Article
Multidisciplinary Sciences
Su Jin Ham, Daewon Lee, Wen Jun Xu, Eunjoo Cho, Sekyu Choi, Soohong Min, Sunghyouk Park, Jongkyeong Chung
Summary: The loss of UCHL1 destabilizes pyruvate kinase and mitigates PD-related phenotypes, activating AMPK to promote mitophagy. Additionally, UCHL1 interacts antagonistically with TRIM63 to regulate PD-related pathologies, suggesting a link between glycolysis and PD pathology.
Article
Neurosciences
Sinthuja Pachchek, Zied Landoulsi, Lukas Pavelka, Claudia Schulte, Elena Buena-Atienza, Caspar Gross, Ann-Kathrin Hauser, Dheeraj Reddy Bobbili, Nicolas Casadei, Patrick May, Rejko Krueger, Geeta Acharya, Gloria Aguayo, Myriam Alexandre, Muhammad Ali, Wim Ammerlann, Giuseppe Arena, Rudi Balling, Michele Bassis, Roxane Batutu, Katy Beaumont, Regina Becker, Camille Bellora, Guy Berchem, Daniela Berg, Alexandre Bisdorff, Ibrahim Boussaad, David Bouvier, Kathrin Brockmann, Jessica Calmes, Lorieza Castillo, Gessica Contesotto, Nancy De Bremaeker, Nico Diederich, Rene Dondelinger, Nancy E. Ramia, Daniela Esteves, Guy Fagherazzi, Jean-Yves Ferrand, Katrin Frauenknecht, Manon Gantenbein, Thomas Gasser, Piotr Gawron, Soumyabrata Ghosh, Marijus Giraitis, Enrico Glaab, Martine Goergen, Elisa Gomez De Lope, Jerome Graas, Mariella Graziano, Valentin Groues, Anne Gruenewald, Wei Gu, Gael Hammot, Anne-Marie Hanff, Linda Hansen, Michael Heneka, Estelle Henry, Sylvia Herbrink, Sascha Herzinger, Michael Heymann, Michele Hu, Alexander Hundt, Nadine Jacoby, Jacek Jaroslaw Lebioda, Yohan Jarosz, Sonja Jonsdottir, Quentin Klopfenstein, Jochen Klucken, Pauline Lambert, Roseline Lentz, Inga Liepelt, Robert Liszka, Laura Longhino, Victoria Lorentz, Paula Cristina Lupu, Taina M. Marques, Clare Mackay, Walter Maetzler, Katrin Marcus, Guilherme Marques, Patricia Martins Conde, Deborah Mcintyre, Chouaib Mediouni, Francoise Meisch, Myriam Menster, Maura Minelli, Michel Mittelbronn, Brit Mollenhauer, Friedrich Muehlschlegel, Romain Nati, Ulf Nehrbass, Sarah Nickels, Beatrice Nicolai, Jean-Paul Nicolay, Fozia Noor, Marek Ostaszewski, Clarissa P. C. Gomes, Claire Pauly, Laure Pauly, Magali Perquin, Rosalina Ramos Lima, Armin Rauschenberger, Rajesh Rawal, Kirsten Roomp, Eduardo Rosales, Isabel Rosety, Estelle Sandt, Stefano Sapienza, Venkata Satagopam, Margaux Schmitt, Sabine Schmitz, Reinhard Schneider, Jens Schwamborn, Raquel Severino, Amir Sharify, Ekaterina Soboleva, Kate Sokolowska, Hermann Thien, Elodie Thiry, Rebecca Ting Jiin Loo, Christophe Trefois, Johanna Trouet, Olena Tsurkalenko, Michel Vaillant, Mesele Valenti, Gilles Van Cutsem, Carlos Vega, Liliana Vilas Boas, Maharshi Vyas, Richard Wade-Martins, Paul Wilmes, Evi Wollscheid-Lengeling, Gelani Zelimkhanov
Summary: Heterozygous variants in the GBA1 gene are recognized as a risk factor for Parkinson's disease. A study in Luxembourg using long-read DNA sequencing technology revealed a high prevalence of GBA1 variants as the major genetic risk for PD, providing an important advancement in accurate variant calling and access to treatment options for GBA1 carriers.
NPJ PARKINSONS DISEASE
(2023)
Article
Geriatrics & Gerontology
Prabhjyot Saini, Uladzislau Rudakou, Eric Yu, Jennifer A. Ruskey, Farnaz Asayesh, Sandra B. Laurent, Dan Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupre, Lior Greenbaum, Sharon Hassin-Baer, Alberto J. Espay, Guy A. Rouleau, Roy N. Alcalay, Edward A. Fon, Ronald B. Postuma, Ziv Gan-Or
Summary: Rare mutations in genes discovered in multigenerational families have been linked to increased risk of Parkinson's disease, but the role of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 loci in PD remains poorly understood. After sequencing these 5 genes in PD patients and controls, no significant association with PD was found, suggesting that they may not play a significant role in the disease and questioning their designation as PARK genes.
NEUROBIOLOGY OF AGING
(2021)
Review
Biochemistry & Molecular Biology
Karim E. Shalaby, Omar M. A. El-Agnaf
Summary: Gene therapy has the potential to replace current treatments for Parkinson's disease and has been shown to be safe and effective in current trials.
Article
Pharmacology & Pharmacy
N. Li, J-X Wang, T-T Huo, J-R Zhao, T. J. Wang
Summary: The study reveals a significant association between interleukin-1 beta (IL-1 beta) and IL-6 gene polymorphisms and the pathogenesis of Parkinson's disease. Certain allele distributions at specific loci were found to be significantly different between the disease group and the control group, indicating a potential relationship between these gene polymorphisms and the development of Parkinson's disease.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Immunology
Minhan Yi, Jiaxin Li, Shijie Jian, Binbin Li, Zini Huang, Li Shu, Yuan Zhang
Summary: The study analyzed the quantitative and causal relationship between inflammatory genes and the risk of Parkinson's disease (PD). It found that polymorphisms in IL-6, TNF-alpha, PON1, CYP2D6, HLA-DRB, BST1, CCDC62 genes were statistically associated with the susceptibility of PD. Additionally, there was evidence of causal relationships between ADP-ribosyl cyclase and PON1 genes with PD risk. These findings contribute to a better understanding of the mechanisms and pathways underlying PD pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bensu Karahalil, Ece Miser Salihoglu, Aylin Elkama, Gurdal Orhan, Evrim Saygin, Sevgi Akaydin Yardim
Summary: Oxidative stress is important in the degeneration of dopaminergic neurons in Parkinson's disease. Individual susceptibility may be associated with the development of oxidative stress-based PD, and measuring oxidative stress-related biomarkers can help manage the detrimental effects of the disease.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Clinical Neurology
Wei Quan, Jia Li, Li Liu, Qinghui Zhang, Yidan Qin, Xiaochen Pei, Jiajun Chen
Summary: The association between FGF20 rs1721100 and rs12720208 polymorphisms and the risk of sporadic PD has been controversial in previous studies, but this meta-analysis concludes that neither of these variants are significantly associated with susceptibility to sporadic PD.
NEUROLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Jian-Yong Wang, Lei Cui, Hong-Yi Shi, Ling-Hao Chen, Ren-Wei Jin, Xiao-Xia Jiang, Zhu-Ling Chen, Jian-Hong Zhu, Xiong Zhang
Summary: This study found that the single nucleotide polymorphisms (SNPs) of the DNMT1 gene are associated with the risk of Parkinson's disease (PD). Among them, rs9305012 is significantly associated with PD risk, and rs9305012/C is a protective allele. The haplotypes of the 4 tag-SNPs show significant differences between PD patients and controls. The ACC module composed of the 3 alleles is the highest-risk haplotype associated with PD.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Jiali Su, Yidong Deng, Benchi Cai, Si Teng, Shan Zhang, Yanhui Liu, Jie Lin, Qiang Yang, Danting Zeng, Xiuying Zhao, Tao Chen
Summary: This study found that Parkinson's disease patients have elevated serum levels of PI3K, which are associated with disease severity, disease duration, and cognitive impairment. However, there were no significant differences in PI3K SNPs between patients with normal cognitive function and those with cognitive impairment.
Article
Geriatrics & Gerontology
Hui-Hui Fan, Jing Zheng, Xiao-Ya Huang, Ke-Yun Wu, Lei Cui, Hao-Jia Dong, Zhen Wang, Xiong Zhang, Jian-Hong Zhu
Summary: This study reveals a significant association between the antisense Alu element insertion/deletion polymorphism of ALDH1A1 and Parkinson's disease susceptibility, suggesting that this polymorphism may have an impact on the pathogenesis of PD by suppressing gene transcription.
Article
Clinical Neurology
Jiaxin Li, Minhan Yi, Binbin Li, Shujuan Yin, Ying Zhang, Zini Huang, Li Shu, Yuan Zhang
Summary: This study conducted a systematic meta-analysis of variants related to neurodegenerative genes and their association with the risk of Parkinson's disease (PD). The results showed that several variants were statistically associated with PD risk, which may contribute to a deeper understanding of PD pathogenesis and improvement of clinical treatment strategies.
NEUROLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Keelan Jagaran, Moganavelli Singh
Summary: Neurodegenerative disorders result in the gradual degeneration of axons and neurons in the central nervous system, causing major disruptions in patients' lives. Current treatments are only palliative, highlighting the need for a therapeutic strategy targeting the root cause of the diseases. The synergistic use of gene therapy and nanomedicine shows promise in effectively treating these diseases by targeting the causative mutated genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Apoorva Tangri, Kinzie Lighty, Jagadish Loganathan, Fahmi Mesmar, Ram Podicheti, Chi Zhang, Marcin Iwanicki, Ronny Drapkin, Harikrishna Nakshatri, Sumegha Mitra
Summary: The study found that the overexpression of neuronal deubiquitinating enzyme UCHL1 in HGSOC promotes tumor growth by maintaining protein homeostasis. Inhibition of UCHL1 can reduce tumor cell proliferation and invasion, as well as decrease the metastatic growth of ovarian cancer xenografts. This indicates that UCHL1 plays a crucial role in HGSOC progression through the regulation of protein homeostasis.
MOLECULAR CANCER RESEARCH
(2021)
Article
Immunology
Divisha Bhatia, Veselin Grozdanov, Wolfgang P. Ruf, Jan Kassubek, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer
Summary: The dysregulation of peripheral immunity in Parkinson's Disease leads to a decrease in T-cell numbers, particularly CD8(+) cytotoxic T cells, and an upregulation of inflammatory genes, which are associated with disease severity. Additionally, PD T cells show increased activation upon stimulation, correlating with disease severity.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)