Review
Cell Biology
Daniel Z. Radecki, Jayshree Samanta
Summary: Oligodendrogenesis in the adult mammalian brain varies in different regions, with the subventricular zone and the subgranular zone being the primary regions of adult neurogenesis.
Review
Neurosciences
Myriam Cayre, Marie Falque, Oceane Mercier, Karine Magalon, Pascale Durbec
Summary: It is possible for brain repair to occur through myelin regeneration, which involves various cell populations including oligodendrocyte progenitor cells. Factors such as aging, chronic inflammation, and extracellular matrix protein production can limit endogenous repair. Understanding the cells and mechanisms involved in myelin regeneration is crucial for developing new therapeutic strategies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Lucie Janeckova, Tomas Knotek, Jan Kriska, Zuzana Hermanova, Denisa Kirdajova, Jan Kubovciak, Linda Berkova, Jana Tureckova, Sara Camacho Garcia, Katerina Galuskova, Michal Kolar, Miroslava Anderova, Vladimir Korinek
Summary: In this study, the properties and functions of NG2 glia in the ischemic brain were investigated using transgenic mice and single-cell RNA sequencing. The findings suggest the potential development of neuron-like cells arising from NG2 glia in the ischemic tissue, providing insights into the plasticity of NG2 glia and their capacity for neurogenesis after stroke.
Article
Multidisciplinary Sciences
Xiaoqing Zhu, Yicheng Guo, Chu Chu, Dahai Liu, Kui Duan, Yu Yin, Chenyang Si, Yu Kang, Junjun Yao, Xuewei Du, Junliang Li, Shumei Zhao, Zongyong Ai, Qingyuan Zhu, Weizhi Ji, Yuyu Niu, Tianqing Li
Summary: This study found that BRN2 is a conserved gene that plays a key role in primate brain development. Through gene knockout experiments in cynomolgus monkeys, it was found that the absence of BRN2 leads to embryonic death before midgestation and has negative effects on brain development. Further analysis revealed that BRN2 is responsible for controlling the specification and differentiation of ganglionic eminences. Additionally, the study also found that BRN2 has a similar function in retinal ganglion cells of cynomolgus monkeys and humans.
Article
Biology
Kotaro Sekine, Masahiro Onoguchi, Michiaki Hamada
Summary: A single-cell level analysis of public data from scATAC-seq reveals the importance of transposable element-derived cis-elements in specific cell types for gene regulatory networks. DNA elements derived from TEs, MER130 and MamRep434, are found to function as transcription factor-binding sites in glutamatergic neuronal progenitors. The amplification of MER130- and MamRep434-derived cis-elements occurred in the ancestors of Amniota and Eutheria, respectively, suggesting their contribution to different functions or morphologies in the brain.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Megan E. Rowland, Yan Jiang, Sarfraz Shafiq, Alireza Ghahramani, Miguel A. Pena-Ortiz, Vanessa Dumeaux, Nathalie G. Berube
Summary: The ATRX gene regulates myelination in mice by modulating systemic thyroxine levels and supporting oligodendrocyte progenitor differentiation. These findings help explain white matter pathogenesis observed in ATR-X syndrome patients.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
A. D. Rivera, F. Pieropan, G. Williams, F. Calzolari, A. M. Butt, K. Azim
Summary: This study highlights the importance of drug repurposing in promoting oligodendrocyte regeneration and myelin repair, and identifies compounds with concentration-dependent effects on oligodendrocytes using a combination of systems biology and neurobiological approaches. The research demonstrates the bipartite effect of LY294002 on oligodendrocytes, indicating the need for careful consideration of drug concentrations in therapeutic strategies for neurodegenerative disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ziyu Lu, Melissa Zhang, Jasper Lee, Andras Sziraki, Sonya Anderson, Zehao Zhang, Zihan Xu, Weirong Jiang, Shaoyu Ge, Peter T. Nelson, Wei Zhou, Junyue Cao
Summary: Progenitor cells in the aged brain play a critical role in maintaining organismal homeostasis, but their diversity and dynamics have been overlooked. A new single-cell genomic method called TrackerSci was introduced to characterize the transcriptome and chromatin landscape of proliferating progenitor cells in vivo. The study revealed diverse progenitor cell types in the brain and identified aging-associated shifts in cell-type-specific proliferation and differentiation. Conserved genetic signatures across species were also discovered in the progenitor cells of the aged human brain, along with region-specific cellular dynamics.
Review
Neurosciences
Riccardo Bocchi, Giacomo Masserdotti, Magdalena Goetz
Summary: A successful experiment conducted 20 years ago opened up the field of neuronal reprogramming, which has since made significant progress. These studies are not only important for clinical applications, but also provide fundamental insights into the mechanisms of cell conversion into neurons and the maintenance of neuronal identity.
Article
Neurosciences
Stanley F. Bazarek, Mentor Thaqi, Patrick King, Amol R. Mehta, Ronil Patel, Clark A. Briggs, Emily Reisenbigler, Jonathon E. Yousey, Elis A. Miller, Grace E. Stutzmann, Robert A. Marr, Daniel A. Peterson
Summary: Adult rat cortical OPCs can be re-specified to a neuronal lineage both in vitro and in vivo by expressing the transcription factor Ngn2. This results in the expression of neuronal lineage markers and genes, as well as the development of functional pyramidal cortical neurons. The re-specification of OPCs does not require prior injury, indicating the potential for engineering additional neurons in the adult cerebral cortex.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Zhongfu Shen, Yang Lin, Jiajun Yang, David J. Jorg, Yuwei Peng, Xiuli Zhang, Yifan Xu, Luisirene Hernandez, Jian Ma, Benjamin D. Simons, Song-Hai Shi
Summary: This study reveals the precise behavior of radial glial progenitors (RGPs) and the gliogenesis program in the mouse neocortex at single-cell resolution, showing the transition from neurogenesis to gliogenesis and the role of fate-restricted intermediate precursor cells (IPCs) in producing astrocytes and oligodendrocytes. It also highlights the impact of clonal loss of tumor suppressor Neurofibromatosis type 1 in excessive production of glia, especially oligodendrocyte precursor cells, quantitatively delineating the cellular program of neocortical gliogenesis and suggesting the cellular origin of primary brain tumors.
Article
Multidisciplinary Sciences
Satoshi Yoshinaga, Minkyung Shin, Ayako Kitazawa, Kazuhiro Ishii, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-Ichiro Kubo, Kazunori Nakajima
Summary: The study revealed regional differences in neuronal migration profiles in different regions of the mammalian cerebral neocortex, depending on developmental stage. These differences, observed using FlashTag technology, were not well-replicated by thymidine analogs, suggesting a biological significance different from neurogenic gradient. The findings advance understanding of cortical development and demonstrate the utility of FlashTag in studying migration for future neurodevelopmental research.
Review
Clinical Neurology
Luisa Klotz, Jack Antel, Tanja Kuhlmann
Summary: Despite the availability of immunomodulatory treatments for relapsing-remitting multiple sclerosis (MS), successful treatment of the progressive phase of the disease has not yet been achieved due to limited understanding of disease progression mechanisms. The review summarizes current knowledge on mechanisms of remyelination and failure in MS and animal models, highlighting the need to overcome translation barriers in developing remyelination-promoting therapies.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Biochemical Research Methods
Yao Lulu Xing, Jasmine Poh, Bernard H. A. Chuang, Kaveh Moradi, Stanislaw Mitew, William D. Richardson, Trevor J. Kilpatrick, Yasuyuki Osanai, Tobias D. Merson
Summary: Approaches to investigate adult oligodendrocyte progenitor cells (OPCs) have limitations, but a pharmacogenetic approach for conditional OPC ablation eliminates the majority of OPCs throughout the brain. The depletion of OPCs induces V-SVZ-derived NPCs to generate a large number of proliferating and migrating PDGFRA+NG2+ cells. This approach will enhance our knowledge of the function of OPCs and oligodendrogenic NPCs in health and disease.
CELL REPORTS METHODS
(2023)
Article
Cell & Tissue Engineering
Dina A. Finkel, Ana Malfa, Yanling Liao, Deepti Purohit, Furong Hu, Davud Sulaymankhil, Sai Abhishek Narra, Karen Hussein, Selvakumar Subbian, Mitchell S. Cairo, Govindaiah Vinukonda, Edmund F. La Gamma
Summary: Intraventricular hemorrhage (IVH) is a severe complication of preterm birth that leads to white matter injury and reduced neurogenesis. This study found that injecting unrestricted somatic stem cells (USSCs) can aid in the recovery of myelination and is associated with changes in growth factor expression.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Xin Zhu, Anshan Shan, Zhi Ma, Wei Xu, Jiajun Wang, Shuli Chou, Baojing Cheng
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Behavioral Sciences
Angela Allen, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2013)
Article
Behavioral Sciences
Taylor Hatchard, Jaimee J. Ting, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Cell Biology
Darren J. Yip, Chelsea P. Corcoran, Matias Alvarez-Saavedra, Adriana DeMaria, Stephen Rennick, Alan J. Mears, Michael A. Rudnicki, Claude Messier, David J. Picketts
DEVELOPMENTAL CELL
(2012)
Article
Neurosciences
Andra M. Smith, Claude Messier
FRONTIERS IN HUMAN NEUROSCIENCE
(2014)
Article
Geriatrics & Gerontology
Delyana Miller, Michle Gagnon, Vincent Talbot, Claude Messier
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2013)
Review
Geriatrics & Gerontology
Delyana I. Miller, Vanessa Taler, Patrick S. R. Davidson, Claude Messier
NEUROBIOLOGY OF AGING
(2012)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier, Lindsey S. MacLeod
Review
Neurosciences
J. J. Boulanger, C. Messier
Article
Health Care Sciences & Services
Delyana Ivanova Miller, France Aube, Vincent Talbot, Michele Gagnon, Claude Messier
TELEMEDICINE AND E-HEALTH
(2014)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Neurosciences
Alexandria Beland-Millar, Masaki Takimoto, Taku Hamada, Claude Messier
Article
Endocrinology & Metabolism
Shirin Haddady, Emma Pinjic, Stephanie L. Lee
Summary: The study compared the performance of Tg obtained at 48 versus 72 hours after rhTSH administration. The results showed that both time points had comparable value in predicting treatment response. This encourages further research on new protocols for obtaining rhTSH-Tg.
ENDOCRINE PRACTICE
(2021)
Article
Behavioral Sciences
Jenna J. Boulanger, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Psychology, Educational
Delyana I. Miller, Patrick S. R. Davidson, Dwayne Schindler, Claude Messier
JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
(2013)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.