Review
Behavioral Sciences
Jette Borawski, Marietta Papadatou-Pastou, Julian Packheiser, Sebastian Ocklenburg
Summary: The aim of this meta-analysis was to examine handedness in post-traumatic stress disorder. A total of 14 studies were included, with a sample size of 2939 participants. The results showed higher frequencies of non-right-handedness and mixed-handedness in PTSD patients compared to controls. No significant difference was found for left-handedness.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Medicine, General & Internal
Sergio Martinez-Vazquez, Julian Rodriguez-Almagro, Antonio Hernandez-Martinez, Miguel Delgado-Rodriguez, Juan Miguel Martinez-Galiano
Summary: During childbirth, some clinical practices, such as formula-feeding of the newborn at discharge or types of obstetric violence towards the mother, were associated with a higher risk of PTSD symptoms one year after delivery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Behavioral Sciences
Reihaneh Ahmadi, Sama Rahimi-Jafari, Mahnaz Olfati, Nooshin Javaheripour, Farnoosh Emamian, Mohammad Rasoul Ghadami, Habibolah Khazaie, David C. Knight, Masoud Tahmasian, Amir A. Sepehry
Summary: Posttraumatic stress disorder (PTSD) is strongly associated with insomnia, and the prevalence of insomnia in PTSD patients is high. Screening and managing insomnia in PTSD patients are of great importance.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychiatry
Catrin Lewis, Katie Lewis, Alice Roberts, Bethan Edwards, Claudia Evison, Ann John, Alan Meudell, Patrick Parry, Holly Pearce, Natalie Richards, Ian Jones, Jonathan Bisson
Summary: This study aimed to investigate factors associated with ICD-11 post-traumatic stress disorder (PTSD) and complex PTSD (CPTSD), and examine the psychiatric burden associated with these disorders. The prevalence of CPTSD was found to be higher than PTSD in individuals with psychiatric disorders, and it was associated with interpersonal trauma, personality disorders, and lower rates of bipolar disorder. Individuals with CPTSD experienced higher levels of anxiety and depression symptoms, and lower psychological wellbeing compared to those with PTSD or neither disorder. The findings highlight the importance of routine screening for trauma histories and PTSD/CPTSD in clinical settings, and the need for interventions to address CPTSD.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychology, Multidisciplinary
Thiemo Knaust, Matthias B. D. Siebler, Dagmar Tarnogorski, Philipp Skiberowski, Helge Hoellmer, Christian Moritz, Holger Schulz
Summary: This study compared hippocampal subfield volumes among soldiers with PTSD, MDD, and AdjD using routine clinical data. The results showed no significant volume differences between these stress-related mental disorders.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychiatry
Amber N. Edinoff, Tanner L. Hegefeld, Murray Petersen, James C. Patterson, Christopher Yossi, Jacob Slizewski, Ashley Osumi, Elyse M. Cornett, Adam Kaye, Jessica S. Kaye, Vijayakumar Javalkar, Omar Viswanath, Ivan Urits, Alan D. Kaye
Summary: Post-traumatic stress disorder (PTSD) affects three functional networks in the brain and Transcranial Magnetic Stimulation (TMS) is used to treat this condition. High-frequency stimulation has shown better efficacy than low-frequency stimulation posttreatment, and the most common side effect is headache and scalp pain.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Verity Fox, Christina Dalman, Henrik Dal, Anna-Clara Hollander, James B. Kirkbride, Alexandra Pitman
Summary: The study found that individuals with PTSD in the general population in Sweden had higher suicide rates regardless of sex, and if causal, 1.6% of general population suicides could be attributed to PTSD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychology, Multidisciplinary
Ferozkhan Jadhakhan, Nichola Lambert, Nicola Middlebrook, David W. Evans, Deborah Falla
Summary: Exercise has been shown to reduce symptoms of post-traumatic stress disorder (PTSD), but it is still unclear which type of exercise, intensity, and duration are most effective. A systematic review found that a combined exercise intervention had the best evidence for reducing PTSD symptoms.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Medicine, General & Internal
Catherine A. McCall, Nathaniel F. Watson
Summary: Obstructive sleep apnea (OSA) and post-traumatic stress disorder (PTSD) frequently coexist, with evidence of bidirectional effects. Sleep disturbance may play a role in the pathophysiology of PTSD. Treatment for OSA not only improves OSA symptoms but also PTSD symptoms. Positive airway pressure (PAP) therapy may reduce PTSD symptoms, but tolerance is a challenge in the PTSD population. Alternative OSA treatments may be more effective for improving both OSA and PTSD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Qi Li, Chunqing Wang, Jinglu Hu, Wencheng Jiao, Ziyan Tang, Xingshuang Song, Yanping Wu, Jing Dai, Peng Gao, Lina Du, Yiguang Jin
Summary: The blood-brain barrier hinders conventional drugs for PTSD, but a bionic delivery system using CBD-loaded macrophage-membrane nanovesicles proves effective in targeting and treating PTSD. Ultrasound is also evaluated as a potential method to improve brain-targeted CBD delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Physiology
Emily C. Reed, Adam J. Case
Summary: Post-traumatic stress disorder (PTSD) is a mental health disorder that lacks definitive biological signatures for diagnosis. The field of redox biology, a potential area for biomarker research, has been overlooked and undervalued.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Surgery
Laura M. Drudi, Mario D'Oria, Jonathan Bath, Johan Van Nispen, Matthew R. Smeds
Summary: This study examines the emotional responses of vascular surgeons to postoperative complications and finds an association with symptoms of post-traumatic stress disorder (PTSD). The study also suggests that surgeons commonly experience emotional issues when faced with complications that are unexpected or caused by surgical mistakes, and female surgeons may be more prone to this. Most surgeons desire the ability to discuss complications with respected peers.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Psychology, Multidisciplinary
Elodie Fraile, Pierre Gagnepain, Francis Eustache, Mathilde Groussard, Herve Platel
Summary: Playing and listening to music can promote emotion regulation and cognitive control, which can help reduce symptoms of posttraumatic stress disorder (PTSD). Future research should explore the protective effects of musical experience before trauma and develop pre-trauma training to prevent PTSD in at-risk populations.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Aki Yazawa, Koichiro Shiba, Sakurako Shiba Okuzono, Hiroyuki Hikichi, Ichiro Kawachi
Summary: This study aimed to examine the bidirectional associations between post-traumatic stress symptoms (PTSS) and sleep quality in older disaster survivors. The results showed that individuals with pre-disaster sleep problems were more likely to develop PTSS after being exposed to disaster trauma. Individuals reporting sleep problems after the disaster were less likely to recover from PTSS and more likely to develop delayed onset of PTSS. Intervening to alleviate lingering sleep problems may help the recovery of disaster survivors from post-traumatic symptoms.
Article
Biochemistry & Molecular Biology
Burook Misganaw, Ruoting Yang, Aarti Gautam, Seid Muhie, Synthia H. Mellon, Owen M. Wolkowitz, Kerry J. Ressler, Francis J. Doyle, Charles R. Marmar, Marti Jett, Rasha Hammamieh
Summary: There is a significant link between post-traumatic stress disorder (PTSD) and metabolic syndrome (MetS), both in terms of phenotype and genetics, which may help explain the increased prevalence of MetS among PTSD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Nida Hashmi, Mushk Noorani, Antonio Ventriglio, Domenico De Berardis, Irfan Ullah, Sanaz Askari, Mohamad Goldust
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Substance Abuse
Maria Pepe, Marco Di Nicola, Isabella Panaccione, Raffaella Franza, Domenico De Berardis, Mauro Cibin, Luigi Janiri, Gabriele Sani
Summary: This study examines the longitudinal predictors of relapse in alcohol use disorder patients. The findings suggest that impulsivity and alexithymia are risk factors for relapse, with different time-varying effects. These findings emphasize the importance of careful assessment and personalized interventions to promote long-term abstinence.
DRUG AND ALCOHOL REVIEW
(2023)
Review
Clinical Neurology
M. Fornaro, C. I. Cattaneo, D. De Berardis, F. V. Ressico, G. Martinotti, E. Vieta
Summary: There is limited evidence about antidepressant discontinuation syndrome (ADS) and related outcomes, but it may have a significant impact on some patients. Gradual tapering and integrative management should be considered to minimize adverse effects during the discontinuation process.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Giuseppe Marano, Marianna Mazza, Francesco Maria Lisci, Michele Ciliberto, Gianandrea Traversi, Georgios Demetrios Kotzalidis, Domenico De Berardis, Lucrezia Laterza, Gabriele Sani, Antonio Gasbarrini, Eleonora Gaetani
Summary: There is increasing interest in the role of intestinal microbiota and autoimmune processes in psychiatric diseases. Altered communication between the microbiota-gut-brain axis may be a cause of psychiatric disorders. This review explores the evidence for the involvement of gut microbiota in psychiatric diseases and the impact of diet on microbiota and mental health. Changes in gut microbiota composition can lead to increased intestinal permeability, resulting in a cytokine storm, systemic inflammation, and immune response. These events can affect neurotransmitter release, alter the hypothalamic-pituitary-adrenal axis, and reduce trophic brain factors. Further research is needed to understand the underlying mechanisms connecting gut microbiota and psychiatric disorders.
Review
Neurosciences
Andrea Amerio, Eleonora Vai, Edoardo Bruno, Alessandra Costanza, Andrea Escelsior, Anna Odone, Domenico De Berardis, Andrea Aguglia, Gianluca Serafini, Mario Amore, Seyyed Nassir Ghaemi
Summary: Despite the pandemic triggering a wave of research, few studies have looked into the impact of COVID-19 on Italy's community-based mental health care system. This study aimed to summarize existing evidence and also drew from daily clinical practice. Despite reduced hospital care, community mental health centers promoted continuity of care through teleconsultation, leading to lower risk of deterioration and hospitalization for patients. This model received satisfaction from both patients and mental health workers.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Editorial Material
Psychiatry
Domenico De Berardis, Michele Fornaro, Claudia Carmassi
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Najma Iqbal Malik, Sidra Saleem, Irfan Ullah, Syeda Tayyaba Rehan, Domenico De Berardis, Mohsin Atta
Summary: The present study aimed to investigate the impact of psychosocial factors on the stigma of mental illness among relapsed drug addicts in Punjab, Pakistan. A sample of 116 relapsed drug addicts was collected using purposive sampling technique, and self-report measures were used to assess the variables of interest. The results revealed that self-efficacy, social support, conscientiousness were negative predictors, while neuroticism was a positive predictor of stigma. Moreover, social support was found to moderate the relationship between self-efficacy and stigma, and self-efficacy moderated the relationship between social support and stigma. These findings highlight the significant role of psychosocial factors in addiction relapse.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Ambra Craba, Giuseppe Marano, Georgios D. Kotzalidis, Carla Avallone, Francesco Maria Lisci, Maria Luigia Crosta, Antonino Callea, Laura Monti, Domenico De Berardis, Carlo Lai, Marta Balocchi, Ilenia Sessa, Desiree Harnic, Gabriele Sani, Marianna Mazza
Summary: This study aimed to investigate the correlation between attachment and resilience in patients with major depressive disorder (MDD) and bipolar disorder (BD). The results showed that patients had lower resilience than healthy controls, and a lower proportion of secure attachment was found among patients. These findings suggest that early life experiences and attachment play a crucial role in the development of resilience in individuals with mood disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Muneeza Ali, Irfan Ullah, Mufaddal Najmuddin Diwan, Alifiya Aamir, Hashir Ali Awan, Abdul Waris Durrani, Qudrat Ullah Qudrat, Sheikh Shoib, Domenico De Berardis
Summary: English Summary: This article provides an overview of Major Depressive Disorder (MDD), including its classification, symptoms, global prevalence, and the potential use of Zuranolone as a therapeutic treatment.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2023)
Article
Neurosciences
Bernardo Dell'Osso, Antonello Bellomo, Andreas Pietro Maria Conca, Virginio Salvi, Alberto Siracusano, Carmelo Zaffora, Domenico De Berardis, Massimo Di Giannantonio
Summary: Italian psychiatrists generally agree on the efficacy and safety of cariprazine in the treatment of schizophrenia at different stages of the disorder. The drug is particularly suitable for young first-episode schizophrenia patients, with or without substance abuse, as well as adult and elderly patients. However, there is limited experience with the use of cariprazine and lack of knowledge on the most recent real-life data.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Neurosciences
Domenico De Berardis, Anna Ceci, Emanuela Zenobi, Dosolina Rapacchietta, Manuela Pisanello, Filippo Bozzi, Lia Ginaldi, Viviana Marasco, Maurizio Di Giosia, Maurizio Brucchi, Guendalina Graffigna, Jacopo Santambrogio, Antonio Ventriglio, Marianna Mazza, Giovanni Muttillo
Summary: This study aimed to assess the frequency of and relationships between alexithymia, burnout, and hopelessness in healthcare workers during the third wave of COVID-19 in Italy. The findings showed that individuals with alexithymia and higher levels of burnout were more likely to experience hopelessness. Higher working seniority, emotional exhaustion, irritability, depression, anxiety, and difficulty in describing feelings were associated with higher levels of hopelessness. It is important to implement comprehensive strategies to support healthcare workers' mental health and mitigate the negative consequences of alexithymia, burnout, and hopelessness.
Review
Medicine, General & Internal
Mohsen Khosravi, Domenico De Berardis, Sakineh Mazloom, Amir Adibi, Negin Javan, Zahra Ghiasi, Mohammad Nafeli, Negar Rahmanian
Summary: The occurrence of malingered psychosis has increased due to the shift towards community care and the closure of long-stay psychiatric institutions. Differentiating between true and malingered psychosis remains a challenge despite the existence of some practical psychological tools and strategies. Therefore, there is a need to identify innovative and reliable diagnostic alternatives. This article summarizes evidence that can be used to improve the future assessment of oropharyngeal microbiome composition as a potential diagnostic marker for true psychosis in forensic psychiatric settings.
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Samrah Jamshaid, Najma Iqbal Malik, Irfan Ullah, Sundas Saboor, Fauzia Arain, Domenico De Berardis
Summary: This study aimed to evaluate the association of postpartum depression (PPD) with insomnia, mental health, and physical health. The results revealed a significant positive relationship between PPD and physical health, and negative relationships with insomnia and perceived social support. The study concluded that perceived social support plays an important role in PPD and the health of Pakistani women.
Meeting Abstract
Psychiatry
V. Martiadis, E. Pessina, A. Martini, F. Raffone, D. De Berardis
EUROPEAN PSYCHIATRY
(2023)
Meeting Abstract
Psychiatry
V. Martiadis, E. Pessina, A. Martini, F. Raffone, P. Giunnelli, D. De Berardis
EUROPEAN PSYCHIATRY
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.