Review
Biochemistry & Molecular Biology
Svenja Rink-Notzon, Jannika Reuscher, Klaus Nohroudi, Marilena Manthou, Tessa Gordon, Doychin N. N. Angelov
Summary: The recovery of mimic function after facial nerve transection is poor due to poor axonal navigation, axonal crosstalk, and insufficient synaptic input. Intensifying trigeminal sensory input can improve the specificity of reinnervation and promote the recovery of facial mimic function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Maria Eleni Manthou, Dilyana Gencheva, Nektarios Sinis, Svenja Rink, Theodora Papamitsou, Diana Abdulla, Habib Bendella, Levent Sarikcioglu, Doychin N. Angelov
Summary: This study found that using a muscle-vein-combined conduit (MVCC) has a positive effect on improving whisking function after repairing the facial nerve.
TISSUE ENGINEERING PART A
(2021)
Review
Cell Biology
Kazuyuki Nakajima, Takashi Ishijima
Summary: Transection of the rat facial nerve leads to alterations in motoneurons, glial cells, and inhibitory neurons. Injured motoneurons show changes in energy metabolism and neurofunction-related molecules. Glial cells and inhibitory neurons also exhibit changes, suggesting a close interaction with injured motoneurons and potential tissue remodeling in the facial nucleus.
Article
Biochemistry & Molecular Biology
Amalia Callado Perez, Maxime Demers, Arash Fassihi, Jeffrey D. Moore, David Kleinfeld, Martin Deschenes
Summary: The brainstem contains neural circuits that control vital functions' homeostasis, such as breathing depth, rate, and apnea. The reflex for apnea is believed to be mediated by sensory pathways involving vagal and glossopharyngeal afferents, as well as trigeminal afferents from the nasal cavity.
Article
Cell Biology
Elizabeth M. Runge, Deborah O. Setter, Abhirami K. Iyer, Eric J. Regele, Felicia M. Kennedy, Virginia M. Sanders, Kathryn J. Jones
Summary: Facial motoneuron survival after facial nerve axotomy is mediated by IL-10 produced by CD4+ T cells. This study found that IL-10 is constitutively produced by FMN and induced in astrocytes after axotomy, but not in microglia. The coordinated production of IL-10 by neurons and astrocytes is necessary for FMN survival and has roles in neuronal homeostasis.
Article
Cell Biology
Bruno Henrique de Melo Lima, Andre Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues De Oliveira
Summary: The expression of MHC-I and other related molecules following peripheral nerve injury is associated with the recovery of neurons, glial cells, sensorimotor function, gait, and nociceptive threshold in mice. Different strains of mice exhibit varying recovery capacities.
Article
Neurosciences
J. R. Nadeau, B. M. Arnold, J. M. Johnston, G. D. Muir, V. M. K. Verge
Summary: Brief electrical stimulation (ES) or acute intermittent hypoxia (AIH) treatment during surgical repair can enhance the regeneration of injured peripheral nerves by influencing the expression of regeneration-associated genes (RAG). These treatments lead to significant improvements in growth indicators and functional recovery, showing promising potential for non-invasive therapies in nerve regeneration.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Biology
Takashi Ishijima, Kazuyuki Nakajima
Summary: Although microglia are a minor glial cell type in the brain, they proliferate in response to disorders and injuries. The researchers investigated the mechanism of microglial proliferation using a facial nerve transection model and found that macrophage colony-stimulating factor (M-CSF) plays a role in inducing microglial proliferation. The activation of c-Jun N-terminal kinase (JNK) and p38 was also observed, and their inhibitors arrested the mitosis of microglia.
Article
Neurosciences
Rolando Torrado-Arevalo, Julieta Troncoso, Alejandro Munera
Summary: Facial nerve axotomy induces changes in the central nervous system beyond facial motoneurons, affecting sensorimotor cortex and hippocampal-dependent memory tasks. In animal experiments, it was found that peripheral axotomy affects basal transmission and long-term plasticity of CA3-CA1 synapses, with enhanced release probability and impairment in long-term potentiation induction. These synaptic changes may explain impairments in hippocampal-dependent memory tasks and suggest a direct hippocampal involvement in sensorimotor integration.
Article
Neurosciences
Sara Salvany, Anna Casanovas, Lidia Piedrafita, Olga Tarabal, Sara Hernandez, Jordi Caldero, Josep E. Esquerda
Summary: Following peripheral nerve section, activated microglia internalize small membranous-vesicular fragments from synaptic terminals, likely via the endocytic activity of Rab7 and Rab10. These fragments, originating from disrupted synapses and containing C1q immunoreactivity, are transferred to microglia and may be related to the necroptotic pathway. Complement-mediated opsonization may also contribute to microglial-mediated synaptic disruption after nerve injury.
Article
Neurosciences
Oscar Bolivar-Baquero, Julieta Troncoso
Summary: Facial nerve injury has been widely used in rats to study the changes in motoneurons and other central nervous system structures related to sensorimotor processing. Recent studies have found that this injury is associated with a decrease in long-term potentiation, increased corticosterone levels, impairment in spatial memory consolidation, and hippocampal microglial activation. In this study, the neuronal morphology of hippocampal pyramidal neurons in rats with reversible or irreversible facial nerve injury was analyzed. The results showed significant decreases in dendritic tree complexity, dendritic length, branch points, and spine density of hippocampal neurons in both types of injuries, but the timing and sensitivity varied depending on the hippocampal area, dendritic area, and lesion type.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jae-Min Lee, You Jung Choi, Myung Chul Yoo, Seung Geun Yeo
Summary: Peripheral facial nerve injury causes changes in neuroactive substances that affect nerve cell damage, survival, growth, and regeneration. This review explores the biomolecules involved in peripheral facial nerve damage and their impact on the central nervous system (CNS), aiming to identify potential strategies for treating facial nerve injury and functional recovery. By identifying the biomolecules in the CNS that change after peripheral nerve damage, this review could contribute to the development of effective treatment strategies for peripheral facial palsy.
Article
Otorhinolaryngology
Teresa Mato-Patino, Jose Manuel Morales-Puebla, Susana Moraleda, Isabel Sanchez-Cuadrado, Miryam Calvino, Teresa Gonzalez-Otero, Julio Penarrocha, Borja Hernandez, Javier Gavilan, Luis Lassaletta
Summary: Side-to-end hypoglossal-to-facial transfer surgery can improve facial function and preserve tongue function in patients. Dual nerve transfers appear to contribute to better surgical outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Surgery
Bernardo Bianchi, Michela Bergonzani, Enrica Stella, Giuseppe Perlangeli, Elisa De Stefani, Enrico Sesenna, Andrea Ferri
Summary: This novel technique of mixed neurotization for gracilis transplant shows consistent results with powerful contraction and good smile coordination. It also allows us to extend the indications for mixed neurotization techniques.
Article
Biochemistry & Molecular Biology
Takashi Ishijima, Kazuyuki Nakajima
Summary: Axotomy of the rat facial nerve leads to downregulation of motoneuron-specific molecules and activation of microglia, promoting the survival, repair, and regeneration of motoneurons. This study investigates the changes and localizations of several signaling molecules and suggests the involvement of c-Jun in motoneuron survival, repair, and regeneration, and the association of p-CREB/CREB, p-ERK/ERK, and p-JNK/JNK with the downregulation of motoneuron-specific molecules. Additionally, it suggests the involvement of p-p38/p38 and p-CREB/CREB in the activation/proliferation of microglia.
JOURNAL OF CHEMICAL NEUROANATOMY
(2022)
Article
Clinical Neurology
Louise M. Goodes, Gabrielle K. King, Alethea Rea, Kevin Murray, Peter Boan, Anne Watts, Jen Bardsley, Carly Hartshorn, Jeffrey Thavaseelan, Matthew Rawlins, James A. Brock, Sarah A. Dunlop
Article
Neurosciences
Sataporn Jamsuwan, Lars Klimaschewski, Barbara Hausott
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Editorial Material
Pharmacology & Pharmacy
Anastazja M. Gorecki, Sarah A. Dunlop, Jennifer Rodger, Ryan S. Anderton
EXPERT OPINION ON THERAPEUTIC TARGETS
(2020)
Article
Clinical Neurology
Louise M. Goodes, Gabrielle K. King, Denise M. Goodwin, Anne Watts, Jen Bardsley, James Middleton, Peter Bragge, Sarah A. Dunlop
Article
Clinical Neurology
Svenja Rink, Stoyan Pavlov, Aliona Woehler, Habib Bendella, Marilena Manthou, Theodora Papamitsou, Sarah A. Dunlop, Doychin N. Angelov
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)
Article
Clinical Neurology
Svenja Rink, Christina Chatziparaskeva, Luisa Elles, Stoyan Pavlov, Klaus Nohroudi, Habib Bendella, Levent Sarikcioglu, Marilena Manthou, Sarah Dunlop, Tessa Gordon, Doychin N. Angelov
Article
Clinical Neurology
Maya G. Panisset, Doa El-Ansary, Sarah Alison Dunlop, Ruth Marshall, Jillian Clark, Leonid Churilov, Mary P. Galea
Summary: This study conducted a per-protocol analysis on thigh muscle volume outcomes in patients with spinal cord injury who participated in functional electrical stimulation-assisted cycling or passive cycling for 12 weeks. The results showed that 42% of the patients had a partial response and 25% had a beneficial response, regardless of the mode of intervention. The study also found a significant correlation between exercise frequency and thigh muscle volumes.
JOURNAL OF SPINAL CORD MEDICINE
(2022)
Article
Geriatrics & Gerontology
Anastazja M. Gorecki, Megan C. Bakeberg, Frances Theunissen, Jade E. Kenna, Madison E. Hoes, Abigail L. Pfaff, P. Anthony Akkari, Sarah A. Dunlop, Sulev Koks, Frank L. Mastaglia, Ryan S. Anderton
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Pediatrics
Bhedita J. Seewoo, Lauren A. Hennessy, Liz A. Jaeschke, Leah A. Mackie, Sarah J. Etherington, Sarah A. Dunlop, Paul E. Croarkin, Jennifer Rodger
Summary: This preliminary study found that an accelerated low-intensity TMS protocol outperformed the standard protocol in adolescent male animals with depression-like behaviors, without any toxicity or tolerability concerns. These results support the idea that novel TMS dosing strategies should be studied in adolescent humans and will inform future clinical protocols.
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2022)
Review
Pediatrics
Christos Symeonides, Manuel Brunner, Yannick Mulders, Priyanka Toshniwal, Matthew Cantrell, Louise Mofflin, Sarah Dunlop
Summary: Between 1950 and 2015, over 8 billion tonnes of plastic were produced globally, with an exponential growth rate and an annual production of approximately 380 million tonnes. This rapid increase in plastic production poses hazards to human and planetary health, as the journey of plastic from synthesis to disposal impacts the environment.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2021)
Review
Cell Biology
Barbara Hausott, Rudolf Glueckert, Anneliese Schrott-Fischer, Lars Klimaschewski
Summary: Intracellular signal transduction in response to growth factor receptor activation plays a key role in nervous system regeneration. The signal transduction regulators Sprouty (SPRY) and PTEN have been identified as important inhibitors of neuronal growth factor signaling. They interfere with major signaling pathways such as ERK or PI3K/Akt in neurons and glial cells. Understanding the effects of SPRY, PTEN, and their regulators in axonal regeneration can have significant implications for the treatment of neurological injuries.
Article
Medicine, General & Internal
Helen Abing, Carina Pick, Tabea Steffens, Jenny Shachi Sharma, Jens Peter Klussmann, Maria Grosheva
Summary: This study evaluated the reanimation of the smile using gracilis muscle transplant with masseteric nerve reinnervation in five patients with long-standing peripheral facial palsy. Results showed that the surgery was feasible and led to rapid and reliable reinnervation of the lower face muscles, resulting in a spontaneous smile within 10 months.
Article
Clinical Neurology
Gabrielle K. King, Louise M. Goodes, Carly Hartshorn, Jeffery Thavaseelan, Sheryl Jonescu, Anne Watts, Matthew Rawlins, Peter Woodland, Emma-Leigh Synnott, Trent Barrett, Dickon Hayne, Peter Boan, Sarah A. Dunlop
Summary: Intravesical hyaluronic acid with chondroitin sulphate (HA+CS) instillations can effectively and safely prevent urinary tract infections after spinal cord injury. The treatment course is well-tolerated in both acute and chronic spinal cord injury patients, although recruitment is more challenging in the acute setting.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Review
Medicine, General & Internal
Louise M. Goodes, Enoch V. S. Wong, Jennifer Alex, Louise Mofflin, Priyanka Toshniwal, Manuel Brunner, Terena Solomons, Emily White, Omrik Choudhury, Bhedita J. Seewoo, Yannick R. Mulders, Tristan Dale, Hamish J. Newman, Alina Naveed, Andrew B. Lowe, Delia Hendrie, Christos Symeonides, Sarah A. Dunlop
Summary: This article describes a scoping review that aims to comprehensively map the existing research on plastic exposure and human health. The study will collect and summarize a range of literature on exposure to plastic chemicals and their impact on health, providing necessary references and an overview for future research.
SYSTEMATIC REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Priya S. R. Naidu, Eleanor Denham, Carole A. Bartlett, Terry McGonigle, Nicolas L. Taylor, Marck Norret, Nicole M. Smith, Sarah A. Dunlop, K. Swaminathan Iyer, Melinda Fitzgerald
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.