Article
Biology
Ophelie Helissen, Marc Kermorgant, Sebastien Dejean, Aurelie Mercadie, Sophie Le Gonidec, Rana Zahreddine, Denis Calise, Nathalie Nasr, Celine Gales, Dina N. Arvanitis, Anne Pavy-Le Traon
Summary: The kinetics of cardiovascular adaptation and its regulation by the autonomic nervous system (ANS) remain controversial in both real or simulated microgravity environments for humans or animals. In this study, hindlimb unloading (HU) was used in conscious mice to explore the effects on blood pressure, heart rate, temperature, and locomotor activity. The study found that HU initially induced a decrease in heart rate accompanied by an increase in markers of vagal activity. It also disrupted the day/night rhythmicity of locomotor activity, temperature, and blood pressure.
Article
Horticulture
Rui-Cheng Liu, Yu-E Ding, Qiang-Sheng Wu, Ying-Ning Zou
Summary: The study found that arbuscular mycorrhizal fungus can regulate the circadian clock of trifoliate orange, promoting plant growth and enhancing drought tolerance under drought conditions.
SCIENTIA HORTICULTURAE
(2022)
Article
Medicine, General & Internal
Magdalena Gebska, Bartosz Dalewski, Lukasz Palka, Lukasz Kolodziej, Ewa Sobolewska
Summary: This study analyzed the importance of chronotype profile for stress level, depression and TMD occurrence in young adults with type D personalities. The results showed that evening chronotypes and type D personalities were associated with higher stress levels, more frequent depression, and TMD symptoms. Female gender and mild to moderate depression were also found to have an impact on the occurrence of type D personalities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Lisa A. Gottlieb, Karin Larsen, Ganesh Halade, Martin E. Young, Morten B. Thomsen
Summary: Mice with cardiomyocyte-specific disruption of the molecular clock genes have lower heart rate and prolonged ventricular repolarization. The QT interval shows diurnal and circadian rhythms independent of heart rate, with increased arrhythmia vulnerability when the cardiac clock is disrupted.
Article
Behavioral Sciences
Max de Leeuw, Sanne I. Verhoeve, Nic J. A. van der Wee, Albert M. van Hemert, Erno Vreugdenhil, Claudia P. Coomans
Summary: Circadian rhythms are closely related to depression, and disruption of circadian rhythms may contribute to the development of depression. A better understanding of the connection between disturbed circadian rhythms and the etiology of depression could lead to novel therapeutic and preventative strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Caroline W. Grant, Angelina R. Wilton, Rima Kaddurah-Daouk, Michelle Skime, Joanna Biernacka, Taryn Mayes, Thomas Carmody, Liewei Wang, Konstantinos Lazaridis, Richard Weinshilboum, William V. Bobo, Madhukar H. Trivedi, Paul E. Croarkin, Arjun P. Athreya
Summary: This study used network science approaches to establish a multi-omics signature of antidepressant response and lifetime history of attempted suicide in patients with major depressive disorder. The results showed differences in circadian processes and circulating metabolites between patients with and without a prior suicide attempt, providing insights for pharmacotherapy selection and suicide risk assessment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Joseph D. D. Vondrasek, Shaea A. A. Alkahtani, Abdulrahman A. A. Al-Hudaib, Syed Shahid Habib, Abeer A. A. Al-Masri, Gregory J. J. Grosicki, Andrew A. A. Flatt
Summary: This study aimed to investigate the associations between morning heart rate variability, its diurnal change, and chronotype. The results showed that morning heart rate variability was significantly higher than evening values and was associated with its absolute and relative diurnal changes, but not with chronotype.
Article
Immunology
Ruotong Tian, Yimin Li, Minfeng Shu
Summary: This study investigates the impact of circadian rhythm on tumor heterogeneity and tumor microenvironment (TME) in gliomas. By analyzing transcriptome data and clinical parameters of glioma patients, the researchers construct a CRscore to quantify CR patterns of individual tumors and demonstrate its role in prognostic prediction. The CRscore not only predicts the prognosis of glioma patients but also guides treatment strategy selection. Evaluating the CRscore of an individual tumor enhances the understanding of tumor immune status, improves prognostic accuracy, and suggests more effective treatment options.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tao Yu, Jianguo Zhang, Jingsheng Cao, Quan Cai, Xin Li, Yan Sun, Sinan Li, Yunlong Li, Guanghui Hu, Shiliang Cao, Changhua Liu, Gangqing Wang, Lishan Wang, Yajuan Duan
Summary: Maize responds to cold stress through structural and functional modifications, as well as changes in photosynthesis and energy metabolism. Inbred lines with different cold tolerance potentials exhibit varied physiological and transcriptomic responses. Cold tolerant line B144 protects photosystem II by upregulating D1 proteins, while sensitive line Q319 fails to close its stomata.
Article
Sport Sciences
Nicholas Ravanelli, Ollie Jay
Summary: This study found that the effect of circadian rhythm on core temperature and sweating during 60 minutes of exercise at 23 degrees Celsius and 33 degrees Celsius was the same when exercise intensity was prescribed to elicit comparable rates of metabolic heat production (H-prod), suggesting that scheduling exercise trials at the same time of day for thermoregulatory studies is unnecessary.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Biochemistry & Molecular Biology
Marina Maria Bellet, Claudia Stincardini, Claudio Costantini, Marco Gargaro, Stefania Pieroni, Marilena Castelli, Danilo Piobbico, Paolo Sassone-Corsi, Maria Agnese Della-Fazia, Luigina Romani, Giuseppe Servillo
Summary: The circadian clock regulates fundamental physiological processes and can impact the response to anticancer treatments, but the molecular mechanisms linking circadian rhythms to anticancer actions are still poorly understood, limiting the application of chronotherapy in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Mingjun Cheng, Kuoshu Cui, Mingmin Zheng, Tao Yang, Junjun Zheng, Xiaofeng Li, Xuan Luo, Yang Zhou, Ruizhen Zhang, Donghai Yan, Mingjiu Yao, Muhammad Zafar Iqbal, Qingping Zhou, Ruyu He
Summary: This study provides insights into the molecular mechanisms of H. virescens response to low temperature stress and identifies key regulatory genes involved in specific biological processes. The content of chlorophylls decreased during low temperature stress, and the expression of related differential genes was up-regulated. The circadian pathway plays a crucial role in the response to cold stress.
Review
Plant Sciences
Alena Patnaik, Hemasundar Alavilli, Jnanendra Rath, Kishore C. S. Panigrahi, Madhusmita Panigrahy
Summary: Circadian clock components exhibit structural variations in different plant systems, and functional variations during various abiotic stresses. These variations are crucial for plant fitness and adaptation.
Article
Physics, Multidisciplinary
Yan Xu, Changgui Gu, Jiangsheng Wang, Man Wang, Haiying Wang, Huijie Yang, Yuxuan Song
Summary: Light serves as the crucial external cue for the circadian rhythms of organisms. This study focused on Neurospora and revealed that constant light exposure led to amplitude suppression in wild-type strains and shortened circadian rhythms in vivid strains. The Goodwin model was employed to explain these observations, showing that the degradation rate of the circadian oscillator in Neurospora varied between strains. Higher light intensity resulted in amplitude suppression with a lower degradation rate, while a negative relationship existed between the oscillator period and constant light intensity at a low or moderate degradation rate. Analytical solutions obtained through asymptotic techniques supported the simulation results, shedding light on the mechanisms of light affecting the circadian clock.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Dongwon Baek, Hyun Min Cho, Ye Jin Cha, Byung Jun Jin, Su Hyeon Lee, Mi Suk Park, Hyun Jin Chun, Min Chul Kim
Summary: The calmodulin-binding transcription activators (CAMTAs) play important roles in the regulation of development and stress responses in plants. In this study, we investigated the expression patterns of 15 GmCAMTA genes in response to abiotic stresses in soybean. Our results showed that the GmCAMTA genes were regulated by circadian rhythms and exhibited different expression patterns under salt, drought, and cold stresses. We also found that GmCAMTA2 and GmCAMTA8 function as negative regulators in development and drought stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Christiaan H. Vinkers, Elbert Geuze, Sanne J. H. van Rooij, Mitzy Kennis, Remmelt R. Schur, Danny M. Nispeling, Alicia K. Smith, Caroline M. Nievergelt, Monica Uddin, Bart P. F. Rutten, Eric Vermetten, Marco P. Boks
Summary: This study showed that successful treatment of PTSD is associated with significant changes in DNA methylation of certain genes, such as ZFP57. The longitudinal evidence suggests that ZFP57 methylation plays a role in both the development and successful treatment of deployment-related PTSD.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Clinical
Judith M. C. van Leeuwen, Christiaan H. Vinkers, Matthijs Vink, Rene S. Kahn, Marian Joels, Erno J. Hermans
Summary: The study found that healthy controls showed increased functional connectivity within the SN during acute stress, while unaffected siblings of schizophrenia patients did not exhibit this effect. In the late aftermath of stress, functional connectivity within the SN decreased in both groups, but with significant differences between the two. Furthermore, increased functional connectivity between the ECN and the cerebellum was observed in both groups after stress exposure.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Nini de Boer, Sinan Guloksuz, Caroline van Baal, Leonie Willebrands, Jeroen Deenik, Christiaan H. Vinkers, Inge Winter-van Rossum, Janneke Zinkstok, Ingeborg Wilting, Jasper B. Zantvoord, Frank Backx, Wilma E. Swildens, Marieke Schouw, Jan Bogers, Folkwin Hulshof, Rudolf de Knijff, Peter Duindam, Mike Veereschild, Maarten Bak, Geert Frederix, Lieuwe de Haan, Jim van Os, Wiepke Cahn, Jurjen J. Luykx
Summary: This study aims to evaluate the use of metformin for the treatment of antipsychotic-induced weight gain by comparing metformin with placebo in those receiving treatment as usual. The primary outcome measure is the difference in body weight between the two arms at 26 weeks compared to baseline.
Editorial Material
Neurosciences
Judith R. Homberg, Roger A. H. Adan, Natalia Alenina, Antonis Asiminas, Michael Bader, Tom Beckers, Denovan P. Begg, Arjan Blokland, Marilise E. Burger, Gertjan van Dijk, Ulrich L. M. Eisel, Ype Elgersma, Bernhard Englitz, Antonio Fernandez-Ruiz, Carlos P. Fitzsimons, Anne-Marie van Dam, Peter Gass, Joanes Grandjean, Robbert Havekes, Marloes J. A. G. Henckens, Christiane Herden, Roelof A. Hut, Wendy Jarrett, Kate Jeffrey, Daniela Jezova, Andries Kalsbeek, Maarten Kamermans, Martien J. Kas, Nael Nadif Kasri, Amanda J. Kiliaan, Sharon M. Kolk, Aniko Korosi, S. Mechiel Korte, Tamas Kozicz, Steven A. Kushner, Kirk Leech, Klaus-Peter Leech, Heidi Lesscher, Paul J. Lucassen, Anita Luthi, Liya Ma, Anne S. Mallien, Peter Meerlo, Jorge F. Mejias, Frank J. Meye, Anna S. Mitchell, Joram D. Mul, Umberto Olcese, Azahara Oliva Gonzalez, Jocelien D. A. Oliver, Massimo Pasqualetti, CyrielM. A. Pennartz, Piotr Popik, Jos Prickaerts, Liset M. de la Prida, Sidarta Ribeiro, Benn Roozendaal, Janine I. Rossato, Ali-Akbar Salari, Regien G. Schoemaker, August B. Smit, Tomonori Takeuchi, Rixt van der Veen, Marten P. Smidt, Vladyslav V. Vyazovskiy, Maximilian Wiesmann, Corette J. Wierenga, Bella Williams, Ingo Willuhn, Markus Woehr, Monique Wolvekamp, Eddy A. van der Zee, Lisa Genzel, Louk J. M. J. Vanderschuren
Summary: Policymakers are working towards promoting animal-free alternatives in scientific research and have implemented strict regulations for animal research. However, in the field of neuroscience research, it is argued that the use of animals should not be compromised until viable and translational alternatives are available and proven to be valuable.
Article
Psychology, Clinical
Marieke J. H. Begemann, Maya J. L. Schutte, Edwin van Dellen, Lucija Abramovic, Marco P. Boks, Neeltje E. M. van Haren, Rene C. W. Mandl, Christiaan H. Vinkers, Marc M. Bohlken, Iris E. C. Sommer
Summary: This study investigated the relationship between childhood trauma severity and gray matter volume. The findings suggest that childhood trauma is associated with reduced gray matter in the frontal lobe, regardless of psychiatric diagnoses. These results indicate that childhood trauma contributes significantly to neurobiological changes observed in various psychiatric disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Mirko Manchia, Anouk W. Gathier, Hale Yapici-Eser, Mathias Schmidt, Dominique de Quervain, Therese van Amelsvoort, Jonathan Bisson, John F. Cryan, Oliver D. Howes, Luisa Pinto, Nic J. Van der Wee, Katharina Domschke, Igor Branchi, Christiaan H. Vinkers
Summary: The global public health crisis caused by COVID-19 has had a lasting impact on mental health, with most individuals showing surprising resilience and quick recovery from the pandemic measures. However, vulnerable groups that have been severely impacted by the pandemic still exist, highlighting the need for more comprehensive and integrative assessments of resilience, as well as personalized help and interventions tailored to specific needs for vulnerable groups in future pandemics.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Michelle Lancee, Marleen Schuring, Joeri K. Tijdink, An-Wen Chan, Christiaan H. Vinkers, Jurjen J. Luykx
Summary: The study found discrepancies between trial registrations and publications in research investigating medication for depressive, bipolar, and psychotic disorders, especially in non-industry funded trials.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2022)
Article
Medicine, General & Internal
Anne-Sophie C. A. M. Koning, Djaina D. Satoer, Christiaan H. Vinkers, Amir H. Zamanipoor Najafabadi, Nienke R. Biermasz, Rishi D. S. Nandoe Tewarie, Wouter A. Moojen, Elisabeth F. C. van Rossum, Clemens M. F. Dirven, Alberto M. Pereira, Wouter R. van Furth, Onno C. Meijer
Summary: The study aims to reduce the neuropsychiatric adverse effects of dexamethasone treatment by reactivating the mineralocorticoid receptor using cortisol. It is a double-blind placebo-controlled trial evaluating patients' Brief Psychiatric Rating Scale scores postoperatively.
Article
Biochemistry & Molecular Biology
Willem M. Otte, Christiaan H. Vinkers, Philippe C. Habets, David G. P. van IJzendoorn, Joeri K. Tijdink
Summary: The power of language to shape the interpretation of biomedical results is significant, and misreporting and misinterpretation are pressing issues in randomized controlled trials (RCTs). A quantitative analysis of 567,758 English full texts of RCTs recorded in PubMed between 1990 and 2020 was conducted, revealing the prevalence of phrases describing results that approach but do not cross the threshold of statistical significance. The study highlights the need for responsible interpretation of RCT results, focusing on clinical relevance rather than formal statistical significance thresholds.
Article
Psychiatry
Heidi Taipale, Johannes Schneider-Thoma, Justo Pinzon-Espinosa, Joaquim Radua, Orestis Efthimiou, Christiaan H. Vinkers, Ellenor Mittendorfer-Rutz, Narcis Cardoner, Luis Pintor, Antti Tanskanen, Anneka Tomlinson, Paolo Fusar-Poli, Andrea Cipriani, Eduard Vieta, Stefan Leucht, Jari Tiihonen, Jurjen J. Luykx
Summary: Most evidence about the efficacy and safety of antipsychotics in schizophrenia spectrum disorders comes from randomized clinical trials (RCTs), which only represent a small portion of real-world patients. This study quantified the proportion of ineligible patients with schizophrenia spectrum disorders for RCTs and explored the differences in clinical outcomes between eligible and ineligible individuals. The findings showed that underrepresented patients had slightly higher risks of admission due to psychosis while receiving maintenance treatment than RCT-eligible patients.
Article
Neurosciences
Adam X. Maihofer, Karmel W. Choi, Jonathan R. Coleman, Nikolaos P. Daskalakis, Christy A. Denckla, Elizabeth Ketema, Rajendra A. Morey, Renato Polimanti, Andrew Ratanatharathorn, Katy Torres, Aliza P. Wingo, Clement C. Zai, Allison E. Aiello, Lynn M. Almli, Ananda B. Amstadter, Soren B. Andersen, Ole A. Andreassen, Paul A. Arbisi, Allison E. Ashley-Koch, S. Bryn Austin, Esmina Avdibegovic, Anders D. Borglum, Dragan Babic, Marie Baekvad-Hansen, Dewleen G. Baker, Jean C. Beckham, Laura J. Bierut, Jonathan Bisson, Marco P. Boks, Elizabeth A. Bolger, Bekh Bradley, Meghan Brashear, Gerome Breen, Richard A. Bryant, Angela C. Bustamante, Jonas Bybjerg-Grauholm, Joseph R. Calabrese, Jose M. Caldas-de-Almeida, Chia-Yen Chen, Anders M. Dale, Shareefa Dalvie, Jurgen Deckert, Douglas L. Delahanty, Michelle F. Dennis, Seth G. Disner, Katharina Domschke, Laramie E. Duncan, Alma Dzubur Kulenovic, Christopher R. Erbes, Alexandra Evans, Lindsay A. Farrer, Norah C. Feeny, Janine D. Flory, David Forbes, Carol E. Franz, Sandro Galea, Melanie E. Garrett, Aarti Gautam, Bizu Gelaye, Joel Gelernter, Elbert Geuze, Charles F. Gillespie, Aferdita Goci, Scott D. Gordon, Guia Guffanti, Rasha Hammamieh, Michael A. Hauser, Andrew C. Heath, Sian M. J. Hemmings, David Michael Hougaard, Miro Jakovljevic, Marti Jett, Eric Otto Johnson, Ian Jones, Tanja Jovanovic, Xue-Jun Qin, Karen-Inge Karstoft, Milissa L. Kaufman, Ronald C. Kessler, Alaptagin Khan, Nathan A. Kimbrel, Anthony P. King, Nastassja Koen, Henry R. Kranzler, William S. Kremen, Bruce R. Lawford, Lauren A. M. Lebois, Catrin Lewis, Israel Liberzon, Sarah D. Linnstaedt, Mark W. Logue, Adriana Lori, Bozo Lugonja, Jurjen J. Luykx, Michael J. Lyons, Jessica L. Maples-Keller, Charles Marmar, Nicholas G. Martin, Douglas Maurer, Matig R. Mavissakalian, Alexander McFarlane, Regina E. McGlinchey, Katie A. McLaughlin, Samuel A. McLean, Divya Mehta, Rebecca Mellor, Vasiliki Michopoulos, William Milberg, Mark W. Miller, Charles Phillip Morris, Ole Mors, Preben B. Mortensen, Elliot C. Nelson, Merete Nordentoft, Sonya B. Norman, Meaghan O'Donnell, Holly K. Orcutt, Matthew S. Panizzon, Edward S. Peters, Alan L. Peterson, Matthew Peverill, Robert H. Pietrzak, Melissa A. Polusny, John P. Rice, Victoria B. Risbrough, Andrea L. Roberts, Alex O. Rothbaum, Barbara O. Rothbaum, Peter Roy-Byrne, Kenneth J. Ruggiero, Ariane Rung, Bart P. F. Rutten, Nancy L. Saccone, Sixto E. Sanchez, Dick Schijven, Soraya Seedat, Antonia Seligowski, Julia S. Seng, Christina M. Sheerin, Derrick Silove, Alicia K. Smith, Jordan W. Smoller, Scott R. Sponheim, Dan J. Stein, Jennifer S. Stevens, Martin H. Teicher, Wesley K. Thompson, Edward Trapido, Monica Uddin, Robert J. Ursano, Leigh Luella van den Heuvel, Miranda Van Hooff, Eric Vermetten, Christiaan H. Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Thomas Werge, Michelle A. Williams, Douglas E. Williamson, Sherry Winternitz, Christiane Wolf, Erika J. Wolf, Rachel Yehuda, Keith A. Young, Ross McD Young, Hongyu Zhao, Lori A. Zoellner, Magali Haas, Heather Lasseter, Allison C. Provost, Rany M. Salem, Jonathan Sebat, Richard A. Shaffer, Tianying Wu, Stephan Ripke, Mark J. Daly, Kerry J. Ressler, Karestan C. Koenen, Murray B. Stein, Caroline M. Nievergelt
Summary: This study combines a quantitative measurement of posttraumatic stress disorder (PTSD) phenotype with lifetime trauma exposure (LTE) information to identify novel risk loci and demonstrate a high genetic overlap between PTSD and LTE.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Tommy A. A. Broeders, Alex A. Bhogal, Lisan M. Morsinkhof, Menno M. Schoonheim, Christian H. Roder, Mirte Edens, Dennis W. J. Klomp, Jannie P. Wijnen, Christiaan H. Vinkers
Summary: Glutamate levels in deep gray matter structures, particularly the caudate and putamen, are lower in patients with psychotic disorders compared to healthy controls. These findings suggest a link between glutamate levels and psychomotor speed.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Review
Clinical Neurology
Caroline M. B. Kwee, Joop M. A. van Gerven, Fleur L. P. Bongaerts, Danielle C. Cath, Gabriel Jacobs, Johanna M. P. Baas, Lucianne Groenink
Summary: This study aimed to predict the therapeutic window for anxiety-reducing effects of CBD in humans based on preclinical models. However, due to the variable concentration-effect relations across species and the lack of consistent linear effect of CBD on anxiety reduction, a straightforward dosing recommendation is currently not possible, raising questions about its broad use as a drug for anxiety.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Review
Neurosciences
Lucianne Groenink, P. Monika Verdouw, Yulong Zhao, Freija ter Heegde, Kimberley E. Wever, Elisabeth Y. Bijlsma
Summary: Fear conditioning is an important aspect in the pathophysiology of anxiety disorders. This study aimed to synthesize the available data on drugs tested in the fear-potentiated startle test to further understand the neurotransmitter systems involved in conditioned fear expression. The results showed that most clinically active anxiolytics can reduce fear and certain drug classes have significant effects on conditioned fear.
PSYCHOPHARMACOLOGY
(2023)
Review
Neurosciences
Elise J. Heesbeen, Elisabeth Y. Bijlsma, P. Monika Verdouw, Caspar van Lissa, Carlijn Hooijmans, Lucianne Groenink
Summary: Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat anxiety disorders, but their effects on fear learning are not well understood.
PSYCHOPHARMACOLOGY
(2023)
