Journal
NEUROSCIENCE LETTERS
Volume 445, Issue 1, Pages 62-67Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.08.069
Keywords
Synaptogenesis; LTP; Learning and memory; Synaptic consolidation; Neurotrophins
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Funding
- PAPIIT [IN211507]
- CONACYT [60851]
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Brain-derived neurotrophic factor (BDNF) has been proposed as a key regulator and mediator of long-term synaptic modifications related to learning and memory maintenance. Our previous studies show that application of high-frequency stimulation (HFS) sufficient to elicit LTP at the dentate gyrus (DG)-CA3 pathway produces mossy fiber structural modifications 7 days after tetanic stimulation. In the present study, we show that acute intrahippocampal microinfusion of BDNF induces a lasting potentiation of synaptic efficacy in the DG-CA3 projection of anesthetized adult rats. Furthermore, we show that BDNF functional modifications in synaptic efficacy are accompanied by a presynaptic structural long-lasting reorganization at the hippocampal mossy fiber pathway. These findings support the idea that BDNF plays an important role as synaptic messenger of activity-dependent synaptic plasticity in the adult mammalian brain, in vivo. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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