Article
Physiology
Jamie M. O'Driscoll, Claire Boucher, Meliz Vilda, Katrina A. Taylor, Jonathan D. Wiles
Summary: The study investigated the continuous cardiac autonomic and hemodynamic response to an isometric exercise session in a large female population. Results showed that isometric exercise improved hemodynamic cardiovascular responses in females, with cardiac autonomic responses returning to baseline values. Future mechanistic research is needed to explore the acute and chronic effects of isometric exercise in females with different resting blood pressure profiles.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Neurosciences
Yuanyuan Yao, Zeke Barger, Mohammad Saffari Doost, Chak Foon Tso, Dana Darmohray, Daniel Silverman, Danqian Liu, Chenyan Ma, Ali Cetin, Shenqin Yao, Hongkui Zeng, Yang Dan
Summary: Sleep disturbances are closely linked to cardiovascular diseases. Neurons involved in the baroreflex pathway, a mechanism for cardiovascular regulation, also play a role in promoting sleep-wake states.
Article
Biology
Vera Geraldes, Sergio Laranjo, Catarina Nunes, Isabel Rocha
Summary: Hypertension was investigated in this study to understand the role of specific brain regions in regulating blood pressure. The activity of lateral parabrachial nucleus (LPBN), Kolliker-fuse nucleus (KF), and periductal grey matter (PAG) were altered in hypertensive rats using lentiviral vectors. The study revealed the significant role of LPBN in hypertension-related sympathetic activation and the mechanisms activated by LPBN and KF neurons during chemoreceptor activation. These findings provide insights into the contribution of midbrain and pontine regions to neurogenic hypertension and potential avenues for future treatment approaches.
Article
Multidisciplinary Sciences
Monique E. A. M. van Kleef, Karsten Heusser, Andre Diedrich, P. Liam Oey, Jens Tank, Jens Jordan, Peter J. Blankestijn, Bryan Williams, Wilko Spiering
Summary: The study explored the effects of endovascular baroreflex amplification (EVBA) on muscle sympathetic nerve activity (MSNA) and baroreceptor sensitivity (BRS) in patients with resistant hypertension. EVBA did not significantly decrease MSNA or impair baroreflex function in this proof-of-principle study.
Article
Medicine, Research & Experimental
Daniele T. Alves, Luiz Felipe Mendes, Walkyria O. Sampaio, Leda M. C. Coimbra-Campos, Maria Aparecida R. Vieira, Anderson J. Ferreira, Almir S. Martins, Elena Popova, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Robson A. S. Santos, Maria Jose Campagnole-Santos
Summary: The new transgenic rat line TG7371 exhibits a hypotensive phenotype in the cardiovascular phenotype, characterized by widespread vasodilation and decreased peripheral resistance. This phenotype is associated with an increase in ANP levels, as well as an increase in AVP and sympathetic drive.
Article
Neurosciences
Ke-Xin Li, Yan Feng, Xiong-Xiong Fan, Xun Sun, Ying Li, Di Wu, Li Liu, Chang-Peng Cui, Xue Xiong, Hu-Die Li, Meng Zhou, Hai-Lan Ma, Yang Liu, Rong Zhang, Bai-Yan Li
Summary: The study found that under physiological conditions, bradykinin-induced reductions in mean arterial pressure were dose- and estrogen-dependent, with females showing lower estimated EC50. B2R agonist led to more significant and long-lasting MAP reduction compared to B1R activation. However, under hypertensive conditions, males with N-'-Nitro-L-Arginine-methyl ester induced hypertension showed significantly less dramatic MAP reduction compared to females.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Peripheral Vascular Disease
Dylan Pen, Julia Shanks, Carolyn Barrett, Yonis Abukar, Julian F. R. Paton, Rohit Ramchandra
Summary: This study found that activation of the aortic bodies can increase coronary blood flow, mediated by a cholinergic mechanism. In hypertensive animals, activation of the aortic bodies also increased coronary blood flow without significant difference compared to the normotensive group. However, the coronary vasodilation in hypertensive animals was affected by propranolol. These results reveal the important role of the aortic bodies in modulating coronary blood flow and the alteration of their effector mechanism in hypertension.
Article
Physiology
Chao Ye, Fen Zheng, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Summary: Excessive sympathetic activation plays a crucial role in the pathogenesis of hypertension. The study found that the renal stimulation enhances sympathetic activity, contributing to the development of hypertension. The excitation of renal reflex is enhanced in the early stage of hypertension and attenuated in the later stage of hypertension in SHR, indicating the involvement of abnormal ERR in the development of hypertension.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Lu Wang, Yiqian Wu, Zhanjun Jia, Jing Yu, Songming Huang
Summary: PGE2 exerts its effects through four different receptors, influencing the functions of the kidney and blood vessels, and playing a significant role in fluid metabolism and blood pressure homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Willian Costa-Ferreira, Lucas Gomes-de-Souza, Carlos C. Crestani
Summary: The study suggests that angiotensinergic receptors in the MeA play a significant role in the autonomic imbalance induced by RRS, with the MeA AT(1) receptor also influencing baroreflex responses during blood pressure changes. However, the increase in arterial pressure and impairment of baroreflex responses during spontaneous blood pressure variations caused by RRS are independent of MeA angiotensinergic receptors.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Liwei Shen, Xiaoli Yang, Wenmei Lu, Weijie Chen, Xiaofei Ye, Danhong Wu
Summary: Abnormal blood pressure regulation is a common feature of autonomic dysfunction in Parkinson's disease patients. This study found significant differences in circadian blood pressure rhythm between different disease stages and subtypes of PD patients, with reverse dipping being more common in advanced PD patients. 24-hour ambulatory blood pressure monitoring is crucial for evaluating blood pressure alterations in PD patients and clinicians should be vigilant about reverse dipping to prevent serious clinical events.
BRAIN AND BEHAVIOR
(2022)
Editorial Material
Endocrinology & Metabolism
Takuro Washio, Shigehiko Ogoh
Summary: Exercise is beneficial for preventing cognitive dysfunction, but the physiological mechanism(s) of how it improves cognitive function remains unclear, leading to the lack of an established exercise prescription for preventing dementia. However, recent research suggests that individual differences in cardiovascular responses to exercise or its associated physiological factors may be related to exercise-induced changes in cognitive function. Considering individual cardiovascular responses is therefore important when developing exercise prescriptions to prevent cognitive dysfunction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Alec L. E. Butenas, Rie Ishizawa, Korynne S. Rollins, Masaki Mizuno, Steven W. Copp
Summary: Stimulation of mechanically sensitive channels on sensory endings activates mechanoreflex, and capsaicin injection reduces the pressor and renal sympathetic nerve response to mechanoreflex activation in male rats but not female rats.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Julia Chu-Ning Hsu, Shin-ichi Sekizawa, Ryota Tochinai, Masayoshi Kuwahara
Summary: Baroreflex dysfunction involving NTS neurons and mGluR2/3 signaling contributes to hypertension in SHRs. Chronic stimulation of mGluR2/3 in the brainstem can alleviate hypertension development by promoting parasympathetic activity. Modulating mGluR2/3 expression/stimulation in the dorsal medulla oblongata may offer a novel therapeutic approach for hypertension.
Article
Neurosciences
Yanming Tian, Danyang Geng, Yakun Wang, Luo Shi, Hongxiao Yu, Wei He, Yufang Zhu, Shirui Jun, Congrui Fu, Xin Wang, Xiangjian Zhang, Fang Yuan, Sheng Wang
Summary: This study shows that increased CO2-induced respiratory and cardiovascular responses in SHRs are associated with RTN neurons, particularly involving the activity of TASK-2 channels. The inhibition of TASK-2 channel activity by clofilium diminishes the amplified responses, indicating the important role played by RTN neurons in regulating these responses.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Pharmacology & Pharmacy
Carlos Jose Dias, Herikson Araujo Costa, Carlos Alberto Alves Dias-Filho, Andressa Coelho Ferreira, Bruno Rodrigues, Maria Claudia Irigoyen, Antonio Carlos Romao Borges, Vicenilma de Andadre Martins, Flavia Castello Branco Vidal, Rachel Melo Ribeiro, Natalino Salgado Filho, Cristiano T. Mostarda
Summary: The use of carvacrol in spontaneously hypertensive rats (SHR) showed antihypertensive effects and increased expression of MAS receptors in kidney tissue.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paulo Fernandes Costa Jobim, Carla Eliete Iochims dos Santos, Johnny Ferraz Dias, Mitja Kelemen, Primoz Pelicon, Katarina Vogel Mikus, Lorella Pascolo, Alessandra Gianoncelli, Diana Eva Bedolla, Alberto Antonio Rasia-Filho
Summary: This study explores the use of swift ion beam and synchrotron radiation techniques to differentiate cellular layers in the human neocortex based on elemental distributions and areal density patterns. The results reveal higher zinc values in cortical layers II and V, and a decrease in areal density in regions with a higher density of pyramidal neurons in layers III and V.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Danielle da Silva Dias, Camila P. dos Santos, Amanda A. Araujo, Maycon J. Ferreira, Antonio V. Nascimento-Filho, Nathalia Bernardes, Maria Claudia Irigoyen, Katia De Angelis
Editorial Material
Physiology
Alberto A. Rasia-Filho
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Environmental Sciences
Bruna Eibel, Juliana R. Marques, Thiago Dipp, Gustavo Waclawovsky, Rafael A. Marschner, Liliana C. Boll, Renato A. K. Kalil, Alexandre M. Lehnen, Allan R. K. Sales, Maria Claudia Costa Irigoyen
Summary: The study evaluated the effect of early cardiac rehabilitation on the 6-minute walk test and vascular function in patients undergoing coronary artery bypass grafting. The results showed that ventilatory muscle training improved both functional capacity and blood flow in these patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Clinical Neurology
Larissa Ribas Ribeiro, Rafael Bueno Orcy, Daniel Alberto de Sousa Rocha Nogueira, Fernando Santos, Maria Claudia Irigoyen, Maristela Bohlke
CLINICAL AUTONOMIC RESEARCH
(2022)
Article
Peripheral Vascular Disease
Diego Faria, Renata J. Moll-Bernardes, Laura Testa, Camila M. V. Moniz, Erika C. Rodrigues, Amanda G. Rodrigues, Amanda Araujo, Maria J. N. N. Alves, Bruna E. Ono, Joao E. Izaias, Vera M. C. Salemi, Camila P. Jordao, Graziela Amaro-Vicente, Maria U. P. B. Rondon, Katelyn R. Ludwig, Daniel H. Craighead, Matthew J. Rossman, Fernanda M. Consolim-Colombo, Katia De Angelis, Maria C. C. Irigoyen, Douglas R. Seals, Carlos E. Negrao, Allan R. K. Sales
Summary: COVID-19 survivors exhibit sympathetic overdrive, vascular dysfunction, cardiac morpho-functional changes, and reduced exercise capacity compared to controls. Further investigation is needed to determine whether these manifestations are persistent longer-term and their impact on the cardiovascular health of COVID-19 survivors.
Article
Neurosciences
Ketlyn T. Knak Guerra, Josue Renner, Carlos E. Vasquez, Alberto A. Rasia-Filho
Summary: Visualizing nerve cells is crucial for understanding brain structure and function. This study used Golgi data and open-source software to reconstruct 3D images of human neurons, showing dendrites and spines at different angles. These tools provide high-quality images and enhance our understanding of the structure and function of the human brain.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fernando Dos Santos, Joyce B. B. Li, Nathalia Juocys, Rafi Mazor, Laura Beretta, Nicole G. Coufal, Michael T. Y. Lam, Mazen F. Odish, Maria Claudia Irigoyen, Anthony J. O'Donoghue, Federico Aletti, Erik B. Kistler
Summary: This study investigates the patterns of plasma protease activity in COVID-19-induced sepsis with bacterial superinfection, as well as the implications of enhanced proteolysis on major protein systems. The results suggest that elevated proteolysis occurs in COVID-19-induced septic shock with bacterial superinfection, and provide insight into malfunctioning protease-mediated systems.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Physiology
Bruno Nascimento-Carvalho, Adriano Dos-Santos, Nicolas Da Costa-Santos, Sabrina L. Carvalho, Oscar A. de Moraes, Camila P. Santos, Katia De Angelis, Erico C. Caperuto, Maria-Claudia Irigoyen, Katia B. Scapini, Iris C. Sanches
Summary: The objective of this study was to evaluate the effects of food readjustment and/or exercise training on metabolic, hemodynamic, autonomic, and inflammatory parameters in a model of loss of ovarian function with diet-induced obesity. The findings demonstrate that the combination of food readjustment and exercise training is effective in managing cardiometabolic risk.
PHYSIOLOGICAL REPORTS
(2023)
Article
Medicine, Research & Experimental
Fernanda Lais Loro, Riane Martins, Cintia Laura Pereira de Araujo, Lucio Rene Prade, Denis Lima do Rosario, Marcos Cesar da Rocha Seruffo, Italo Adriano Moraes de Freitas, Jeferson Nobre, Cristiano Bonato Both, Pedro Dal Lago
Summary: This project aims to enhance engagement in physical activities to prevent cardiovascular diseases through innovative technologies. The study consists of three phases: sensor development and validation, integration of biofeedback and gamification into an app, and a noninferiority clinical trial.
Article
Endocrinology & Metabolism
Lucas Ribeiro da Silva, Giuseppe Potrick Stefani, Gilson Pires Dorneles, Aline Marcadenti, Pedro Dal Lago
Summary: The aim of this study was to compare the effects of high carbohydrate and high-fat meals on substrate oxidation during an exercise incremental test. Ten untrained male subjects underwent two days of testing, with each day consisting of either a high carbohydrate meal or a high-fat meal. The high-fat meal led to increased fat oxidation and decreased respiratory exchange ratio compared to the high carbohydrate meal during the exercise. However, there were no significant differences in the maximum oxidation point of substrates, oxidation rate over time, and heart rate between the two meals.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Meeting Abstract
Peripheral Vascular Disease
Maycon Ferreira Junior, Gabriel Do Carmo Silva, Nathalia Bernardes, Amanda Aparecida De Araujo, Danielle Da Silva Dias, Maria Claudia Irigoyen, Katia De Angelis
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Maycon Junior Ferreira, Gabriel Do Carmo Silva, Nathalia Bernardes, Amanda Aparecida De Araujo, Danielle Da Silva Dias, Maria Claudia Irigoyen, Katia De Angelis
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Maycon Junior Ferreira, Gabriel Do Carmo Silva, Nathalia Bernardes, Amanda Aparecida De Araujo, Danielle Da Silva Dias, Maria Claudia Irigoyen, Katia De Angelis
JOURNAL OF HYPERTENSION
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.