Article
Neurosciences
Samuel Singleton, Tim G. Hales
Summary: Morphine diminishes pain, but its long-term use is compromised by tolerance and hyperalgesia. Our study examined the involvement of d receptors, b-arrestin2, and Src kinase in morphine-induced hypersensitivity (MIH) and found that a common pathway might provide a target for improved analgesic approaches. We used quantitative RT-PCR to explore the expression of opioid genes in the spinal cord and found that MIH is caused by a tolerance-induced reduction in endogenous opioid signaling.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Anesthesiology
Sam Singleton, Claire Sneddon, Alice Bakina, Jeremy J. Lambert, Tim G. Hales
Summary: Fragmented maternal care in mice affects pain sensitivity, morphine response, and inflammatory hypersensitivity, resulting in decreased basal sensitivity and enhanced vulnerability to persistent inflammatory hypersensitivity.
Article
Neurosciences
Lewis S. Crawford, Emily P. Mills, Theo Hanson, Paul M. Macey, Rebecca Glarin, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: Perception of pain can be influenced by expectations and beliefs. This study used ultra-high-field fMRI to investigate the brainstem pathways involved in placebo analgesia and nocebo hyperalgesia, revealing differential activation of key pain modulatory nuclei during these phenomena.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Christophe Mallet, Ludivine Boudieu, Sylvain Lamoine, Catherine Coudert, Yves Jacquot, Alain Eschalier
Summary: The peptide ER alpha 17p derived from human estrogen receptor alpha (ER alpha) shows anti-proliferative effects in breast cancer cells through GPER, and reduces xenografted human breast tumors in mice. It also demonstrates anti-hyperalgesic effects in a chronic mice model of inflammation, and reduces paw swelling in a carrageenan-induced inflammation model. This suggests that ER alpha 17p, as a GPER inverse agonist, could be a potential treatment for controlling hyperalgesia and inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rodrigo Maia-Marques, Igor M. R. Nascimento, Pedro S. S. Lauria, Ellen C. P. da Silva, Darizy F. Silva, Luciana L. Casais-e-Silva
Summary: Venom from Bothrops leucurus induces severe pain and mechanical hyperalgesia, involving neurotransmitters, nitric oxide, and prostaglandins. Inhibiting specific inflammatory mediators pathways may be an effective therapeutic strategy for pain management during envenoming.
Article
Neurosciences
Roni Hogri, Bozhidar Baltov, Ruth Drdla-Schutting, Valeria Mussetto, Holzinger Raphael, Lidia Trofimova, Juergen Sandkuehler
Summary: The aversive aspect of pain is a major burden for pain patients. Recent studies have used unconditioned escape as a measure of pain aversion in animals. This study presents the Heat Escape Threshold (HET) paradigm for assessing heat aversion in rats and demonstrates its utility in detecting the effects of an inflammatory pain model.
Review
Neurosciences
Lijia Mai, Qing Liu, Fang Huang, Hongwen He, Wenguo Fan
Summary: Mast cells play important roles in immune responses, participating not only in allergic diseases but also in host defense, immunity, and immunoregulation. Activation of mast cells releasing various mediators has effects on the nervous system, being involved in different pain conditions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Sara Facchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli
Summary: Increasing anandamide levels through FAAH inhibition can reduce pronociceptive responses and inflammatory mediators in animal models of migraine. This study evaluated the pharmacological activity of the FAAH inhibitor JZP327A in the mediation of spontaneous and nocifensive behavior in a nitroglycerin-induced migraine model. The results suggest that JZP327A has an anti-hyperalgesic effect by inhibiting the inflammatory cascade, independent of changes in endocannabinoid and lipid levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mingyun Zhang, Eden Alamaw, Katechan Jampachaisri, Monika Huss, Cholawat Pacharinsak
Summary: This study compares the effects of high and low doses of extended-release buprenorphine on thermal hypersensitivity in neonatal rats. The results show that the high dose attenuates postoperative thermal hypersensitivity for up to 4 hours, while the low dose has a longer-lasting effect.
Article
Biochemistry & Molecular Biology
Oksana Sintsova, Irina Gladkikh, Anna Klimovich, Yulia Palikova, Viktor Palikov, Olga Styshova, Margarita Monastyrnaya, Igor Dyachenko, Sergey Kozlov, Elena Leychenko
Summary: The study demonstrated the analgesic and anti-inflammatory effects of HCRG21, a peptide blocker of TRPV1, in a mice model of carrageenan-induced paw edema. HCRG21 effectively inhibited edema formation, reduced TNF-alpha production, and showed potent analgesic effects on mechanical and thermal hyperalgesia models. These results highlight the potential of TRPV1 blockers like HCRG21 in managing pain and inflammation.
Review
Biochemistry & Molecular Biology
Lamees Alhassen, Travis Dabbous, Allyssa Ha, Leon Hoang Lam Dang, Olivier Civelli
Summary: Corydalis yanhusuo extract contains over 160 compounds, with alkaloids being the most important for analgesic effects, as over 80 have been isolated and identified. This review aims to comprehensively discuss the phytochemical and pharmacological effects of these alkaloids in relation to pain relief.
Article
Anesthesiology
James C. Eisenach, Regina S. Curry, Timothy T. Houle
Summary: This study compared the effects of intrathecal oxytocin and placebo on neuropathic pain and mechanical hyperalgesia. The results showed that oxytocin reduced pain intensity more than placebo, but also increased the hyperalgesic area. Although limited by the small sample size, further research on spinal oxytocin in this population is warranted.
Review
Neurosciences
Hugues Petitjean, Elea Heberle, Louis Hilfiger, Olga Lapies, Guillaume Rodrigue, Alexandre Charlet
Summary: This review examines the correlation between the content of monoterpenes in plants and their historical therapeutic properties. It also discusses the mechanism by which monoterpenes exert their anti-inflammatory and antihyperalgesia effects through modulation of TRP channels activity. The review highlights the importance and potential of characterizing new plant extracts and reassessing studied plant extracts for the development of innovative treatments for chronic pain based on ethnopharmacology.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Sergio Lopez-Estevez, Georgia Gris, Beatriz de la Puente, Alicia Carceller, Vicente Martinez
Summary: Sigma-1 receptors play an important role in intestinal inflammation-associated referred hyperalgesia, with knockout mice showing significant attenuation in inflammation associated hypersensitivity. The absence of sigma(1)Rs had little impact on colitis generation and progression, but did show reduction in edema and down-regulation of iNOS gene expression during the chronic phase.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Integrative & Complementary Medicine
Barbara B. Garrido-Suarez, Gabino Garrido, Addis Bellma Menendez, Nelson Merino, Odalys Valdes, Nilia de la Paz, Aylema Romero, Livan Delgado, Miguel D. Fernandez, Octavio Pineros, Rene Delgado-Hernandez
Summary: The present study evaluated the antinociceptive activity of Calendula officinalis L. cream on inflammatory hypernociception. The results showed that 10% or 30% concentration of Calendula cream could reduce licking/biting behavior and edema in rats, and it worked through antioxidant stress and peripheral opioid mechanisms. These findings may have an impact on the clinical management of painful inflammatory diseases.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Review
Medicine, Research & Experimental
Josefa Belen Alarcon, Priscila Belen Chuhuaicura, Kathleen Anne Sluka, Carol G. T. Vance, Valeria Paula Sasoli Fazan, Karina Alejandra Godoy, Ramon Eduardo Fuentes, Fernando Jose Dias
Summary: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive electrical stimulation therapy that can accelerate nerve regeneration and increase axon quantity and diameter. Low-frequency TENS application can promote normal myelination, while high-frequency TENS application can stimulate motor regeneration but may increase the risk of neuropathic pain. Although further research is needed, TENS seems to be a promising treatment for nerve injury.
Article
Anesthesiology
Muath A. Shraim, Kathleen A. Sluka, Michele Sterling, Lars Arendt-Nielsen, Charles Argoff, Karl S. Bagraith, Ralf Baron, Helena Brisby, Daniel B. Carr, Ruth L. Chimenti, Carol A. Courtney, Michele Curatolo, Beth D. Darnall, Jon J. Ford, Thomas Graven-Nielsen, Melissa C. Kolski, Eva Kosek, Richard E. Liebano, Shannon L. Merkle, Romy Parker, Felipe J. J. Reis, Keith Smart, Rob J. E. M. Smeets, Peter Svensson, Bronwyn L. Thompson, Rolf-Detlef Treede, Takahiro Ushida, Owen D. Williamson, Paul W. Hodges
Summary: This study used the Delphi expert consensus method to identify classification features and generated a list of candidate features that could aid in discrimination between types of musculoskeletal pain.
Article
Clinical Neurology
Dana L. Dailey, Carol G. T. Vance, Ruth Chimenti, Barbara A. Rakel, Miriam Bridget Zimmerman, Jon M. Williams, Kathleen A. Sluka, Leslie J. Crofford
Summary: This study found that regular use of opioid medications does not diminish the effectiveness of transcutaneous electrical nerve stimulation (TENS) for movement-evoked pain. However, women with fibromyalgia regularly taking opioids did experience greater bodily pain and fatigue compared to those not regularly taking opioids. These differences, while statistically significant, may not have clear clinical significance.
Article
Anesthesiology
Joseph B. Lesnak, Alexis Fahrion, Amber Helton, Lynn Rasmussen, Megan Andrew, Stefanie Cunard, Michaela Huey, Austin Kreber, Joseph Landon, Travis Siwiec, Kenan Todd, Laura A. Frey-Law, Kathleen A. Sluka
Summary: Resistance training can prevent the development of muscle pain through the activation of androgen receptors. It acutely increases lactate and testosterone, and increases strength over time.
Article
Anesthesiology
Melissa E. Lenert, Rachelle Gomez, Brandon T. Lane, Dana L. Dailey, Carol G. T. Vance, Barbara A. Rakel, Leslie J. Crofford, Kathleen A. Sluka, Ericka N. Merriwether, Michael D. Burton
Summary: The study investigates the translatability of clinical behavioral assessments for spontaneous pain and movement-evoked pain in a preclinical model of fibromyalgia. The findings suggest that MEP is significantly associated with mechanical pain sensitivity in both preclinical and clinical settings.
Article
Medicine, General & Internal
Giovanni Berardi, Laura Frey-Law, Kathleen A. Sluka, Emine O. Bayman, Christopher S. Coffey, Dixie Ecklund, Carol G. T. Vance, Dana L. Dailey, John Burns, Asokumar Buvanendran, Robert J. McCarthy, Joshua Jacobs, Xiaohong Joe Zhou, Richard Wixson, Tessa Balach, Chad M. Brummett, Daniel Clauw, Douglas Colquhoun, Steven E. Harte, Richard E. Harris, David A. Williams, Andrew C. Chang, Jennifer Waljee, Kathleen M. Fisch, Kristen Jepsen, Louise C. Laurent, Michael Olivier, Carl D. Langefeld, Timothy D. Howard, Oliver Fiehn, Jon M. Jacobs, Panshak Dakup, Wei-Jun Qian, Adam C. Swensen, Anna Lokshin, Martin Lindquist, Brian S. Caffo, Ciprian Crainiceanu, Scott Zeger, Ari Kahn, Tor Wager, Margaret Taub, James Ford, Stephani P. Sutherland, Laura D. Wandner
Summary: Chronic pain is a global health problem that reduces quality of life, but its clinical management has been hindered by incomplete understanding of risk factors and molecular mechanisms. The A2CPS Program aims to predict chronic pain development following surgery using biomarkers. This study collects standardized data from multiple clinical sites to advance understanding of the transition from acute to chronic postsurgical pain.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Saman Haider, Adam J. Janowski, Joseph B. Lesnak, Kazuhiro Hayashi, Dana L. Dailey, Ruth Chimenti, Laura A. Frey-Law, Kathleen A. Sluka, Giovanni Berardi
Summary: An increasing number of individuals experience prolonged symptoms after having COVID-19, known as post-COVID-19 condition. This study aimed to compare the symptom profiles of individuals with post-COVID-19, fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS). The study found that all three conditions had elevated levels of pain, fatigue, anxiety, depression, catastrophizing, and kinesiophobia. Physical and cognitive function were similarly affected in post-COVID-19, FMS, and CFS, but post-COVID-19 individuals reported lower levels of pain and fatigue compared to FMS and CFS. The comorbidity of post-COVID-19 with FMS and/or CFS worsened pain, fatigue, and psychological aspects. These findings suggest the importance of a biopsychosocial approach in managing post-COVID-19 symptoms.
Article
Anesthesiology
Ruth L. Chimenti, Andrew A. Post, Ebonie K. Rio, G. Lorimer Moseley, Megan Dao, Hadley Mosby, Mederic Hall, Cesar de Cesar Netto, Jason M. Wilken, Jessica Danielson, Emine O. Bayman, Kathleen A. Sluka
Summary: Exercise is the standard treatment for Achilles tendinopathy (AT), but a significant number of patients still experience pain after rehabilitation. Adding pain science education (PSE) to an exercise program may improve clinical outcomes, but this has not been studied in AT patients. Moreover, we have limited knowledge about how AT rehabilitation affects fear of movement and central nervous system nociceptive processing.
Article
Orthopedics
Andrew A. Post, Ebonie K. Rio, Kathleen A. Sluka, G. Lorimer Moseley, Emine O. Bayman, Mederic M. Hall, Cesar de Cesar Netto, Jason M. Wilken, Jessica Danielson, Ruth L. Chimenti
Summary: The study compared the efficacy of physical therapy delivered via telehealth or hybrid format with in-person format for individuals with chronic Achilles tendinopathy (AT). The results showed that there was no significant difference in pain outcomes between the telehealth/hybrid groups and the in-person group. This suggests that telehealth-based physical therapy can improve accessibility to AT rehabilitation and prioritize patient preferences for treatment format.
Review
Orthopedics
Kazuhiro Hayashi, Adam Janowski, Joseph B. Lesnak, Kathleen A. Sluka
Summary: Preoperative exercise can reduce postoperative pain and improve function, as well as decrease the risk of complications. This systematic review found that preoperative exercise in joint replacement surgery can significantly reduce pain within 2-5 months after surgery and improve quality of life and function within the first 2 months. However, the effect on pain and function after 6 months is not significant, and the impact on other surgery types is inconclusive.
Article
Anesthesiology
Kazuhiro Hayashi, Joseph B. B. Lesnak, Ashley N. N. Plumb, Lynn A. A. Rasmussen, Kathleen A. A. Sluka
Summary: We developed an animal model of activity-induced muscle pain that relies on the activation of macrophages and the release of interleukin-1 β. The P2X7/NLRP3/Caspase-1 pathway plays a crucial role in the initiation and early maintenance phases of muscle pain in male mice. However, this pathway does not contribute to late maintenance phases in male mice or to muscle pain in female mice.
Review
Anesthesiology
Kathleen A. Sluka, Tor D. Wager, Stephani P. Sutherland, Patricia A. Labosky, Tessa Balach, Emine O. Bayman, Giovanni Berardi, Chad M. Brummett, John Burns, Asokumar Buvanendran, Brian Caffo, Vince D. Calhoun, Daniel Clauw, Andrew Chang, Christopher S. Coffey, Dana L. Dailey, Dixie Ecklund, Oliver Fiehn, Kathleen M. Fisch, Laura A. Frey Law, Richard E. Harris, Steven E. Harte, Timothy D. Howard, Joshua Jacobs, Jon M. Jacobs, Kristen Jepsen, Nicolas Johnston, Carl D. Langefeld, Louise C. Laurent, Rebecca Lenzi, Martin A. Lindquist, Anna Lokshin, Ari Kahn, Robert J. McCarthy, Michael Olivier, Linda Porter, Wei-Jun Qian, Cheryse A. Sankar, John Satterlee, Adam C. Swensen, Carol G. T. Vance, Jennifer Waljee, Laura D. Wandner, David A. Williams, Richard L. Wixson, Xiaohong Joe Zhou
Summary: Chronic pain affects a large number of Americans and there is a lack of understanding of the underlying mechanisms. Biomarkers have the potential to identify and measure changes caused by pain, provide treatment targets, and identify at-risk patients. The A2CPS program aims to evaluate and develop biomarkers for chronic pain after surgery, including genomic, proteomic, metabolomic, and neuroimaging measures.
Article
Engineering, Biomedical
Adam J. Janowski, Andrew A. Post, Alberto M. Heredia-Rizo, Hadley Mosby, Megan Dao, Laura Frey Law, Emine O. Bayman, Jason M. Wilken, Kathleen A. Sluka, Ruth L. Chimenti
Summary: This study characterized movement-evoked pain in individuals with Achilles tendinopathy during tendon loading and stretching tasks, and found associations between movement-evoked pain and biomechanical and psychological variables.
CLINICAL BIOMECHANICS
(2023)
Review
Medicine, General & Internal
Carol G. T. Vance, Dana L. Dailey, Ruth L. Chimenti, Barbara J. Van Gorp, Leslie J. Crofford, Kathleen A. Sluka
Summary: TENS is a non-pharmacological intervention used for acute and chronic pain conditions. Research has improved understanding of TENS efficacy mechanisms, but uncertainty remains regarding clinical effectiveness, requiring further high-quality studies to evaluate the therapeutic potential.
MEDICINA-LITHUANIA
(2022)
Article
Clinical Neurology
Nathan Augeard, Geoff Bostick, Jordan Miller, David Walton, Yannick Tousignant-Laflamme, Anne Hudon, Andre Bussieres, Lynn Cooper, Nicol McNiven, Aliki Thomas, Lesley Singer, Scott M. Fishman, Marie H. Bement, Julia M. Hush, Kathleen A. Sluka, Judy Watt-Watson, Lisa C. Carlesso, Sinead Dufour, Roland Fletcher, Katherine Harman, Judith Hunter, Suzy Ngomo, Neil Pearson, Kadija Perreault, Barbara Shay, Peter Stilwell, Susan Tupper, Timothy H. Wideman
Summary: This study aimed to create a consensus-based competency profile for pain management specific to the Canadian context of physiotherapy. Through a modified Delphi design, a total of 15 competencies reached consensus, and the majority of participants reported being very satisfied with the process. This study contributes to the field of integrated research in pain management.
CANADIAN JOURNAL OF PAIN-REVUE CANADIENNE DE LA DOULEUR
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.