Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychiatry
Emily E. Noble, Christine A. Olson, Elizabeth Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa Liu, Andrea Suarez, Roshonda B. Jones, Claire de la Serre, Xia Yang, Elaine Y. Hsiao, Scott E. Kanoski
Summary: Research indicates that excessive early life consumption of sugar negatively impacts memory function in rats during adulthood, affecting hippocampal-dependent memory function and altering the gut microbiome, including the abundance of specific Parabacteroides species. Enrichment of these bacterial taxa during adolescence impairs hippocampal-dependent memory in adulthood, while early life sugar consumption and Parabacteroides microbial enrichment lead to alterations in gene expression related to intracellular kinase, neurotransmitter signaling, metabolic function, neurodegenerative disease, and dopaminergic signaling pathways.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Robert E. Featherstone, Raymond L. Gifford, Lindsey M. Crown, Felix Amirfathi, Jon P. Alaniz, Janice Yi, AiVi Tran, Derrick Adomian, Andrew Schwenk, Olya Melnychenko, Christina Duval, Krishna Parekh, Darrin J. Lee, Steven J. Siegel
Summary: Early life social stress in mice can have long-term effects on behavior and cognition, including anxiety, affect, sociability, aggression, motivation, and recognition memory. These effects may be mediated by persistent changes in moderators of the stress cascade.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Behavioral Sciences
Soniya Assudani Patel, Karyn M. Frick, Paul A. Newhouse, Robert S. Astur
Summary: The study examined the role of estradiol in hippocampal-dependent spatial memory in women. Results showed that the high estradiol group demonstrated superior spatial reference memory, while the low estradiol group exhibited the poorest probe trial performance. There were no group differences in performance on the virtual memory tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Food Science & Technology
Rae Yi Xin Par, Cheryl Wei Ling Teo, Javier Joon Kiat Tan, Yee Wei Ung, Kiang Soon Heng, Li Ting Hang, Mervyn Yeo, Wei Ney Yap
Summary: This study aimed to investigate the beneficial effects of tocotrienols (T3) supplementation on attention and memory. The results showed that T3 supplementation significantly improved memory and reaction speed, and reduced brainwave power, indicating enhanced neural efficacy and cognitive performance.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Neurosciences
David A. Cinalli, Sarah J. Cohen, Mariah Calubag, Goksu Oz, Lylybell Zhou, Robert W. Stackman
Summary: This study used the DREADDs method to investigate the effects of CA1 pyramidal neurons in the hippocampus on the retrieval of long-term memory for nonspatial and spatial information in mice. The results showed that the inhibition of CA1 neuronal activity significantly impaired the memory retrieval in mice. These findings support the use of mice as a model system to study the neurobiological mechanisms of human episodic memory.
Article
Behavioral Sciences
Hassina Belblidia, Thomas Freret, Marianne Leger, Pascale Schumann-Bard
Summary: This study investigated the effect of normal aging on temporal order memory and found that it is particularly vulnerable to the deleterious effect of aging.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Cheryl A. Frye, Vincent F. Lembo, Alicia A. Walf
Summary: The study found that progesterone can enhance cognitive performance in male mice by increasing allopregnanolone concentrations, BDNF levels, and GABA(A) activity. These effects may be independent of traditional progestin receptors' trophic actions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Mariah Mesquita de Figueiredo Cerqueira, Micaele Maria Lopes Castro, Amanda Almeida Vieira, Juliana Ayumi Azevedo Kurosawa, Fabio Leite do Amaral Junior, Fabiola de Carvalho Chaves de Siqueira Mendes, Marcia Consentino Kronka Sosthenes
Summary: Anxiety is increasingly being diagnosed in the elderly, and it is associated with cognitive decline, morbidity, and even mortality. The environment and age have an impact on anxiety-like behavior in mice, as assessed by the Elevated Plus Maze (EPM) and Open Field (OF) tests. The results from these tests suggest the need for a better evaluation of the parameters analyzed in each test.
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Computer Science, Artificial Intelligence
Jiaqi Wang, Kai Chen, Rui Xu, Ziwei Liu, Chen Change Loy, Dahua Lin
Summary: CARAFE++ is a universal, lightweight, and highly effective operator for feature reassembly in convolutional networks. It aggregates contextual information within a large receptive field, generates adaptive kernels for instance-specific content-aware handling, and introduces little computational overhead. It consistently shows significant improvements in various tasks, making it a strong building block for modern deep networks.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2022)
Article
Robotics
Zhongxiang Zhou, Yifei Yang, Yue Wang, Rong Xiong
Summary: Detecting both known and unknown objects is essential for robots in unstructured environments. In this letter, we propose Openset RCNN, a method to address open-set object detection challenges. We use a classification-free region proposal network (CF-RPN) to separate unknown objects and background, and a prototype learning network (PLN) to represent unknown objects in a latent space. We introduce a new benchmark dataset for evaluation and demonstrate the effectiveness of our approach through extensive experiments. Our Openset RCNN enables robots to perceive open-set objects in cluttered environments.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2023)
Article
Multidisciplinary Sciences
Anuck Sawangjit, Maximilian Harkotte, Carlos N. Oyanedel, Niels Niethard, Jan Born, Marion Inostroza
Summary: Memory consolidation is promoted by both sleep and wakefulness, but their effects on hippocampal and nonhippocampal representations differ. Sleep consolidation involves event-context binding, while wake consolidation tends to strengthen context-independent representations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.