Article
Rehabilitation
Eugene Nizeyimana, Conran Joseph, Joliana Phillips
Summary: This study aimed to identify factors influencing the quality of life among individuals with traumatic spinal cord injuries (TSCI) in South Africa. A cross-sectional survey was conducted among 108 adults living in the community, and the results showed that employment and time since injury were the most significant factors. These findings highlight the importance of employment for individuals with TSCI.
DISABILITY AND REHABILITATION
(2022)
Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Rehabilitation
Alejandro Garcia-Rudolph, Blanca Cegarra, Eloy Opisso, Josep Maria Tormos, Joan Sauri
Summary: This study aimed to investigate the relationships between functional and psychological aspects and community integration and quality of life in individuals with chronic traumatic spinal cord injury. The results showed that self-care and transfers were strongly associated with home integration, while anhedonia was strongly related to all dimensions of quality of life, with depression being the most relevant predictor of physical and psychological dimensions.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Review
Clinical Neurology
Lintao Xu, Jingyu Wang, Yueming Ding, Linlin Wang, Yong-Jian Zhu
Summary: Microglia undergo activation, proliferation, and changes in gene and protein expression and morphology after traumatic spinal cord injury (SCI), leading to both detrimental and beneficial effects. Understanding and regulating microglial activation status is crucial for reducing harmful effects, promoting repair, and developing effective therapies for SCI.
FRONTIERS IN NEUROLOGY
(2022)
Review
Physiology
Chun Yao, Xuemin Cao, Bin Yu
Summary: Traumatic spinal cord injury (SCI) leads to a series of complex pathological reactions, affecting the local microenvironment. Although endogenous angiogenesis is triggered, the new vessels often do not function normally. Many blood vessel interventions have been applied in SCI treatment.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Fan Bie, Kaiyang Wang, Tao Xu, Jishan Yuan, Hua Ding, Bin Lv, Yuwen Liu, Min Lan
Summary: Studies have shown that circRNAs are highly expressed in the spinal cord and play key roles in various neurological disease processes. Recent research has emerged on the role of circRNAs in SCI, leading to continued relevant studies. The analysis of circRNAs in affecting the processes of SCI and their potential clinical value as therapeutic targets has been conducted.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Thomas Liebscher, Johanna Ludwig, Tom Lubstorf, Martin Kreutztraeger, Thomas Auhuber, Ulrike Grittner, Benedikt Schaefer, Grit Wuestner, Axel Ekkernkamp, Marcel A. Kopp
Summary: This study investigated the effects of spinal surgical adverse events (SSAE) on clinical and functional outcome, length of stay, and treatment costs after traumatic cervical spinal cord injury (SCI). The results showed that SSAE had significant impacts on neurological recovery, functional outcome, and healthcare costs. Reducing SSAE is important for protecting the limited intrinsic capacity for recovery from SCI.
Review
Clinical Neurology
Damilola Jesuyajolu, Temitayo Ayantayo, Emmanuel Oyesiji, Sofia Bakare, Okere Madeleine, Olaniyan Adewale, Abdulahi Zubair, Jamike Ekennia-Ebeh, Eghosa Morgan
Summary: The incidence of traumatic spinal cord injury varies significantly across Africa, with higher rates compared to other regions. Urgent action is needed to address the main drivers of this condition.
WORLD NEUROSURGERY
(2023)
Article
Critical Care Medicine
Victor Lim, Andreane Richard-Denis, Antoine Dionne, Gilles Maurais, Etienne Bourassa-Moreau, Jean-Marc Mac-Thiong
Summary: This study examines the influence of older age on the expectations of achieving normal health-related quality of life (HRQoL) in Canadians after a traumatic spinal cord injury (TSCI). The findings suggest that older patients are more likely to achieve normal physical component summary (PCS) of HRQoL compared to younger patients, while age does not have an association with achieving normal mental component summary (MCS) of HRQoL.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Health Care Sciences & Services
James Guest, Nilanjana Datta, George Jimsheleishvili, David R. Gater
Summary: The spinal cord serves as a communication conduit between the brain and the body, responsible for transmitting information and controlling various functions. Following a spinal cord injury, various complications can arise, including paralysis, pain, and autonomic dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Rehabilitation
Jillian M. R. Clark, James S. Krause
Summary: This study investigated the relationships between self-reported biological, psychological, and social factors and life satisfaction in individuals with traumatic spinal cord injury. The results indicated that less severe depressive symptoms and greater social support were associated with higher levels of life satisfaction in global, vocational, and home life domains.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Orthopedics
Fater A. Khadour, Younes A. Khadour, Ling Meng, Lixin Cui, Xu Tao
Summary: This hospital-based retrospective study described the epidemiological characteristics of traumatic spinal cord injury in Wuhan, China. Findings revealed a higher proportion of males, with falls and traffic accidents being the leading causes. Farmers and workers were the most vulnerable occupations, and attention should be paid to the fall risk among the elderly. The importance of SCI rehabilitation should be highlighted.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Li Deng, Jun Qiao Lv, Lin Sun
Summary: This study systematically analyzed the experimental treatments and their mechanisms for reducing blood spinal cord barrier (BSCB) injury in the early stage of traumatic spinal cord injury (t-SCI). BMSC-Exos, which inhibit matrix metalloproteinases (MMPs) expression, are currently the most effective therapeutic modality for alleviating BSCB damage. In addition, the regulation of MMPs, the Akt pathway, and the ER stress pathway play important roles in alleviating BSCB injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Perry Dhaliwal, Alwyn Gomez, Frederick Adam Zeiler
Summary: Acute traumatic spinal cord injury is commonly treated with surgical decompression and instrumentation of the spine. However, the evidence for these methods is limited. There is now interest in measuring spinal cord perfusion pressure through monitoring mean arterial pressure and intraspinal pressure. This study successfully used a strain gauge pressure transducer to measure intraspinal pressure and derive spinal cord perfusion pressure.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Raban Arved Heller, Julian Seelig, Helena Lucia Crowell, Maximilian Pilz, Patrick Haubruck, Qian Sun, Lutz Schomburg, Volker Daniel, Arash Moghaddam, Bahram Biglari
Summary: This study aimed to evaluate the correlation between remission after traumatic spinal cord injury and the dynamics of monocyte subsets, lymphocytes' responsive potential, cytokine expression, patterns of trace element concentration, and clinical covariates. Clinical research findings suggest that early dynamics in monocyte subsets can predict recovery from traumatic spinal cord injury.
Article
Clinical Neurology
Jose A. Canseco, Gregory D. Schroeder, Parthik D. Patel, Giovanni Grasso, Michael Chang, Frank Kandziora, Emiliano N. Vialle, F. Cumhur Oner, Klaus J. Schnake, Marcel F. Dvorak, Jens R. Chapman, Lorin M. Benneker, Shanmuganathan Rajasekaran, Christopher K. Kepler, Alexander R. Vaccaro
Summary: Regardless of geographic location or years of practice experience, over half of responding surgeons identified MRI as the preferred imaging modality for managing cervical facet dislocation injuries, and tend to choose an anterior approach for surgical management. The study found a general consensus in management preferences for cervical facet dislocation injuries globally.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Said Sadiqi, Marcel W. Post, Allard J. Hosman, Marcel F. Dvorak, Jens R. Chapman, Lorin M. Benneker, Frank Kandziora, S. Rajasekaran, Klaus J. Schnake, Alexander R. Vaccaro, F. Cumhur Oner
Summary: The Dutch version of AOSpine PROST demonstrated excellent reliability, validity, and responsiveness, making it a valuable tool for evidence-based and patient-centered care in both clinical practice and research settings.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Gregory D. Schroeder, Jose A. Canseco, Parthik D. Patel, Srikanth N. Divi, Brian A. Karamian, Frank Kandziora, Emiliano N. Vialle, F. Cumhur Oner, Klaus J. Schnake, Marcel F. Dvorak, Jens R. Chapman, Lorin M. Benneker, Shanmuganathan Rajasekaran, Christopher K. Kepler, Alexander R. Vaccaro
Summary: The study validates the AO Spine Subaxial Cervical Spine Injury Classification system, showing high generalizability and reliability. Through surveys of surgeons with different practice experiences across the globe, it provides a consistent method of communication among physicians and covers the majority of traumatic injuries in the subaxial cervical spine.
Article
Clinical Neurology
Jose A. Canseco, Gregory D. Schroeder, Taylor M. Paziuk, Brian A. Karamian, Frank Kandziora, Emiliano N. Vialle, F. Cumhur Oner, Klaus J. Schnake, Marcel F. Dvorak, Jens R. Chapman, Lorin M. Benneker, Shanmuganathan Rajasekaran, Christopher K. Kepler, Alexander R. Vaccaro
Summary: The aim of this study was to develop an injury score for the AO Spine Subaxial Cervical Spine Injury Classification System in order to develop a surgical algorithm. By numerically grading each variable within the classification system for severity, the Subaxial Cervical AO Spine Injury Score was developed.
GLOBAL SPINE JOURNAL
(2022)
Article
Critical Care Medicine
Sophie Stukas, Jasmine Gill, Jennifer Cooper, Lise Belanger, Leanna Ritchie, Angela Tsang, Kevin Dong, Femke Streijger, John Street, Scott Paquette, Tamir Ailon, Nicolas Dea, Raphaele Charest-Morin, Charles G. Fisher, Sanjay Dhall, Jean-Marc Mac-Thiong, Jefferson R. Wilson, Christopher Bailey, Sean Christie, Marcel F. Dvorak, Cheryl Wellington, Brian K. Kwon
Summary: The study found that CSF UCH-L1 levels were significantly elevated in acute SCI patients, could distinguish between different AIS grades at 24 hours post-injury, and predict who would remain motor complete at 6 months post-injury. However, serum UCH-L1 levels were not informative about injury severity or outcome.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Jan Rosner, Michael Negraeff, Lise M. Belanger, Angela Tsang, Leanna Ritchie, Jean-Marc Mac-Thiong, Sean Christie, Jefferson R. Wilson, Sanjay Dhall, Raphaele Charest-Morin, John Street, Tamir Ailon, Scott Paquette, Nicolas Dea, Charles G. Fisher, Marcel F. Dvorak, Nanna B. Finnerup, Brian K. Kwon, John L. K. Kramer
Summary: There is a lack of information about neuropathic pain in the early stages of spinal cord injury. This study used the DN4 questionnaire to assess neuropathic pain in patients within the first 5 days of injury and at follow-up times up to 12 months. The results showed that both at- and below-level neuropathic pain were reported in the early stages, and late presenting neuropathic pain had different characteristics compared to hyperacute pain. These findings are important for clinical trial design and understanding the mechanisms of neuropathic pain after spinal cord injury.
Article
Clinical Neurology
Nader Fallah, Vanessa K. Noonan, Zeina Waheed, Carly S. Rivers, Tova Plashkes, Manekta Bedi, Mahyar Etminan, Nancy P. Thorogood, Tamir Ailon, Elaine Chan, Nicolas Dea, Charles Fisher, Raphaele Charest-Morin, Scott Paquette, SoEyun Park, John T. Street, Brian K. Kwon, Marcel F. Dvorak
Summary: This study developed and validated a prognostic tool called SCIRS for predicting mortality following tSCI. By using machine learning techniques on patient-level data, the study found that SCIRS outperformed the ISS in predicting in-hospital and 1-year mortality.
Article
Clinical Neurology
Dandurand Charlotte, N. Hindi Mathew, Ailon Tamir, Boyd Michael, Charest-Morin Raphaele, Dea Nicolas, Dvorak Marcel, Fisher Charles, K. Kwon Brian, Paquette Scott, Street John
Summary: This study aimed to assess trends in length of hospital stay (LOS) at a high-volume quaternary care spine center. The results showed that LOS has not changed overall, but has increased for patients with degenerative pathology. Factors such as age and diagnostic category were found to be associated with LOS and adverse events.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Brian A. Karamian, Gregory D. Schroeder, Mark J. Lambrechts, Jose A. Canseco, Emiliano N. Vialle, Shanmuganathan Rajasekaran, Lorin M. Benneker, Marcel R. Dvorak, Frank Kandziora, Cumhur Oner, Klaus Schnake, Christopher K. Kepler, Alexander R. Vaccaro
Summary: This study aimed to explore the influence of geographic region on the AO Spine Sacral Classification System. The results showed that both fracture morphology and subtype classification had substantial reliability across all geographic regions.
GLOBAL SPINE JOURNAL
(2023)
Article
Rehabilitation
James A. G. Crispo, Lisa J. W. Liu, Vanessa K. Noonan, Nancy P. Thorogood, Brian K. Kwon, Marcel F. Dvorak, Dylan Thibault, Allison Willis, Jacquelyn J. Cragg
Summary: This study examined tSCI hospitalizations among children in the United States and found that older, male, and Black children were disproportionately affected by tSCI. Hospitalizations involving Black children were more likely to be caused by firearm incidents or assault compared to hospitalizations of White children.
TOPICS IN SPINAL CORD INJURY REHABILITATION
(2022)
Article
Nanoscience & Nanotechnology
Azimatu Fangnon, Marc Dvorak, Ville Havu, Milica Todorovic, Jingrui Li, Patrick Rinke
Summary: The protection of halide perovskites is crucial for the performance and stability of optoelectronic technologies. This study investigates the effectiveness of ZnO, SrZrO3, and ZrO2 as protective coatings for CsPbI3 perovskite. The atomic structure and level alignment at the coating-substrate interfaces are analyzed using density functional theory. The results suggest that ZnO and SrZrO3 act as insulators, while ZrO2 could potentially be used as an electron transport layer.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Milos Dvorak, Manuel Miro, Pavel Kuban
Summary: A hyphenated analytical platform integrating sequential injection (SI) and capillary electrophoresis (CE) is proposed for fully automated analyses of dried blood spots (DBSs). The platform demonstrates high precision, flexibility, and applicability.
ANALYTICAL CHEMISTRY
(2022)
Article
Clinical Neurology
Cameron M. Gee, Angela Tsang, Lise M. Belanger, Leanna Ritchie, Tamir Ailon, Scott Paquette, Raphaele Charest-Morin, Nicolas Dea, John Street, Charles G. Fisher, Marcel F. Dvorak, Brian K. Kwon
Summary: This study examined the feasibility of meeting clinical guidelines for hemodynamic management in acute spinal cord injury patients. The findings suggest that maintaining mean arterial pressure within the recommended range is challenging due to minute-to-minute fluctuations and variability.
Article
Clinical Neurology
S. Mohammed Karim, Charles Fisher, Andrew Glennie, Raja Rampersaud, John Street, Marcel Dvorak, Scott Paquette, Brian K. Kwon, Raphaele Charest-Morin, Tamir Ailon, Neil Manson, Edward Abraham, Ken Thomas, Jennifer Urquhart, Christopher S. Bailey
Summary: The aim of this study was to evaluate the correlation between sagittal and spinopelvic alignment and preoperative patient-reported outcomes (PROs) in degenerative lumbar spondylolisthesis (DLS) with spinal stenosis. The study found that sagittal and spinopelvic malalignment do not appear to significantly influence baseline PROs in patients with DLS.
Article
Clinical Neurology
Mark J. Lambrechts, Gregory D. Schroeder, Brian A. Karamian, Jose A. Canseco, Cumhur Oner, Emiliano Vialle, Shanmuganathan Rajasekaran, Olesja Hazenbiller, Marcel R. Dvorak, Lorin M. Benneker, Frank Kandziora, Klaus Schnake, Christopher K. Kepler, Alexander R. Vaccaro
Summary: With optimized webinar-based validation techniques, the AO Spine Subaxial Injury Classification System demonstrated significant improvements in interobserver reliability and intraobserver reproducibility in 2020 compared to 2018. Stringent fracture classification methodology is crucial for obtaining accurate classification results.
GLOBAL SPINE JOURNAL
(2022)