Article
Biochemistry & Molecular Biology
Daniele Lana, Elisabetta Gerace, Giada Magni, Francesca Cialdai, Monica Monici, Guido Mannaioni, Maria Grazia Giovannini
Summary: The study revealed that microglia undergo rapid changes in phenotype in response to oxygen-glucose deprivation in rat organotypic hippocampal slices, depending on factors such as location and time, and play different roles in damaged neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Osmar Vieira Ramires Junior, Josiane Silva Silveira, Tiago Marcon dos Santos, Fernanda Silva Ferreira, Adriana Fernanda K. Vizuete, Carlos Alberto Goncalves, Angela T. S. Wyse
Summary: This study verified the effects of Homocysteine (Hcy) on neurochemical parameters and signaling pathway in hippocampal slices, and investigated the neuroprotective effects of ibuprofen and rivastigmine. Hcy increased cellular and tissue damage, while ibuprofen reduced its damaging effects. The combination treatment of rivastigmine and ibuprofen attenuated Hcy-induced damage by regulating the signaling pathway.
MOLECULAR NEUROBIOLOGY
(2023)
Editorial Material
Oncology
Aaron M. Hosios, Brendan D. Manning
Summary: Research has deepened the understanding of oncogenic control of metabolism, particularly glycolysis. Current focus is on understanding the benefits and risks associated with glycolytic metabolism, and finding inhibitors that could be clinically beneficial for targeting glycolytic cancer cells.
Article
Neurosciences
Niamh Moreton, Martina Puzio, John J. O'Connor
Summary: This study investigated the effects of the ROS scavenger MnTMPyP on synaptic transmission in hypoxia and OGD models, revealing a modulatory effect specific to the CA1 region of the hippocampus and a protective role in cell viability post hypoxia and OGD.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Zulfiye Gul, R. Levent Buyukuysal
Summary: Glutamate increases alpha-ketoglutarate release under control conditions and enhances it further during reoxygenation. Oxygen-glucose deprivation and reoxygenation cause declines in pyruvate and lactate outputs, but glutamate does not alter lactate output.
Article
Multidisciplinary Sciences
Dong Sun, Zhi-Bing Tan, Xiang-Dong Sun, Zhi-Peng Liu, Wen -Bing Chen, Leena Milibari, Xiao Ren, Ling-Ling Yao, Daehoon Lee, Chen Shen, Jin-Xiu Pan, Zhi-Hui Huang, Lin Mei, Wen-Cheng Xiong
Summary: The loss of NEO1 is associated with the development of epilepsy, as evidenced by reduced NEO1 expression in the hippocampi of epilepsy patients and elevated seizure susceptibility in Neo1 knockout mice. The interaction between NEO1 and GLAST in astrocytes plays a crucial role in regulating the epileptic phenotype by affecting GABAergic transmission and extracellular glutamate clearance. The findings suggest that NEO1 could be a potential therapeutic target for protecting the brain from epilepsy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Bradley S. Heit, Patricia Dykas, Alex Chu, Abhay Sane, John Larson
Summary: The key event in the pathophysiology of stroke is anoxic depolarization (AD) of neurons in the ischemic core, and the time between AD and re-oxygenation determines the synaptic recovery after anoxic challenge. Adenosine released during anoxia suppresses synaptic glutamate release, while antagonism of glutamate receptors prolongs AD latency and alters depolarizing waves. In experiments, AD latency was longer in CA1 than CA3, with differences between genders.
Article
Biochemistry & Molecular Biology
Victor Coelho, Luisa Bandeira Binder, Naiani Ferreira Marques, Leandra Celso Constantino, Gianni Mancini, Carla Ines Tasca
Summary: Alzheimer's disease is a progressive neurodegenerative illness that causes cognitive impairment and dementia. Guanosine has been shown to prevent behavioral and biochemical alterations evoked by A beta, suggesting a potential role against damage caused by A beta in the hippocampus.
Article
Biochemistry & Molecular Biology
Camila Gherardelli, Pedro Cisternas, Joel Gutierrez, Milka Martinez, Nibaldo C. Inestrosa
Summary: Cerebral glucose hypometabolism is a common feature in many neurodegenerative diseases, and it has been shown that metabolic disturbances precede clinical symptoms. Andrographolide can enhance neuronal glucose uptake and metabolism, dependent on the activity of AMP-activated protein kinase.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Laura Mikel Mcnair, Jens Velde Andersen, Helle Sonderby Waagepetersen
Summary: This study reveals fundamental alterations in cellular energy and neurotransmitter metabolism in the aging brain, which may contribute to age-related hippocampal deficits.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Martina Puzio, Niamh Moreton, Mairead Sullivan, Caitriona Scaife, Jeffrey C. Glennon, John J. O'Connor
Summary: Metabolic stress and ROS production contribute to neuronal damage and synaptic plasticity in acute ischemic stroke. MnTMPyP has a neuroprotective effect in hippocampal slices and regulates synaptic transmission during hypoxia and OGD. This study investigates the molecular changes and mechanisms involved in the effect of MnTMPyP, revealing impairments in vesicular trafficking and cell differentiation signaling. These findings provide insights into the role of MnTMPyP in synaptic transmission and plasticity during ischemia.
Article
Biochemistry & Molecular Biology
Rafael S. Ferreira, Jessica Teles-Souza, Cleide dos Santos Souza, Erica P. L. Pereira, Fillipe M. de Araujo, Alessandra Bispo da Silva, Juliana H. Castro e Silva, Yasmine Nonose, Yanier Nunez-Figueredo, Adriano M. de Assis, Diogo O. Souza, Maria de Fatima D. Costa, Jose Claudio F. Moreira, Silvia L. Costa, Victor D. A. da Silva
Summary: Rutin is considered as a neuroprotective agent that prevents glutamate excitotoxicity, and its mechanism may involve the regulation of astrocytic metabolism.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Endocrinology & Metabolism
Xiaoyan Ren, Jiangang Yu, Lili Guo, Zaili Zhang
Summary: This study identifies CDGSH iron sulfur domain 2 (Cisd2) as a potential determinant factor for neuronal injury during cerebral ischemia/reperfusion injury. Cisd2 protects neurons from injury caused by oxygen-glucose deprivation/reoxygenation (OGD/R) by enhancing Nrf2 activation via Akt.
METABOLIC BRAIN DISEASE
(2022)
Article
Oncology
Che-Chia Hsu, Danni Peng, Zhen Cai, Hui-Kuan Lin
Summary: The activation of AMPK is crucial for maintaining energy homeostasis and metabolic regulation. AMPK has been identified as a potential therapeutic target for metabolic disorders and cancer. However, its role in cancer is complex and can either suppress or promote tumor growth.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Ines Belo do Nascimento, Marie Verfaillie, Gamze Ates, Pauline Beckers, Virginie Joris, Nathalie Desmet, Ann Massie, Emmanuel Hermans
Summary: Astrocytes in the central nervous system play a crucial role in energy homeostasis and metabolism support, with AMP-activated protein kinase (AMPK) being an important factor in helping cells adapt and maintain stable function under metabolic stress conditions.
Article
Cell Biology
Elaine C. D. Goncalves, Graziela Vieira, Tainara R. Goncalves, Roli R. Simoes, Indiara Brusco, Sara M. Oliveira, Joao B. Calixto, Maira Cola, Adair R. S. Santos, Rafael C. Dutra
Summary: This study evaluated the association between BK receptors and chronic pain development in mice, finding that BKR antagonists mitigated CPIP-induced mechanical allodynia and oedematogenic response, while BKR agonists exacerbated pain response. These results suggest the involvement of BKRs in the pathogenesis of CRPS-I.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Graziela Vieira, Juliana Cavalli, Elaine C. D. Goncalves, Saulo F. P. Braga, Rafaela S. Ferreira, Adair R. S. Santos, Maira Cola, Nadia R. B. Raposo, Raffaele Capasso, Rafael C. Dutra
Article
Endocrinology & Metabolism
Rafael Tamborena Malheiros, Helena Oliveira Delgado, Daniel Tassinari Felber, Scheila Iria Kraus, Adair Roberto Soares dos Santos, Vanusa Manfredini, Morgana Duarte da Silva
Summary: The study demonstrated that a hypercaloric diet led to increased body weight and fat percentage in rats, along with depression- and anxiety-like behaviors. These changes were associated with reduced BDNF expression levels in the hippocampus.
METABOLIC BRAIN DISEASE
(2021)
Article
Endocrinology & Metabolism
Cristina Martins-Silva, Natalie de Souza Pinho, Glenda G. Ferreira, Rafael Moraes Aguiar, Tamara Alarcon Ferreira, Rita G. W. Pires, Tiago Tizziani, Moacir G. Pizzolatti, Adair R. S. Santos
Summary: Stroke is a leading cause of death worldwide, with limited treatment options. Studies have shown that the medicinal plant Polygala sabulosa W. Bennett has potential therapeutic properties for stroke. Research suggests that HEPs treatment can prevent motor and cognitive impairments caused by ischemic stroke, making it a promising therapy option.
METABOLIC BRAIN DISEASE
(2021)
Article
Behavioral Sciences
Leandra C. Constantino, Fabricio A. Pamplona, Filipe C. Matheus, Cristiane R. de Carvalho, Fabiana K. Ludka, Caio M. Massari, Carina R. Boeck, Rui D. Prediger, Carla Tasca
Summary: This study investigated the relationship between adenosine A(1) and A(2A) receptors activities and NMDA preconditioning, revealing that activation of A(2A)R can block the increase of glutamate uptake induced by NMDA preconditioning and increase freezing time in a new environment. These results demonstrate changes in A(2A)R functionality in mice following NMDA preconditioning.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Biochemistry & Molecular Biology
C. M. Massari, L. C. Constantino, C. I. Tasca
Summary: The study demonstrated that the A(1) receptor antagonist DPCPX prevented the effects of guanosine on 6-OHDA-induced ROS formation and mitochondrial membrane potential depolarization, while the A(1) receptor agonist CCPA did not affect GUO effects. In terms of A(2A) receptors, the antagonist SCH58261 exhibited similar protective effects as guanosine in ROS formation and mitochondrial membrane potential. These results suggest a crucial role of adenosine receptor modulation in the protective effect of guanosine.
PURINERGIC SIGNALLING
(2021)
Editorial Material
Pharmacology & Pharmacy
Caio M. Massari, Mariachiara Zuccarini, Patrizia Di Iorio, Carla I. Tasca
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
P. Di Iorio, S. Beggiato, M. Ronci, C. B. Nedel, C. I. Tasca, M. Zuccarini
FRONTIERS IN PHARMACOLOGY
(2021)
Correction
Neurosciences
Tetsade C. B. Piermartiri, Claudia P. Figueiredo, Daniel Rial, Filipe S. Duarte, Sarah C. Bezerra, Gianni Mancini, Andreza F. de Bem, Rui D. S. Prediger, Carla I. Tasca
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Laise Figueiredo de Oliveira, Gabriela Godoy Poluceno, Tuane Bazanella Sampaio, Leandra Celso Constantino, Ana Paula Costa, Wagner Carbolin Martins, Tharine Dal-Cim, Karen Andrineia de Oliveira, Fabiana Kalyne Ludka, Rui Daniel Prediger, Frederico C. Pereira, Carla Ines Tasca
Summary: This study investigated the effects of neonatal exposure to isoflurane on the developing rat brain. The findings showed that a single exposure to isoflurane had different effects during infancy and adulthood. Behavioral analysis in adult rats revealed impaired short-term memory following neonatal isoflurane exposure, but no effects on anxiety-like behavior and locomotor activity.
NEUROTOXICITY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Victor Coelho, Luisa Bandeira Binder, Naiani Ferreira Marques, Leandra Celso Constantino, Gianni Mancini, Carla Ines Tasca
Summary: Alzheimer's disease is a progressive neurodegenerative illness that causes cognitive impairment and dementia. Guanosine has been shown to prevent behavioral and biochemical alterations evoked by A beta, suggesting a potential role against damage caused by A beta in the hippocampus.
Article
Dermatology
Rosane Schenkel de Aquino, Aledson Rosa Torres, Alcir Luiz Dafre, Adair Roberto Soares Santos
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Biochemistry & Molecular Biology
Camila A. Zanella, Naiani Marques, Stella Junqueira, Rui D. Prediger, Carla I. Tasca, Helena I. Cimarosti
Summary: The nucleoside guanosine can modulate the SUMOylation process in neurons and astrocytes in vivo, improving short-term memory in young mice but not in aged mice. Guanosine has no effect on depressive-like behaviors but does play a role in behavioral coping strategies. This study highlights the involvement of SUMOylation in guanosine's modulatory and neuroprotective effects.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bianca Zimmermann dos Santos, Rafael Cypriano Dutra, Adair Roberto Soares dos Santos, Maisa Casarin, Eliane Maria Goldfeder, Vera Lucia Bosco, Mabel Mariela Rodriguez Cordeiro
Summary: Understanding the biological mechanisms behind root resorption in deciduous teeth is crucial for the development of preventive measures and treatments. This study compared the expression and immunostaining of several substances in the periodontal ligament of deciduous teeth with different types of root resorption. The results showed that inflammatory root resorption exhibited higher expression of certain factors and enzymes related to tissue degradation, which explains the increased susceptibility of deciduous teeth to root resorption.
BRAZILIAN ORAL RESEARCH
(2022)
Article
Rehabilitation
Leonardo Avila, Marcos Lisboa Neves, Andre Rogerio Abreu, Cibelle Ramos Fiuza, Leandro Fukusawa, Ney Meziat-Filho, Adair Roberto Soares Santos
Summary: This study is a randomized controlled clinical trial comparing the efficacy of CFT and CTE on pain and specific disability in FBSS patients. By increasing sample size and reducing bias, the study aims to investigate the effectiveness of CFT for treating FBSS and chronic low back pain.
JOURNAL OF BODYWORK AND MOVEMENT THERAPIES
(2021)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.