Journal
NEUROSCIENCE LETTERS
Volume 449, Issue 1, Pages 48-51Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.10.077
Keywords
MTHFR; Bipolar; Methylation; Folate
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Funding
- Chinese Academy of Sciences [KSCX2-YW-R-01]
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The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T is suspected to be a risk factor for psychiatric disorders, but it remains uncertain whether the MTHFR C677T variant is associated with bipolar disorders. To investigate possible association, unrelated controls (n=461) with no history of psychiatric disorders and patients (n=501) diagnosed with bipolar disorder were recruited in this study. In addition, six association studies published up to June 2008 were included in a subsequent meta-analysis. No significant difference was found in either allele frequencies or genotype distribution between patients and controls in our association study in the Chinese population. Similarly, the meta-analysis result showed no significant association between MTHFR C677T and bipolar disorder. In conclusion, the MTHFR C677T variant is unlikely to play a major role in the susceptibility to bipolar disorder, although MTHFR plays an important role in the one-carbon metabolism and DNA methylation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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