Article
Cell Biology
Suthakar Ganapathy, Jian Liu, Tianqi Yu, Rui Xiong, Qiang Zhang, Alexandros Makriyannis, Changyan Chen
Summary: Hexavalent chromium (Cr(VI)) pollution is a serious environmental and health concern. This study reveals the role of protein kinase C (PKC) in Cr(VI)-induced carcinogenesis and drug resistance, and suggests that PKC can be a potential biomarker for early detection of health damages and a therapeutic target for developing new treatments for diseases caused by Cr(VI).
Article
Biochemistry & Molecular Biology
Jiutao Wang, Ning Yao, Yamei Hu, Mingjuan Lei, Meixian Wang, Lu Yang, Satyananda Patel, Xiang Li, Kangdong Liu, Zigang Dong
Summary: This study identified the potential mechanism of how Ras is activated in glioblastoma multiforme (GBM) through the interaction between Ras and PHLDA1. The overexpression of PHLDA1 promoted cell proliferation and tumor growth by regulating the Ras/Raf/Mek/Erk signaling pathway. In addition, Src phosphorylated Ras at tyrosine 32 to enhance its GTPase activity. PHLDA1 competed with Src for binding to Ras, inhibiting Ras phosphorylation by Src and rescuing Ras activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kelsie J. Anson, Giulia A. Corbet, Amy E. Palmer
Summary: In this study, the researchers investigated how changes in intracellular zinc ion levels affect kinase signaling pathways using fluorescent biosensors and cell perturbations. The results showed that zinc ion fluctuations are not toxic and do not activate stress-dependent kinase signaling. Additionally, the study demonstrated that while zinc ions can inhibit phosphatases, ERK and Akt are primarily activated through upstream signaling pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Ana Herrero, Piero Crespo
Summary: Signals transmitted through the RAS-ERK pathway play a crucial role in cancer-related cellular processes. RAS dimerization, especially at membrane microdomains, is essential for RAF activation and can be targeted pharmacologically to prevent tumorigenesis.
Article
Oncology
M. Hanief Sofi, Linlu Tian, Steven Schutt, Imran Khan, Hee-Jin Choi, Yongxia Wu, David Bastian, Taylor Ticer, Mohamed Faisal Kassir, Firdevs Cansu Atilgan, Jisun Kim, Xiaohui Sui, Aleksandra Zivkovic, Shikhar Mehrotra, John P. O'Bryan, Holger Stark, Paul J. Martin, Besim Ogretmen, Xue-Zhong Yu
Summary: Targeting CerS6 can prevent and reverse GVHD while preserving GVL effect. Specific inhibition of CerS6 improves GVHD without impairing GVL activity. CerS6 plays a critical role at both cellular and molecular levels。
Article
Multidisciplinary Sciences
Lick Pui Lai, Nicole Fer, William Burgan, Vanessa E. Wall, Bingfang Xu, Daniel Soppet, Dominic Esposito, Dwight Nissley, Frank McCormick
Summary: RAF inhibitors unexpectedly activate ERK signaling in both normal and tumor cells with elevated RAS activity. This study demonstrates that RAF inhibitors can cause paradoxical ERK activation in KRAS(G12C)-dependent lung cancer cell lines. It also reveals that classical RAS proteins are not essential for this process, and the MRAS/SHOC2 complex plays a vital role.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Shiela C. C. Samson, Akib M. M. Khan, Michelle C. C. Mendoza
Summary: The RAS-ERK pathway is crucial in promoting cell migration and invasion, with steady-state ERK activity playing a role in promoting both single cell and collective migration and invasion. ERK drives actin polymerization and adhesion turnover for edge protrusion, while cell contraction stimulates cell movement in epithelial sheets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Jing Xie, Ying-Yan Qian, Yang Yang, Lin-Jie Peng, Jia-Ying Mao, Ming-Rong Yang, Yang Tian, Jun Sheng
Summary: In this study, the researchers found that MIC-1 from Moringa oleifera Lam. inhibited the growth and migration of renal cell carcinoma cells. They also identified that MIC-1 inhibited the Src/Ras/Raf/ERK signaling pathway by targeting PTP1B. Furthermore, MIC-1 induced apoptosis and cell cycle arrest in RCC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Shanjun Huang, Weiqi Wang, Li Li, Ting Wang, Yihan Zhao, Ya Lin, Weijian Huang, Yonghua Wang, Zhouqing Huang
Summary: The study showed that P2X7R plays an important role in the pathogenesis of STZ-induced diabetic cardiac damage and remodeling through the PKC beta/ERK axis. These findings suggest that P2X7R might be a potential target in the treatment of diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miguel A. Zaballos, Adrian Acuna-Ruiz, Marta Morante, Garcilaso Riesco-Eizaguirre, Piero Crespo, Pilar Santisteban
Summary: The study demonstrates that BRAF- and RAS-mutant thyroid cells respond differently to DEL-22379, which cannot be explained by the previously described mechanism of action of the inhibitor. Nonetheless, DEL-22379 exhibits significant anti-tumor effects against BRAF-mutant cells in vivo, while the anti-tumor effects are mild for RAS-mutant cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Mona G. El-Sisi, Sara M. Radwan, Alia M. Saeed, Hala O. El-Mesallamy
Summary: The study suggests that FAK, MR-1, EphA4, Src, and PKC may serve as early diagnostic and prognostic markers with high sensitivity and specificity in AML patients, potentially being included in the patients' early diagnostic and prognostic panels.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Shanjun Huang, Weiqi Wang, Li Li, Ting Wang, Yihan Zhao, Ya Lin, Weijian Huang, Yonghua Wang, Zhouqing Huang
Summary: The study indicates that P2X7R plays an important role in STZ-induced diabetic cardiac damage and remodeling, and may be a potential target for the treatment of diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Rheumatology
Zoe Rutter -Locher, Nikita Arumalla, Sam Norton, Leonie S. Taams, Bruce W. Kirkham, Kirsty Bannister
Summary: The prevalence of pain sensitivity and neuropathic-like pain in patients with inflammatory arthritis is significant, with up to 42% of patients affected. Self-reported questionnaires can provide valuable insights into different pain types and guide targeted treatment. Pain sensitivity and neuropathic-like pain are associated with worse pain severity, disease activity, disability, and quality of life measures, highlighting the importance of addressing these factors in managing inflammatory arthritis.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Neurosciences
Kufreobong E. Inyang, Susan R. George, Geoffroy Laumet
Summary: The study reveals the significant role of the μ-δOR heteromer in latent pain sensitization, which can be targeted by a specific interfering peptide. Antagonism of the μ-δOR heteromer leads to reinstatement of pain hypersensitivity, offering a potential novel therapeutic target for controlling chronic pain.
Article
Behavioral Sciences
Zhong Ding, Gregory T. Knipp, Richard M. van Rijn, Julia A. Chester, Val J. Watts
Summary: Heterologous sensitization of adenylyl cyclase is enhanced cAMP response following G alpha(i/o)-coupled receptors activation, which can be abolished by pharmacological inhibition of Cullin3 with MLN4924. MLN4924 was found to reduce alcohol-induced locomotor sensitization and allodynia in an inflammatory pain model, potentially through blocking AC sensitization. These findings suggest a new pathway for drug development for disorders associated with AC sensitization.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.