Article
Biochemistry & Molecular Biology
Juan David Olivares-Hernandez, Martha Carranza, Jerusa Elienai Balderas-Marquez, David Epardo, Rosario Baltazar-Lara, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Maricela Luna, Carlos Aramburo
Summary: This study investigates the neuroprotective and regenerative effects of growth hormone (GH) in prenatal hypoxic-ischemic (HI) injury using chicken embryo models. The results demonstrate that GH has an anti-apoptotic effect and promotes cell survival and proliferation in HI-injured pallial neurons through the activation of ERK1/2 and Bcl-2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ewelina Bratek-Gerej, Apolonia Ziembowicz, Elzbieta Salinska
Summary: This study found that activation of group II mGlu receptors can prevent brain damage and regulate apoptosis and neuroprotective mechanisms in experimental birth asphyxia. Agonists LY379268 and NAAG can inhibit excessive glutamate release and apoptotic damage, and restore the concentration of neurotrophins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aneta Michna, Agata Pomorska, Ozlem Ozcan
Summary: Growth factors are proteins that affect cell proliferation and differentiation. They have both positive and negative effects on disease progression and can be used in gene therapy and wound healing. However, their instability and susceptibility to degradation make them require carriers for protection and delivery. This review focuses on the physicochemical properties and potential uses of macroions, growth factors, and macroion-growth factor assemblies in medicine.
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Review
Biochemistry & Molecular Biology
Ouada Nebie, Luc Buee, David Blum, Thierry Burnouf
Summary: Neurodegenerative disorders and brain traumatic insults involve complex pathophysiological changes, and a single pharmacological approach may not be effective. Recent preclinical data support the use of biotherapies based on neurotrophic factors and extracellular vesicles present in human platelet lysates. The administration of human platelet lysates has shown beneficial neuroprotective effects in rodent models of neurodegenerative diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Yolanda Fernandez-Cladera, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Agustin F. Gonzalez-Rivero, Antonia De Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between VEGF and sVEGFR with SLE disease-related features and found that serum levels of VEGF and sVEGFR in SLE patients were associated with disease damage, with musculoskeletal manifestations being the most commonly associated feature.
Article
Biochemistry & Molecular Biology
Pablo Torres-Vergara, Felipe Troncoso, Jesenia Acurio, Ellen Kupka, Lina Bergman, Anna-Karin Wikstro, Carlos Escudero
Summary: Disruption of blood-brain barrier is a central issue in the pathophysiology of acute cerebral complications in women with preeclampsia. The underlying mechanisms are unclear. This study found that plasma from women with preeclampsia increased cell apoptosis and permeability in human brain endothelial cells, possibly through activation of VEGFR2. The different phosphorylation patterns of VEGFR2 suggest that further investigation is needed to determine its specific activation status.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Huang Zeng, Shuangshuang Kang, Yu Zhang, Ke Liu, Qian Yu, Ding Li, Lin-Kun An
Summary: The study identified oleanolic acid as a novel chemotype for selective ligands of VEGF i-motif. Compound 3c was found to effectively downregulate VEGF gene transcription and expression in MCF-7 cells, inhibit tumor cells proliferation and migration, and induce cancer cells apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Jun-Hei Chang, Chen-Chuan Cheng, Yen-Yu Lu, Cheng-Chih Chung, Yung-Hsin Yeh, Yao-Chang Chen, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: VEGF reduces PV arrhythmogenesis by modulating sodium/calcium homeostasis through VEGFR-1/NOS signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Engineering, Biomedical
Deepti Rana, Prasanna Padmanaban, Malin Becker, Fabian Stein, Jeroen Leijten, Bart Koopman, Jeroen Rouwkema
Summary: Given the need for control over evolving biochemical cues within synthetic matrices, this study focused on the incorporation of VEGF165 specific aptamers into cell-instructive polymer networks to regulate VEGF bioactivity. Bicomponent micropatterns were fabricated via photopatterning and demonstrated the retention of aptamers, molecular recognition, and VEGF sequestration. The study also revealed the ability of aptamer-tethered VEGF to spatiotemporally regulate vascular morphogenesis.
MATERIALS TODAY BIO
(2023)
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.