Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Immunology
Qianyan He, Yinzhong Ma, Jie Liu, Dianhui Zhang, Jiaxin Ren, Ruoyu Zhao, JunLei Chang, Zhen-Ni Guo, Yi Yang
Summary: Ischemic stroke, caused by inadequate cerebrovascular blood and oxygen supply, poses a significant global health burden. HIF-1α, a key regulator of oxygen homeostasis, plays a critical role in various aspects of stroke pathophysiology and is an important target for potential therapeutic interventions. Further research into the differential regulation of HIF-1α in different cell types during ischemic stroke is crucial for understanding the disease mechanism and identifying novel treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam
Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Xin-Chi Jiang, Hong-Hui Wu, Tianyuan Zhang, Yun-Fei Dong, Yao-Sheng Li, Ting Huang, An-Hao Tian, Peng-Xiang Chen, Xian-Ming Lin, Ying-Zhi Huang, Chong Liu, Xiang-Nan Zhang, Zhong Chen, Yasuhiko Tabata, Jian-Qing Gao
Summary: Hypoxic preconditioning of neural stem cells (NSCs) can produce hypoxic exosomes, which can effectively treat ischemic stroke. These exosomes can target the injured brain and regulate the microenvironment to inhibit neuroinflammation and promote blood-brain barrier permeability recovery. Furthermore, they can also activate autologous NSCs and facilitate nerve regeneration. Hypoxic exosomes have therapeutic effects on both survival and behavioral outcomes in ischemic stroke mice.
Article
Nanoscience & Nanotechnology
Wen-Sheng Tzeng, Wei-Lin Teng, Pao-Hsien Huang, Tzu-Ching Lin, Feng-Lin Yen, Yow-Ling Shiue
Summary: The study demonstrated that the prepared PTS nanoparticles (PSN) showed better antihepatoma activities in HepG2 cells, especially under hypoxic conditions, and effectively improved the water solubility and drug release of PTS.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yiwei Liu, Qipeng Luo, Zhanhao Su, Junyue Xing, Jinlin Wu, Li Xiang, Yuan Huang, Haizhou Pan, Xie Wu, Xiaoling Zhang, Jun Li, Fuxia Yan, Hao Zhang
Summary: Cyanotic congenital heart disease (CCHD) leads to maladaptation of cardiac metabolism during puberty, accompanied by impaired cardiac function. The study identified HIF-1 alpha as the key regulator of cardiac metabolic adaptation in CH animal models, with pubertal insulin resistance potentially suppressing its expression.
Review
Neurosciences
Mypinder S. Sekhon, Sophie Stukas, Veronica Hirsch-Reinshagen, Sonny Thiara, Tison Schoenthal, Michael Tymko, Kelly M. Mcnagny, Cheryl Wellington, Ryan Hoiland
Summary: Hypoxic ischaemic brain injury after resuscitation from cardiac arrest is associated with the response of the innate immune system, including pro-inflammatory cytokines, leucocyte migration and activation, and complement cascade. Inhibiting an immunopathological response may be an effective therapeutic strategy.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Clinical Neurology
Yaqi Wan, Lu Huang, Yanmin Liu, Weizhong Ji, Changxing Li, Ri-li Ge
Summary: Intermittent hypobaric hypoxia preconditioning exerts neuroprotective effects in a rat stroke model, while persistent hypobaric hypoxia stimulation does not show significant neuroprotective effects. Intermittent hypoxic preconditioning for 6 hours/day for 10 days upregulates key proteins in clathrin-dependent endocytosis of neurons in the cortex.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Syed Faizan Ali Rizvi, Bushra Wasim, Shumaila Usman, Kevin Joseph Jerome Borges, Iqra Sahibdad, Asmat Salim, Irfan Khan
Summary: This study investigated the effects of ZnCl2 on the proliferation, morphology, migration, and gene expression of BM-MSCs under hypoxic and normoxic environments. It was found that zinc significantly enhanced BM-MSC proliferation, promoted cell migration, and improved cell morphology during the aging process.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Geriatrics & Gerontology
Yuan Xu, Ronghua Chen, Feng Zhi, Shiying Sheng, Leena Khiati, Yilin Yang, Ya Peng, Ying Xia
Summary: Neuroinflammation is the underlying cause of many age-related neurological disorders, and microglia play a crucial role in regulating neuroinflammation and neuronal survival. Recent studies have shown that activation of the δ-opioid receptor (DOR) can protect neurons by inhibiting microglial inflammation. In contrast, inhibiting DOR or reducing its activity can promote microglial activation and worsen cell injury. This finding suggests that targeting microglia through modulation of neuroinflammation by DOR has therapeutic potential for age-related neurological disorders.
Article
Physiology
Caitlin P. Jarrard, Mercedes J. Nagel, Sten Stray-Gundersen, Hirofumi Tanaka, Sophie Lalande
Summary: Ischemic preconditioning and intermittent hypoxia can attenuate the reduction in brachial artery endothelial function caused by ischemia-reperfusion injury in young healthy individuals.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Thuy-Hang Nguyen, Stephanie Conotte, Alexandra Belayew, Anne-Emilie Decleves, Alexandre Legrand, Alexandra Tassin
Summary: Muscular dystrophies are genetic degenerative muscle disorders characterized by muscle wasting, often accompanied by respiratory impairments and hypoxemia. Hypoxic stress activates compensatory mechanisms, with HIF-1α playing a key role. Alterations in HIF-1α in muscle may impact the pathophysiology of muscular dystrophies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
P. Brancaccio, S. Anzilotti, O. Cuomo, A. Vinciguerra, M. Campanile, A. Herchuelz, S. Amoroso, L. Annunziato, G. Pignataro
Summary: Researchers are studying endogenous neuroprotective strategies to identify alternative interventions for neonatal hypoxic-ischemic encephalopathy. They found that hypoxic preconditioning can promote neurogenesis and provide neuroprotection by regulating ionic homeostasis.
CELL DEATH DISCOVERY
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.