Article
Biophysics
Yuxia Fan, Weizhu Chen, Ninglong Zhang, Mingyang Li, Yiwen Zhu, Gaole Chen, Yin Zhang, Yuan Liu
Summary: A self-assembled biosensor based on matured taste receptor cells (TRCs) was developed, which successfully detected L-monosodium glutamate (MSG) and other umami substances, providing insights into taste signal transduction mechanisms and suggesting the potential for biomimetic sensors in intelligent perception applications.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Gastroenterology & Hepatology
Yolanda Lopez-Tofino, Gema Vera, Laura Lopez-Gomez, Rocio Giron, Kulmira Nurgali, Jose A. Uranga, Raquel Abalo
Summary: Monosodium glutamate can prevent cisplatin-induced neuropathy and partially improve intestinal transit, with little impact on gastric dysmotility. It does not improve histological damage of the gut wall, but prevents changes in the colonic myenteric plexus induced by cisplatin. Our results suggest that MSG may have neuroprotectant effects and could be a useful adjuvant to reduce chemotherapy-induced sequelae.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Chemistry, Multidisciplinary
Jiajia Zhong, Wenjie Yu, Yuzhao Tang, Xiaojie Zhou
Summary: This research utilized SR-FTIR microspectroscopy to investigate the biomolecular alterations in WRL68 cells induced by vincristine treatment. The results revealed changes in lipid structures, decreased protein alpha-helical content, and decreased nucleic acid content in vincristine-treated WRL68 cells.
Article
Cell Biology
Soo-Yeon Woo, Hansong Lee, Su Min Park, Hee-Seon Choi, Jayoung Kim, Munju Kwon, Jihyung Sohn, Ji Ho Nam, Hyung-Sik Kim, Parkyong Song, Ninib Baryawno, Yun-Hak Kim, Koanhoi Kim, Dongjun Lee
Summary: 27HC, an oxygenated derivative of cholesterol, regulates the quantity and function of various cell populations in the bone marrow and may serve as a new therapeutic target for hematological malignancies. Exogenous 27HC treatment induces oxidative stress and apoptosis in the bone marrow.
CELL DEATH & DISEASE
(2022)
Article
Food Science & Technology
Seon-Tea Joo, Jung-Suk Choi, Sun-Jin Hur, Gap-Don Kim, Chan-Jin Kim, Eun-Yeong Lee, Allah Bakhsh, Young-Hwa Hwang
Summary: The study investigated the amino acid and nucleotide-related compound composition and taste characteristics of cultured muscle tissue obtained from satellite cells isolated from chicken and cattle compared to traditional meat. Significant differences were found in the composition and taste characteristics between CMT and TM, suggesting the need to develop methods to enhance umami and bitterness intensity in CMT.
FOOD SCIENCE OF ANIMAL RESOURCES
(2022)
Article
Biochemistry & Molecular Biology
Luis R. Raposo, Ana Silva, Dario Silva, Catarina Roma-Rodrigues, Margarida Espadinha, Pedro Baptista, Maria M. M. Santos, Alexandra R. Fernandes
Summary: This study assessed the antiproliferative activity of five spiropyrazoline oxindoles in ovarian cancer cells and identified a compound with the highest effectiveness and selectivity. The compound induced cell death through mitochondria-mediated apoptosis and autophagy, with interaction with DNA by groove-binding without genotoxicity. Proteomic studies revealed the compound's role in promoting ER stress and triggering cell death in ovarian cancer cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Yu-Seon Han, Eui-Yeun Yi, Myeong-Eun Jegal, Yung-Jin Kim
Summary: Mitochondrial dysfunction can transform cancer cells into cancer stem-like cells, as shown by the generation of mitochondria dysfunctional (rho(0)) cells from the Hep3B hepatocellular carcinoma cell line. These rho(0) cells exhibited increased cancer stem-like properties, such as self-renewal, chemotherapy resistance, and angiogenesis. The data suggest that mitochondrial dysfunction plays a significant role in driving the transition of cancer cells towards a stem-like phenotype.
Article
Multidisciplinary Sciences
Celine Bonnet, Panhong Gou, Simon Girel, Vincent Bansaye, Catherine Lacout, Karine Bailly, Marie-Helene Schlagetter, Evelyne Lauret, Sylvie Meleard, Stephane Giraudier
Summary: This study reconciled steady-state and stress hematopoiesis by analyzing the effects of a stress condition on mouse hematopoietic stem and progenitor cells. A mathematical model incorporating time-dependent regulation was developed and successfully replicated biological data under different stress conditions. The findings provide new insights into both normal and pathological hematopoiesis.
Article
Oncology
Assuntina G. Sacco, Ruifeng Chen, Francis P. Worden, Deborah J. L. Wong, Douglas Adkins, Paul Swiecicki, Wanxing Chai-Ho, Peter Oppelt, Debanjali Ghosh, Julie Bykowski, Alfredo Molinolo, Emily Pittman, M. Valeria Estrada, Kathryn Gold, Gregory Daniels, Scott M. Lippman, Amanda Natsuhara, Karen Messer, Ezra E. W. Cohen
Summary: The study aimed to evaluate the anti-tumour activity of PD-1 blockade with EGFR inhibition in recurrent or metastatic head and neck squamous cell carcinoma. Results showed a 45% overall response rate at 6 months for the combination of pembrolizumab and cetuximab.
Article
Chemistry, Physical
Aleli Campbell, Denisse A. Gutierrez, Colin Knight, Charlotte M. Vines, Rosalinda Heydarian, Alexander Philipovskiy, Armando Varela-Ramirez, Thomas Boland
Summary: This study utilized bioprinting technology to investigate the sensitivity of breast cancer cells to treatment with palbociclib and letrozole. The results suggest that bioprinting technology could be a feasible strategy for developing and testing new anticancer drugs.
Article
Neurosciences
Ken Steffen Frahm, Sabata Gervasio
Summary: The study found that the two-point discrimination threshold (2PDT) is highly influenced by both the stimulation modality and intensity. Noxious intensities have different effects on the 2PDT for thermal stimuli and mechanical stimuli.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Review
Medicine, General & Internal
Joseph E. Maakaron, Marie Hu, Najla El Jurdi
Summary: Chimeric antigen receptor T cells (CAR-T cells) have revolutionized the treatment of hematological malignancies in the past five years, providing impressive treatment response rates and durable remissions for patients without viable options. This review provides a brief historical overview of their development, focuses on the practical aspects of patient journey and the management of unique toxicities, discusses key registration trials leading to approvals for various types of malignancies, and considers future development and research directions of this cutting-edge therapy.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Oncology
Christine H. Chung, Jiannong Li, Conor E. Steuer, Priyanka Bhateja, Matthew Johnson, Jude Masannat, Maria I. Poole, Feifei Song, Juan C. Hernandez-Prera, Helen Molina, Bruce M. Wenig, Sunil Kumar, Charlotte Kuperwasser, Philip J. Stephens, Joaquim M. Farinhas, Dong M. Shin, Julie A. Kish, Jameel Muzaffar, Kedar Kirtane, James W. Rocco, Michael J. Schell, Nabil F. Saba, Marcelo Bonomi
Summary: A phase II multi-institutional clinical trial was conducted to evaluate the overall survival (OS) of patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) treated with a combination of cetuximab and nivolumab. The results showed that this combination therapy was effective in both previously treated and untreated patients, and the expression of p16 and PD-L1 was associated with treatment response and survival.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wagner da S. Terra, Erika S. Bull, Samila R. Morcelli, Rafaela R. Moreira, Leide Laura F. Maciel, Joao Carlos de A. Almeida, Milton M. Kanashiro, Christiane Fernandes, Adolfo Horn Jr
Summary: This study reported the cytotoxicity of three water-soluble copper(II) coordination compounds on five human tumor cell lines, with one complex showing the best antiproliferative effect and selectivity against lung cancer cell line NCI-H460. The mechanism of cell death promoted by this complex was found to be apoptosis, leading to damage of mitochondrial membrane potential and other organelles.
Article
Nanoscience & Nanotechnology
Diptendu Patra, Pawan Kumar, Tapendu Samanta, Ipsita Chakraborty, Raja Shunmugam
Summary: Magnetic resonance imaging-aided real-time diagnosis and dual-targeting polymer theranostic hold promise for effective and precise cancer treatment. In this study, a polymer was constructed with chemotherapeutic agent, receptor targeting agent, mitochondria targeting agent, and fluorescence-MR imaging agent. The polymer demonstrated advantages in nanosphere self-assembly, water proton relaxation, and cell targeting, while showing enhanced anticancer efficacy.
ACS APPLIED BIO MATERIALS
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.