Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Pauline S. Effenberger, Tabea S. Send, Maria Gilles, Josef Frank, Stephan Bongard, Robert Kumsta, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Fabian Streit, Isabell A. C. Wolf
Summary: There is no strong association between urbanicity and behavior problems or HPA axis regulation in preschool age, and urinary cortisol and salivary cortisol response after stress exposure are not identified as mediators of this relationship.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Nathan S. Pentkowski, Samuel J. Bouquin, Carlos R. Maestas-Olguin, Zachary M. Villasenor, Benjamin J. Clark
Summary: Alzheimer's disease is a progressive neurodegenerative disorder associated with cognitive and functional impairments. Chronic stress has been linked as a risk factor for AD-related pathology, but a study found that two weeks of daily restraint stress did not further enhance anxiety- or fear-like behaviors in TgF344-AD rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biology
Ayeisha Milligan Armstrong, Tenielle Porter, Hazel Quek, Anthony White, John Haynes, Connie Jackaman, Victor Villemagne, Kylie Munyard, Simon M. Laws, Giuseppe Verdile, David Groth
Summary: Chronic psychosocial stress is recognized as a risk factor for sporadic Alzheimer's disease. Factors such as dysregulation of the HPA axis and elevated levels of cortisol may contribute to the disease process. Individual differences in sensitivities to glucocorticoid and stress responses could also impact an individual's risk of developing AD.
BIOLOGICAL REVIEWS
(2021)
Article
Critical Care Medicine
Laura B. Tucker, Amanda H. Fu, Joseph T. McCabe
Summary: Cognitive dysfunction is a common complaint following acquired traumatic brain injuries, with hippocampal circuits often implicated in resulting deficits. The study aimed to phenotype cognitive deficits in male and female mice following TBI induced by the CHIMERA device, showing significant impairment in spatial learning and memory skills. Differences in injury-induced deficits between male and female mice were observed, with cognitive impairment assessment potentially confounded by motor and visual impairments post-injury.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Behavioral Sciences
Hannah Klusmann, Noemi Luecking, Sinha Engel, Meike Katharina Blecker, Christine Knaevelsrud, Sarah Schumacher
Summary: Sex disparities in the biological response to acute stressors were investigated in this systematic review and meta-analysis, with a focus on the influence of ovarian hormones on HPA axis functioning. The study found higher cortisol reactivity in the luteal phase compared to the follicular phase, suggesting a difference in HPA axis reactivity between menstrual cycle phases. However, more high-quality primary studies are needed to further explore this association. This review was not funded and was pre-registered in PROSPERO.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Moustafa Algamal, Andrew J. Pearson, Coral Hahn-Townsend, Ioana Burca, Michael Mullan, Fiona Crawford, Joseph O. Ojo
Summary: This study assessed the impact of chronic stress on HPA axis function and fear memory deficits in a mouse model, finding that mice exposed to chronic stress exhibited exaggerated fear memory recall and weakened HPA axis functionality. Neuroendocrinal testing suggested that alterations in adrenal MC2 receptor reactivity may be related to the attenuated stress response in the model.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Krzysztof Miler, Inon Scharf
Summary: Recent research has shown that antlions have cognitive abilities in terms of operant conditioning and T-maze solving, and these abilities can be influenced by temperature. High temperatures can lead to impaired retention of learned behaviors in antlion larvae after moulting.
Article
Endocrinology & Metabolism
Samuel Rosin, Kai Xia, M. Andrea Azcarate-Peril, Alexander L. Carlson, Cathi B. Propper, Amanda L. Thompson, Karen Grewen, Rebecca C. Knickmeyer
Summary: The study shows that gut microbial composition may influence HPA axis reactivity in early human development, suggesting potential for future clinical interventions targeting gut microbes to promote the development of stress-response systems.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Mariah Mesquita de Figueiredo Cerqueira, Micaele Maria Lopes Castro, Amanda Almeida Vieira, Juliana Ayumi Azevedo Kurosawa, Fabio Leite do Amaral Junior, Fabiola de Carvalho Chaves de Siqueira Mendes, Marcia Consentino Kronka Sosthenes
Summary: Anxiety is increasingly being diagnosed in the elderly, and it is associated with cognitive decline, morbidity, and even mortality. The environment and age have an impact on anxiety-like behavior in mice, as assessed by the Elevated Plus Maze (EPM) and Open Field (OF) tests. The results from these tests suggest the need for a better evaluation of the parameters analyzed in each test.
Article
Behavioral Sciences
Kehinde E. Cole, Ryan G. Parsons
Summary: There is evidence that prior experience can alter memory formation, but little is known about whether this effect is similar in both sexes. This study found that male rats trained with auditory fear conditioning showed facilitated learning to subsequent visual fear conditioning, while females only showed facilitation with a one-hour interval.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Raquel Cardoso Brito, Thairyne Olivato, Takae Tamy Kitabatake, Kelly Zhang, Elaine Caldeira de Oliveira Guirro, Joao Eduardo de Araujo
Summary: Studies have found that psychotropic drugs can alter rat behavior in the elevated plus-maze test. This study aimed to investigate whether static magnetic fields could impact alprazolam-induced rat behavior in the same test. The results showed that the south magnetic pole of the static magnetic field blocked the effect of alprazolam on the space-time variables of the open arms and ethological anxiolytic-like behavior in the elevated plus-maze test.
NEUROSCIENCE LETTERS
(2023)
Article
Pharmacology & Pharmacy
Vandna, Shruti Ahlawat, Krishna Kant Sharma, Hari Mohan
Summary: This study found that the co-administration of ketoprofen with Yersinia enterocolitica can cause significant damage to the rat gut, leading to altered expression of gut proteins and profound effects on the NF-kB signaling pathway, immune system, dysbiosis, and gut injury. Additionally, the biochemical and histopathological analysis of treated rats showed evidence of liver enzyme activity alteration and behavioral response changes, indicating the detrimental effects of the co-administration.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Psychology, Developmental
Emma McKeon, Jennifer Torres, Andrew M. Kazama, Jocelyne Bachevalier, Jessica Raper
Summary: The hippocampus is crucial for long-term memory storage and regulation of the hypothalamic-pituitary-adrenal axis and emotional behaviors. Early hippocampal damage in monkeys results in increased anxiety behaviors and decreased HPA responses to acute stressors. The hippocampus plays a role in regulating responses to aversive stimuli and HPA axis functioning.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Review
Cell Biology
P. Darrell Neufer, Marcas M. Bamman, Deborah M. Muoio, Claude Bouchard, Dan M. Cooper, Bret H. Goodpaster, Frank W. Booth, Wendy M. Kohrt, Robert E. Gerszten, Mark P. Mattson, Russell T. Hepple, William E. Kraus, Michael B. Reid, Sue C. Bodine, John M. Jakicic, Jerome L. Fleg, John P. Williams, Lyndon Joseph, Mary Evans, Padma Maruvada, Mary Rodgers, Mary Roary, Amanda T. Boyce, Jonelle K. Drugan, James I. Koenig, Richard H. Ingraham, Danuta Krotoski, Mary Garcia-Cazarin, Joan A. McGowan, Maren R. Laughlin
Article
Psychiatry
Gregory P. Strauss, William R. Keller, James I. Koenig, James M. Gold, Kathryn L. Ossenfort, Robert W. Buchanan
SCHIZOPHRENIA RESEARCH
(2015)
Article
Psychiatry
Gregory P. Strauss, William R. Keller, James I. Koenig, Sara K. Sullivan, James M. Gold, Robert W. Buchanan
SCHIZOPHRENIA RESEARCH
(2015)
Article
Psychiatry
Gregory P. Strauss, William R. Keller, James I. Koenig, James M. Gold, Katherine H. Frost, Robert W. Buchanan
SCHIZOPHRENIA RESEARCH
(2015)
Review
Cell Biology
Roderick A. Corriveau, Francesca Bosetti, Marian Emr, Jordan T. Gladman, James I. Koenig, Claudia S. Moy, Katherine Pahigiannis, Salina P. Waddy, Walter Koroshetz
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Francesca Bosetti, Zorina S. Galis, Margaret S. Bynoe, Marc Charette, Marilyn J. Cipolla, Gregory J. del Zoppo, Douglas Gould, Thomas S. Hatsukami, Teresa L. Z. Jones, James I. Koenig, Gerard A. Lutty, Christine Maric-Bilkan, Troy Stevens, H. Eser Tolunay, Walter Koroshetz
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2016)
Article
Clinical Neurology
Francesca Bosetti, James I. Koenig, Cenk Ayata, Stephen A. Back, Kyra Becker, Joseph P. Broderick, S. Thomas Carmichael, Sunghee Cho, Marilyn J. Cipolla, Dale Corbett, Roderick A. Corriveau, Steven C. Cramer, Adam R. Ferguson, Seth P. Finklestein, Byron D. Ford, Karen L. Furie, Thomas M. Hemmen, Costantino Iadecola, Lyn B. Jakeman, Scott Janis, Edward C. Jauch, Karen C. Johnston, Patrick M. Kochanek, Harold Kohn, Eng H. Lo, Patrick D. Lyden, Carina Mallard, Louise D. McCullough, Linda M. McGavern, James F. Meschia, Claudia S. Moy, Miguel A. Perez-Pinzon, Ipolia Ramadan, Sean I. Savitz, Lee H. Schwamm, Gary K. Steinberg, Mary P. Stenzel-Poore, Michael Tymianski, Steven Warach, Lawrence R. Wechsler, John H. Zhang, Walter Koroshetz
Review
Clinical Neurology
Veronica Schiariti, Eileen Fowler, Joline E. Brandenburg, Eric Levey, Sarah Mcintyre, Theresa Sukal-Moulton, Sharon L. Ramey, Jessica Rose, Susan Sienko, Elaine Stashinko, Laura Vogtle, Robin S. Feldman, James I. Koenig
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2018)
Article
Clinical Neurology
Christina A. Wilson, James I. Koenig
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Clinical Neurology
Alyssa M. Day, Adrienne M. Hammill, Csaba Juhasz, Anna L. Pinto, E. Steve Roach, Charles E. McCulloch, Anne M. Comi, Karen L. Ball, Brian J. Fisher, Jim Koenig, Michael T. Lawton, Warren D. Lo, Douglas A. Marchuk, Daniel K. Miles, Marsha A. Moses, Angus A. Wilfong
PEDIATRIC NEUROLOGY
(2019)
Article
Psychiatry
Gregory P. Strauss, Hannah C. Chapman, William R. Keller, James I. Koenig, James M. Gold, William T. Carpenter, Robert W. Buchanan
JOURNAL OF PSYCHIATRIC RESEARCH
(2019)
Editorial Material
Clinical Neurology
Francesca Bosetti, James Koenig, L. Scott Janis, Clinton B. Wright
Article
Clinical Neurology
Patrick D. Lyden, Francesca Bosetti, Marcio A. Diniz, Andre Rogatko, James Koenig, Jessica Lamb, Karisma A. Nagarkatti, Ryan P. Cabeen, David C. Hess, Pradip K. Kamat, Mohammad B. Khan, Kristofer Wood, Krishnan Dhandapani, Ali S. Arbab, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Andreia Morais, Takahiko Imai, Tao Qin, Cenk Ayata, Ligia S. B. Boisserand, Alison L. Herman, Hannah E. Beatty, Sofia E. Velazquez, Sebastian Diaz-Perez, Basavaraju G. Sanganahalli, Jelena M. Mihailovic, Fahmeed Hyder, Lauren H. Sansing, Raymond C. Koehler, Steven Lannon, Yanrong Shi, Senthilkumar S. Karuppagounder, Adnan Bibic, Kazi Akhter, Jaroslaw Aronowski, Louise D. McCullough, Anjali Chauhan, Andrew Goh
Summary: Cerebral ischemia and reperfusion lead to neurological disabilities, and developing successful stroke treatments has been challenging. The Stroke Preclinical Assessment Network (SPAN) aims to reduce bias in treatment selection for clinical studies by rigorously assessing candidate treatments across multiple research laboratories. The first stage of SPAN successfully implemented standardized procedures, randomization, and blinded assessment. Subsequent stages will evaluate candidate treatments using aged animals and animals with comorbid conditions.
Article
Clinical Neurology
Andreia Morais, Joseph J. J. Locascio, Lauren H. H. Sansing, Jessica Lamb, Karisma Nagarkatti, Takahiko Imai, Klaus van Leyen, Jaroslaw Aronowski, James I. I. Koenig, Francesca Bosetti, Patrick Lyden, Cenk Ayata, SPAN Investigators
Summary: The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform that uses rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In this study, we report the heterogeneity introduced by allowing variations in biological and experimental model variables among the 6 SPAN laboratories and its impact on middle cerebral artery occlusion (MCAo) performance.
Editorial Material
Clinical Neurology
Clinton B. Wright, Francesca Bosetti, James I. Koenig, L. Scott Janis
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.