Article
Clinical Neurology
Julia S. Yarrington, Meghan Vinograd, Alexander L. Williams, Kate B. Wolitzky-Taylor, Richard E. Zinbarg, Susan Mineka, Allison M. Waters, Michelle G. Craske
Summary: This study used SR and SCR to predict longitudinal changes in anxiety and depression symptoms. The results showed that SR and SCR were associated with an increase in these symptom factors over time.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Deepa Gautam, Ulhas P. Naik, Meghna U. Naik, Santosh K. Yadav, Rameshwar Nath Chaurasia, Debabrata Dash
Summary: This paper explores the role of platelets in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as the critical role of glutamate receptors in the pathophysiology of these diseases. By reviewing data from clinical trials, animal models, and cellular studies, it reveals the involvement of glutamate receptor dysfunction in neurodegenerative processes and provides an overview of current treatments, including glutamate receptor antagonists, for AD and PD.
Review
Cell Biology
Maggie L. Kalev-Zylinska, Marie-Christine Morel-Kopp, Christopher M. Ward, James Hearn, Justin R. Hamilton, Anna Y. Bogdanova
Summary: Ionotropic glutamate receptors, including AMPAR, KAR, and NMDAR, play distinct roles in platelet function, with AMPAR and KAR amplifying platelet function and thrombus formation, and the contribution of NMDAR being less well defined.
Article
Neurosciences
Fernando M. C. V. Reis, Dean Mobbs, Newton S. Canteras, Avishek Adhikari
Summary: This article discusses the central role of the midbrain periaqueductal gray (PAG) in controlling various defensive responses and explores how PAG-centered circuits influence both innate and learned defensive actions in rodents and humans. It highlights the use of traditional methods like lesions, electrical stimulation, and pharmacology, as well as recent advancements in neural activity imaging and anatomical and genetic control methods to gain a better understanding of PAG function.
Article
Neurosciences
Fernando M. C. V. Reis, Jinhan Liu, Peter J. Schuette, Johannes Y. Lee, Sandra Maesta-Pereira, Meghmik Chakerian, Weisheng Wang, Newton S. Canteras, Jonathan C. Kao, Avishek Adhikari
Summary: The study reveals that the dorsal periaqueductal gray (dPAG) uses shared patterns of activity to encode distance and predict defensive behaviors when encountering threats, indicating its crucial role in defensive responses.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Lucianne Groenink, P. Monika Verdouw, Yulong Zhao, Freija ter Heegde, Kimberley E. Wever, Elisabeth Y. Bijlsma
Summary: Fear conditioning is an important aspect in the pathophysiology of anxiety disorders. This study aimed to synthesize the available data on drugs tested in the fear-potentiated startle test to further understand the neurotransmitter systems involved in conditioned fear expression. The results showed that most clinically active anxiolytics can reduce fear and certain drug classes have significant effects on conditioned fear.
PSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Biological
Philip Newsome, Sonia G. Ruiz, Andrea L. Gold, Daniel S. Pine, Rany Abend
Summary: An alternative fear potentiated startle (FPS) scoring method was used to examine threat conditioning and extinction in individuals with anxiety disorders. The study found that individuals with anxiety disorders exhibited stronger retention of threat contingency during extinction. These findings support extinction theories of anxiety and suggest the importance of further research on aberrant extinction in pathological anxiety.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Psychology, Biological
Vanessa A. van Ast, Floris Klumpers, Raoul P. P. P. Grasman, Angelos-Miltiadis Krypotos, Karin Roelofs
Summary: Freezing in response to impending threat is a core defensive mechanism in humans. Research has shown that human freezing is highly sensitive to fear conditioning and intensifies with the proximity of threat. This animal-like freezing response aids in active preparation for unexpected attacks and captures real-life expressions of anxiety.
Article
Biology
Weisheng Wang, Peter J. Schuette, Mimi Q. La-Vu, Anita Torossian, Brooke C. Tobias, Marta Ceko, Philip A. Kragel, Fernando M. C. Reis, Shiyu Ji, Megha Sehgal, Sandra Maesta-Pereira, Meghmik Chakerian, Alcino J. Silva, Newton S. Canteras, Tor Wager, Jonathan C. Kao, Avishek Adhikari
Summary: The study showed that PMd-cck cells in mice are activated during escape, and inhibition of the PMd decreases escape speed. The PMd-dlPAG circuit is identified as a central node controlling escape behavior in response to threats.
Article
Clinical Neurology
Yuanhui Li, Nan Li, Liqun Zhang, Yanru Liu, Tianjiao Zhang, Dai Li, Dexiang Bai, Xiang Liu, Lingjiang Li
Summary: This study develops a fear-potentiated startle paradigm and a machine learning approach to accurately predict PTSD symptoms in Chinese firefighters. The machine learning model can identify firefighters with a PCL-C score of 38 or above with sensitivity and specificity both above 0.85 when 5-fold cross validated on a 1107-person sample.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Guendalina Olivero, Alessandra Roggeri, Anna Pittaluga
Summary: Autoantibodies against NMDA and AMPA receptors in the central nervous system can lead to neurological and psychiatric symptoms and disrupt synaptic communication. Understanding the molecular mechanisms involved in these autoantibody-mediated effects is crucial for understanding their pathogenic role in central disorders and developing new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Patrick Vizeli, Isabelle Straumann, Urs Duthaler, Nimmy Varghese, Anne Eckert, Martin P. Paulus, Victoria Risbrough, Matthias E. Liechti
Summary: This study aims to explore the potential of MDMA as a treatment for posttraumatic stress disorder (PTSD) and its mechanism of action. The results show that MDMA treatment can enhance fear extinction learning and recall, but this effect may be limited to certain forms of learned fear responses. Additionally, MDMA does not influence fear reactions to conditioned cues.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Angela M. Mabb
Summary: Transcription-translation coupling leads to the production of key proteins for controlling essential neuronal processes, while posttranslational signaling pathways, such as ubiquitination, also play a crucial role in regulating these processes. Ubiquitin attaches to its targets and plays a role in multiple signaling pathways, primarily by removing substrates via the proteasome. This review focuses on 40 years of progress on ubiquitination in the nervous system at glutamatergic synapses, highlighting its importance in various neuronal processes.
Article
Neurosciences
Panos Zanos, Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate Jr, Scott M. Thompson, Todd D. Gould
Summary: Ketamine, a well-known NMDA receptor antagonist, exerts rapid antidepressant effects by enhancing excitatory synaptic strength. These findings suggest that promoting NMDA receptor activation or enhancing NMDA receptor-dependent synaptic potentiation may be an effective strategy for antidepressant treatment.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Jeremy M. Henley, Jithin D. Nair, Richard Seager, Busra P. Yucel, Gavin Woodhall, Benjamin S. Henley, Karolina Talandyte, Hope I. Needs, Kevin A. Wilkinson
Summary: Epilepsy is caused by abnormal neuronal network activity. The review focuses on the role and regulation of kainate and AMPA receptors in seizure activity, discussing the impact of GluK2 and GluA2 subunits on their respective receptors' properties.
Article
Neurosciences
Thiago Oliari Ribeiro, Leticia Morais Bueno-de-Camargo, Ana Paula Farias Waltrick, Amanda Ribeiro de Oliveira, Marcus Lira Brandao, Carolina Demarchi Munhoz, Janaina Menezes Zanoveli
PSYCHOPHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Laura A. Leon, Marcus L. Brandao, Fernando P. Cardenas, Diana Parra, Thomas E. Krahe, Antonio Pedro Mello Cruz, J. Landeira-Fernandez
Article
Neurosciences
Geiza Fernanda Antunes, Flavia Venetucci Gouveia, Fabiana Strambio Rezende, Midia Dias de Jesus Seno, Milene Cristina de Carvalho, Caroline Cruz de Oliveira, Lennon Cardoso Tosati dos Santos, Marina Correia de Castro, Mayra Akemi Kuroki, Manoel Jacobsen Teixeira, Jose Pinhata Otoch, Marcus Lira Brandao, Erich Talamoni Fonoff, Raquel Chacon Ruiz Martinez
NEUROBIOLOGY OF STRESS
(2020)
Review
Neurosciences
Isabelle Waku, Mylena S. Magalhaes, Camila O. Alves, Amanda R. de Oliveira
Summary: This systematic review aimed to identify publications that used the haloperidol-induced catalepsy model for parkinsonism and explore methodological characteristics and main questions addressed in these studies. Most studies utilized the model to investigate potential treatments for parkinsonism.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Vivian M. de Vita, Heloisa R. Zapparoli, Adriano E. Reimer, Marcus L. Brandao, Amanda R. de Oliveira
Summary: Dopamine mediates fear conditioning through its action on D2 receptors in the mesolimbic pathway, primarily influencing the expression rather than acquisition of conditioned fear. Sulpiride reduces the expression of fear without affecting extinction recall, while haloperidol has cataleptic and motor-impairing effects.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Amanda R. de Oliveira, Adriano E. Reimer, Gregory J. Simandl, Sumedh S. Nagrale, Alik S. Widge
Summary: This study aimed to replicate a model of compulsive behavior previously reported in mice in outbred rats, but failed to do so. Although physiological changes in the OFC-VMS circuitry were induced in rats, no compulsive self-grooming or other compulsive behaviors were observed. This suggests possible limitations in translating mouse findings to species higher on the phylogenetic chain.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychiatry
Marcus L. Brandao, Manoel Jorge Nobre, Ruth Estevao
Summary: Fear and anxiety are responses to threatening environments or stimuli, depending on the distance of the threat. This study used virtual reality to examine the effects of threat intensity on behavior and physiological responses in volunteers, revealing a relationship between individual emotional susceptibility and anxiety development.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Debora Fabris, Milene C. Carvalho, Marcus L. Brandao, Wiliam A. Prado, Antonio W. Zuardi, Jose A. Crippa, Amanda R. de Oliveira, Thelma A. Lovick, Karina Genaro
Summary: CBD exhibits anxiolytic effects in both male and female rats, with potential mechanisms involving GABA(A) receptor expression in females and 5-HT1A receptor activation in males. The responsiveness of female rats to CBD is influenced by the stage of the estrous cycle, with higher responsiveness observed in the late diestrus phase. After sub-chronic treatment, female rats in late diestrus maintain their responsiveness to CBD, while those in proestrus remain unresponsive.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Juliana Diniz, Paulo Bazan, Carlos Alberto Pereira, Erlandson Saraiva, Paula Ramos, Amanda Oliveira, Adriano Reimer, Marcus Brandao, Marcelo Hoexter, Roseli Shavitt, Euripedes Miguel, Marcelo Batistuzzo
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Neurosciences
Adriano Reimer, Amanda de Oliveira, Meng-chen Lo, Gregory Simandl, Aaron Wald, Alik Widge
BIOLOGICAL PSYCHIATRY
(2021)
Meeting Abstract
Neurosciences
Rebecca Younk, Meng-chen Lo, Ethan Blackwood, Adriano Reimer, Sonia Olson, Alik Widge
BIOLOGICAL PSYCHIATRY
(2020)
Meeting Abstract
Neurosciences
Amanda de Oliveira, Adriano Reimer, Gregory Simandl, Alik Widge
BIOLOGICAL PSYCHIATRY
(2020)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.