Review
Pharmacology & Pharmacy
Arash Salehi, Keely Puchalski, Yalda Shokoohinia, Behzad Zolfaghari, Sedigheh Asgary
Summary: Hemp and marijuana differ in terms of chemical and genetic composition, production practices, product uses, and regulatory status. Hemp seed and hemp seed oil have nutritional value, and the non-intoxicating phytocannabinoid CBD has high medicinal potential. It is now easier to differentiate between hemp and marijuana in the laboratory, and regulations and testing guidelines for cannabis are still evolving.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agricultural Engineering
Avia Saloner, Nirit Bernstein
Summary: Nitrogen supply affects cannabinoid and terpenoid metabolism, with the optimal N level for both yield quantity and relatively high secondary metabolites content being 160 mg L-1. High N supply has adverse effects on the production of secondary compounds in cannabis, while promoting plant growth and biomass production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Agricultural Engineering
Nadav Danziger, Nirit Bernstein
Summary: Plant architecture modulation can increase standardization of the cannabinoid profile in cannabis by increasing concentrations at the lower parts of the plant. Genotype and architectural modulation have specific effects on cannabinoid standardization.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Pharmacology & Pharmacy
Zaid H. Maayah, Pamela J. F. Raposo, Heidi Silver, Rupasri Mandal, Lee Ellis, Abrar S. Alam, Shingo Takahara, Mourad Ferdaoussi, Kyle E. Mathewson, Dean T. Eurich, Karim Fouad, David S. Wishart, Jason R. B. Dyck
Summary: This study aimed to identify a panel of blood-based metabolites that can predict behavioral effects induced by cannabis. The results showed that only rats treated with full-spectrum cannabis extract exhibited behavioral changes, while the other groups did not show any behavioral changes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Matthew M. Cousins, Mary L. Jannausch, Lara N. Coughlin, Reshma Jagsi, Mark A. Ilgen
Summary: The study found that patients with cancer were less likely to report cannabis use, but there were different cannabis perceptions and use patterns among patients of different ages.
Article
Agricultural Engineering
Jafar Mehdi, Danish Husain, Abhilasha Srivastava, Namita Gupta, Karuna Shanker, Mohammad Talha, Raj Kishori Lal, Birendra Kumar, Anil Kumar Gupta
Summary: This study conducted extensive morphometric and chemometric mapping of natural populations of Cannabis in India, revealing a strong correlation between their genetic diversity and regional distribution. The findings provide a foundation for identifying and selecting lines with key agronomic traits for maximizing the potential of this promising crop.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Agricultural Engineering
Kai Su, Elizabeth Maghirang, Jia Wen Tan, Ju Young Yoon, Paul Armstrong, Pradeep Kachroo, David Hildebrand
Summary: This study demonstrates the use of near-infrared spectroscopy for rapid measurement of industrial hemp, allowing for accurate identification of legal and illegal hemp. It shows good prediction results and will be beneficial for the hemp industry, regulators, farmers, and consumers.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Psychology, Clinical
Evan A. Winiger, Leah N. Hitchcock, Angela D. Bryan, L. Cinnamon Bidwell
Summary: The study aimed to investigate the relationship between cannabis use, expectations of cannabis as a sleep aid, subjective sleep outcomes, and the influence of age. Results showed that endorsing current cannabis use and more days of use were associated with increased expectations of improved sleep, while frequency of edible use showed negative associations with sleep efficiency, duration, and overall sleep quality. Age was found to moderate the relationship between CBD concentration and sleep duration and quality. The study suggests that while cannabis users have high expectations of cannabis as a sleep aid, actual associations with sleep outcomes are limited.
ADDICTIVE BEHAVIORS
(2021)
Article
Anesthesiology
Rebecca M. Craft, Hannah Y. Gogulski, Timothy G. Freels, Nicholas C. Glodosky, Ryan J. McLaughlin
Summary: Preclinical studies show strong antinociceptive effects of cannabinoids in rodent pain models, however, clinical trials in chronic pain patients report limited pain relief. Discrepancies may be due to differences in administration, type of cannabis, and pain measurement. Vaporized THC-dominant extract shows modest effectiveness against inflammatory pain, while CBD-dominant extract may only be effective in male rats.
Article
Plant Sciences
Victorio Morello, Vincent Desaulniers Brousseau, Natalie Wu, Bo-Sen Wu, Sarah MacPherson, Mark Lefsrud
Summary: This study investigated the impact of six different light spectra on cannabis growth and secondary metabolite profiles. Results showed that blue light treatment had a significant effect on THC concentration and certain terpene concentrations, increasing their levels. Choosing the appropriate spectral design based on the specific goals of cannabis production may lead to improved outcomes in cannabinoid production.
Article
Plant Sciences
Alessandra Manca, Alice Palermiti, Jacopo Mula, Elisa Delia De Vivo, Sandra Zeaiter, Marco Simiele, Amedeo De Nicolo, Marco Cantu, Jessica Cusato, Antonio D'Avolio
Summary: This study investigates the variability of cannabis oil preparations among different galenic laboratories, highlighting the importance of titration activity. The results reveal significant differences in the composition of cannabis oil among different galenic laboratories, and the concentrations of compounds are also influenced by seasonal variability.
Article
Pharmacology & Pharmacy
Noof Aloufi, Yoon Namkung, Hussein Traboulsi, Emily T. Wilson, Stephane A. Laporte, Barbara L. F. Kaplan, Matthew K. Ross, Parameswaran Nair, David H. Eidelman, Carolyn J. Baglole
Summary: Cannabis is a commonly used illicit product globally and the second most popular smoking plant after tobacco. This study developed a standardized protocol for generating cannabis smoke extract (CaSE) and investigated its impact on cellular mechanisms in vitro. The results showed that CaSE contains cannabinoids and induces an inflammatory response in human lung fibroblasts.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Clinical
Toni C. Spinella, Jeremy Bartholomeusz, Sherry H. Stewart, Sean P. Barrett
Summary: This study evaluated individuals' expectancies about the effects of CBD, THC, and THC & CBD combined, and whether this differs with prior cannabis experience. The results showed that products containing higher CBD levels were perceived to have better therapeutic effects, while products with higher THC levels were perceived to have better non-therapeutic positive and negative effects. Individuals with prior cannabis use experience held higher expectations for most therapeutic effects and lower expectations for some negative effects.
ADDICTIVE BEHAVIORS
(2023)
Article
Agronomy
Sarah Jane Purdy, Amitha K. Hewavitharana, Razlin Azman Halimi, Nelson Joel Magner, Tyson James Peterswald, Amy Trebilco, Tobias Kretzschmar, Deborah Hailstones
Summary: This study developed a grafting methodology specifically for medicinal Cannabis, which improved yield without requiring additional cultivation time. Additionally, it uncovered the potential influence of roots on cannabinoid content in Cannabis.
Review
Clinical Neurology
Rob Velzeboer, Adeeb Malas, Pierre Boerkoel, Katie Cullen, Michelle Hawkins, Jordanna Roesler, Wayne Wei-Ku Lai
Summary: The systematic review suggests that cannabis may have a positive effect on sleep in patients with pain-related disorders. However, due to the heterogeneity in cannabis types, doses, timing of administration, and sleep outcome measures, specific dosing recommendations cannot be made.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.