training strategies and those in development, while also considering the impact of training on non-respiratory networks. Insights are given on advances in pre-clinical and translational research in this area, with a look into future directions for enhancing plasticity and improving functional outcomes after SCI.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Critical Care Medicine
Kun-Ze Lee, Li-Min Liou, Stephane Vinit, Ming-Yue Ren
Summary: This study aimed to investigate the rostral-caudal effect of spinal magnetic stimulation on diaphragmatic motor-evoked potentials after cervical spinal cord injury. The results showed that caudal cervical magnetic stimulation produced more robust diaphragmatic motor-evoked potentials compared with rostral cervical magnetic stimulation. Interestingly, despite weaker inspiratory diaphragmatic activity in contused rats, the diaphragmatic motor-evoked potentials were similar between uninjured and contused rats. Additionally, in contused animals, diaphragmatic motor-evoked potentials were greater at the chronic stage than during earlier injury stages.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Physiology
Pauline Michel-Flutot, Lyandysha V. Zholudeva, Margo L. Randelman, Therese B. Deramaudt, Arnaud Mansart, Jean-Claude Alvarez, Kun-Ze Lee, Michel Petitjean, Marcel Bonay, Michael A. Lane, Stephane Vinit
Summary: rTMS is a promising non-invasive therapy to ameliorate psychiatric disorders and neuropathic pain through neuromodulation, although the specific neural circuits involved are still not fully understood. This study demonstrated that a single high frequency rTMS protocol at 10 Hz can increase phrenic motoneuron excitability, mediated by local GABAergic disinhibition. Understanding how rTMS can affect neural circuits non-invasively may help harness its therapeutic potential for promoting recovery after disease or central nervous system injury.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Biology
Pauline Michel-Flutot, Isley Jesus, Valentin Vanhee, Camille H. Bourcier, Laila Emam, Abderrahim Ouguerroudj, Kun-Ze Lee, Lyandysha Zholudeva, Michael A. Lane, Arnaud Mansart, Marcel Bonay, Stephane Vinit
Summary: High spinal cord injuries (SCIs) often result in permanent diaphragmatic paralysis. This study investigated the effects of repetitive transcranial magnetic stimulation (rTMS) as a potential noninvasive therapeutic tool for enhancing respiratory function and reducing post-traumatic inflammation in cervical spinal cord injuries. The results suggest that chronic high-frequency rTMS can improve respiratory dysfunction, promote neuronal plasticity, and reduce harmful post-traumatic inflammatory processes. This therapy could be combined with other interventions to enhance outcomes.
Article
Biology
Afaf Bajjig, Pauline Michel-Flutot, Tiffany Migevent, Florence Cayetanot, Laurence Bodineau, Stephane Vinit, Isabelle Vivodtzev
Summary: This study used spinal cord contusion in mice to mimic human tetraplegia and found that the C3 model was an appropriate model for interventions aimed at restoring breathing following tetraplegia.
Article
Physiology
Ming-Yue Ren, Li-Min Liou, Stephane Vinit, Kun-Ze Lee
Summary: This study investigated the position effect of trans-spinal magnetic stimulation on the diaphragm using a figure-of-eight coil. The results showed that midline stimulation induced coactivation of the bilateral diaphragm, while lateral stimulation resulted in stronger motor evoked potentials in the ipsilateral diaphragm. These findings suggest the feasibility of inducing diaphragmatic motor evoked potentials with trans-spinal magnetic stimulation and reveal a lateral-midline effect on the diaphragm.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pauline Michel-Flutot, Laurie Efthimiadi, Lynda Djerbal, Therese B. Deramaudt, Marcel Bonay, Stephane Vinit
Summary: This study evaluated the antioxidant response in phrenic motoneurons following C2 spinal cord lateral hemi-section in rats, and found that the AMPK-Nrf2 signaling pathway plays a significant role in the oxidative stress response after high SCI. Harnessing this pathway could improve the antioxidant response and help in improving diaphragm activity in patients with high SCI.
Article
Neurosciences
Pauline Michel-Flutot, Camille H. Bourcier, Laila Emam, Adeline Gasser, Simon Glatigny, Stephane Vinit, Arnaud Mansart
Summary: Spinal cord injuries can result in permanent loss of function due to primary and secondary injuries. Extracellular traps, composed of chromatin, granular enzymes, and histones, are known to induce tissue damage and may contribute to secondary injury. This study showed, for the first time, that microglia and neutrophils form extracellular traps in the spinal cord following injury. It is important to determine the mechanisms and kinetics of trap formation to develop interventions for mitigating inflammatory processes and improving functional outcomes after spinal cord injury.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Pauline Michel-Flutot, Arnaud Mansart, Abdallah Fayssoil, Stephane Vinit
Summary: High cervical spinal cord injuries lead to permanent neuromotor and autonomic deficits, affecting respiratory and cardiovascular functions. This study evaluated the impact of C2 hemisection on vital functions in rats and found that diaphragm activity and systolic function were impacted up to 7 days post-injury, while the respiratory and cardiovascular systems displayed adaptation to maintain function.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biology
Pauline Michel-Flutot, Isley Jesus, Arnaud Mansart, Marcel Bonay, Kun-Ze Lee, Karine Aure, Stephane Vinit
Summary: Peripheral nerve injuries can cause long-lasting physiological and severe functional impairments. In this study, we demonstrated that trans-spinal magnetic stimulation is a reliable and non-invasive diagnostic tool for assessing peripheral nerve damage and subsequent recovery. This technique can be used to evaluate nerve conductance and neuromuscular junction property in preclinical models and clinical settings.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
