Article
Endocrinology & Metabolism
Kisoo Pahk, Chanmin Joung, Hyun Woo Kwon, Sungeun Kim
Summary: This study aimed to assess the impact of physical exercise on the psychological stress levels of obese women. The results showed that chronic physical exercise can alleviate psychological stress and reduce inflammation in the body. Furthermore, physical exercise can also reduce the risk of cardiovascular disease. This study provides an explanation for the health benefits of exercise on cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Hematology
Andrew Wirth, N. George Mikhaeel
Summary: This study demonstrates that in patients with DLBCL, those who are EOT PET-negative may be spared from radiotherapy, while selected patients with EOT PET-positive sites can achieve outcomes comparable to PET-negative patients when receiving selective treatment.
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Frank J. Borm, Jasper Smit, Daniela E. Oprea-Lager, Maurits Wondergem, John B. A. G. Haanen, Egbert F. Smit, Adrianus J. de Langen
Summary: Immunotherapy is becoming increasingly important in cancer treatment, but many patients do not respond to it, making predicting treatment response challenging. Positron emission tomography (PET) is being studied as a biomarker to predict and evaluate treatment response to immunotherapy.
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiyan Wang, Yaping Wu, Zhenxing Huang, Zhicheng Li, Na Zhang, Fangfang Fu, Nan Meng, Haining Wang, Yun Zhou, Yongfeng Yang, Xin Liu, Dong Liang, Hairong Zheng, Greta S. P. Mok, Meiyun Wang, Zhanli Hu
Summary: Our proposed deep learning method can synthesize highly correlated and consistent dynamic parametric images obtained from static lung PET. The image quality of the synthesized images was evaluated qualitatively and quantitatively, and statistical analysis of correlation and consistency was performed on the synthetic images.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Ken Kudura, Florentia Dimitriou, Lucas Basler, Robert Forster, Daniela Mihic-Probst, Tim Kutzker, Reinhard Dummer, Joanna Mangana, Irene A. Burger, Michael C. Kreissl
Summary: For melanoma patients undergoing immune checkpoint inhibition, FDG-PET/CT can predict early treatment response. SUV peak and volume variation of metastases are strong outcome predictive biomarkers on a metastasis-level. On a patient-level, total tumor volume and semiquantitative parameters of all metastases show promise as outcome predictive biomarkers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qianrui Li, Wenxiu Hou, Mei Wu, Ling Li, Minggang Su, Bin Ma, Futao Cui, Yan Ren, Jiayue Xu, Kang Zou, Rong Tian, Xin Sun
Summary: This study systematically appraised the methodologies used for PET imaging guidelines and compared the consistency of these recommendations. The findings showed that current guidelines for PET imaging vary in methodological quality and provided considerably inconsistent recommendations. Efforts are needed to improve adherence to guideline development methodologies, to synthesize high-quality evidence, and to adopt standard terminologies.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon A. Castro, Daniele Muser, Hwan Lee, Emily C. Hancin, Austin J. Borja, Oswaldo Acosta, Thomas J. Werner, Anders Thomassen, Caius Constantinescu, Poul Flemming Hoilund-Carlsen, Abass Alavi
Summary: The study investigated the relationship between arterial mineralization in the left common carotid artery assessed by [F-18]fluoride PET/CT and cardiovascular/thromboembolic risk. Results showed that arterial [F-18]fluoride uptake was significantly increased in patients with unfavorable cardiovascular and thromboembolic risk profiles. Age, body mass index, arterial hypertension, and level of physical activity were identified as independent associations of arterial [F-18]fluoride uptake.
EUROPEAN RADIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Giordana Salvi de Souza, Dimitri B. A. Mantovani, Pascalle Mossel, Bartholomeus C. M. Haarman, Ana Maria Marques da Silva, Hendrikus H. Boersma, Cristiane R. G. Furini, Adriaan A. Lammertsma, Charalampos Tsoumpas, Gert Luurtsema
Summary: The oral route is widely used and preferred for drug administration. Accurate quantification of drug absorption, distribution, metabolism, excretion, and characterization is crucial for drug development. In vivo methods such as gamma-scintigraphy, MRI, and PET have been used to analyze gastrointestinal absorption. This review focuses on PET studies using oral tracers, revealing variations in acquisition protocols, quantification methods, and pharmacokinetic parameters. Human studies showed 10-30 minutes for tracer to reach the intestine and about 100 minutes to reach peak concentration in the brain. Rodent studies estimated different pharmacokinetic parameters, indicating PET's potential for non-invasive measurement of drug absorption and distribution. Long Axial Field of View (LAFOV) PET scanners can reduce administered dose, making oral administration feasible for clinical studies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Crystallography
Xin Yu, Xi Zhang, Heng Zhang, Hao Peng, Qiushi Ren, Jianfeng Xu, Qiyu Peng, Siwei Xie
Summary: Positron emission tomography (PET) is widely used for the diagnosis of tumors, cardiovascular diseases, and neurological diseases. This article introduces the principle and requirements of scintillation crystals in PET and analyzes the performance of different crystals. LYSO is currently the best-performing crystal, while LaBr3 has better timing characteristics and light output. GAGG detectors have a high depth of interaction resolution and great potential for applications.
Article
Biochemical Research Methods
Palak Wadhwa, Kris Thielemans, Nikos Efthimiou, Kristen Wangerin, Nicholas Keat, Elise Emond, Timothy Deller, Ottavia Bertolli, Daniel Deidda, Gaspar Delso, Michel Tohme, Floris Jansen, Roger N. Gunn, William Hallett, Charalampos Tsoumpas
Summary: This research demonstrates successful computational and physical modelling of the PET-MR system for image acquisition, generating images comparable to those from the manufacturer; the new software developments will be integrated into STIR, providing researchers worldwide with opportunities to establish and expand their image reconstruction methods; by modelling all effects within the system matrix, PET images showing the metabolic uptake of administered radiopharmaceuticals were reconstructed accurately.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan Moore, Manil Subesinghe, Aida Santaolalla, Michael Green, Harriet Deere, Mieke Van Hemelrijck, Jesper Lagergren, Sugama Chicklore, Nick Maisey, James Gossage, Mark Kelly, Cara Baker, Andrew Davies
Summary: This study evaluated the role of FDG PET-CT in predicting pathological tumor response, nodal response, and survival in neoadjuvant therapy for esophageal cancer. The study found that metabolic tumor and nodal response can predict pathological tumor response and nodal response, and these responses are independent predictors of patient survival.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Roelof J. Beukinga, Floris B. Poelmann, Gursah Kats-Ugurlu, Alain R. Viddeleer, Ronald Boellaard, Robbert J. De Haas, John Th M. Plukker, Jan Binne Hulshoff
Summary: This study demonstrates that a radiomic model using baseline F-18-FDG PET can predict non-response to neoadjuvant chemoradiotherapy in esophageal cancer patients, providing a potential clinical benefit.
Article
Medicine, General & Internal
Cecile Tissot, Joseph Therriault, Peter Kunach, Andrea L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, Joao Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Summary: This study investigated the agreement between [F-18]MK6240 tau-PET, plasma pTau181, and pTau231 in Alzheimer's disease. The findings suggest that these biomarkers reflect different stages of tau progression and can be useful in diagnosing and evaluating the disease stage.
Article
Neurosciences
Yohsuke Ohtsubo, Masahiro Matsunaga, Toshiyuki Himichi, Kohta Suzuki, Eiji Shibata, Reiko Hori, Tomohiro Umemura, Hideki Ohira
SOCIAL NEUROSCIENCE
(2020)
Article
Psychology, Multidisciplinary
Junko Yamada, Yo Nakawake, Qiulu Shou, Kuniyuki Nishina, Masahiro Matsunaga, Haruto Takagishi
Summary: The study found a negative association between salivary oxytocin levels and spiritual/religious faith, indicating that individuals with higher levels of oxytocin tend to have more negative spiritual/religious beliefs. This association was significant in individuals not interested in a specific religion, and the uniqueness of spirituality/religiosity in Japan may help interpret the findings.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Multidisciplinary
Yohsuke Ohtsubo, Masahiro Matsunaga, Takahiko Masuda, Yasuki Noguchi, Hidenori Yamasue, Keiko Ishii
Summary: The study found that aspects of early life environment can influence subjective well-being and loneliness in adulthood, but there is no significant gene-environment interaction effect.
JAPANESE PSYCHOLOGICAL RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Keiko Ishii, Takahiko Masuda, Masahiro Matsunaga, Yasuki Noguchi, Hidenori Yamasue, Yohsuke Ohtsubo
Summary: This study replicated previous findings on the interaction between the DRD4 gene and cultural differences in social orientation, showing Westerners' emphasis on independence and East Asians' emphasis on interdependence. However, the interaction effects between culture and DRD4 were not significant. Implications for candidate gene research on gene-environment and gene-culture interactions are discussed.
Article
Multidisciplinary Sciences
Shaofeng Zheng, Takahiko Masuda, Masahiro Matsunaga, Yasuki Noguchi, Yohsuke Ohtsubo, Hidenori Yamasue, Keiko Ishii
Summary: Previous research has shown that East Asians are less willing to seek social support compared to Westerners. Factors such as empathic concern and relational concern account for this cultural difference. Japanese individuals with lower empathic concern but higher relational concern are less likely to seek social support during stressful times, contributing to higher levels of loneliness among them compared to European Americans.
Article
Behavioral Sciences
Masahiro Matsunaga, Yohsuke Ohtsubo, Takahiko Masuda, Yasuki Noguchi, Hidenori Yamasue, Keiko Ishii
Summary: The study found that Y-DNA haplogroup D-M55 is associated with physiological and psychological characteristics in Japanese males, such as higher BMI and more close friends. Additionally, the research revealed gene-gene interactions between D-M55 and the dopamine D2 receptor gene in BMI.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Masahiro Matsunaga, Yohsuke Ohtsubo, Takahiko Masuda, Yasuki Noguchi, Hidenori Yamasue, Keiko Ishii
Summary: The study found that a single nucleotide polymorphism in the HTR2A gene rs6311 site is associated with positive emotional contagion in Japanese individuals. Specifically, individuals carrying the G allele were found to be happier in the presence of a friend compared to those with the AA genotype. These findings suggest that the impact of HTR2A polymorphisms on social sharing of happiness in Japanese populations may also translate to American populations.
JAPANESE PSYCHOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Qiulu Shou, Junko Yamada, Kuniyuki Nishina, Masahiro Matsunaga, Toko Kiyonari, Haruto Takagishi
Summary: The study found that oxytocin is positively correlated with caution rather than general trust, indicating that oxytocin regulates caution trust rather than general trust. Salivary oxytocin levels can partially predict an individual's trust level, especially caution trust.
Article
Anatomy & Morphology
Qiulu Shou, Junko Yamada, Kuniyuki Nishina, Masahiro Matsunaga, Tetsuya Matsuda, Haruto Takagishi
Summary: This study investigated the association between salivary oxytocin levels and the volume of the amygdala and hippocampus. The results showed that there were sex differences in the effects of salivary oxytocin levels on amygdala volume, with men showing a positive correlation and women showing a negative correlation. There was no significant effect on hippocampal volume.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Psychology, Biological
Shaofeng Zheng, Keiko Ishii, Takahiko Masuda, Masahiro Matsunaga, Yasuki Noguchi, Hidenori Yamasue, Yohsuke Ohtsubo
Summary: This study examined the association between perceived parental attention in early adulthood and social support seeking, and found that this association is moderated by OPRM1 gene polymorphism.
ADAPTIVE HUMAN BEHAVIOR AND PHYSIOLOGY
(2022)
Article
Psychiatry
Reiko Hori, Eiji Shibata, Iwao Okajima, Masahiro Matsunaga, Tomohiro Umemura, Akihiko Narisada, Kohta Suzuki
Summary: This study aims to clarify the association between remote teaching and Japanese university students' sleeping habits. The analysis of medical students at Aichi Medical University showed that during the remote teaching period in 2020, students' sleep duration increased on weekdays and decreased on weekends.
BIOPSYCHOSOCIAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hirohito Tsuboi, Masahiro Matsunaga, Hiromasa Tsujiguchi, Takayuki Kannon, Kazuyoshi Hosomichi, Takehiro Sato, Atsushi Tajima, Naoko Yoshida, Akinori Hara, Hiroyuki Nakamura
Summary: This study investigated the serum levels of endocannabinoids (eCBs) and daily intake of polyunsaturated fatty acids (PUFAs) among subjects with high and low depressive symptoms. The results showed that the ratio of AEA serum level to ARA intake was significantly higher in participants with high depressive symptoms, suggesting an accelerated conversion rate of ARA to AEA in depressive individuals.
NEUROENDOCRINOLOGY LETTERS
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Tomohiro Umemura, Akihiko Narisada, Rei Wakayama, Reiko Hori, Masahiro Matsunaga, Eiji Shibata, Kohta Suzuki
SAFETY AND HEALTH AT WORK
(2022)
Article
Nutrition & Dietetics
Hirohito Tsuboi, Hiroyuki Sakakibara, Masahiro Matsunaga, Asami Tatsumi, Kimiko Yamakawa-Kobayashi, Naoko Yoshida, Kayoko Shimoi
Article
Psychology, Clinical
Kentaro Shirotsuki, Shuhei Izawa, Nagisa Sugaya, Kenta Kimura, Namiko Ogawa, Kosuke Chris Yamada, Yuichiro Nagano
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2020)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.