Article
Chemistry, Multidisciplinary
Zeng Wang, Xiancheng Wang, Ruidong Li
Summary: This study focuses on the physiological effects of the mechanical properties of treadmill decks on runners. By improving the human motion model and using the particle swarm optimization algorithm, the results show that the hardness of the treadmill deck can affect muscle activity, providing references for the design of treadmill deck parameters.
APPLIED SCIENCES-BASEL
(2023)
Article
Sport Sciences
Abdulkerim Darendeli, Hayri Ertan, Roger Maro Enoka
Summary: This study compared the activation levels of lower body muscles during overground running and treadmill running at different grades. The results showed that the activation level of thigh muscles was highest when running on the treadmill at 1% and 2% grades, while the activation level of shank muscles was highest when running at speeds of 2.92 and 4.58 m/s.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Clinical Neurology
Kelsey R. R. Sewell, Stephanie R. R. Rainey-Smith, Jeremiah Peiffer, Hamid R. R. Sohrabi, Kevin Taddei, David Ames, Paul Maruff, Colin L. L. Masters, Christopher C. C. Rowe, Ralph N. N. Martins, Kirk I. I. Erickson, Belinda M. M. Brown
Summary: This study examined the association between objectively measured physical activity and cognition in older adults over 8 years. The results showed that higher energy expenditure, physical activity intensity, and total activity were associated with better episodic recall memory and global cognition. These findings suggest that physical activity may preserve cognitive function, with activity intensity playing a significant role.
ALZHEIMERS & DEMENTIA
(2023)
Article
Chemistry, Analytical
Dominik Fohrmann, Daniel Hamacher, Alberto Sanchez-Alvarado, Wolfgang Potthast, Patrick Mai, Steffen Willwacher, Karsten Hollander
Summary: Running stability refers to the ability to withstand minor perturbations during running. This study aimed to evaluate the reliability of running stability measurements in different laboratory and outdoor conditions. The results showed moderate to excellent reliability for both overground and treadmill running.
Article
Biology
Pedro V. R. Andrade, William C. Damasceno, Alexandre S. R. Hudson, Michele M. Moraes, Francisco Teixeira-Coelho, Maicon R. Albuquerque, Samuel P. Wanner
Summary: This study examined the reliability of rats' performance and thermoregulatory parameters during incremental-speed running and found that core temperature was the most reproducible parameter. Additionally, exercise in a warm environment produced detectable thermoregulatory changes relative to exercise under temperate conditions.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Cell Biology
Xiao Li, Ting Li, Xiao Yue Hong, Jian Jun Liu, Xi Fei Yang, Gong Ping Liu
Summary: Acer truncatum seed oil treatment significantly improves learning and memory abilities in normal aging mice, activates the BDNF/TrkB signaling pathway, and reduces inflammatory factors expression, suggesting its potential as a therapeutic food supplement for delaying aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Chris Chow Li Tee, Mee Chee Chong, Viswanath Sundar, Chuen Leang Chok, Wee Kian Yeo, Olivier Girard
Summary: This study aimed to investigate the effects of manipulating running velocity and hypoxic exposure on gait asymmetry during treadmill running. The results showed that trained runners exhibited low-to-moderate mechanical asymmetries across a range of submaximal running velocities and varying levels of hypoxia severity.
Article
Orthopedics
Reed Handlery, Jill Campbell Stewart, Christine Pellegrini, Courtney Monroe, Garrett Hainline, Alicia Flach, Kaci Handlery, Stacy Fritz
Summary: People with Parkinson's disease are encouraged to take at least 4200 steps per day to meet physical activity guidelines through walking. High-intensity treadmill exercise was found to increase daily steps and moderate- to vigorous-intensity physical activity in individuals with Parkinson's disease, but these changes were not associated with improvements in fitness levels.
Article
Biochemistry & Molecular Biology
Margarita R. Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jeronia Llado, Antoni Miralles, Susana Esteban
Summary: The study found that physical activity in elderly rats can improve age-related memory and learning deficits, correlating with the restoration of brain neurotransmitters and SIRT1 protein levels. The combination of the antioxidant catechin with exercise can further enhance monoaminergic pathways, beneficial for brain health.
Article
Multidisciplinary Sciences
Reine Khoury, Joelle Saad, Vanessa Jabre, Litsa Maria Ghayad, Mohamad Khalifeh, Rouba Houbeika, Perla El Ahmad, Amar Mezher, Diala El Masri, Zena Haddad, Fady Eid, Nour Barmo, Patrick Nasrallah, Sama F. Sleiman, Joseph S. Stephan
Summary: Exercise enhances learning and memory recall and counteracts cognitive decline associated with aging. The positive effects of exercise are mediated by circulatory factors, specifically Brain Derived Neurotrophic Factor (BDNF) signaling in the hippocampus. Identifying the mechanisms behind the release of these factors and their effects on hippocampal Bdnf expression will help harness the therapeutic potential of exercise.
Article
Multidisciplinary Sciences
Marcel Lemire, Robin Faricier, Alain Dieterlen, Frederic Meyer, Gregoire P. Millet
Summary: The objective of this study was to determine if the relationships between energy cost of running and running mechanics could be related to fitness level. The results showed that running mechanics were related to energy cost during uphill running, but not during level and downhill running. Longer stance duration during uphill running contributes to lower energy expenditure and running cost, suggesting potential for optimizing specific running training programs.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Andrea Zignoli, Antoine Godin, Laurent Mourot, Alessandro Mengarelli
Summary: Inertial measurement units (IMU) are a light and cost-effective alternative to gold-standard measurement systems for assessing running temporal variables. This study used IMU data to predict stride frequency, duty factor, and running variability indices for 20 runners at different speeds and treadmill inclinations. The findings suggest that using IMU configurations for estimating stride frequency is effective and comparable to the gold-standard. However, caution should be exercised when using IMU technology for measuring running variability indices.
Article
Neurosciences
Carolina Luft, Isadora Perez Levices, Mariana Severo da Costa, Jarbas Rodrigues de Oliveira, Marcio Vinicius Fagundes Donadio
Summary: The study found that pregestational exercise can prevent the effects of maternal stress on hippocampal BDNF IV gene expression in females, but has no effect on stress-induced memory impairment in males.
NEUROSCIENCE LETTERS
(2021)
Article
Orthopedics
Kellee Harper-Hanigan, Allison H. Gruber
Summary: Overuse injuries from running occur when the loading stimulus exceeds the tissue-specific loading capacity, and excessive running exposure is an important precursor to injury. There is currently no definitive safe loading exposure that can reliably differentiate between injured and uninjured groups.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2022)
Article
Chemistry, Physical
Tainara P. Calheiro, Steffany Z. Franceschini, Pablo A. Nogara, Joao B. T. Rocha, Nilo A. Zanatta, Marcos A. P. G. Martins, Bernardo Iglesias, Helio Bonacorso
Summary: A series of new N-quinoxaline-based boron complexes have been successfully synthesized and characterized. These compounds demonstrated weak generation of (1)O(2) but showed excellent photostability under irradiation. Furthermore, selective interactions with DNA and BSA were observed in binding studies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Neurosciences
Tao Ke, Abel Santamaria, Marcelo Farina, Joao B. T. Rocha, Aaron B. Bowman, Michael Aschner
Summary: This study used the Caenorhabditis elegans model to investigate the toxic effects of methylmercury and revealed the crucial role of the sti-1 gene in modulating protein quality control and antioxidant response in the defense against methylmercury toxicity.
NEUROTOXICITY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Adeola O. Adedara, Ayoade D. Babalola, Flora Stephano, Ifeoluwa O. Awogbindin, James O. Olopade, Joao B. T. Rocha, Alexander J. Whitworth, Amos O. Abolaji
Summary: This study evaluated the rescue action of resveratrol in parkin mutant fruit flies. The results showed that resveratrol improved survival rate and climbing activity, protected against oxidative stress, and mitigated accumulations of hydrogen peroxide, nitric oxide, and malondialdehyde in the parkin mutant flies. Resveratrol also attenuated downregulation of genes related to dopamine synthesis and antioxidant activity, and alleviated mitochondrial dysfunction. Overall, resveratrol may be useful for the management of Parkinson's disease.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Bruna Graziele Marques da Silva, Ana Paula Pinto, Juliene Cristina da Silva Passos, Joao Batista Teixeira da Rocha, Carlos Alberto-Silva, Maricilia Silva Costa
Summary: This study demonstrated the inhibitory effects of PhSe2 and pCl-PhSe2 on adherence, biofilm formation, and growth of C. krusei, with PhSe2 showing higher antifungal activity.
Article
Biochemistry & Molecular Biology
Opeyemi B. Ogunsuyi, Folorunsho B. Omage, Omamuyovwi M. Ijomone, Ganiyu Oboh, Joao B. T. Rocha
Summary: The study investigated the impact of chlorogenic acid on the therapeutic properties of donepezil in a rat model of amnesia induced by scopolamine. The results showed that chlorogenic acid improved the impaired biochemical parameters, glial cells, and neuronal function in scopolamine-treated rats. Docking analysis also revealed a higher binding energy between donepezil and chlorogenic acid with acetylcholinesterase and butyrylcholinesterase compared to individual interactions. This study suggests that chlorogenic acid could enhance the therapeutic effects of donepezil.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Opeyemi Babatunde Ogunsuyi, Folorunsho Bright Omage, Olawande Chinedu Olagoke, Ganiyu Oboh, Joao Batista Teixeria Rocha
Summary: This study tested the inhibitory effects of African eggplant and black nightshade leaf extracts on human erythrocyte AChE and investigated their potential molecular mechanisms using molecular docking and MD simulation. The findings suggest that certain compounds with dual-binding properties may serve as potential inhibitors of human AChE.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Pedro Pauletto, Marco Bortoli, Folorunsho Omage Bright, Cassia Pereira Delgado, Pablo Andrei Nogara, Laura Orian, Joao Batista Teixeira da Rocha
Summary: Acid Sphingomyelinase (ASM), involved in plasma membrane cell repair, is activated during SARS-CoV-2 infection. In silico analysis suggests that drugs like fluoxetine might inhibit ASM by breaking its interactions and disrupting its structure.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Pharmacology & Pharmacy
Stela Karine Braun, Daiane Wagner Jorge, Geovani Bortolanza, Joao Batista Teixeira da Rocha
Summary: This systematic review and meta-analysis found that the use of statins before lower-limb arterial angioplasty was associated with improved patency and overall survival, as well as decreased limb loss.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Information Science & Library Science
Carolina Bittencourt Gomes, Luciana Calabro, Suzana Rachel de Oliveira, Leo Anderson Meira Martins, Diogo Onofre Souza, Ediane Maria Gheno
Summary: This article evaluated the characteristics of grantees in the Health Sciences area of the National Council for Scientific and Technological Development. Various indicators were used to assess 1,634 researchers with current grants in 2021. The study found differences in the distribution of articles among Committees and the influence of article numbers on the level of grants. It provides important insights for public policies in Science and Technology and contributes to the field by evaluating the Health Sciences area using diverse indicators.
Review
Biochemistry & Molecular Biology
Pedro Jose Tronco Pauletto, Cassia Pereira Delgado, Joao Batista Teixeira da Rocha
Summary: In the past two years, various drugs have been identified as potential inhibitors of SARS-CoV-2 in laboratory studies. Among them, drugs known as functional inhibitors of acid sphingomyelinase (FIASMAs) have been shown to effectively inhibit the replication of SARS-CoV-2 in different types of cells. These drugs have similar chemical structures, with examples including fluoxetine, escitalopram, and fluvoxamine. They are already used as therapeutic agents for other diseases and can be considered as candidates for drug repositioning. This review summarizes two proposed mechanisms by which FIASMAs inhibit the replication of SARS-CoV-2 by targeting acid sphingomyelinase (ASM).
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Chemistry, Medicinal
Folorunsho Bright Omage, Andrea Madabeni, Amanda Resende Tucci, Pablo Andrei Nogara, Marco Bortoli, Alice dos Santos Rosa, Vivian Neuza dos Santos Ferreira, Joao Batista Teixeira Rocha, Milene Dias Miranda, Laura Orian
Summary: This study investigates the mechanism of SARS-CoV-2 inhibition by (PhSe)2 and reveals its potential as a therapeutic agent. The results show that (PhSe)2 effectively inhibits viral replication in a cell culture model and provides insights into the non-covalent and covalent inhibition modes of the viral proteases.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Environmental Sciences
Isaac A. Adedara, Oluwadarasimi E. Atanda, Camila Sant'Anna Monteiro, Denis B. Rosemberg, Michael Aschner, Ebenezer O. Farombi, Joao B. T. Rocha, Ana Flavia Furian, Tatiana Emanuelli
Summary: This review discusses the neurotoxicity of Aflatoxin B1 (AFB1) and its impact on the nervous system. Mechanisms of AFB1-induced neuronal dysregulation and neurotoxic effects are uncovered through studies using brain homogenates, neuroblastoma cell line IMR-32, human brain microvascular endothelial cells, microglial cells, and astrocytes, as well as mammalian and non-mammalian models. Furthermore, naturally occurring bioactive compounds with therapeutic effects on AFB1-induced neurotoxicity are reviewed.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Blessing A. Obafemi, Isaac A. Adedara, Ana L. A. Segatto, Diogo O. Souza, Joao B. T. da Rocha, Olawande C. Olagoke
Summary: In this study, the mechanism of inflammatory response to organometallic cation methylmercury, common cooking seasoning (NaCl and MSG), and their crosstalk with redox signaling were investigated using the lobster cockroach as a model. The activation of Nox/Duox NADPH oxidases, along with JNK and Rel signaling pathways, was found to play crucial roles during methylmercury and MSG exposure.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Pablo A. A. Nogara, Meire E. Pereira, Claudia S. Oliveira, Laura Orian, Joao B. T. Rocha
Summary: Organoselenium compounds (OSeCs) have significant therapeutic applications, but their mechanisms are still unclear. By using models and analytical methods, it is possible to elucidate the metabolism, reactivity, and specificity of OSeCs in vivo, leading to further advancements in their pharmacological applications.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
