Journal
NEUROSCIENCE LETTERS
Volume 436, Issue 3, Pages 317-320Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.03.046
Keywords
Alzheimer's disease; folate; fibroblasts; folate carrier; folate receptor alpha
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We compared the levels of serum folate from Alzheimer's disease (AD) patients and from age-matched healthy subjects and used primary cultures of fibroblasts, obtained from the two groups, to assess possible differences in their ability to bind folate. The results show that the levels of circulating folate are significantly (p < 0.01; n = 30) lower in AD patients than in controls (4.91 +/- 2.44 and 7.56 +/- 2.5 ng/mL, respectively). Moreover, the folate binding of AD fibroblasts is significantly (p < 0.01; n = 8) higher (2-4-fold) with respect to controls. RT-PCR experiments suggest that the higher folate binding could be due to an enhanced expression in AD fibroblasts of folate receptor U. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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