Article
Medicine, Research & Experimental
Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
Summary: The study highlights the role of the glutamate/NMDAR axis in obesity-related metabolic syndrome, with evidence showing that targeting NMDAR can be a promising therapeutic strategy. In obese mice, increased glutamate levels and blockade of NMDAR by Memantine improved insulin sensitivity and reduced hepatic steatosis, while NMDA treatment induced obesity and metabolic disorders. In vitro studies demonstrated that NMDAR activation promoted lipid accumulation and impaired fatty acid oxidation through PPARa signaling, suggesting a potential mechanism for NMDAR-mediated metabolic syndrome in obesity.
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Rischka, Chrysoula Vraka, Verena Pichler, Sazan Rasul, Lukas Nics, Gregor Gryglewski, Patricia Handschuh, Matej Murgas, Godber M. Godbersen, Leo R. Silberbauer, Jakob Unterholzner, Christoph Wotawa, Ahmed Haider, Hazem Ahmed, Roger Schibli, Thomas Mindt, Markus Mitterhauser, Wolfgang Wadsak, Andreas Hahn, Rupert Lanzenberger, Marcus Hacker, Simon M. Ametamey
Summary: This study reports on the performance characteristics of (R)-C-11-Me-NB1, a radioligand used to map GluN2B-enriched NMDARs in the human brain. The radioligand demonstrated high and heterogeneous uptake and a high test-retest reliability. It shows promise in deepening our understanding of the role of GluN2B-containing NMDARs in neurodegenerative and neuropsychiatric diseases such Alzheimer's disease and major depression.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Neurosciences
Annalise N. Binette, Jianfeng Liu, Hugo Bayer, Kennedi L. Crayton, Laila Melissari, Samantha O. Sweck, Stephen Maren
Summary: Stress has a significant impact on fear extinction and affects the activity of PV interneurons in the mPFC. PV interneurons regulate extinction learning under stress in a sex-dependent manner, and this effect is mediated by amygdaloprefrontal projections.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Boyoung Lee, Santosh Pothula, Min Wu, Hyeyeon Kang, Matthew J. Girgenti, Marina R. Picciotto, Ralph J. DiLeone, Jane R. Taylor, Ronald S. Duman
Summary: Researchers tested a novel NMDAR-positive modulator, NYX-783, in rodent models of PTSD and found that it significantly reduced spontaneous recovery and enhanced fear extinction. The study elucidated the cellular targets and molecular mechanisms underlying NYX-783's effects on PTSD symptoms.
MOLECULAR PSYCHIATRY
(2022)
Review
Chemistry, Medicinal
Amir Parsa Abhari, Masoud Etemadifar, Niloufar Yazdanpanah, Nima Rezaei
Summary: N-methyl-D-aspartate receptors (NMDARs) play a crucial role in regulating physiological processes in the brain and nervous system. Dysfunction of NMDARs can contribute to various pathologies, including cell death and brain dysfunction. Research has shown the significant involvement of NMDARs in demyelinating disorders and anti-NMDAR encephalitis.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Asami Umino, Hisayuki Iwama, Masakazu Umino, Dai Shimazu, Yuji Kiuchi, Toru Nishikawa
Summary: d-Serine has been shown to play an important role in brain functions through its interaction with NMDAR. The selective destruction of neuronal cell bodies in the medial prefrontal cortex results in a significant decrease in tissue and extracellular d-serine concentrations, suggesting that the prefrontal cortical region contains substantial amounts of d-serine. The reduction in GABA levels in the prefrontal cortex supports the perikarya-selective nature of the lesion.
NEUROCHEMICAL RESEARCH
(2022)
Article
Physiology
Yi-Shiou Tseng, Chun-Hou Liao, Wen-Bin Wu, Ming-Chieh Ma
Summary: The study demonstrates that NMDAR blockade alleviates D-serine-induced renal injury, possibly through the involvement of NOX4-mediated oxidative stress. These findings have important implications for preventing acute renal injury caused by D-serine.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nathalie Sala, Caterina Paoli, Tiziana Bonifacino, Jessica Mingardi, Emanuele Schiavon, Luca La Via, Marco Milanese, Paolo Tornese, Ashok K. Datusalia, Jessica Rosa, Roberta Facchinetti, Giulia Frumento, Giulia Carini, Floramarida Salerno Scarzella, Caterina Scuderi, Lia Forti, Alessandro Barbon, Giambattista Bonanno, Maurizio Popoli, Laura Musazzi
Summary: Stress is a major risk factor for psychiatric disorders, including PTSD. Ketamine has been found to block the detrimental effects of acute stress on the glutamate system and improve depressive, anxious, and fear extinction behaviors in rats.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Evelyn Ordones Sanchez, Debra A. Bangasser
Summary: Impulsivity is a common symptom in various psychiatric disorders, and early life stress has been found to affect impulsive behaviors and brain circuits associated with impulsivity, which is essential for developing treatments aimed at reducing impulsivity symptoms in psychiatric disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Ilaria Bertocchi, Florbela Rocha-Almeida, Maria Teresa Romero-Barragan, Marco Cambiaghi, Alejandro Carretero-Guillen, Paolo Botta, Godwin K. Dogbevia, Mario Trevino, Paolo Mele, Alessandra Oberto, Matthew E. Larkum, Agnes Gruart, Rolf Sprengel, Jose Maria Delgado-Garcia, Mazahir T. Hasan
Summary: The organization and formation of fear memory involve multiple brain regions. The activity of NMDARs plays a crucial role in fear memory formation, and the consolidation of multi-trace systems is essential for the sequential printing and flexible retrieval of fear memory.
Article
Biochemistry & Molecular Biology
Xiaoyu Ma, Chen Chen, Yaxin Lu, Ling Fang, Baohua Cao, Xueqiang Hu, Wei Qiu, Yaqing Shu
Summary: This study found that serum levels of GSDMD are elevated in patients with anti-NMDAR encephalitis and are associated with disease prognosis. After treatment, GSDMD levels decreased and clinical symptoms improved in patients, indicating a potential role of GSDMD in monitoring and predicting disease progression of anti-NMDAR encephalitis.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Immunology
Fanshi Zhang, Mei Liu, Jinmei Tuo, Li Zhang, Jun Zhang, Changyin Yu, Zucai Xu
Summary: This article reviews how neuroinflammation mediates the development of levodopa-induced dyskinesia (LID) through the regulation of NMDA receptors. It also evaluates the potential of common anti-inflammatory drugs and NMDA receptor antagonists to mitigate the development of LID by regulating central neuroinflammation, providing a new theoretical basis for finding new therapeutic targets for LID.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Eui-Ho Park, Nam-Soo Kim, Yeon-Kyung Lee, June-Seek Choi
Summary: Accumulating evidence suggests that the medial prefrontal cortex (mPFC) plays a crucial role in the acquisition of fear memory during trace fear conditioning. Specifically, the prelimbic (PL) subregion within the mPFC is involved in short- and long-term trace fear memory formation. Furthermore, NMDA receptor-mediated neurotransmission in PL is required for the acquisition of trace fear memory.
Article
Psychiatry
Daniel Y. Rubinstein, Daniel P. Eisenberg, Frederick W. Carver, Tom Holroyd, Jose A. Apud, Richard Coppola, Karen F. Berman
Summary: This study used magnetoencephalography to investigate working memory-related beta band activity in schizophrenic patients compared to healthy controls. The results showed altered beta band activation in medication-free patients, which were largely observed in prefrontal, parietal, and visual cortices. Antipsychotic medication altered the neural responses in these regions to resemble those of controls.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.