Article
Cell Biology
Xiangrong Cui, Hongping Liang, Chonghua Hao, Xuan Jing
Summary: Liraglutide protects cardiomyocytes under hypoxia/reoxygenation conditions by regulating homer1 gene expression, inhibiting intracellular calcium overload, and enhancing cell survival.
Article
Reproductive Biology
Alexandra Spirkova, Veronika Kovarikova, Zuzana Sefcikova, Jozef Pisko, Martina Ksinanova, Juraj Koppel, Dusan Fabian, Stefan Cikos
Summary: The study reveals that glutamic acid can affect preimplantation embryo development through cell membrane receptors. High extracellular concentrations of glutamic acid can inhibit blastocyst development, which is of practical significance.
BIOLOGY OF REPRODUCTION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Anita V. Devineni
Summary: A recent study has uncovered a novel form of crosstalk between olfactory pathways in the antennal lobe of the fly brain. This crosstalk has the ability to reshape odor coding and potentially explain why carbon dioxide can elicit both attraction and aversion.
Article
Agriculture, Dairy & Animal Science
Izabela Szpregiel, Danuta Wronska, Michal Kmiecik, Sylwia Palka, Bogdan F. Kania
Summary: Glutamic acid decarboxylase (GAD) is an enzyme responsible for the synthesis of gamma-aminobutyric acid (GABA) from glutamic acid (Glu), a key balance between neurotransmitters in the central and peripheral nervous systems. The study aimed to investigate the effects of stress and Glu on the GAD concentrations in rabbit brain structures, revealing varying levels of the enzyme under different conditions, particularly in response to stress. The study highlighted the potential impact of glutamate receptor activity on GAD concentrations and suggested the importance of further research on the Glu-GAD-GABA system in stress and homeostasis modulation.
Article
Biology
Nicola Forte, Charlene Roussel, Brenda Marfella, Anna Lauritano, Rosaria Villano, Elvira De Leonibus, Emanuela Salviati, Tina Khalilzadehsabet, Giada Giorgini, Cristoforo Silvestri, Fabiana Piscitelli, Maria Pina Mollica, Vincenzo Di Marzo, Luigia Cristino
Summary: N-oleoylglycine and N-oleoylalanine reduce the rewarding properties of palatable food, dopamine neuron firing, and the obesogenic effect of a high-fat diet by activating PPAR alpha. Olive oil-rich diets can also decrease weight gain by increasing oleoylglycine levels and enhancing gut microbial diversity.
COMMUNICATIONS BIOLOGY
(2023)
Article
Psychiatry
Daniel W. Chung, Matthew A. Geramita, David A. Lewis
Summary: The variability in excitatory synaptic strength across PVIs may contribute to the lower prefrontal gamma power in schizophrenia. This variability affects network synchrony and leads to a reduction in gamma power.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Kenneth N. Fish, Brad R. Rocco, James D. Wilson, David A. Lewis
Summary: This study found that GABA neurons in the prefrontal cortex of patients with schizophrenia are impaired. The decrease in GAD67 messenger RNA levels in these patients affects a subset of calbindin-expressing GABA neurons.
BIOLOGICAL PSYCHIATRY
(2023)
Review
Biotechnology & Applied Microbiology
Zheng Zhang, Penghui He, Dongbo Cai, Shouwen Chen
Summary: This review focuses on the genetic and metabolic engineering of microorganisms for gamma-PGA production, including strategies to enhance raw materials utilization, precursor supply, gamma-PGA synthetase gene cluster, transcription regulation, cofactor regeneration, energy engineering, and blocking synthetic pathways of by-products. The expression of gamma-PGA synthetase, glutamate racemase, and gamma-PGA hydrolase were manipulated to obtain gamma-PGA with different configurations and molecular weights. The review also discusses the metabolic engineering of other hosts for high-level production of gamma-PGA.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuhang Ge, Fei Zhen, Ziqi Liu, Zhaowei Feng, Gui Wang, Chu Zhang, Xingqi Wang, Ying Sun, Xiaohui Zheng, Yajun Bai, Ruiqin Yao
Summary: The study showed that α-asaronol can promote OPC differentiation and myelination in a rat model of PWMI by regulating glutamate levels through astrocyte PPAR gamma-GLT-1 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Da-Ran Kim, Chang-Wook Jeon, Gyeongjun Cho, Linda S. Thomashow, David M. Weller, Man-Jeong Paik, Yong Bok Lee, Youn-Sig Kwak
Summary: The composition of plant microbiota can be controlled by external supply of biostimulants, such as glutamic acid, enriching specific microbial populations and reshaping the microbial community structure.
Article
Chemistry, Applied
Zuying Zhang, Wenchao Chen, Liu Tao, Xixing Wei, Lingling Gao, Yadi Gao, Jinwei Suo, Weiwu Yu, Yuanyuan Hu, Baoru Yang, Huifeng Jiang, Mohamed A. Farag, Jiasheng Wu, Lili Song
Summary: Exogenous ethylene treatment significantly increased the levels of amino acids, especially umami amino acids, in Torreya grandis nuts. Glutamic and aspartic acids showed a 1.9-fold and 2.1-fold increase, respectively. Transcriptome analysis revealed differential expression of genes involved in alanine, aspartate, and glutamate metabolism. RT-qPCR confirmed upregulation of biosynthesis genes (TgGOGAT1, TgAATC1, TgAATC4) and suppression of degradation enzymes (TgGS2, TgGAD1, TgGAD3, TgASNS1) after ethylene treatment. Ethylene treatment appears to enhance umami taste-active amino acids and improve the quality of T. grandis nuts.
Article
Chemistry, Multidisciplinary
Hanlin Shen, Yuanqi Ding, Donglin Li, Wei Xu
Summary: Amino acids offer unique advantages for two-dimensional materials and bio-based devices. The interaction and adsorption of amino acid molecules on substrates have been extensively studied, aiming to understand the driving forces behind the formation of nanostructures. However, the interactions within amino acid molecules on inert surfaces have not been fully understood.
Article
Environmental Sciences
Xin Tang, Jingyu Wen, Li Mu, Ziwei Gao, Jingxian Weng, Xiaokang Li, Xiangang Hu
Summary: This study examined the interaction between pyrite and glutamic acid in arsenite solution, evaluated the influence of pyrite and glutamic acid on arsenite plant toxicity, and clarified the metabolic regulation mechanism of pyrite and glutamic acid on the arsenite phytotoxic effect through metabolomics analysis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Jin Quan, Weiwei Zheng, Jingru Tan, Zewei Li, Meifang Wu, Seung-Beom Hong, Yanting Zhao, Zhujun Zhu, Yunxiang Zang
Summary: This study investigated the potential of glutamic acid (Glu) and poly-gamma-glutamic acid (gamma-PGA) biostimulants in enhancing the thermotolerance of Chinese cabbage under heat stress. The results showed that both Glu and gamma-PGA treatments improved the parameters of vegetative growth, gas exchange, and chlorophyll fluorescence. Moreover, these treatments increased the contents of total chlorophyll and carotenoid and reduced oxidative damage by enhancing the activity levels of antioxidant enzymes. Transcriptome analysis revealed that the expression levels of genes involved in various metabolic pathways were up-regulated by both Glu and gamma-PGA priming. Overall, Glu was found to be more effective than gamma-PGA in enhancing the thermotolerance of Chinese cabbage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Pei-Shin Gu, Kuan-Wen Su, Kuo-Wei Yeh, Jing-Long Huang, Fu-Sung Lo, Chih-Yung Chiu
Summary: This study used metabolomics-based approaches to investigate the molecular mechanisms of childhood hypercholesterolemia and identified metabolites significantly associated with different cholesterol levels. Glutamic acid and tyrosine were identified as crucial amino acids in lipid metabolism, with glutamic acid-related amino acid metabolism playing a significant role in regulating cholesterol levels.
Review
Oncology
Yiming Li, Juan Tang, Jianli Jiang, Zhinan Chen
Summary: Immunotherapy has achieved significant success in treating cancer, but resistance to this treatment often occurs due to the complex metabolic networks in the tumor microenvironment. Metabolic checkpoints play a crucial role in regulating T cell development, differentiation, and function, as well as coordinating metabolic competition between tumor cells and infiltrating T cells. Thus, targeting metabolic checkpoints may enhance the efficacy of immunotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Chen, Gang Nan, Ding Wei, Ren-You Zhai, Ming Huang, Wu-Wei Yang, Bao-Cai Xing, Xu Zhu, Hai-Feng Xu, Xiao-Dong Wang, Xiao-Yong Zhang, Bao-Rang Zhu, Peng Liu, Guang Cao, Song Gao, Chun-Yi Hao, Ren-Jie Yang, Jian-Hai Guo, Xin Zhang, Kun Gao, Kun Wang, Jian-Feng Wang, Zi-Yu Li, Lin-Zhong Zhu, Rong Ding, Jing Li, Ling Zhao, Yu-Jun Shao, Hai-Chun Liu, Jie-Lai Xia, Ling Wang, Ling-Min Kong, Zhi-Nan Chen, Huijie Bian
Summary: In the adjuvant treatment of unresectable hepatocellular carcinoma, the combination of TACE and I-131-MabThera showed superior antirecurrence efficacy, significantly improved 5-year survival rate of patients, and was well tolerated.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Cell Biology
Huijie Bian, Ye-Mao Liu, Zhi-Nan Chen
Summary: Two recent studies have found new strategies for ACC targeting in NASH therapy, successfully resolving the unwanted side effects of ACC inhibitors and bringing new hope to NASH treatment.
Article
Oncology
Qi Yuan, Jie Zhang, Yu Liu, Haiqiang Chen, Haiyang Liu, Jinyan Wang, Meng Niu, Lingling Hou, Zhenlong Wu, Zhinan Chen, Jinhua Zhang
Summary: MyD88 in myofibroblasts plays a critical role in promoting hepatocellular carcinoma by affecting aerobic glycolysis in cancer cells. MyD88 deficiency in myofibroblasts attenuates liver fibrosis and liver cancer tissue. Mechanistically, MyD88 signaling in myofibroblasts increases the secretion of CCL20, which promotes aerobic glycolysis in cancer cells. This process is dependent on the CCR6 receptor and ERK/PKM2 signaling.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gang Nan, Shu-Hua Zhao, Ting Wang, Dong Chao, Ruo-Fei Tian, Wen-Jing Wang, Xin Fu, Peng Lin, Ting Guo, Bin Wang, Xiu-Xuan Sun, Xi Chen, Zhi-Nan Chen, Shi-Jie Wang, Hong-Yong Cui
Summary: This study investigates the role and mechanisms of CD147 in paclitaxel resistance. It demonstrates that CD147 protects cancer cells from paclitaxel-induced apoptosis and interacts with the C-terminal tail of RanBP1 to regulate microtubule stability and dynamics as well as response to paclitaxel treatment. Targeting CD147 may be a potential strategy for preventing paclitaxel resistance.
Article
Biochemistry & Molecular Biology
Cheng-Gong Liao, Xiao-Hua Liang, Yuan Ke, Li Yao, Man Liu, Ze-Kun Liu, Lin He, Yi-Xiao Guo, Huijie Bian, Zhi-Nan Chen, Ling-Min Kong
Summary: This study reveals that active demethylation of CD147 is involved in the metastasis of non-small cell lung cancer (NSCLC), and targeted methylation of CD147 can inhibit the invasion and metastasis of NSCLC, providing a promising therapeutic target for NSCLC.
Article
Oncology
Xiao-Hong Chen, Ruo Chen, Ming-Yan Shi, Ruo-Fei Tian, Hai Zhang, Zhi-Qian Xin, Zhi-Nan Chen, Ke Wang
Summary: This study evaluated the significant role of CD147 in NSCLC through bioinformatics analysis and confirmed the efficacy and safety of CD147-CART cells in treating NSCLC through experiments.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiao Wu, Zhuan Feng, Liang Chen, Yong Li, Huijie Bian, Jiejie Geng, Zhao-Hui Zheng, Xianghui Fu, Zhuo Pei, Yifei Qin, Liu Yang, Yilin Zhao, Ke Wang, Ruo Chen, Qian He, Gang Nan, Xuejun Jiang, Zhi-Nan Chen, Ping Zhu
Summary: In this study, the authors use a mouse model of rheumatoid arthritis (RA) and single-cell RNA sequencing to show that inducing ferroptosis and suppressing TNF signaling can reduce the number of fibroblasts in the synovium and improve experimental arthritis. They further identify two groups of fibroblasts with distinct susceptibility to ferroptosis and show that TNF signaling protects fibroblasts from ferroptosis through promoting cystine uptake and glutathione biosynthesis. Finally, the combination of low-dose ferroptosis inducer and TNF antagonist attenuates arthritis progression in the mouse model.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ming Zheng, Yi-Ming Li, Zhen-Yu Liu, Xin Zhang, Yinghui Zhou, Jian-Li Jiang, Ping Zhu, Xiang-Min Yang, Juan Tang, Zhi-Nan Chen
Summary: Immunotherapy targeting tumor-infiltrating lymphocytes has shown promising potential as a treatment for various cancers, but its efficacy varies across different cancer types and patients. The distribution of TIL-T and TIL-B cells and their interactions with the tumor microenvironment play a crucial role in determining the clinical outcomes. Understanding the prognostic significance of these factors can have important implications for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Nai-Shan Zheng, Xiang-Yu Zhao, Ding Wei, Jin-Lin Miao, Ze-Kun Liu, Yu-Le Yong, Ren-Yu Zhang, Yi-Xiao Guo, Lin He, Bin Wang, Xiu-Xuan Sun, Hai-Jiao Yang, Tian-Jiao Zhang, Qian He, Xiao-Min Li, Hai Zhang, Rong Hou, Peng Lin, Ying-Ming Xu, Xiao-Jun Huang, Zhi-Nan Chen, Huijie Bian
Summary: CD147-CAR T cell therapy shows potent anti-tumor activity against T cell acute lymphoblastic leukemia (T-ALL) and potential safety towards normal cells and CD147-deficient cells.
Article
Immunology
Yun-Qi Zhou, Ke Wang, Xue-Yan Wang, Hong-Yong Cui, Yongxiang Zhao, Ping Zhu, Zhi-Nan Chen
Summary: This study reveals that SARS-CoV-2 enters host cells through CD147-mediated endocytosis, highlighting the potential of blocking this pathway as a preventive approach against SARS-CoV-2 infection.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Oncology
Ze-Kun Liu, Ke-Fei Wu, Ren-Yu Zhang, Ling-Min Kong, Run-Ze Shang, Jian-Jun Lv, Can Li, Meng Lu, Yu-Le Yong, Cong Zhang, Nai-Shan Zheng, Yan-Hong Li, Zhi-Nan Chen, Huijie Bian, Ding Wei
Summary: In this study, a prognostic signature based on pyroptosis-related lncRNAs in hepatocellular carcinoma (HCC) was constructed, showing significant predictive value for HCC patient prognosis and potential clinical guidance for individualized immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hong-Yong Cui, Wei Wei, Mei-Rui Qian, Ruo-Fei Tian, Xin Fu, Hong-Wei Li, Gang Nan, Ting Yang, Peng Lin, Xi Chen, Yu-Meng Zhu, Bin Wang, Xiu-Xuan Sun, Jian-Hua Dou, Jian-Li Jiang, Ling Li, Shi-Jie Wang, Zhi-Nan Chen
Summary: This study identified PDAP1 as a key player in colorectal cancer (CRC) development. PDAP1 overexpression was associated with cell proliferation, migration, invasion, and metastasis in CRC. Inhibiting PDAP1 may be an effective strategy for treating CRC patients with PDAP1 overexpression.
CANCER COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jiejie Geng, Liang Chen, Yufeng Yuan, Ke Wang, Youchun Wang, Chuan Qin, Guizhen Wu, Ruo Chen, Zheng Zhang, Ding Wei, Peng Du, Jun Zhang, Peng Lin, Kui Zhang, Yongqiang Deng, Ke Xu, Jiangning Liu, Xiuxuan Sun, Ting Guo, Xu Yang, Jiao Wu, Jianli Jiang, Ling Li, Kun Zhang, Zhe Wang, Jing Zhang, Qingguo Yan, Hua Zhu, Zhaohui Zheng, Jinlin Miao, Xianghui Fu, Fengfan Yang, Xiaochun Chen, Hao Tang, Yang Zhang, Ying Shi, Yumeng Zhu, Zhuo Pei, Fei Huo, Xue Liang, Yatao Wang, Qingyi Wang, Wen Xie, Yirong Li, Mingyan Shi, Huijie Bian, Ping Zhu, Zhi-Nan Chen
Summary: SARS-CoV-2 mutations increase viral transmissibility and immune escape, requiring in-depth investigation on COVID-19 pathogenesis for strategy development. CD147 is identified as a universal receptor for SARS-CoV-2 and its variants, and Meplazeumab effectively inhibits viral entry and inflammation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Hong-Yong Cui, Shi-Jie Wang, Fei Song, Xu Cheng, Gang Nan, Yu Zhao, Mei-Rui Qian, Xi Chen, Jia-Yue Li, Fen-Ling Liu, Yu-Meng Zhu, Ruo-Fei Tian, Bin Wang, Bin Wu, Yang Zhang, Xiu-Xuan Sun, Ting Guo, Xiang-Min Yang, Hai Zhang, Ling Li, Jing Xu, Hui-Jie Bian, Jian-Li Jiang, Zhi-Nan Chen
Summary: Major gaps in understanding the molecular mechanisms of colorectal cancer progression and mucosal repair have hindered therapeutic development for gastrointestinal disorders. TFF3 plays a crucial role in CRC progression and mucosal repair, with upregulated TFF3 predicting worse survival rates in CRC patients. The interaction between TFF3 and CD147 enhances CRC progression by activating STAT3 and PTGS2, leading to increased migration, proliferation, and invasion of cancer cells.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
