Journal
NEUROSCIENCE
Volume 262, Issue -, Pages 156-164Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2014.01.004
Keywords
experimental autoimmune neuritis; chrysin; inducible nitric oxide synthase; cyclooxygenase-2; nuclear factor kappa B
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Funding
- National Basic Research Program of China [2013CB966900]
- National Natural Science Foundation of China [81322018, 81273287, 81100887]
- Program for New Century Excellent Talents in University of China [NCET 111067]
- Key Project of Natural Science Foundation of Tianjin Province [12JCZDJC24200]
- Key Project of Chinese Ministry of Education [212005]
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Guillain-Barre syndrome (GBS) is an acute, post-infectious, immune-mediated, demyelinating disease of peripheral nerves and nerve roots. Experimental autoimmune neuritis (EAN) is an animal model of GBS. Chrysin, which is a naturally occurring flavonoid, exhibits various biological activities. This study was designed to investigate the anti-inflammatory and neuroprotective properties of preventative and therapeutic chrysin treatment in EAN rats. For preventative treatment, chrysin was administered orally from day 1 to day 16 (50 mg/kg once daily) while, for therapeutic treatment, rats received chrysin from day 7 to day 16 at the same dose once daily. Control animals received the same volume of the vehicle (phosphate-buffered saline/2% dimethylsulfoxide). Regardless of the treatment regimen, chrysin attenuated the severity and duration of the clinical course of EAN and reduced inflammatory cell infiltration and demyelination of sciatic nerves. In the sciatic nerves, the expression of inducible nitric oxide synthase, cyclooxygenase-2 and nuclear factor kappa B was reduced. Furthermore, chrysin inhibited the splenic mononuclear cell secretion of interleukin-1 beta, interleukin-2, interleukin-6, inteleukin-12, interferon gamma and tumor necrosis factor alpha, and elevated the level of inteleukin-4. In summary, our data demonstrate that chrysin is a potentially useful agent for the treatment of EAN with its anti-inflammatory and neuroprotective effects. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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